int-snw-29107

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	3.066	4.28e-18	2.30e-05	3.91e-04

chia-screen-data-Fav-int-snw-29107 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
NCBP1	4686	6	-2.510	3.149	40	Yes	Yes
[ NXT1 ]	29107	1	-1.499	3.066	7	-	-
NXF1	10482	10	-2.426	3.538	65	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	NXF1	10482	pp	--	int.I2D: MINT, HPRD; int.Mint: MI:0407(direct interaction), MI:0915(physical association)
HNRNPU	3192	NXF1	10482	pp	--	int.Intact: MI:0914(association)
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
NXF1	10482	NXT1	29107	pp	--	int.Intact: MI:0915(physical association), MI:0407(direct interaction); int.I2D: MINT, BioGrid, BIND, HPRD, IntAct_Fly, MGI, VidalHuman_core, IntAct; int.Mint: MI:0915(physical association); int.HPRD: in vitro, yeast 2-hybrid
NCBP1	4686	NXF1	10482	pp	--	int.Mint: MI:0914(association)
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo

Related GO terms (120)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005654	nucleoplasm	9.82e-08	1.42e-03	3.544	7	64	1082
GO:0006406	mRNA export from nucleus	3.97e-06	5.73e-02	6.470	3	4	61
GO:0010467	gene expression	1.05e-05	1.52e-01	3.752	5	45	669
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0000398	mRNA splicing, via spliceosome	7.75e-05	1.00e+00	5.043	3	15	164
GO:0044212	transcription regulatory region DNA binding	8.33e-05	1.00e+00	5.009	3	17	168
GO:0016607	nuclear speck	8.93e-05	1.00e+00	4.975	3	12	172
GO:0044822	poly(A) RNA binding	9.68e-05	1.00e+00	3.094	5	50	1056
GO:0008380	RNA splicing	2.06e-04	1.00e+00	4.568	3	22	228
GO:0031124	mRNA 3'-end processing	2.29e-04	1.00e+00	6.424	2	2	42
GO:0006369	termination of RNA polymerase II transcription	2.63e-04	1.00e+00	6.324	2	2	45
GO:0005643	nuclear pore	4.23e-04	1.00e+00	5.983	2	11	57
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0003723	RNA binding	6.77e-04	1.00e+00	3.983	3	18	342
GO:0005515	protein binding	9.24e-04	1.00e+00	1.260	8	198	6024
GO:0005846	nuclear cap binding complex	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0060242	contact inhibition	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006366	transcription from RNA polymerase II promoter	1.22e-03	1.00e+00	3.690	3	30	419
GO:0030529	ribonucleoprotein complex	1.62e-03	1.00e+00	5.009	2	5	112
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0006405	RNA export from nucleus	1.66e-03	1.00e+00	9.231	1	2	3
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0045292	mRNA cis splicing, via spliceosome	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.77e-03	1.00e+00	8.494	1	2	5
GO:0031442	positive regulation of mRNA 3'-end processing	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006974	cellular response to DNA damage stimulus	2.93e-03	1.00e+00	4.578	2	7	151
GO:0070937	CRD-mediated mRNA stability complex	3.32e-03	1.00e+00	8.231	1	3	6
GO:0003714	transcription corepressor activity	4.04e-03	1.00e+00	4.340	2	11	178
GO:0000339	RNA cap binding	4.43e-03	1.00e+00	7.816	1	1	8
GO:0016973	poly(A)+ mRNA export from nucleus	4.43e-03	1.00e+00	7.816	1	1	8
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0042405	nuclear inclusion body	4.98e-03	1.00e+00	7.646	1	2	9
GO:0006379	mRNA cleavage	4.98e-03	1.00e+00	7.646	1	1	9
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005829	cytosol	5.45e-03	1.00e+00	1.853	5	86	2496
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0005845	mRNA cap binding complex	6.09e-03	1.00e+00	7.357	1	1	11
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0008334	histone mRNA metabolic process	6.64e-03	1.00e+00	7.231	1	1	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0071480	cellular response to gamma radiation	7.19e-03	1.00e+00	7.116	1	1	13
GO:0000346	transcription export complex	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0005487	nucleocytoplasmic transporter activity	7.74e-03	1.00e+00	7.009	1	3	14
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0000166	nucleotide binding	8.37e-03	1.00e+00	3.799	2	13	259
GO:0043274	phospholipase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0034660	ncRNA metabolic process	1.27e-02	1.00e+00	6.293	1	1	23
GO:0008536	Ran GTPase binding	1.38e-02	1.00e+00	6.172	1	2	25
GO:0006611	protein export from nucleus	1.38e-02	1.00e+00	6.172	1	3	25
GO:0031047	gene silencing by RNA	1.38e-02	1.00e+00	6.172	1	2	25
GO:0006355	regulation of transcription, DNA-templated	1.42e-02	1.00e+00	2.440	3	43	997
GO:0035329	hippo signaling	1.43e-02	1.00e+00	6.116	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0000387	spliceosomal snRNP assembly	1.49e-02	1.00e+00	6.061	1	2	27
GO:0006370	7-methylguanosine mRNA capping	1.65e-02	1.00e+00	5.909	1	5	30
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.76e-02	1.00e+00	5.816	1	2	32
GO:0006446	regulation of translational initiation	1.98e-02	1.00e+00	5.646	1	4	36
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0050434	positive regulation of viral transcription	2.42e-02	1.00e+00	5.357	1	5	44
GO:0003677	DNA binding	2.44e-02	1.00e+00	2.151	3	49	1218
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0006396	RNA processing	3.23e-02	1.00e+00	4.933	1	5	59
GO:0005737	cytoplasm	3.28e-02	1.00e+00	1.259	5	124	3767
GO:0016032	viral process	3.30e-02	1.00e+00	2.755	2	26	534
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0006368	transcription elongation from RNA polymerase II promoter	3.66e-02	1.00e+00	4.750	1	6	67
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0003729	mRNA binding	3.93e-02	1.00e+00	4.646	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.25e-02	1.00e+00	4.531	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	5	92
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	4	114
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0005634	nucleus	7.14e-02	1.00e+00	0.984	5	159	4559
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	9.76e-02	1.00e+00	3.293	1	22	184
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	8	223
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	8	247
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0005739	mitochondrion	4.37e-01	1.00e+00	0.853	1	23	998
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681
GO:0005886	plasma membrane	7.94e-01	1.00e+00	-0.518	1	49	2582

chia-Fav

int-snw-29107

Statistics

Genes (8)

Interactions (8)

Related GO terms (120)