int-snw-3162

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
chia-screen-data-Fav 2.821 2.37e-15 5.75e-04 3.83e-03
chia-screen-data-Fav-int-snw-3162 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency chia-screen-data-Fav gene score Best subnetwork score Degree Chia-Hits Primary Chia-Hits Secondary
HCFC1 3054 40-2.9253.44971YesYes
MALL 7851 1-2.4442.8213Yes-
LARS 51520 14-2.5743.157105YesYes
PSMD2 5708 47-4.1723.157386YesYes
TADA2B 93624 11-3.0613.08219Yes-
EIF2B2 8892 8-2.4622.96895YesYes
CREB3 10488 1-1.5622.821124--
POU5F1 5460 133-5.1483.538179YesYes
[ HMOX1 ] 3162 1-0.9752.82111--
DDIT3 1649 60-2.8253.504343YesYes
TMEM14B 81853 1-2.8792.8215YesYes

Interactions (10)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HMOX1 3162 CREB3 10488 pp -- int.I2D: MINT
EIF2B2 8892 TADA2B 93624 pp -- int.I2D: BioGrid_Fly, BIND_Fly, FlyLow, IntAct_Fly, MINT_Fly
HCFC1 3054 CREB3 10488 pp -- int.Intact: MI:0915(physical association), MI:0407(direct interaction);
int.I2D: BioGrid, HPRD, IntAct, BCI;
int.Ravasi: -;
int.HPRD: in vitro, in vivo
PSMD2 5708 LARS 51520 pp -- int.I2D: BioGrid_Yeast
HCFC1 3054 POU5F1 5460 pp -- int.I2D: BioGrid_Mouse, IntAct_Mouse
HMOX1 3162 PSMD2 5708 pp -- int.I2D: BioGrid
MALL 7851 CREB3 10488 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, BioGrid, MINT, VidalHuman_core;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
PSMD2 5708 EIF2B2 8892 pp -- int.I2D: IntAct_Yeast
CREB3 10488 TMEM14B 81853 pp -- int.I2D: MINT
DDIT3 1649 CREB3 10488 pp -- int.I2D: BIND

Related GO terms (232)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0019046release from viral latency5.29e-077.63e-0310.357222
GO:0070461SAGA-type complex5.28e-067.62e-029.035225
GO:0042789mRNA transcription from RNA polymerase II promoter4.11e-055.92e-017.6562213
GO:0006986response to unfolded protein6.35e-041.00e+005.7132450
GO:0034976response to endoplasmic reticulum stress6.61e-041.00e+005.6842251
GO:0060795cell fate commitment involved in formation of primary germ layer7.63e-041.00e+0010.357111
GO:2000016negative regulation of determination of dorsal identity7.63e-041.00e+0010.357111
GO:0043305negative regulation of mast cell degranulation7.63e-041.00e+0010.357111
GO:0090308regulation of methylation-dependent chromatin silencing7.63e-041.00e+0010.357111
GO:0090081regulation of heart induction by regulation of canonical Wnt signaling pathway7.63e-041.00e+0010.357111
GO:2000326negative regulation of ligand-dependent nuclear receptor transcription coactivator activity7.63e-041.00e+0010.357111
GO:0060965negative regulation of gene silencing by miRNA7.63e-041.00e+0010.357111
GO:0005829cytosol7.94e-041.00e+001.8797862496
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity8.84e-041.00e+005.4742659
GO:0003700sequence-specific DNA binding transcription factor activity1.37e-031.00e+002.908439699
GO:0019043establishment of viral latency1.52e-031.00e+009.357112
GO:0006788heme oxidation1.52e-031.00e+009.357122
GO:0006429leucyl-tRNA aminoacylation1.52e-031.00e+009.357112
GO:0032764negative regulation of mast cell cytokine production1.52e-031.00e+009.357112
GO:0002246wound healing involved in inflammatory response1.52e-031.00e+009.357112
GO:0014806smooth muscle hyperplasia1.52e-031.00e+009.357112
GO:0009786regulation of asymmetric cell division1.52e-031.00e+009.357112
GO:0004823leucine-tRNA ligase activity1.52e-031.00e+009.357112
GO:0004392heme oxygenase (decyclizing) activity1.52e-031.00e+009.357122
GO:0044324regulation of transcription involved in anterior/posterior axis specification1.52e-031.00e+009.357112
GO:1990440positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress1.52e-031.00e+009.357112
GO:0003682chromatin binding1.66e-031.00e+003.588319327
GO:0045944positive regulation of transcription from RNA polymerase II promoter2.15e-031.00e+002.733441789
GO:0090045positive regulation of deacetylase activity2.29e-031.00e+008.772113
GO:0006990positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response2.29e-031.00e+008.772123
GO:0031670cellular response to nutrient2.29e-031.00e+008.772113
GO:0060913cardiac cell fate determination2.29e-031.00e+008.772113
GO:0003130BMP signaling pathway involved in heart induction2.29e-031.00e+008.772113
GO:0034395regulation of transcription from RNA polymerase II promoter in response to iron2.29e-031.00e+008.772113
GO:0051716cellular response to stimulus3.05e-031.00e+008.357144
GO:0046523S-methyl-5-thioribose-1-phosphate isomerase activity3.05e-031.00e+008.357134
GO:0006366transcription from RNA polymerase II promoter3.38e-031.00e+003.231330419
GO:0006325chromatin organization3.48e-031.00e+004.474212118
GO:0001714endodermal cell fate specification3.81e-031.00e+008.035115
GO:0043620regulation of DNA-templated transcription in response to stress3.81e-031.00e+008.035115
GO:0004630phospholipase D activity3.81e-031.00e+008.035115
GO:0002686negative regulation of leukocyte migration3.81e-031.00e+008.035115
GO:0043619regulation of transcription from RNA polymerase II promoter in response to oxidative stress3.81e-031.00e+008.035115
GO:0042167heme catabolic process4.57e-031.00e+007.772126
GO:0031726CCR1 chemokine receptor binding4.57e-031.00e+007.772116
GO:0005851eukaryotic translation initiation factor 2B complex4.57e-031.00e+007.772146
GO:0010656negative regulation of muscle cell apoptotic process4.57e-031.00e+007.772116
GO:0006355regulation of transcription, DNA-templated5.05e-031.00e+002.395443997
GO:0071243cellular response to arsenic-containing substance5.33e-031.00e+007.549117
GO:0034383low-density lipoprotein particle clearance5.33e-031.00e+007.549117
GO:0034101erythrocyte homeostasis5.33e-031.00e+007.549117
GO:0002161aminoacyl-tRNA editing activity5.33e-031.00e+007.549127
GO:0001955blood vessel maturation6.09e-031.00e+007.357118
GO:0008140cAMP response element binding protein binding6.09e-031.00e+007.357118
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0043254regulation of protein complex assembly6.09e-031.00e+007.357118
GO:0005654nucleoplasm6.78e-031.00e+002.2774641082
GO:0043995histone acetyltransferase activity (H4-K5 specific)6.85e-031.00e+007.187159
GO:0046972histone acetyltransferase activity (H4-K16 specific)6.85e-031.00e+007.187159
GO:0019509L-methionine biosynthetic process from methylthioadenosine6.85e-031.00e+007.187139
GO:0048188Set1C/COMPASS complex6.85e-031.00e+007.187149
GO:0006983ER overload response6.85e-031.00e+007.187119
GO:0006450regulation of translational fidelity6.85e-031.00e+007.187129
GO:0045080positive regulation of chemokine biosynthetic process6.85e-031.00e+007.187119
GO:0043996histone acetyltransferase activity (H4-K8 specific)6.85e-031.00e+007.187159
GO:0044212transcription regulatory region DNA binding6.92e-031.00e+003.964217168
GO:0035413positive regulation of catenin import into nucleus7.60e-031.00e+007.0351210
GO:0000982RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity7.60e-031.00e+007.0351110
GO:0090026positive regulation of monocyte chemotaxis8.36e-031.00e+006.8971111
GO:0045662negative regulation of myoblast differentiation8.36e-031.00e+006.8971311
GO:0060391positive regulation of SMAD protein import into nucleus8.36e-031.00e+006.8971411
GO:0005838proteasome regulatory particle9.12e-031.00e+006.7721112
GO:0001935endothelial cell proliferation9.12e-031.00e+006.7721112
GO:0035198miRNA binding9.12e-031.00e+006.7721112
GO:0030914STAGA complex9.87e-031.00e+006.6561313
GO:0042994cytoplasmic sequestering of transcription factor9.87e-031.00e+006.6561113
GO:0030234enzyme regulator activity9.87e-031.00e+006.6561213
GO:0071276cellular response to cadmium ion9.87e-031.00e+006.6561113
GO:0003677DNA binding1.03e-021.00e+002.1064491218
GO:0050930induction of positive chemotaxis1.06e-021.00e+006.5491114
GO:0043981histone H4-K5 acetylation1.14e-021.00e+006.4501515
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex1.14e-021.00e+006.4501315
GO:0001824blastocyst development1.14e-021.00e+006.4501215
GO:0043982histone H4-K8 acetylation1.14e-021.00e+006.4501515
GO:0002230positive regulation of defense response to virus by host1.14e-021.00e+006.4501115
GO:0042176regulation of protein catabolic process1.21e-021.00e+006.3571216
GO:0010467gene expression1.24e-021.00e+002.556345669
GO:0022624proteasome accessory complex1.29e-021.00e+006.2691117
GO:0006778porphyrin-containing compound metabolic process1.36e-021.00e+006.1871218
GO:0008134transcription factor binding1.40e-021.00e+003.438218242
GO:0043025neuronal cell body1.43e-021.00e+003.42029245
GO:0043984histone H4-K16 acetylation1.44e-021.00e+006.1091519
GO:0051090regulation of sequence-specific DNA binding transcription factor activity1.52e-021.00e+006.0351320
GO:0014003oligodendrocyte development1.52e-021.00e+006.0351520
GO:0032757positive regulation of interleukin-8 production1.52e-021.00e+006.0351120
GO:0055072iron ion homeostasis1.59e-021.00e+005.9641221
GO:0000123histone acetyltransferase complex1.59e-021.00e+005.9641621
GO:0045787positive regulation of cell cycle1.67e-021.00e+005.8971222
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.67e-021.00e+005.8971422
GO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors1.74e-021.00e+005.8331123
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress1.74e-021.00e+005.8331123
GO:0045765regulation of angiogenesis1.82e-021.00e+005.7721224
GO:0035094response to nicotine1.89e-021.00e+005.7131225
GO:0043392negative regulation of DNA binding1.97e-021.00e+005.6561426
GO:0045909positive regulation of vasodilation1.97e-021.00e+005.6561126
GO:0051209release of sequestered calcium ion into cytosol1.97e-021.00e+005.6561126
GO:0051928positive regulation of calcium ion transport1.97e-021.00e+005.6561126
GO:0071339MLL1 complex2.04e-021.00e+005.6021627
GO:0048662negative regulation of smooth muscle cell proliferation2.12e-021.00e+005.5491228
GO:0008219cell death2.12e-021.00e+005.5491228
GO:0016604nuclear body2.34e-021.00e+005.4021331
GO:0042594response to starvation2.34e-021.00e+005.4021431
GO:0042552myelination2.64e-021.00e+005.2271435
GO:0007588excretion2.64e-021.00e+005.2271235
GO:0006446regulation of translational initiation2.71e-021.00e+005.1871436
GO:0043565sequence-specific DNA binding2.74e-021.00e+002.922211346
GO:0001541ovarian follicle development2.79e-021.00e+005.1471237
GO:0042542response to hydrogen peroxide2.94e-021.00e+005.0711139
GO:0045786negative regulation of cell cycle2.94e-021.00e+005.0711339
GO:0000139Golgi membrane2.96e-021.00e+002.86127361
GO:0009408response to heat3.01e-021.00e+005.0351640
GO:0035019somatic stem cell maintenance3.01e-021.00e+005.0351640
GO:0016020membrane3.09e-021.00e+001.6424461681
GO:0030136clathrin-coated vesicle3.16e-021.00e+004.9641542
GO:0006418tRNA aminoacylation for protein translation3.16e-021.00e+004.9641342
GO:0043434response to peptide hormone3.38e-021.00e+004.8651545
GO:0043525positive regulation of neuron apoptotic process3.45e-021.00e+004.8331446
GO:0042632cholesterol homeostasis3.60e-021.00e+004.7721148
GO:0008630intrinsic apoptotic signaling pathway in response to DNA damage3.68e-021.00e+004.7421249
GO:0048661positive regulation of smooth muscle cell proliferation3.68e-021.00e+004.7421149
GO:0003743translation initiation factor activity3.68e-021.00e+004.7421749
GO:0006521regulation of cellular amino acid metabolic process3.75e-021.00e+004.7131150
GO:0045454cell redox homeostasis3.82e-021.00e+004.6841151
GO:0006879cellular iron ion homeostasis3.82e-021.00e+004.6841351
GO:0005515protein binding3.84e-021.00e+000.80081986024
GO:0009611response to wounding3.90e-021.00e+004.6561552
GO:0030176integral component of endoplasmic reticulum membrane3.97e-021.00e+004.6291153
GO:0043627response to estrogen4.19e-021.00e+004.5491556
GO:0008217regulation of blood pressure4.26e-021.00e+004.5241157
GO:0000502proteasome complex4.34e-021.00e+004.4991358
GO:0001558regulation of cell growth4.56e-021.00e+004.4261161
GO:0006987activation of signaling protein activity involved in unfolded protein response4.56e-021.00e+004.4261261
GO:0005901caveola4.63e-021.00e+004.4021162
GO:0009749response to glucose4.78e-021.00e+004.3571764
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.78e-021.00e+004.3571164
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.85e-021.00e+004.3341265
GO:0044267cellular protein metabolic process4.87e-021.00e+002.468220474
GO:0045893positive regulation of transcription, DNA-templated4.95e-021.00e+002.456224478
GO:0010468regulation of gene expression5.07e-021.00e+004.2691268
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.21e-021.00e+004.2271270
GO:0005085guanyl-nucleotide exchange factor activity5.29e-021.00e+004.2071571
GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding5.29e-021.00e+004.2071471
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.36e-021.00e+004.1871172
GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity5.50e-021.00e+004.1471474
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.50e-021.00e+004.1471274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281175
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.58e-021.00e+004.1281175
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process5.86e-021.00e+004.0531279
GO:0030968endoplasmic reticulum unfolded protein response5.86e-021.00e+004.0531279
GO:0016032viral process6.03e-021.00e+002.296226534
GO:0009653anatomical structure morphogenesis6.15e-021.00e+003.9821283
GO:0090090negative regulation of canonical Wnt signaling pathway6.37e-021.00e+003.9301886
GO:0006979response to oxidative stress6.44e-021.00e+003.9141687
GO:0005783endoplasmic reticulum6.48e-021.00e+002.238213556
GO:0050821protein stabilization6.51e-021.00e+003.8971388
GO:0045766positive regulation of angiogenesis6.51e-021.00e+003.8971288
GO:0005789endoplasmic reticulum membrane6.77e-021.00e+002.20229570
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331392
GO:0002474antigen processing and presentation of peptide antigen via MHC class I6.80e-021.00e+003.8331192
GO:0005770late endosome6.87e-021.00e+003.8171293
GO:0020037heme binding6.87e-021.00e+003.8171193
GO:0007417central nervous system development7.09e-021.00e+003.7721596
GO:0042803protein homodimerization activity7.30e-021.00e+002.140219595
GO:0006935chemotaxis7.73e-021.00e+003.64213105
GO:0016023cytoplasmic membrane-bounded vesicle7.73e-021.00e+003.64218105
GO:0042127regulation of cell proliferation8.01e-021.00e+003.58814109
GO:0000209protein polyubiquitination8.50e-021.00e+003.49913116
GO:0043524negative regulation of neuron apoptotic process8.57e-021.00e+003.48615117
GO:0046983protein dimerization activity8.64e-021.00e+003.47415118
GO:0007050cell cycle arrest9.06e-021.00e+003.40215124
GO:0030335positive regulation of cell migration9.27e-021.00e+003.36815127
GO:0006413translational initiation9.55e-021.00e+003.32317131
GO:0005634nucleus9.78e-021.00e+000.78761594559
GO:0016055Wnt signaling pathway1.00e-011.00e+003.24814138
GO:0051260protein homooligomerization1.05e-011.00e+003.17713145
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling1.05e-011.00e+003.17714145
GO:0010628positive regulation of gene expression1.06e-011.00e+003.16717146
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription1.07e-011.00e+003.15716147
GO:0000082G1/S transition of mitotic cell cycle1.08e-011.00e+003.13713149
GO:0006974cellular response to DNA damage stimulus1.09e-011.00e+003.11817151
GO:0042981regulation of apoptotic process1.09e-011.00e+003.12814150
GO:0045121membrane raft1.13e-011.00e+003.07113156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.990112165
GO:0034641cellular nitrogen compound metabolic process1.23e-011.00e+002.93912171
GO:0007049cell cycle1.25e-011.00e+002.91416174
GO:0005667transcription factor complex1.26e-011.00e+002.905117175
GO:0031625ubiquitin protein ligase binding1.28e-011.00e+002.88115178
GO:0003714transcription corepressor activity1.28e-011.00e+002.881111178
GO:0043547positive regulation of GTPase activity1.29e-011.00e+002.86519180
GO:0005737cytoplasm1.33e-011.00e+000.79951243767
GO:0001525angiogenesis1.36e-011.00e+002.77917191
GO:0004871signal transducer activity1.48e-011.00e+002.65614208
GO:0016071mRNA metabolic process1.58e-011.00e+002.55618223
GO:0006412translation1.62e-011.00e+002.51118230
GO:0003713transcription coactivator activity1.67e-011.00e+002.468124237
GO:0016070RNA metabolic process1.73e-011.00e+002.40818247
GO:0016021integral component of membrane1.84e-011.00e+000.9893171982
GO:0019899enzyme binding1.92e-011.00e+002.24319277
GO:0007264small GTPase mediated signal transduction1.93e-011.00e+002.23313279
GO:0035556intracellular signal transduction2.08e-011.00e+002.11319303
GO:0005525GTP binding2.13e-011.00e+002.081112310
GO:0044281small molecule metabolic process2.35e-011.00e+001.1152201211
GO:0046982protein heterodimerization activity2.55e-011.00e+001.78718380
GO:0005524ATP binding2.60e-011.00e+001.0152311298
GO:0000278mitotic cell cycle2.61e-011.00e+001.746115391
GO:0045892negative regulation of transcription, DNA-templated2.74e-011.00e+001.667124413
GO:0043066negative regulation of apoptotic process2.80e-011.00e+001.629116424
GO:0055085transmembrane transport2.86e-011.00e+001.59218435
GO:0006351transcription, DNA-templated3.04e-011.00e+000.8592571446
GO:0042802identical protein binding3.13e-011.00e+001.438119484
GO:0048471perinuclear region of cytoplasm3.23e-011.00e+001.38518502
GO:0006915apoptotic process3.51e-011.00e+001.240112555
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.58e-011.00e+001.202137570
GO:0005730nucleolus3.61e-011.00e+000.6762661641
GO:0005794Golgi apparatus3.78e-011.00e+001.10419610
GO:0005615extracellular space5.30e-011.00e+000.454120957
GO:0008270zinc ion binding5.45e-011.00e+000.395127997
GO:0005739mitochondrion5.46e-011.00e+000.394123998
GO:0044822poly(A) RNA binding5.67e-011.00e+000.3121501056
GO:0046872metal ion binding6.48e-011.00e+000.0051291307
GO:0070062extracellular vesicular exosome8.65e-011.00e+00-0.8721572400
GO:0005886plasma membrane8.86e-011.00e+00-0.9781492582