int-snw-154796

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.924	1.79e-16	1.61e-04	1.55e-03

chia-screen-data-Fav-int-snw-154796 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
YAP1	10413	94	-4.256	3.538	53	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
MYBPC2	4606	1	-2.199	2.924	30	Yes	-
[ AMOT ]	154796	1	-1.282	2.924	43	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
WWTR1	25937	2	-1.886	3.171	40	-	-

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
YAP1	10413	WWTR1	25937	pp	--	int.I2D: IntAct_Mouse
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
YAP1	10413	AMOT	154796	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, IntAct
WWTR1	25937	AMOT	154796	pp	--	int.Intact: MI:0914(association)
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
MYBPC2	4606	AMOT	154796	pp	--	int.Intact: MI:0915(physical association)

Related GO terms (135)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0035329	hippo signaling	1.81e-07	2.61e-03	7.893	3	5	26
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.57e-05	2.27e-01	8.308	2	2	13
GO:0005654	nucleoplasm	4.35e-05	6.28e-01	3.251	5	64	1082
GO:0044212	transcription regulatory region DNA binding	5.25e-05	7.57e-01	5.201	3	17	168
GO:0003714	transcription corepressor activity	6.24e-05	9.00e-01	5.118	3	11	178
GO:0005829	cytosol	1.59e-04	1.00e+00	2.308	6	86	2496
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060390	regulation of SMAD protein import into nucleus	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0006355	regulation of transcription, DNA-templated	6.71e-04	1.00e+00	3.047	4	43	997
GO:0090090	negative regulation of canonical Wnt signaling pathway	7.24e-04	1.00e+00	5.582	2	8	86
GO:0001649	osteoblast differentiation	8.28e-04	1.00e+00	5.485	2	5	92
GO:0060242	contact inhibition	9.70e-04	1.00e+00	10.009	1	1	2
GO:0043532	angiostatin binding	9.70e-04	1.00e+00	10.009	1	1	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0003365	establishment of cell polarity involved in ameboidal cell migration	9.70e-04	1.00e+00	10.009	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	9.70e-04	1.00e+00	10.009	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0006974	cellular response to DNA damage stimulus	2.21e-03	1.00e+00	4.770	2	7	151
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	198	6024
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.42e-03	1.00e+00	8.687	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.42e-03	1.00e+00	8.687	1	2	5
GO:0072307	regulation of metanephric nephron tubule epithelial cell differentiation	2.42e-03	1.00e+00	8.687	1	1	5
GO:0070937	CRD-mediated mRNA stability complex	2.91e-03	1.00e+00	8.424	1	3	6
GO:0040019	positive regulation of embryonic development	2.91e-03	1.00e+00	8.424	1	1	6
GO:0005667	transcription factor complex	2.95e-03	1.00e+00	4.558	2	17	175
GO:0010467	gene expression	3.02e-03	1.00e+00	3.208	3	45	669
GO:0006367	transcription initiation from RNA polymerase II promoter	3.26e-03	1.00e+00	4.485	2	22	184
GO:0017145	stem cell division	3.39e-03	1.00e+00	8.201	1	1	7
GO:0001955	blood vessel maturation	3.88e-03	1.00e+00	8.009	1	1	8
GO:0042074	cell migration involved in gastrulation	3.88e-03	1.00e+00	8.009	1	1	8
GO:0035414	negative regulation of catenin import into nucleus	4.36e-03	1.00e+00	7.839	1	1	9
GO:0006983	ER overload response	4.36e-03	1.00e+00	7.839	1	1	9
GO:0045793	positive regulation of cell size	4.36e-03	1.00e+00	7.839	1	2	9
GO:0032835	glomerulus development	4.36e-03	1.00e+00	7.839	1	1	9
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.83e-03	1.00e+00	2.970	3	41	789
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0043116	negative regulation of vascular permeability	4.84e-03	1.00e+00	7.687	1	1	10
GO:0034260	negative regulation of GTPase activity	4.84e-03	1.00e+00	7.687	1	2	10
GO:0043534	blood vessel endothelial cell migration	4.84e-03	1.00e+00	7.687	1	1	10
GO:0045662	negative regulation of myoblast differentiation	5.33e-03	1.00e+00	7.549	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0003713	transcription coactivator activity	5.35e-03	1.00e+00	4.120	2	24	237
GO:0008134	transcription factor binding	5.57e-03	1.00e+00	4.090	2	18	242
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0007043	cell-cell junction assembly	5.81e-03	1.00e+00	7.424	1	1	12
GO:0071480	cellular response to gamma radiation	6.29e-03	1.00e+00	7.308	1	1	13
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0032982	myosin filament	7.26e-03	1.00e+00	7.102	1	1	15
GO:0043536	positive regulation of blood vessel endothelial cell migration	8.22e-03	1.00e+00	6.921	1	3	17
GO:0032757	positive regulation of interleukin-8 production	9.67e-03	1.00e+00	6.687	1	1	20
GO:0001702	gastrulation with mouth forming second	1.01e-02	1.00e+00	6.616	1	1	21
GO:0036464	cytoplasmic ribonucleoprotein granule	1.06e-02	1.00e+00	6.549	1	2	22
GO:0043565	sequence-specific DNA binding	1.11e-02	1.00e+00	3.574	2	11	346
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.11e-02	1.00e+00	6.485	1	1	23
GO:0010718	positive regulation of epithelial to mesenchymal transition	1.21e-02	1.00e+00	6.365	1	4	25
GO:0051209	release of sequestered calcium ion into cytosol	1.26e-02	1.00e+00	6.308	1	1	26
GO:0009986	cell surface	1.48e-02	1.00e+00	3.358	2	9	402
GO:0042594	response to starvation	1.50e-02	1.00e+00	6.055	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.54e-02	1.00e+00	6.009	1	2	32
GO:0003677	DNA binding	1.62e-02	1.00e+00	2.343	3	49	1218
GO:0008180	COP9 signalosome	1.64e-02	1.00e+00	5.921	1	7	34
GO:0045599	negative regulation of fat cell differentiation	1.69e-02	1.00e+00	5.879	1	2	35
GO:0001933	negative regulation of protein phosphorylation	1.73e-02	1.00e+00	5.839	1	2	36
GO:0060271	cilium morphogenesis	1.78e-02	1.00e+00	5.799	1	3	37
GO:0030049	muscle filament sliding	1.83e-02	1.00e+00	5.761	1	3	38
GO:0051496	positive regulation of stress fiber assembly	1.83e-02	1.00e+00	5.761	1	4	38
GO:0035019	somatic stem cell maintenance	1.93e-02	1.00e+00	5.687	1	6	40
GO:0008307	structural constituent of muscle	1.97e-02	1.00e+00	5.651	1	2	41
GO:0030139	endocytic vesicle	2.12e-02	1.00e+00	5.549	1	2	44
GO:0034613	cellular protein localization	2.12e-02	1.00e+00	5.549	1	2	44
GO:0005884	actin filament	2.12e-02	1.00e+00	5.549	1	3	44
GO:0043525	positive regulation of neuron apoptotic process	2.21e-02	1.00e+00	5.485	1	4	46
GO:0006986	response to unfolded protein	2.40e-02	1.00e+00	5.365	1	4	50
GO:0030334	regulation of cell migration	2.40e-02	1.00e+00	5.365	1	5	50
GO:0034976	response to endoplasmic reticulum stress	2.45e-02	1.00e+00	5.336	1	2	51
GO:0045454	cell redox homeostasis	2.45e-02	1.00e+00	5.336	1	1	51
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0016525	negative regulation of angiogenesis	2.50e-02	1.00e+00	5.308	1	1	52
GO:0001725	stress fiber	2.64e-02	1.00e+00	5.227	1	4	55
GO:0001570	vasculogenesis	2.69e-02	1.00e+00	5.201	1	2	56
GO:0006396	RNA processing	2.83e-02	1.00e+00	5.126	1	5	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	2.83e-02	1.00e+00	5.126	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	2.92e-02	1.00e+00	5.078	1	2	61
GO:0006469	negative regulation of protein kinase activity	3.11e-02	1.00e+00	4.986	1	4	65
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.58e-02	1.00e+00	4.780	1	1	75
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	159	4559
GO:0071013	catalytic step 2 spliceosome	3.73e-02	1.00e+00	4.723	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	3.77e-02	1.00e+00	4.705	1	2	79
GO:0001726	ruffle	3.82e-02	1.00e+00	4.687	1	4	80
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0005923	tight junction	4.10e-02	1.00e+00	4.582	1	2	86
GO:0003700	sequence-specific DNA binding transcription factor activity	4.19e-02	1.00e+00	2.560	2	39	699
GO:0005770	late endosome	4.43e-02	1.00e+00	4.470	1	2	93
GO:0006935	chemotaxis	4.99e-02	1.00e+00	4.294	1	3	105
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	5	112
GO:0051056	regulation of small GTPase mediated signal transduction	5.45e-02	1.00e+00	4.163	1	3	115
GO:0030036	actin cytoskeleton organization	5.82e-02	1.00e+00	4.066	1	3	123
GO:0007050	cell cycle arrest	5.87e-02	1.00e+00	4.055	1	5	124
GO:0030027	lamellipodium	5.91e-02	1.00e+00	4.043	1	7	125
GO:0007179	transforming growth factor beta receptor signaling pathway	6.05e-02	1.00e+00	4.009	1	11	128
GO:0016055	Wnt signaling pathway	6.51e-02	1.00e+00	3.900	1	4	138
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0005737	cytoplasm	8.13e-02	1.00e+00	1.130	4	124	3767
GO:0009897	external side of plasma membrane	8.28e-02	1.00e+00	3.541	1	3	177
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0044822	poly(A) RNA binding	8.79e-02	1.00e+00	1.964	2	50	1056
GO:0004872	receptor activity	8.82e-02	1.00e+00	3.446	1	8	189
GO:0001701	in utero embryonic development	9.36e-02	1.00e+00	3.358	1	8	201
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	22	228
GO:0003779	actin binding	1.22e-01	1.00e+00	2.953	1	10	266
GO:0008283	cell proliferation	1.49e-01	1.00e+00	2.651	1	14	328
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0007155	cell adhesion	1.66e-01	1.00e+00	2.481	1	5	369
GO:0046982	protein heterodimerization activity	1.71e-01	1.00e+00	2.439	1	8	380
GO:0008284	positive regulation of cell proliferation	1.71e-01	1.00e+00	2.431	1	10	382
GO:0045892	negative regulation of transcription, DNA-templated	1.84e-01	1.00e+00	2.319	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	1.87e-01	1.00e+00	2.298	1	30	419
GO:0044267	cellular protein metabolic process	2.09e-01	1.00e+00	2.120	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.10e-01	1.00e+00	2.108	1	24	478
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	37	570
GO:0042803	protein homodimerization activity	2.55e-01	1.00e+00	1.792	1	19	595
GO:0005524	ATP binding	4.83e-01	1.00e+00	0.667	1	31	1298
GO:0006351	transcription, DNA-templated	5.23e-01	1.00e+00	0.511	1	57	1446
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	66	1641
GO:0016020	membrane	5.80e-01	1.00e+00	0.294	1	46	1681
GO:0016021	integral component of membrane	6.45e-01	1.00e+00	0.056	1	17	1982

chia-Fav

int-snw-154796

Statistics

Genes (7)

Interactions (7)

Related GO terms (135)