int-snw-23559

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.840	1.45e-15	4.54e-04	3.24e-03

chia-screen-data-Fav-int-snw-23559 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
CACNA1A	773	1	-1.161	2.840	99	-	-
MED28	80306	16	-2.404	3.216	80	Yes	-
VWF	7450	1	-2.381	2.840	23	Yes	Yes
YAP1	10413	94	-4.256	3.538	53	Yes	-
VARS	7407	2	-2.366	2.847	80	Yes	-
[ WBP1 ]	23559	1	-0.822	2.840	7	-	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (10)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CACNA1A	773	VARS	7407	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid
PSMD2	5708	VARS	7407	pp	--	int.I2D: BioGrid_Yeast
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
CACNA1A	773	WBP1	23559	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
DDIT3	1649	VARS	7407	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
YAP1	10413	WBP1	23559	pp	--	int.I2D: BioGrid, BIND_Mouse, HPRD; int.HPRD: in vitro, in vivo
CACNA1A	773	VWF	7450	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (204)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0044212	transcription regulatory region DNA binding	1.75e-04	1.00e+00	4.687	3	17	168
GO:0005654	nucleoplasm	4.31e-04	1.00e+00	2.737	5	64	1082
GO:0009611	response to wounding	5.63e-04	1.00e+00	5.794	2	5	52
GO:0032353	negative regulation of hormone biosynthetic process	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:0021679	cerebellar molecular layer development	6.93e-04	1.00e+00	10.494	1	1	1
GO:0021590	cerebellum maturation	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0010467	gene expression	7.70e-04	1.00e+00	3.108	4	45	669
GO:0019865	immunoglobulin binding	1.39e-03	1.00e+00	9.494	1	1	2
GO:0021750	vestibular nucleus development	1.39e-03	1.00e+00	9.494	1	1	2
GO:0004832	valine-tRNA ligase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0060242	contact inhibition	1.39e-03	1.00e+00	9.494	1	1	2
GO:0014056	regulation of acetylcholine secretion, neurotransmission	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006438	valyl-tRNA aminoacylation	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0050883	musculoskeletal movement, spinal reflex action	2.08e-03	1.00e+00	8.909	1	1	3
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0042133	neurotransmitter metabolic process	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0051151	negative regulation of smooth muscle cell differentiation	2.77e-03	1.00e+00	8.494	1	1	4
GO:0014051	gamma-aminobutyric acid secretion	2.77e-03	1.00e+00	8.494	1	2	4
GO:0033093	Weibel-Palade body	2.77e-03	1.00e+00	8.494	1	1	4
GO:0048791	calcium ion-dependent exocytosis of neurotransmitter	2.77e-03	1.00e+00	8.494	1	1	4
GO:0060024	rhythmic synaptic transmission	2.77e-03	1.00e+00	8.494	1	1	4
GO:0017158	regulation of calcium ion-dependent exocytosis	2.77e-03	1.00e+00	8.494	1	1	4
GO:0006355	regulation of transcription, DNA-templated	3.40e-03	1.00e+00	2.533	4	43	997
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	3.46e-03	1.00e+00	8.172	1	2	5
GO:0030644	cellular chloride ion homeostasis	3.46e-03	1.00e+00	8.172	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	4.15e-03	1.00e+00	7.909	1	3	6
GO:0006974	cellular response to DNA damage stimulus	4.64e-03	1.00e+00	4.256	2	7	151
GO:0002161	aminoacyl-tRNA editing activity	4.84e-03	1.00e+00	7.687	1	2	7
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0006450	regulation of translational fidelity	6.22e-03	1.00e+00	7.324	1	2	9
GO:0007599	hemostasis	6.22e-03	1.00e+00	7.324	1	2	9
GO:0003714	transcription corepressor activity	6.39e-03	1.00e+00	4.018	2	11	178
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0008331	high voltage-gated calcium channel activity	6.91e-03	1.00e+00	7.172	1	2	10
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0021702	cerebellar Purkinje cell differentiation	8.29e-03	1.00e+00	6.909	1	1	12
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0071480	cellular response to gamma radiation	8.98e-03	1.00e+00	6.794	1	1	13
GO:0031091	platelet alpha granule	8.98e-03	1.00e+00	6.794	1	1	13
GO:0042445	hormone metabolic process	8.98e-03	1.00e+00	6.794	1	1	13
GO:0030234	enzyme regulator activity	8.98e-03	1.00e+00	6.794	1	2	13
GO:0048266	behavioral response to pain	9.67e-03	1.00e+00	6.687	1	1	14
GO:0019226	transmission of nerve impulse	9.67e-03	1.00e+00	6.687	1	1	14
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0021522	spinal cord motor neuron differentiation	1.10e-02	1.00e+00	6.494	1	1	16
GO:0017156	calcium ion-dependent exocytosis	1.10e-02	1.00e+00	6.494	1	1	16
GO:0031589	cell-substrate adhesion	1.10e-02	1.00e+00	6.494	1	1	16
GO:0008134	transcription factor binding	1.15e-02	1.00e+00	3.575	2	18	242
GO:0007274	neuromuscular synaptic transmission	1.17e-02	1.00e+00	6.407	1	1	17
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	1	17
GO:0007597	blood coagulation, intrinsic pathway	1.24e-02	1.00e+00	6.324	1	2	18
GO:0043113	receptor clustering	1.31e-02	1.00e+00	6.246	1	1	19
GO:0051899	membrane depolarization	1.31e-02	1.00e+00	6.246	1	2	19
GO:0007214	gamma-aminobutyric acid signaling pathway	1.31e-02	1.00e+00	6.246	1	2	19
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0050699	WW domain binding	1.45e-02	1.00e+00	6.102	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	2	22
GO:0030864	cortical actin cytoskeleton	1.58e-02	1.00e+00	5.971	1	1	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0005891	voltage-gated calcium channel complex	1.65e-02	1.00e+00	5.909	1	2	24
GO:0070509	calcium ion import	1.65e-02	1.00e+00	5.909	1	1	24
GO:0086010	membrane depolarization during action potential	1.72e-02	1.00e+00	5.850	1	2	25
GO:0035329	hippo signaling	1.79e-02	1.00e+00	5.794	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0050770	regulation of axonogenesis	1.79e-02	1.00e+00	5.794	1	2	26
GO:0005829	cytosol	1.81e-02	1.00e+00	1.531	5	86	2496
GO:0000096	sulfur amino acid metabolic process	1.86e-02	1.00e+00	5.739	1	1	27
GO:0007628	adult walking behavior	1.93e-02	1.00e+00	5.687	1	3	28
GO:0008219	cell death	1.93e-02	1.00e+00	5.687	1	2	28
GO:0048813	dendrite morphogenesis	2.06e-02	1.00e+00	5.587	1	2	30
GO:0001890	placenta development	2.13e-02	1.00e+00	5.540	1	3	31
GO:0042594	response to starvation	2.13e-02	1.00e+00	5.540	1	4	31
GO:0005245	voltage-gated calcium channel activity	2.20e-02	1.00e+00	5.494	1	2	32
GO:0035249	synaptic transmission, glutamatergic	2.20e-02	1.00e+00	5.494	1	3	32
GO:1903507	negative regulation of nucleic acid-templated transcription	2.20e-02	1.00e+00	5.494	1	2	32
GO:0007416	synapse assembly	2.27e-02	1.00e+00	5.450	1	3	33
GO:0019905	syntaxin binding	2.27e-02	1.00e+00	5.450	1	2	33
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0016592	mediator complex	2.40e-02	1.00e+00	5.365	1	10	35
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0050885	neuromuscular process controlling balance	2.74e-02	1.00e+00	5.172	1	2	40
GO:0006418	tRNA aminoacylation for protein translation	2.88e-02	1.00e+00	5.102	1	3	42
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0019827	stem cell maintenance	3.21e-02	1.00e+00	4.940	1	7	47
GO:0031093	platelet alpha granule lumen	3.28e-02	1.00e+00	4.909	1	2	48
GO:0016049	cell growth	3.35e-02	1.00e+00	4.879	1	3	49
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	1	50
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0001948	glycoprotein binding	3.41e-02	1.00e+00	4.850	1	2	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0005518	collagen binding	3.68e-02	1.00e+00	4.739	1	2	54
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	3	58
GO:0006396	RNA processing	4.02e-02	1.00e+00	4.612	1	5	59
GO:0051087	chaperone binding	4.02e-02	1.00e+00	4.612	1	3	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.02e-02	1.00e+00	4.612	1	6	59
GO:0042995	cell projection	4.08e-02	1.00e+00	4.587	1	3	60
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	2	65
GO:0003677	DNA binding	4.60e-02	1.00e+00	1.829	3	49	1218
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	2	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	2	74
GO:0002020	protease binding	5.02e-02	1.00e+00	4.285	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	1	75
GO:0001889	liver development	5.21e-02	1.00e+00	4.227	1	3	77
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0050796	regulation of insulin secretion	5.48e-02	1.00e+00	4.154	1	1	81
GO:0002576	platelet degranulation	5.54e-02	1.00e+00	4.137	1	2	82
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.81e-02	1.00e+00	4.068	1	8	86
GO:0047485	protein N-terminus binding	5.81e-02	1.00e+00	4.068	1	3	86
GO:0001649	osteoblast differentiation	6.20e-02	1.00e+00	3.971	1	5	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	1	92
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0070588	calcium ion transmembrane transport	6.40e-02	1.00e+00	3.924	1	2	95
GO:0006112	energy reserve metabolic process	6.40e-02	1.00e+00	3.924	1	2	95
GO:0005178	integrin binding	6.46e-02	1.00e+00	3.909	1	4	96
GO:0034765	regulation of ion transmembrane transport	6.59e-02	1.00e+00	3.879	1	2	98
GO:0007204	positive regulation of cytosolic calcium ion concentration	6.85e-02	1.00e+00	3.822	1	2	102
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	5	112
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	3	116
GO:0043524	negative regulation of neuron apoptotic process	7.82e-02	1.00e+00	3.624	1	5	117
GO:0006006	glucose metabolic process	7.89e-02	1.00e+00	3.612	1	5	118
GO:0003700	sequence-specific DNA binding transcription factor activity	8.15e-02	1.00e+00	2.045	2	39	699
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0051260	protein homooligomerization	9.61e-02	1.00e+00	3.314	1	3	145
GO:0000082	G1/S transition of mitotic cell cycle	9.87e-02	1.00e+00	3.275	1	3	149
GO:0042981	regulation of apoptotic process	9.93e-02	1.00e+00	3.265	1	4	150
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.00e-01	1.00e+00	1.870	2	41	789
GO:0016020	membrane	1.01e-01	1.00e+00	1.364	3	46	1681
GO:0031012	extracellular matrix	1.02e-01	1.00e+00	3.227	1	6	154
GO:0005578	proteinaceous extracellular matrix	1.06e-01	1.00e+00	3.172	1	4	160
GO:0000398	mRNA splicing, via spliceosome	1.08e-01	1.00e+00	3.137	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	2	171
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0009897	external side of plasma membrane	1.16e-01	1.00e+00	3.027	1	3	177
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	22	184
GO:0030168	platelet activation	1.33e-01	1.00e+00	2.815	1	6	205
GO:0016071	mRNA metabolic process	1.44e-01	1.00e+00	2.693	1	8	223
GO:0008380	RNA splicing	1.47e-01	1.00e+00	2.661	1	22	228
GO:0030425	dendrite	1.49e-01	1.00e+00	2.649	1	6	230
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0043025	neuronal cell body	1.57e-01	1.00e+00	2.558	1	9	245
GO:0016070	RNA metabolic process	1.59e-01	1.00e+00	2.546	1	8	247
GO:0044822	poly(A) RNA binding	1.63e-01	1.00e+00	1.450	2	50	1056
GO:0003779	actin binding	1.70e-01	1.00e+00	2.439	1	10	266
GO:0005575	cellular_component	1.77e-01	1.00e+00	2.370	1	2	279
GO:0005634	nucleus	1.79e-01	1.00e+00	0.662	5	159	4559
GO:0030198	extracellular matrix organization	1.80e-01	1.00e+00	2.349	1	6	283
GO:0044281	small molecule metabolic process	2.03e-01	1.00e+00	1.252	2	20	1211
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0007268	synaptic transmission	2.08e-01	1.00e+00	2.119	1	5	332
GO:0003723	RNA binding	2.13e-01	1.00e+00	2.076	1	18	342
GO:0005524	ATP binding	2.25e-01	1.00e+00	1.152	2	31	1298
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	5	369
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0008150	biological_process	2.39e-01	1.00e+00	1.891	1	4	389
GO:0000278	mitotic cell cycle	2.40e-01	1.00e+00	1.883	1	15	391
GO:0009986	cell surface	2.46e-01	1.00e+00	1.843	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.52e-01	1.00e+00	1.804	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.55e-01	1.00e+00	1.783	1	30	419
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	16	424
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	11	455
GO:0044267	cellular protein metabolic process	2.84e-01	1.00e+00	1.605	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.86e-01	1.00e+00	1.593	1	24	478
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	19	484
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0006915	apoptotic process	3.25e-01	1.00e+00	1.378	1	12	555
GO:0005783	endoplasmic reticulum	3.25e-01	1.00e+00	1.375	1	13	556
GO:0042803	protein homodimerization activity	3.44e-01	1.00e+00	1.277	1	19	595
GO:0005576	extracellular region	4.91e-01	1.00e+00	0.615	1	13	942
GO:0005737	cytoplasm	5.08e-01	1.00e+00	0.200	3	124	3767
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	23	998
GO:0070062	extracellular vesicular exosome	5.15e-01	1.00e+00	0.265	2	57	2400
GO:0046872	metal ion binding	6.13e-01	1.00e+00	0.142	1	29	1307
GO:0006351	transcription, DNA-templated	6.52e-01	1.00e+00	-0.004	1	57	1446
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	17	1982
GO:0005886	plasma membrane	8.61e-01	1.00e+00	-0.840	1	49	2582

chia-Fav

int-snw-23559

Statistics

Genes (10)

Interactions (10)

Related GO terms (204)