int-snw-23530

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.970	5.48e-17	8.78e-05	1.01e-03

chia-screen-data-Fav-int-snw-23530 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
MED19	219541	30	-2.657	3.449	115	Yes	-
PXN	5829	19	-2.554	3.193	206	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
MVP	9961	16	-2.846	3.193	20	Yes	Yes
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
[ NNT ]	23530	1	-1.066	2.970	4	-	-

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRSF3	6428	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
LUC7L3	51747	MED19	219541	pp	--	int.Intact: MI:0914(association); int.I2D: IntAct
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
MVP	9961	NNT	23530	pp	--	int.Intact: MI:0915(physical association)

Related GO terms (113)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0051435	BH4 domain binding	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0008750	NAD(P)+ transhydrogenase (AB-specific) activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0008746	NAD(P)+ transhydrogenase activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0023057	negative regulation of signaling	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0003957	NAD(P)+ transhydrogenase (B-specific) activity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0072376	protein activation cascade	4.85e-04	1.00e+00	11.009	1	1	1
GO:0006366	transcription from RNA polymerase II promoter	7.81e-04	1.00e+00	3.883	3	30	419
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0038127	ERBB signaling pathway	1.94e-03	1.00e+00	9.009	1	1	4
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0016607	nuclear speck	2.85e-03	1.00e+00	4.582	2	12	172
GO:0061099	negative regulation of protein tyrosine kinase activity	3.39e-03	1.00e+00	8.201	1	1	7
GO:0007172	signal complex assembly	3.88e-03	1.00e+00	8.009	1	1	8
GO:0060396	growth hormone receptor signaling pathway	3.88e-03	1.00e+00	8.009	1	1	8
GO:0031953	negative regulation of protein autophosphorylation	4.36e-03	1.00e+00	7.839	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0008380	RNA splicing	4.96e-03	1.00e+00	4.176	2	22	228
GO:0017166	vinculin binding	5.33e-03	1.00e+00	7.549	1	1	11
GO:0005746	mitochondrial respiratory chain	5.33e-03	1.00e+00	7.549	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.29e-03	1.00e+00	7.308	1	2	13
GO:0005685	U1 snRNP	6.78e-03	1.00e+00	7.201	1	1	14
GO:0034614	cellular response to reactive oxygen species	6.78e-03	1.00e+00	7.201	1	2	14
GO:0006376	mRNA splice site selection	7.26e-03	1.00e+00	7.102	1	1	15
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0043274	phospholipase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0019901	protein kinase binding	9.40e-03	1.00e+00	3.700	2	18	317
GO:0048041	focal adhesion assembly	1.01e-02	1.00e+00	6.616	1	1	21
GO:0044822	poly(A) RNA binding	1.10e-02	1.00e+00	2.549	3	50	1056
GO:0005925	focal adhesion	1.24e-02	1.00e+00	3.493	2	9	366
GO:0048754	branching morphogenesis of an epithelial tube	1.30e-02	1.00e+00	6.254	1	1	27
GO:0050661	NADP binding	1.30e-02	1.00e+00	6.254	1	1	27
GO:0005875	microtubule associated complex	1.35e-02	1.00e+00	6.201	1	1	28
GO:0006099	tricarboxylic acid cycle	1.35e-02	1.00e+00	6.201	1	1	28
GO:0030032	lamellipodium assembly	1.40e-02	1.00e+00	6.151	1	1	29
GO:0015992	proton transport	1.40e-02	1.00e+00	6.151	1	1	29
GO:0072593	reactive oxygen species metabolic process	1.50e-02	1.00e+00	6.055	1	2	31
GO:0051287	NAD binding	1.54e-02	1.00e+00	6.009	1	2	32
GO:0001104	RNA polymerase II transcription cofactor activity	1.59e-02	1.00e+00	5.964	1	8	33
GO:0016592	mediator complex	1.69e-02	1.00e+00	5.879	1	10	35
GO:0034446	substrate adhesion-dependent cell spreading	1.73e-02	1.00e+00	5.839	1	2	36
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0031124	mRNA 3'-end processing	2.02e-02	1.00e+00	5.616	1	2	42
GO:1902600	hydrogen ion transmembrane transport	2.07e-02	1.00e+00	5.582	1	2	43
GO:0006369	termination of RNA polymerase II transcription	2.16e-02	1.00e+00	5.517	1	2	45
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0051028	mRNA transport	2.50e-02	1.00e+00	5.308	1	4	52
GO:0001725	stress fiber	2.64e-02	1.00e+00	5.227	1	4	55
GO:0005643	nuclear pore	2.73e-02	1.00e+00	5.176	1	11	57
GO:0008013	beta-catenin binding	2.88e-02	1.00e+00	5.102	1	9	60
GO:0006406	mRNA export from nucleus	2.92e-02	1.00e+00	5.078	1	4	61
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	2	62
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	3	68
GO:0003729	mRNA binding	3.44e-02	1.00e+00	4.839	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	159	4559
GO:0007229	integrin-mediated signaling pathway	3.73e-02	1.00e+00	4.723	1	3	78
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0006936	muscle contraction	4.15e-02	1.00e+00	4.566	1	3	87
GO:0000187	activation of MAPK activity	4.29e-02	1.00e+00	4.517	1	3	90
GO:0007010	cytoskeleton organization	4.33e-02	1.00e+00	4.501	1	4	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	3	91
GO:0005178	integrin binding	4.57e-02	1.00e+00	4.424	1	4	96
GO:0008360	regulation of cell shape	4.89e-02	1.00e+00	4.322	1	4	103
GO:0005938	cell cortex	4.94e-02	1.00e+00	4.308	1	5	104
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	5	112
GO:0044237	cellular metabolic process	5.54e-02	1.00e+00	4.138	1	2	117
GO:0030027	lamellipodium	5.91e-02	1.00e+00	4.043	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	6.05e-02	1.00e+00	4.009	1	11	128
GO:0018108	peptidyl-tyrosine phosphorylation	6.23e-02	1.00e+00	3.964	1	4	132
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0044212	transcription regulatory region DNA binding	7.88e-02	1.00e+00	3.616	1	17	168
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	124	3767
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0007173	epidermal growth factor receptor signaling pathway	8.82e-02	1.00e+00	3.446	1	5	189
GO:0005654	nucleoplasm	9.17e-02	1.00e+00	1.929	2	64	1082
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	18	242
GO:0003677	DNA binding	1.13e-01	1.00e+00	1.758	2	49	1218
GO:0005515	protein binding	1.14e-01	1.00e+00	0.774	5	198	6024
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.21e-01	1.00e+00	2.964	1	23	264
GO:0005743	mitochondrial inner membrane	1.27e-01	1.00e+00	2.895	1	6	277
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	9	291
GO:0008283	cell proliferation	1.49e-01	1.00e+00	2.651	1	14	328
GO:0015031	protein transport	1.54e-01	1.00e+00	2.595	1	11	341
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	11	346
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	5	369
GO:0005730	nucleolus	1.85e-01	1.00e+00	1.328	2	66	1641
GO:0055114	oxidation-reduction process	1.87e-01	1.00e+00	2.294	1	10	420
GO:0016020	membrane	1.92e-01	1.00e+00	1.294	2	46	1681
GO:0048471	perinuclear region of cytoplasm	2.20e-01	1.00e+00	2.037	1	8	502
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.94e-01	1.00e+00	1.560	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.26e-01	1.00e+00	1.385	1	41	789
GO:0007165	signal transduction	3.65e-01	1.00e+00	1.184	1	13	907
GO:0005886	plasma membrane	3.65e-01	1.00e+00	0.674	2	49	2582
GO:0006355	regulation of transcription, DNA-templated	3.94e-01	1.00e+00	1.047	1	43	997
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	27	997
GO:0005739	mitochondrion	3.95e-01	1.00e+00	1.046	1	23	998
GO:0044281	small molecule metabolic process	4.59e-01	1.00e+00	0.767	1	20	1211
GO:0016021	integral component of membrane	6.45e-01	1.00e+00	0.056	1	17	1982
GO:0070062	extracellular vesicular exosome	7.20e-01	1.00e+00	-0.220	1	57	2400
GO:0005829	cytosol	7.36e-01	1.00e+00	-0.277	1	86	2496

chia-Fav

int-snw-23530

Statistics

Genes (7)

Interactions (6)

Related GO terms (113)