meta-int-snw-3838

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-4800 wolf-screen-ratio-mammosphere-adherent 0.833 7.78e-07 2.65e-03 5.08e-03 7 5
int-snw-3838 wolf-screen-ratio-mammosphere-adherent 0.930 2.46e-15 2.73e-03 4.30e-02 10 8
reg-snw-1478 wolf-screen-ratio-mammosphere-adherent 0.940 8.80e-09 2.25e-04 5.65e-04 7 7
reg-snw-2237 wolf-screen-ratio-mammosphere-adherent 0.894 6.72e-08 6.99e-04 1.55e-03 9 8
reg-snw-9134 wolf-screen-ratio-mammosphere-adherent 0.872 1.64e-07 1.14e-03 2.40e-03 8 7
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-3838 subnetwork

Genes (24)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree Transcription factor wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CCNE2 9134 5-0.1640.872126TF--
COPA 1314 70.4340.833170TFYes-
PSMA2 5683 1121.0931.106108-Yes-
POLA1 5422 170.5930.894114TFYes-
HNRNPC 3183 1081.8120.973181-Yes-
TP53 7157 230.4320.833665TF--
RRM1 6240 150.5870.872117-Yes-
RPA2 6118 961.2501.15176-Yes-
CCNA2 890 540.5500.973246TFYes-
NFYA 4800 70.1980.83380TF--
EIF2S2 8894 391.0750.940103-Yes-
RUVBL1 8607 950.7200.973469TFYes-
EFTUD2 9343 930.8830.956108-Yes-
RPL14 9045 491.2501.113166-Yes-
CSTF2 1478 10-0.0500.94098TF-Yes
PSMB2 5690 1160.8770.956169-Yes-
TUBG1 7283 980.9740.97391-Yes-
PSMD11 5717 1241.0951.106218TFYes-
ACTB 60 1341.1531.151610-Yes-
KPNA2 3838 50.1760.930141TF--
RUVBL2 10856 950.6930.956532TFYes-
KPNB1 3837 170.6131.017296-Yes-
FEN1 2237 100.0140.89489---
ITK 3702 150.6020.95039-Yes-

Interactions (63)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
FEN1 2237 RUVBL1 8607 pd < reg.ITFP.txt: no annot
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
EFTUD2 9343 RUVBL2 10856 pd < reg.ITFP.txt: no annot
EFTUD2 9343 RUVBL2 10856 pp -- int.I2D: BioGrid
KPNB1 3837 TP53 7157 pp -- int.I2D: BioGrid, HPRD;
int.HPRD: in vivo
KPNA2 3838 EIF2S2 8894 pd > reg.ITFP.txt: no annot
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
ACTB 60 KPNB1 3837 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
CCNA2 890 RUVBL1 8607 pd <> reg.ITFP.txt: no annot
ACTB 60 NFYA 4800 pd < reg.pazar.txt: no annot;
reg.oreganno.txt: no annot
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPA2 6118 TP53 7157 pp -- int.Transfac: -
TP53 7157 EIF2S2 8894 pp -- int.Intact: MI:0915(physical association);
int.I2D: HPRD, IntAct, BioGrid, MINT, StelzlHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
KPNB1 3837 RUVBL1 8607 pp -- int.I2D: BioGrid
RRM1 6240 TP53 7157 pd < reg.pazar.txt: no annot;
reg.oreganno.txt: no annot
KPNB1 3837 NFYA 4800 pp -- int.I2D: HPRD;
int.HPRD: in vitro
PSMD11 5717 TP53 7157 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, MINT, StelzlHigh, HPRD, IntAct;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
FEN1 2237 PSMD11 5717 pd < reg.ITFP.txt: no annot
CCNA2 890 RRM1 6240 pd > reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pd <> reg.ITFP.txt: no annot
RUVBL1 8607 RUVBL2 10856 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid;
int.DIP: MI:0915(physical association)
CSTF2 1478 FEN1 2237 pd > reg.ITFP.txt: no annot
HNRNPC 3183 RUVBL1 8607 pd < reg.ITFP.txt: no annot
KPNB1 3837 PSMA2 5683 pp -- int.I2D: Krogan_NonCore, YeastLow
HNRNPC 3183 RUVBL2 10856 pd < reg.ITFP.txt: no annot
HNRNPC 3183 TP53 7157 pd < reg.ITFP.txt: no annot
ACTB 60 COPA 1314 pd < reg.ITFP.txt: no annot
ACTB 60 COPA 1314 pp -- int.I2D: BioGrid_Yeast
CSTF2 1478 EFTUD2 9343 pd > reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 RUVBL2 10856 pd < reg.ITFP.txt: no annot
COPA 1314 PSMB2 5690 pp -- int.I2D: YeastLow
FEN1 2237 CCNE2 9134 pd < reg.ITFP.txt: no annot
TUBG1 7283 RUVBL2 10856 pd < reg.ITFP.txt: no annot
POLA1 5422 TP53 7157 pp -- int.I2D: BCI, BioGrid, HPRD;
int.HPRD: in vivo
COPA 1314 RPL14 9045 pd > reg.ITFP.txt: no annot
NFYA 4800 TP53 7157 pd > reg.pazar.txt: no annot
NFYA 4800 TP53 7157 pp -- int.Intact: MI:0914(association), MI:0915(physical association), MI:0403(colocalization);
int.I2D: BioGrid, HPRD, IntAct, BCI;
int.Ravasi: -;
int.HPRD: in vivo
KPNA2 3838 TP53 7157 pp -- int.I2D: HPRD;
int.HPRD: in vitro, in vivo, yeast 2-hybrid
TUBG1 7283 RUVBL1 8607 pd < reg.ITFP.txt: no annot
CCNA2 890 TP53 7157 pp -- int.I2D: HPRD, BCI, BioGrid;
int.HPRD: in vitro
CSTF2 1478 KPNA2 3838 pd <> reg.ITFP.txt: no annot
FEN1 2237 KPNA2 3838 pd < reg.ITFP.txt: no annot
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
ITK 3702 KPNA2 3838 pp -- int.I2D: BioGrid, HPRD, BIND;
int.HPRD: in vitro, in vivo
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
CCNA2 890 FEN1 2237 pd > reg.ITFP.txt: no annot
CCNA2 890 FEN1 2237 pp -- int.I2D: BioGrid
PSMD11 5717 EFTUD2 9343 pd > reg.ITFP.txt: no annot
CCNA2 890 CCNE2 9134 pd <> reg.ITFP.txt: no annot
PSMD11 5717 RUVBL2 10856 pp -- int.I2D: YeastLow
KPNA2 3838 RUVBL1 8607 pd <> reg.ITFP.txt: no annot
CCNA2 890 NFYA 4800 pd < reg.TRANSFAC.txt: no annot
FEN1 2237 POLA1 5422 pd < reg.ITFP.txt: no annot
KPNB1 3837 KPNA2 3838 pp -- int.I2D: BioGrid, BIND_Mouse, IntAct_Fly, HPRD, MINT;
int.Mint: MI:0915(physical association);
int.HPRD: in vitro, yeast 2-hybrid;
int.DIP: MI:0407(direct interaction)
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RRM1 6240 CCNE2 9134 pd < reg.ITFP.txt: no annot
HNRNPC 3183 KPNA2 3838 pp -- int.Intact: MI:0915(physical association)
KPNB1 3837 PSMD11 5717 pp -- int.I2D: Krogan_NonCore
PSMD11 5717 RRM1 6240 pd > reg.ITFP.txt: no annot
CCNA2 890 KPNA2 3838 pd <> reg.ITFP.txt: no annot
KPNB1 3837 RUVBL2 10856 pp -- int.I2D: BioGrid
ACTB 60 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
PSMD11 5717 EIF2S2 8894 pd > reg.ITFP.txt: no annot
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
COPA 1314 RUVBL2 10856 pp -- int.I2D: YeastLow
COPA 1314 NFYA 4800 pd > reg.ITFP.txt: no annot

Related GO terms (405)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm1.35e-182.21e-143.56119831095
GO:0000278mitotic cell cycle9.61e-111.57e-064.0951052398
GO:0005515protein binding2.45e-094.00e-051.352231726127
GO:0000082G1/S transition of mitotic cell cycle6.40e-081.04e-034.766633150
GO:0005829cytosol2.64e-074.31e-031.993151252562
GO:0016032viral process6.28e-071.02e-023.333855540
GO:0003684damaged DNA binding8.58e-071.40e-025.73741151
GO:0035267NuA4 histone acetyltransferase complex1.01e-061.64e-027.1873414
GO:0005730nucleolus1.16e-061.89e-022.27712701684
GO:0016020membrane1.71e-062.79e-022.22512801746
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.29e-063.74e-025.38742265
GO:0010467gene expression3.14e-065.12e-023.024858669
GO:0032201telomere maintenance via semi-conservative replication4.22e-066.89e-026.5353722
GO:0000722telomere maintenance via recombination7.10e-061.16e-016.2943726
GO:0016363nuclear matrix9.21e-061.50e-014.88641192
GO:0006271DNA strand elongation involved in DNA replication1.22e-051.99e-016.0403931
GO:0006284base-excision repair2.47e-054.02e-015.7093739
GO:0006260DNA replication3.09e-055.05e-014.444412125
GO:0006281DNA repair3.52e-055.75e-013.687522264
GO:0006521regulation of cellular amino acid metabolic process5.23e-058.54e-015.35132150
GO:0000812Swr1 complex5.77e-059.42e-017.409238
GO:0042981regulation of apoptotic process6.48e-051.00e+004.171426151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding6.60e-051.00e+005.2403554
GO:0008139nuclear localization sequence binding7.41e-051.00e+007.240229
GO:0000502proteasome complex8.17e-051.00e+005.13632258
GO:0000723telomere maintenance8.60e-051.00e+005.1123859
GO:0019901protein kinase binding8.79e-051.00e+003.409521320
GO:0006302double-strand break repair9.98e-051.00e+005.0403862
GO:0031571mitotic G1 DNA damage checkpoint1.13e-041.00e+006.9502311
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.15e-041.00e+004.97232465
GO:0043968histone H2A acetylation1.36e-041.00e+006.8252312
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.43e-041.00e+004.86532470
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.62e-041.00e+004.80532373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.69e-041.00e+004.78532474
GO:0006607NLS-bearing protein import into nucleus1.87e-041.00e+006.6022214
GO:0031011Ino80 complex1.87e-041.00e+006.6022314
GO:0005634nucleus1.87e-041.00e+001.172161314828
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.90e-041.00e+004.72832377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2.05e-041.00e+004.69132579
GO:0016071mRNA metabolic process2.91e-041.00e+003.609434223
GO:0005839proteasome core complex3.13e-041.00e+006.24021118
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.43e-041.00e+004.44032394
GO:0003678DNA helicase activity3.49e-041.00e+006.1622319
GO:0004298threonine-type endopeptidase activity3.87e-041.00e+006.08821120
GO:0070062extracellular vesicular exosome4.04e-041.00e+001.57211982516
GO:0016070RNA metabolic process4.29e-041.00e+003.461434247
GO:0006297nucleotide-excision repair, DNA gap filling4.70e-041.00e+005.9502522
GO:0006270DNA replication initiation4.70e-041.00e+005.9502522
GO:0043044ATP-dependent chromatin remodeling5.15e-041.00e+005.8862423
GO:0000060protein import into nucleus, translocation5.61e-041.00e+005.8252424
GO:0030529ribonucleoprotein complex6.04e-041.00e+004.16238114
GO:0000209protein polyubiquitination6.35e-041.00e+004.136321116
GO:0005635nuclear envelope6.35e-041.00e+004.13636116
GO:0044822poly(A) RNA binding6.87e-041.00e+002.1437501078
GO:0071339MLL1 complex7.11e-041.00e+005.6552327
GO:0006325chromatin organization7.53e-041.00e+004.05234123
GO:0043967histone H4 acetylation7.65e-041.00e+005.6022328
GO:0031492nucleosomal DNA binding7.65e-041.00e+005.6022428
GO:0000790nuclear chromatin9.45e-041.00e+003.93937133
GO:0034644cellular response to UV1.00e-031.00e+005.4092532
GO:0006915apoptotic process1.26e-031.00e+002.574534571
GO:0008309double-stranded DNA exodeoxyribonuclease activity1.47e-031.00e+009.409111
GO:0005737cytoplasm1.61e-031.00e+001.15313983976
GO:0003723RNA binding1.66e-031.00e+002.938419355
GO:0032508DNA duplex unwinding1.72e-031.00e+005.0172442
GO:0000398mRNA splicing, via spliceosome1.76e-031.00e+003.628312165
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding1.89e-031.00e+004.9502244
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity2.15e-031.00e+004.8552347
GO:0034641cellular nitrogen compound metabolic process2.15e-031.00e+003.527325177
GO:0040008regulation of growth2.53e-031.00e+004.7372351
GO:0097252oligodendrocyte apoptotic process2.94e-031.00e+008.409112
GO:0006272leading strand elongation2.94e-031.00e+008.409122
GO:1901525negative regulation of macromitophagy2.94e-031.00e+008.409112
GO:0002176male germ cell proliferation2.94e-031.00e+008.409112
GO:0071920cleavage body2.94e-031.00e+008.409112
GO:0032633interleukin-4 production2.94e-031.00e+008.409112
GO:0090343positive regulation of cell aging2.94e-031.00e+008.409112
GO:0001865NK T cell differentiation2.94e-031.00e+008.409112
GO:0008565protein transporter activity3.15e-031.00e+004.5772257
GO:0043066negative regulation of apoptotic process3.41e-031.00e+002.651430433
GO:0019903protein phosphatase binding3.83e-031.00e+004.4322463
GO:0006310DNA recombination4.32e-031.00e+004.3432467
GO:0009263deoxyribonucleotide biosynthetic process4.41e-031.00e+007.825113
GO:0035794positive regulation of mitochondrial membrane permeability4.41e-031.00e+007.825113
GO:0071899negative regulation of estrogen receptor binding4.41e-031.00e+007.825113
GO:0051097negative regulation of helicase activity4.41e-031.00e+007.825113
GO:0005850eukaryotic translation initiation factor 2 complex4.41e-031.00e+007.825113
GO:0071733transcriptional activation by promoter-enhancer looping4.41e-031.00e+007.825113
GO:0035033histone deacetylase regulator activity4.41e-031.00e+007.825113
GO:0002360T cell lineage commitment4.41e-031.00e+007.825113
GO:0034103regulation of tissue remodeling4.41e-031.00e+007.825113
GO:0004748ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor4.41e-031.00e+007.825113
GO:0006289nucleotide-excision repair4.58e-031.00e+004.30121269
GO:0008380RNA splicing4.60e-031.00e+003.136313232
GO:0000785chromatin5.11e-031.00e+004.2202573
GO:0007265Ras protein signal transduction5.39e-031.00e+004.1812375
GO:0008584male gonad development5.67e-031.00e+004.1432277
GO:0000212meiotic spindle organization5.87e-031.00e+007.409114
GO:0005658alpha DNA polymerase:primase complex5.87e-031.00e+007.409114
GO:0043137DNA replication, removal of RNA primer5.87e-031.00e+007.409114
GO:0090403oxidative stress-induced premature senescence5.87e-031.00e+007.409114
GO:0043141ATP-dependent 5'-3' DNA helicase activity5.87e-031.00e+007.409114
GO:0002326B cell lineage commitment5.87e-031.00e+007.409114
GO:0006610ribosomal protein import into nucleus5.87e-031.00e+007.409114
GO:0006273lagging strand elongation5.87e-031.00e+007.409114
GO:0003896DNA primase activity5.87e-031.00e+007.409124
GO:0016602CCAAT-binding factor complex5.87e-031.00e+007.409114
GO:0071782endoplasmic reticulum tubular network5.87e-031.00e+007.409114
GO:0071013catalytic step 2 spliceosome5.96e-031.00e+004.1062779
GO:0005681spliceosomal complex6.56e-031.00e+004.0342383
GO:0047485protein N-terminus binding7.03e-031.00e+003.9832486
GO:0000166nucleotide binding7.15e-031.00e+002.90736272
GO:0001940male pronucleus7.33e-031.00e+007.088115
GO:0001882nucleoside binding7.33e-031.00e+007.088115
GO:2000001regulation of DNA damage checkpoint7.33e-031.00e+007.088115
GO:0097371MDM2/MDM4 family protein binding7.33e-031.00e+007.088115
GO:0006269DNA replication, synthesis of RNA primer7.33e-031.00e+007.088125
GO:0071169establishment of protein localization to chromatin7.33e-031.00e+007.088115
GO:0043248proteasome assembly7.33e-031.00e+007.088115
GO:00171085'-flap endonuclease activity7.33e-031.00e+007.088115
GO:0005827polar microtubule7.33e-031.00e+007.088115
GO:0000730DNA recombinase assembly7.33e-031.00e+007.088135
GO:0004523RNA-DNA hybrid ribonuclease activity7.33e-031.00e+007.088115
GO:0016605PML body8.00e-031.00e+003.8862592
GO:0005200structural constituent of cytoskeleton8.17e-031.00e+003.8702793
GO:0019899enzyme binding8.37e-031.00e+002.825311288
GO:0000018regulation of DNA recombination8.79e-031.00e+006.825116
GO:0010666positive regulation of cardiac muscle cell apoptotic process8.79e-031.00e+006.825116
GO:0001221transcription cofactor binding8.79e-031.00e+006.825116
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process8.79e-031.00e+006.825116
GO:0002309T cell proliferation involved in immune response8.79e-031.00e+006.825116
GO:0030957Tat protein binding8.79e-031.00e+006.825146
GO:0070245positive regulation of thymocyte apoptotic process8.79e-031.00e+006.825116
GO:0007406negative regulation of neuroblast proliferation8.79e-031.00e+006.825116
GO:0043234protein complex9.35e-031.00e+002.766317300
GO:0044281small molecule metabolic process9.57e-031.00e+001.6566571295
GO:0001939female pronucleus1.03e-021.00e+006.602117
GO:0030157pancreatic juice secretion1.03e-021.00e+006.602117
GO:0031497chromatin assembly1.03e-021.00e+006.602117
GO:0000930gamma-tubulin complex1.03e-021.00e+006.602117
GO:0000733DNA strand renaturation1.17e-021.00e+006.409118
GO:0070688MLL5-L complex1.17e-021.00e+006.409118
GO:0019773proteasome core complex, alpha-subunit complex1.17e-021.00e+006.409158
GO:0005524ATP binding1.18e-021.00e+001.5916461354
GO:0019058viral life cycle1.23e-021.00e+003.564210115
GO:00084095'-3' exonuclease activity1.32e-021.00e+006.240119
GO:0005847mRNA cleavage and polyadenylation specificity factor complex1.32e-021.00e+006.240119
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity1.32e-021.00e+006.240119
GO:0032609interferon-gamma production1.32e-021.00e+006.240119
GO:0010389regulation of G2/M transition of mitotic cell cycle1.32e-021.00e+006.240119
GO:0006983ER overload response1.32e-021.00e+006.240129
GO:0031065positive regulation of histone deacetylation1.32e-021.00e+006.240119
GO:0000075cell cycle checkpoint1.32e-021.00e+006.240129
GO:0006379mRNA cleavage1.46e-021.00e+006.0881110
GO:0090399replicative senescence1.46e-021.00e+006.0881110
GO:2000648positive regulation of stem cell proliferation1.46e-021.00e+006.0881110
GO:0000731DNA synthesis involved in DNA repair1.46e-021.00e+006.0881110
GO:0046902regulation of mitochondrial membrane permeability1.46e-021.00e+006.0881110
GO:0006413translational initiation1.57e-021.00e+003.376212131
GO:0021846cell proliferation in forebrain1.61e-021.00e+005.9501111
GO:0008340determination of adult lifespan1.61e-021.00e+005.9501111
GO:0010569regulation of double-strand break repair via homologous recombination1.61e-021.00e+005.9501111
GO:0071850mitotic cell cycle arrest1.61e-021.00e+005.9501111
GO:0045120pronucleus1.61e-021.00e+005.9501111
GO:0033762response to glucagon1.61e-021.00e+005.9501111
GO:2000036regulation of stem cell maintenance1.61e-021.00e+005.9501211
GO:0051290protein heterotetramerization1.61e-021.00e+005.9501211
GO:0000086G2/M transition of mitotic cell cycle1.71e-021.00e+003.31127137
GO:0019985translesion synthesis1.75e-021.00e+005.8251212
GO:0009650UV protection1.75e-021.00e+005.8251112
GO:00709353'-UTR-mediated mRNA stabilization1.75e-021.00e+005.8251212
GO:0070266necroptotic process1.75e-021.00e+005.8251112
GO:0032461positive regulation of protein oligomerization1.75e-021.00e+005.8251112
GO:0009303rRNA transcription1.75e-021.00e+005.8251112
GO:0005838proteasome regulatory particle1.75e-021.00e+005.8251712
GO:0016887ATPase activity1.88e-021.00e+003.24027144
GO:0042273ribosomal large subunit biogenesis1.90e-021.00e+005.7091413
GO:0005662DNA replication factor A complex1.90e-021.00e+005.7091313
GO:0048205COPI coating of Golgi vesicle1.90e-021.00e+005.7091113
GO:0000738DNA catabolic process, exonucleolytic1.90e-021.00e+005.7091213
GO:0030126COPI vesicle coat1.90e-021.00e+005.7091113
GO:0008266poly(U) RNA binding1.90e-021.00e+005.7091113
GO:0061024membrane organization1.93e-021.00e+003.22025146
GO:0006457protein folding2.00e-021.00e+003.19028149
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator2.04e-021.00e+005.6021214
GO:2000378negative regulation of reactive oxygen species metabolic process2.04e-021.00e+005.6021114
GO:0004527exonuclease activity2.04e-021.00e+005.6021114
GO:0007020microtubule nucleation2.04e-021.00e+005.6021114
GO:0030330DNA damage response, signal transduction by p53 class mediator2.04e-021.00e+005.6021114
GO:0007095mitotic G2 DNA damage checkpoint2.04e-021.00e+005.6021114
GO:0009651response to salt stress2.04e-021.00e+005.6021214
GO:0048568embryonic organ development2.04e-021.00e+005.6021114
GO:0035066positive regulation of histone acetylation2.18e-021.00e+005.5031115
GO:0050998nitric-oxide synthase binding2.33e-021.00e+005.4091116
GO:00084083'-5' exonuclease activity2.33e-021.00e+005.4091216
GO:0010243response to organonitrogen compound2.47e-021.00e+005.3221217
GO:0042149cellular response to glucose starvation2.47e-021.00e+005.3221117
GO:0075733intracellular transport of virus2.47e-021.00e+005.3221217
GO:0006309apoptotic DNA fragmentation2.47e-021.00e+005.3221117
GO:0022624proteasome accessory complex2.47e-021.00e+005.3221917
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.51e-021.00e+003.01725168
GO:0071392cellular response to estradiol stimulus2.62e-021.00e+005.2401118
GO:0031122cytoplasmic microtubule organization2.62e-021.00e+005.2401218
GO:0035861site of double-strand break2.62e-021.00e+005.2401118
GO:0051721protein phosphatase 2A binding2.62e-021.00e+005.2401118
GO:0006303double-strand break repair via nonhomologous end joining2.62e-021.00e+005.2401318
GO:0015949nucleobase-containing small molecule interconversion2.62e-021.00e+005.2401218
GO:0005657replication fork2.62e-021.00e+005.2401318
GO:0006259DNA metabolic process2.76e-021.00e+005.1621319
GO:0048863stem cell differentiation2.76e-021.00e+005.1621119
GO:0035035histone acetyltransferase binding2.76e-021.00e+005.1621119
GO:0071158positive regulation of cell cycle arrest2.76e-021.00e+005.1621119
GO:0010165response to X-ray2.76e-021.00e+005.1621219
GO:0031625ubiquitin protein ligase binding2.85e-021.00e+002.918213180
GO:0005719nuclear euchromatin2.90e-021.00e+005.0881220
GO:0002931response to ischemia2.90e-021.00e+005.0881120
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator2.90e-021.00e+005.0881120
GO:0006298mismatch repair2.90e-021.00e+005.0881620
GO:0008156negative regulation of DNA replication3.04e-021.00e+005.0171121
GO:0007369gastrulation3.04e-021.00e+005.0171121
GO:0000718nucleotide-excision repair, DNA damage removal3.04e-021.00e+005.0171521
GO:0005669transcription factor TFIID complex3.19e-021.00e+004.9501122
GO:0090200positive regulation of release of cytochrome c from mitochondria3.19e-021.00e+004.9501122
GO:0006378mRNA polyadenylation3.19e-021.00e+004.9501122
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle3.19e-021.00e+004.9501322
GO:0030863cortical cytoskeleton3.19e-021.00e+004.9501122
GO:0036464cytoplasmic ribonucleoprotein granule3.19e-021.00e+004.9501422
GO:0045893positive regulation of transcription, DNA-templated3.36e-021.00e+002.067317487
GO:0042802identical protein binding3.43e-021.00e+002.055318491
GO:0008135translation factor activity, nucleic acid binding3.47e-021.00e+004.8251424
GO:0001836release of cytochrome c from mitochondria3.47e-021.00e+004.8251224
GO:0000794condensed nuclear chromosome3.47e-021.00e+004.8251224
GO:0006206pyrimidine nucleobase metabolic process3.47e-021.00e+004.8251224
GO:0048147negative regulation of fibroblast proliferation3.47e-021.00e+004.8251124
GO:2000379positive regulation of reactive oxygen species metabolic process3.47e-021.00e+004.8251124
GO:0044267cellular protein metabolic process3.50e-021.00e+002.043324495
GO:0003924GTPase activity3.55e-021.00e+002.74429203
GO:0001816cytokine production3.61e-021.00e+004.7661125
GO:0006890retrograde vesicle-mediated transport, Golgi to ER3.61e-021.00e+004.7661125
GO:0008536Ran GTPase binding3.61e-021.00e+004.7661225
GO:0007569cell aging3.61e-021.00e+004.7661225
GO:0071479cellular response to ionizing radiation3.61e-021.00e+004.7661125
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway3.76e-021.00e+004.7091326
GO:0004519endonuclease activity3.76e-021.00e+004.7091126
GO:0001701in utero embryonic development3.78e-021.00e+002.69526210
GO:0004003ATP-dependent DNA helicase activity3.90e-021.00e+004.6551327
GO:0034080CENP-A containing nucleosome assembly3.90e-021.00e+004.6551227
GO:0001046core promoter sequence-specific DNA binding4.04e-021.00e+004.6021128
GO:0019894kinesin binding4.04e-021.00e+004.6021128
GO:0006184GTP catabolic process4.11e-021.00e+002.62829220
GO:0010332response to gamma radiation4.18e-021.00e+004.5511229
GO:0003730mRNA 3'-UTR binding4.18e-021.00e+004.5511229
GO:0003887DNA-directed DNA polymerase activity4.18e-021.00e+004.5511329
GO:0006606protein import into nucleus4.32e-021.00e+004.5031130
GO:0051262protein tetramerization4.32e-021.00e+004.5031330
GO:0021549cerebellum development4.32e-021.00e+004.5031130
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator4.32e-021.00e+004.5031230
GO:0019221cytokine-mediated signaling pathway4.45e-021.00e+002.56423230
GO:0046677response to antibiotic4.46e-021.00e+004.4551231
GO:0016604nuclear body4.46e-021.00e+004.4551231
GO:0007067mitotic nuclear division4.49e-021.00e+002.558213231
GO:0090502RNA phosphodiester bond hydrolysis, endonucleolytic4.60e-021.00e+004.4091132
GO:0002250adaptive immune response4.60e-021.00e+004.4091132
GO:0006412translation4.63e-021.00e+002.533215235
GO:0030971receptor tyrosine kinase binding4.74e-021.00e+004.3651233
GO:0033077T cell differentiation in thymus4.74e-021.00e+004.3651233
GO:2001244positive regulation of intrinsic apoptotic signaling pathway4.74e-021.00e+004.3651133
GO:0001085RNA polymerase II transcription factor binding4.89e-021.00e+004.3221234
GO:0034332adherens junction organization5.17e-021.00e+004.2401136
GO:0051402neuron apoptotic process5.17e-021.00e+004.2401236
GO:0001895retina homeostasis5.17e-021.00e+004.2401136
GO:0051084'de novo' posttranslational protein folding5.30e-021.00e+004.2001437
GO:00515394 iron, 4 sulfur cluster binding5.30e-021.00e+004.2001337
GO:0001756somitogenesis5.44e-021.00e+004.1621138
GO:0070527platelet aggregation5.44e-021.00e+004.1621238
GO:0000737DNA catabolic process, endonucleolytic5.58e-021.00e+004.1241239
GO:0031490chromatin DNA binding5.58e-021.00e+004.1241239
GO:0000781chromosome, telomeric region5.72e-021.00e+004.0881240
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription5.72e-021.00e+004.0881240
GO:0030145manganese ion binding5.86e-021.00e+004.0521141
GO:0031124mRNA 3'-end processing6.00e-021.00e+004.0171242
GO:0004715non-membrane spanning protein tyrosine kinase activity6.00e-021.00e+004.0171142
GO:0042110T cell activation6.14e-021.00e+003.9831343
GO:0014070response to organic cyclic compound6.14e-021.00e+003.9831343
GO:0010212response to ionizing radiation6.14e-021.00e+003.9831143
GO:0048146positive regulation of fibroblast proliferation6.28e-021.00e+003.9501244
GO:0034613cellular protein localization6.28e-021.00e+003.9501144
GO:0015030Cajal body6.42e-021.00e+003.9181245
GO:0006369termination of RNA polymerase II transcription6.42e-021.00e+003.9181245
GO:0021762substantia nigra development6.55e-021.00e+003.8861146
GO:0043525positive regulation of neuron apoptotic process6.55e-021.00e+003.8861246
GO:0006283transcription-coupled nucleotide-excision repair6.55e-021.00e+003.8861846
GO:0006921cellular component disassembly involved in execution phase of apoptosis6.69e-021.00e+003.8551547
GO:0048511rhythmic process6.69e-021.00e+003.8551247
GO:0005507copper ion binding6.83e-021.00e+003.8251248
GO:0003743translation initiation factor activity6.97e-021.00e+003.7951449
GO:0022625cytosolic large ribosomal subunit6.97e-021.00e+003.7951549
GO:0031100organ regeneration7.10e-021.00e+003.7661450
GO:0035690cellular response to drug7.10e-021.00e+003.7661250
GO:0060041retina development in camera-type eye7.51e-021.00e+003.6821353
GO:0090305nucleic acid phosphodiester bond hydrolysis7.65e-021.00e+003.6551254
GO:0000226microtubule cytoskeleton organization7.79e-021.00e+003.6281355
GO:0097193intrinsic apoptotic signaling pathway7.79e-021.00e+003.6281455
GO:0002039p53 binding7.79e-021.00e+003.6281755
GO:0000932cytoplasmic mRNA processing body7.92e-021.00e+003.6021356
GO:0008104protein localization7.92e-021.00e+003.6021356
GO:0007613memory7.92e-021.00e+003.6021256
GO:0006968cellular defense response7.92e-021.00e+003.6021156
GO:0000724double-strand break repair via homologous recombination8.06e-021.00e+003.5771657
GO:0007202activation of phospholipase C activity8.19e-021.00e+003.5511158
GO:0005525GTP binding8.32e-021.00e+002.052211328
GO:0051087chaperone binding8.33e-021.00e+003.5271659
GO:0045216cell-cell junction organization8.33e-021.00e+003.5271259
GO:0005643nuclear pore8.33e-021.00e+003.5271459
GO:0008283cell proliferation8.45e-021.00e+002.039212331
GO:0003682chromatin binding8.58e-021.00e+002.026212334
GO:0042995cell projection8.87e-021.00e+003.4321663
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway9.00e-021.00e+003.4091164
GO:0006338chromatin remodeling9.54e-021.00e+003.3221468
GO:0003697single-stranded DNA binding9.67e-021.00e+003.3011969
GO:0035264multicellular organism growth9.81e-021.00e+003.2801170
GO:0034329cell junction assembly9.94e-021.00e+003.2601171
GO:0032355response to estradiol1.02e-011.00e+003.2201573
GO:0055086nucleobase-containing small molecule metabolic process1.02e-011.00e+003.2201573
GO:0002020protease binding1.03e-011.00e+003.2001474
GO:0042826histone deacetylase binding1.03e-011.00e+003.2001174
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.05e-011.00e+003.1811175
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.07e-011.00e+003.1431577
GO:0006334nucleosome assembly1.10e-011.00e+003.1061479
GO:0019083viral transcription1.13e-011.00e+003.0701881
GO:0051301cell division1.13e-011.00e+003.0701681
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.14e-011.00e+001.331319811
GO:0046982protein heterodimerization activity1.16e-011.00e+001.769211399
GO:0005179hormone activity1.17e-011.00e+003.0171184
GO:0006415translational termination1.20e-011.00e+002.9671887
GO:0050852T cell receptor signaling pathway1.22e-011.00e+002.9501288
GO:0003690double-stranded DNA binding1.26e-011.00e+002.9021491
GO:0006928cellular component movement1.27e-011.00e+002.8861792
GO:0006414translational elongation1.28e-011.00e+002.87011193
GO:0006366transcription from RNA polymerase II promoter1.28e-011.00e+001.678212425
GO:0051082unfolded protein binding1.31e-011.00e+002.8401695
GO:0001649osteoblast differentiation1.31e-011.00e+002.8401695
GO:0003677DNA binding1.32e-011.00e+001.0104261351
GO:0006364rRNA processing1.32e-011.00e+002.8251596
GO:0071456cellular response to hypoxia1.35e-011.00e+002.7951498
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.42e-011.00e+002.70918104
GO:0014069postsynaptic density1.45e-011.00e+002.68211106
GO:0007596blood coagulation1.48e-011.00e+001.551214464
GO:0005815microtubule organizing center1.50e-011.00e+002.62814110
GO:0006461protein complex assembly1.51e-011.00e+002.61516111
GO:0030308negative regulation of cell growth1.54e-011.00e+002.58916113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.55e-011.00e+002.577110114
GO:0072562blood microparticle1.57e-011.00e+002.55114116
GO:0007219Notch signaling pathway1.69e-011.00e+002.44414125
GO:0007050cell cycle arrest1.70e-011.00e+002.43217126
GO:0006511ubiquitin-dependent protein catabolic process1.71e-011.00e+002.42115127
GO:0007179transforming growth factor beta receptor signaling pathway1.75e-011.00e+002.38713130
GO:0009615response to virus1.77e-011.00e+002.36516132
GO:0018108peptidyl-tyrosine phosphorylation1.78e-011.00e+002.35413133
GO:0044255cellular lipid metabolic process1.87e-011.00e+002.28014140
GO:0003735structural constituent of ribosome1.88e-011.00e+002.27018141
GO:0005911cell-cell junction1.89e-011.00e+002.26013142
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.00e-011.00e+002.17112151
GO:0006974cellular response to DNA damage stimulus2.08e-011.00e+002.10618158
GO:0005198structural molecule activity2.10e-011.00e+002.09714159
GO:0006397mRNA processing2.21e-011.00e+002.00913169
GO:0038095Fc-epsilon receptor signaling pathway2.24e-011.00e+001.99217171
GO:0044212transcription regulatory region DNA binding2.24e-011.00e+001.99216171
GO:0030424axon2.25e-011.00e+001.98313172
GO:0006886intracellular protein transport2.26e-011.00e+001.97514173
GO:0000287magnesium ion binding2.27e-011.00e+001.96715174
GO:0016607nuclear speck2.28e-011.00e+001.95814175
GO:0045087innate immune response2.29e-011.00e+001.143220616
GO:0031965nuclear membrane2.29e-011.00e+001.95014176
GO:0019904protein domain specific binding2.35e-011.00e+001.91016181
GO:0005622intracellular2.85e-011.00e+001.58915226
GO:0005759mitochondrial matrix2.92e-011.00e+001.545112233
GO:0003700sequence-specific DNA binding transcription factor activity3.02e-011.00e+000.863211748
GO:0008134transcription factor binding3.06e-011.00e+001.46718246
GO:0043025neuronal cell body3.14e-011.00e+001.42114254
GO:0043065positive regulation of apoptotic process3.34e-011.00e+001.31118274
GO:0006357regulation of transcription from RNA polymerase II promoter3.35e-011.00e+001.30616275
GO:0007283spermatogenesis3.36e-011.00e+001.30116276
GO:0006200ATP catabolic process3.62e-011.00e+001.166114303
GO:0046872metal ion binding3.67e-011.00e+000.4783241465
GO:0005856cytoskeleton3.70e-011.00e+001.12918311
GO:0035556intracellular signal transduction3.76e-011.00e+001.10116317
GO:0030154cell differentiation3.83e-011.00e+001.06515325
GO:0007411axon guidance3.85e-011.00e+001.05619327
GO:0043231intracellular membrane-bounded organelle3.90e-011.00e+001.03418332
GO:0005813centrosome3.96e-011.00e+001.004112339
GO:0007275multicellular organismal development4.00e-011.00e+000.98315344
GO:0008285negative regulation of cell proliferation4.21e-011.00e+000.890111367
GO:0005925focal adhesion4.23e-011.00e+000.878118370
GO:0005615extracellular space4.43e-011.00e+000.4292171010
GO:0005739mitochondrion4.61e-011.00e+000.3792241046
GO:0045892negative regulation of transcription, DNA-templated4.69e-011.00e+000.682114424
GO:0008270zinc ion binding4.71e-011.00e+000.3502121067
GO:0006355regulation of transcription, DNA-templated4.90e-011.00e+000.3012171104
GO:0055114oxidation-reduction process5.12e-011.00e+000.500111481
GO:0000122negative regulation of transcription from RNA polymerase II promoter5.86e-011.00e+000.207112589
GO:0005783endoplasmic reticulum5.99e-011.00e+000.15719610
GO:0005794Golgi apparatus6.23e-011.00e+000.065114650
GO:0006351transcription, DNA-templated6.92e-011.00e+00-0.2212251585
GO:0007165signal transduction7.63e-011.00e+00-0.482117950