Subnetwork | Dataset | Score | p-value 1 | p-value 2 | p-value 3 | Size | Highlighted genes |
---|---|---|---|---|---|---|---|
reg-snw-4800 | wolf-screen-ratio-mammosphere-adherent | 0.833 | 7.78e-07 | 2.65e-03 | 5.08e-03 | 7 | 5 |
int-snw-3838 | wolf-screen-ratio-mammosphere-adherent | 0.930 | 2.46e-15 | 2.73e-03 | 4.30e-02 | 10 | 8 |
reg-snw-1478 | wolf-screen-ratio-mammosphere-adherent | 0.940 | 8.80e-09 | 2.25e-04 | 5.65e-04 | 7 | 7 |
reg-snw-2237 | wolf-screen-ratio-mammosphere-adherent | 0.894 | 6.72e-08 | 6.99e-04 | 1.55e-03 | 9 | 8 |
reg-snw-9134 | wolf-screen-ratio-mammosphere-adherent | 0.872 | 1.64e-07 | 1.14e-03 | 2.40e-03 | 8 | 7 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | Transcription factor | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|---|
CCNE2 | 9134 | 5 | -0.164 | 0.872 | 126 | TF | - | - |
COPA | 1314 | 7 | 0.434 | 0.833 | 170 | TF | Yes | - |
PSMA2 | 5683 | 112 | 1.093 | 1.106 | 108 | - | Yes | - |
POLA1 | 5422 | 17 | 0.593 | 0.894 | 114 | TF | Yes | - |
HNRNPC | 3183 | 108 | 1.812 | 0.973 | 181 | - | Yes | - |
TP53 | 7157 | 23 | 0.432 | 0.833 | 665 | TF | - | - |
RRM1 | 6240 | 15 | 0.587 | 0.872 | 117 | - | Yes | - |
RPA2 | 6118 | 96 | 1.250 | 1.151 | 76 | - | Yes | - |
CCNA2 | 890 | 54 | 0.550 | 0.973 | 246 | TF | Yes | - |
NFYA | 4800 | 7 | 0.198 | 0.833 | 80 | TF | - | - |
EIF2S2 | 8894 | 39 | 1.075 | 0.940 | 103 | - | Yes | - |
RUVBL1 | 8607 | 95 | 0.720 | 0.973 | 469 | TF | Yes | - |
EFTUD2 | 9343 | 93 | 0.883 | 0.956 | 108 | - | Yes | - |
RPL14 | 9045 | 49 | 1.250 | 1.113 | 166 | - | Yes | - |
CSTF2 | 1478 | 10 | -0.050 | 0.940 | 98 | TF | - | Yes |
PSMB2 | 5690 | 116 | 0.877 | 0.956 | 169 | - | Yes | - |
TUBG1 | 7283 | 98 | 0.974 | 0.973 | 91 | - | Yes | - |
PSMD11 | 5717 | 124 | 1.095 | 1.106 | 218 | TF | Yes | - |
ACTB | 60 | 134 | 1.153 | 1.151 | 610 | - | Yes | - |
KPNA2 | 3838 | 5 | 0.176 | 0.930 | 141 | TF | - | - |
RUVBL2 | 10856 | 95 | 0.693 | 0.956 | 532 | TF | Yes | - |
KPNB1 | 3837 | 17 | 0.613 | 1.017 | 296 | - | Yes | - |
FEN1 | 2237 | 10 | 0.014 | 0.894 | 89 | - | - | - |
ITK | 3702 | 15 | 0.602 | 0.950 | 39 | - | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
FEN1 | 2237 | RUVBL1 | 8607 | pd | < | reg.ITFP.txt: no annot |
PSMD11 | 5717 | RUVBL1 | 8607 | pp | -- | int.I2D: YeastLow |
EFTUD2 | 9343 | RUVBL2 | 10856 | pd | < | reg.ITFP.txt: no annot |
EFTUD2 | 9343 | RUVBL2 | 10856 | pp | -- | int.I2D: BioGrid |
KPNB1 | 3837 | TP53 | 7157 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vivo |
KPNA2 | 3838 | EIF2S2 | 8894 | pd | > | reg.ITFP.txt: no annot |
ACTB | 60 | RUVBL1 | 8607 | pp | -- | int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast |
ACTB | 60 | KPNB1 | 3837 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
CCNA2 | 890 | RUVBL1 | 8607 | pd | <> | reg.ITFP.txt: no annot |
ACTB | 60 | NFYA | 4800 | pd | < | reg.pazar.txt: no annot; reg.oreganno.txt: no annot |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
RPA2 | 6118 | TP53 | 7157 | pp | -- | int.Transfac: - |
TP53 | 7157 | EIF2S2 | 8894 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: HPRD, IntAct, BioGrid, MINT, StelzlHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
ACTB | 60 | PSMB2 | 5690 | pp | -- | int.I2D: BioGrid_Yeast |
KPNB1 | 3837 | RUVBL1 | 8607 | pp | -- | int.I2D: BioGrid |
RRM1 | 6240 | TP53 | 7157 | pd | < | reg.pazar.txt: no annot; reg.oreganno.txt: no annot |
KPNB1 | 3837 | NFYA | 4800 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro |
PSMD11 | 5717 | TP53 | 7157 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BioGrid, MINT, StelzlHigh, HPRD, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
FEN1 | 2237 | PSMD11 | 5717 | pd | < | reg.ITFP.txt: no annot |
CCNA2 | 890 | RRM1 | 6240 | pd | > | reg.ITFP.txt: no annot |
RUVBL1 | 8607 | RUVBL2 | 10856 | pd | <> | reg.ITFP.txt: no annot |
RUVBL1 | 8607 | RUVBL2 | 10856 | pp | -- | int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd; int.Ravasi: -; int.HPRD: in vitro, in vivo, yeast 2-hybrid; int.DIP: MI:0915(physical association) |
CSTF2 | 1478 | FEN1 | 2237 | pd | > | reg.ITFP.txt: no annot |
HNRNPC | 3183 | RUVBL1 | 8607 | pd | < | reg.ITFP.txt: no annot |
KPNB1 | 3837 | PSMA2 | 5683 | pp | -- | int.I2D: Krogan_NonCore, YeastLow |
HNRNPC | 3183 | RUVBL2 | 10856 | pd | < | reg.ITFP.txt: no annot |
HNRNPC | 3183 | TP53 | 7157 | pd | < | reg.ITFP.txt: no annot |
ACTB | 60 | COPA | 1314 | pd | < | reg.ITFP.txt: no annot |
ACTB | 60 | COPA | 1314 | pp | -- | int.I2D: BioGrid_Yeast |
CSTF2 | 1478 | EFTUD2 | 9343 | pd | > | reg.ITFP.txt: no annot |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB2 | 5690 | RUVBL2 | 10856 | pd | < | reg.ITFP.txt: no annot |
COPA | 1314 | PSMB2 | 5690 | pp | -- | int.I2D: YeastLow |
FEN1 | 2237 | CCNE2 | 9134 | pd | < | reg.ITFP.txt: no annot |
TUBG1 | 7283 | RUVBL2 | 10856 | pd | < | reg.ITFP.txt: no annot |
POLA1 | 5422 | TP53 | 7157 | pp | -- | int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vivo |
COPA | 1314 | RPL14 | 9045 | pd | > | reg.ITFP.txt: no annot |
NFYA | 4800 | TP53 | 7157 | pd | > | reg.pazar.txt: no annot |
NFYA | 4800 | TP53 | 7157 | pp | -- | int.Intact: MI:0914(association), MI:0915(physical association), MI:0403(colocalization); int.I2D: BioGrid, HPRD, IntAct, BCI; int.Ravasi: -; int.HPRD: in vivo |
KPNA2 | 3838 | TP53 | 7157 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid |
TUBG1 | 7283 | RUVBL1 | 8607 | pd | < | reg.ITFP.txt: no annot |
CCNA2 | 890 | TP53 | 7157 | pp | -- | int.I2D: HPRD, BCI, BioGrid; int.HPRD: in vitro |
CSTF2 | 1478 | KPNA2 | 3838 | pd | <> | reg.ITFP.txt: no annot |
FEN1 | 2237 | KPNA2 | 3838 | pd | < | reg.ITFP.txt: no annot |
PSMD11 | 5717 | TUBG1 | 7283 | pd | > | reg.ITFP.txt: no annot |
ITK | 3702 | KPNA2 | 3838 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
CCNA2 | 890 | FEN1 | 2237 | pd | > | reg.ITFP.txt: no annot |
CCNA2 | 890 | FEN1 | 2237 | pp | -- | int.I2D: BioGrid |
PSMD11 | 5717 | EFTUD2 | 9343 | pd | > | reg.ITFP.txt: no annot |
CCNA2 | 890 | CCNE2 | 9134 | pd | <> | reg.ITFP.txt: no annot |
PSMD11 | 5717 | RUVBL2 | 10856 | pp | -- | int.I2D: YeastLow |
KPNA2 | 3838 | RUVBL1 | 8607 | pd | <> | reg.ITFP.txt: no annot |
CCNA2 | 890 | NFYA | 4800 | pd | < | reg.TRANSFAC.txt: no annot |
FEN1 | 2237 | POLA1 | 5422 | pd | < | reg.ITFP.txt: no annot |
KPNB1 | 3837 | KPNA2 | 3838 | pp | -- | int.I2D: BioGrid, BIND_Mouse, IntAct_Fly, HPRD, MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro, yeast 2-hybrid; int.DIP: MI:0407(direct interaction) |
PSMB2 | 5690 | PSMD11 | 5717 | pd | < | reg.ITFP.txt: no annot |
PSMB2 | 5690 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
RRM1 | 6240 | CCNE2 | 9134 | pd | < | reg.ITFP.txt: no annot |
HNRNPC | 3183 | KPNA2 | 3838 | pp | -- | int.Intact: MI:0915(physical association) |
KPNB1 | 3837 | PSMD11 | 5717 | pp | -- | int.I2D: Krogan_NonCore |
PSMD11 | 5717 | RRM1 | 6240 | pd | > | reg.ITFP.txt: no annot |
CCNA2 | 890 | KPNA2 | 3838 | pd | <> | reg.ITFP.txt: no annot |
KPNB1 | 3837 | RUVBL2 | 10856 | pp | -- | int.I2D: BioGrid |
ACTB | 60 | RUVBL2 | 10856 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid |
PSMD11 | 5717 | EIF2S2 | 8894 | pd | > | reg.ITFP.txt: no annot |
PSMA2 | 5683 | PSMB2 | 5690 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core |
COPA | 1314 | RUVBL2 | 10856 | pp | -- | int.I2D: YeastLow |
COPA | 1314 | NFYA | 4800 | pd | > | reg.ITFP.txt: no annot |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005654 | nucleoplasm | 1.35e-18 | 2.21e-14 | 3.561 | 19 | 83 | 1095 |
GO:0000278 | mitotic cell cycle | 9.61e-11 | 1.57e-06 | 4.095 | 10 | 52 | 398 |
GO:0005515 | protein binding | 2.45e-09 | 4.00e-05 | 1.352 | 23 | 172 | 6127 |
GO:0000082 | G1/S transition of mitotic cell cycle | 6.40e-08 | 1.04e-03 | 4.766 | 6 | 33 | 150 |
GO:0005829 | cytosol | 2.64e-07 | 4.31e-03 | 1.993 | 15 | 125 | 2562 |
GO:0016032 | viral process | 6.28e-07 | 1.02e-02 | 3.333 | 8 | 55 | 540 |
GO:0003684 | damaged DNA binding | 8.58e-07 | 1.40e-02 | 5.737 | 4 | 11 | 51 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.01e-06 | 1.64e-02 | 7.187 | 3 | 4 | 14 |
GO:0005730 | nucleolus | 1.16e-06 | 1.89e-02 | 2.277 | 12 | 70 | 1684 |
GO:0016020 | membrane | 1.71e-06 | 2.79e-02 | 2.225 | 12 | 80 | 1746 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 2.29e-06 | 3.74e-02 | 5.387 | 4 | 22 | 65 |
GO:0010467 | gene expression | 3.14e-06 | 5.12e-02 | 3.024 | 8 | 58 | 669 |
GO:0032201 | telomere maintenance via semi-conservative replication | 4.22e-06 | 6.89e-02 | 6.535 | 3 | 7 | 22 |
GO:0000722 | telomere maintenance via recombination | 7.10e-06 | 1.16e-01 | 6.294 | 3 | 7 | 26 |
GO:0016363 | nuclear matrix | 9.21e-06 | 1.50e-01 | 4.886 | 4 | 11 | 92 |
GO:0006271 | DNA strand elongation involved in DNA replication | 1.22e-05 | 1.99e-01 | 6.040 | 3 | 9 | 31 |
GO:0006284 | base-excision repair | 2.47e-05 | 4.02e-01 | 5.709 | 3 | 7 | 39 |
GO:0006260 | DNA replication | 3.09e-05 | 5.05e-01 | 4.444 | 4 | 12 | 125 |
GO:0006281 | DNA repair | 3.52e-05 | 5.75e-01 | 3.687 | 5 | 22 | 264 |
GO:0006521 | regulation of cellular amino acid metabolic process | 5.23e-05 | 8.54e-01 | 5.351 | 3 | 21 | 50 |
GO:0000812 | Swr1 complex | 5.77e-05 | 9.42e-01 | 7.409 | 2 | 3 | 8 |
GO:0042981 | regulation of apoptotic process | 6.48e-05 | 1.00e+00 | 4.171 | 4 | 26 | 151 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.60e-05 | 1.00e+00 | 5.240 | 3 | 5 | 54 |
GO:0008139 | nuclear localization sequence binding | 7.41e-05 | 1.00e+00 | 7.240 | 2 | 2 | 9 |
GO:0000502 | proteasome complex | 8.17e-05 | 1.00e+00 | 5.136 | 3 | 22 | 58 |
GO:0000723 | telomere maintenance | 8.60e-05 | 1.00e+00 | 5.112 | 3 | 8 | 59 |
GO:0019901 | protein kinase binding | 8.79e-05 | 1.00e+00 | 3.409 | 5 | 21 | 320 |
GO:0006302 | double-strand break repair | 9.98e-05 | 1.00e+00 | 5.040 | 3 | 8 | 62 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 1.13e-04 | 1.00e+00 | 6.950 | 2 | 3 | 11 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.15e-04 | 1.00e+00 | 4.972 | 3 | 24 | 65 |
GO:0043968 | histone H2A acetylation | 1.36e-04 | 1.00e+00 | 6.825 | 2 | 3 | 12 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.43e-04 | 1.00e+00 | 4.865 | 3 | 24 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.62e-04 | 1.00e+00 | 4.805 | 3 | 23 | 73 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.69e-04 | 1.00e+00 | 4.785 | 3 | 24 | 74 |
GO:0006607 | NLS-bearing protein import into nucleus | 1.87e-04 | 1.00e+00 | 6.602 | 2 | 2 | 14 |
GO:0031011 | Ino80 complex | 1.87e-04 | 1.00e+00 | 6.602 | 2 | 3 | 14 |
GO:0005634 | nucleus | 1.87e-04 | 1.00e+00 | 1.172 | 16 | 131 | 4828 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 1.90e-04 | 1.00e+00 | 4.728 | 3 | 23 | 77 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.05e-04 | 1.00e+00 | 4.691 | 3 | 25 | 79 |
GO:0016071 | mRNA metabolic process | 2.91e-04 | 1.00e+00 | 3.609 | 4 | 34 | 223 |
GO:0005839 | proteasome core complex | 3.13e-04 | 1.00e+00 | 6.240 | 2 | 11 | 18 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 3.43e-04 | 1.00e+00 | 4.440 | 3 | 23 | 94 |
GO:0003678 | DNA helicase activity | 3.49e-04 | 1.00e+00 | 6.162 | 2 | 3 | 19 |
GO:0004298 | threonine-type endopeptidase activity | 3.87e-04 | 1.00e+00 | 6.088 | 2 | 11 | 20 |
GO:0070062 | extracellular vesicular exosome | 4.04e-04 | 1.00e+00 | 1.572 | 11 | 98 | 2516 |
GO:0016070 | RNA metabolic process | 4.29e-04 | 1.00e+00 | 3.461 | 4 | 34 | 247 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 4.70e-04 | 1.00e+00 | 5.950 | 2 | 5 | 22 |
GO:0006270 | DNA replication initiation | 4.70e-04 | 1.00e+00 | 5.950 | 2 | 5 | 22 |
GO:0043044 | ATP-dependent chromatin remodeling | 5.15e-04 | 1.00e+00 | 5.886 | 2 | 4 | 23 |
GO:0000060 | protein import into nucleus, translocation | 5.61e-04 | 1.00e+00 | 5.825 | 2 | 4 | 24 |
GO:0030529 | ribonucleoprotein complex | 6.04e-04 | 1.00e+00 | 4.162 | 3 | 8 | 114 |
GO:0000209 | protein polyubiquitination | 6.35e-04 | 1.00e+00 | 4.136 | 3 | 21 | 116 |
GO:0005635 | nuclear envelope | 6.35e-04 | 1.00e+00 | 4.136 | 3 | 6 | 116 |
GO:0044822 | poly(A) RNA binding | 6.87e-04 | 1.00e+00 | 2.143 | 7 | 50 | 1078 |
GO:0071339 | MLL1 complex | 7.11e-04 | 1.00e+00 | 5.655 | 2 | 3 | 27 |
GO:0006325 | chromatin organization | 7.53e-04 | 1.00e+00 | 4.052 | 3 | 4 | 123 |
GO:0043967 | histone H4 acetylation | 7.65e-04 | 1.00e+00 | 5.602 | 2 | 3 | 28 |
GO:0031492 | nucleosomal DNA binding | 7.65e-04 | 1.00e+00 | 5.602 | 2 | 4 | 28 |
GO:0000790 | nuclear chromatin | 9.45e-04 | 1.00e+00 | 3.939 | 3 | 7 | 133 |
GO:0034644 | cellular response to UV | 1.00e-03 | 1.00e+00 | 5.409 | 2 | 5 | 32 |
GO:0006915 | apoptotic process | 1.26e-03 | 1.00e+00 | 2.574 | 5 | 34 | 571 |
GO:0008309 | double-stranded DNA exodeoxyribonuclease activity | 1.47e-03 | 1.00e+00 | 9.409 | 1 | 1 | 1 |
GO:0005737 | cytoplasm | 1.61e-03 | 1.00e+00 | 1.153 | 13 | 98 | 3976 |
GO:0003723 | RNA binding | 1.66e-03 | 1.00e+00 | 2.938 | 4 | 19 | 355 |
GO:0032508 | DNA duplex unwinding | 1.72e-03 | 1.00e+00 | 5.017 | 2 | 4 | 42 |
GO:0000398 | mRNA splicing, via spliceosome | 1.76e-03 | 1.00e+00 | 3.628 | 3 | 12 | 165 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | 1.89e-03 | 1.00e+00 | 4.950 | 2 | 2 | 44 |
GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity | 2.15e-03 | 1.00e+00 | 4.855 | 2 | 3 | 47 |
GO:0034641 | cellular nitrogen compound metabolic process | 2.15e-03 | 1.00e+00 | 3.527 | 3 | 25 | 177 |
GO:0040008 | regulation of growth | 2.53e-03 | 1.00e+00 | 4.737 | 2 | 3 | 51 |
GO:0097252 | oligodendrocyte apoptotic process | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0006272 | leading strand elongation | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 2 | 2 |
GO:1901525 | negative regulation of macromitophagy | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0002176 | male germ cell proliferation | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0071920 | cleavage body | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0032633 | interleukin-4 production | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0090343 | positive regulation of cell aging | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0001865 | NK T cell differentiation | 2.94e-03 | 1.00e+00 | 8.409 | 1 | 1 | 2 |
GO:0008565 | protein transporter activity | 3.15e-03 | 1.00e+00 | 4.577 | 2 | 2 | 57 |
GO:0043066 | negative regulation of apoptotic process | 3.41e-03 | 1.00e+00 | 2.651 | 4 | 30 | 433 |
GO:0019903 | protein phosphatase binding | 3.83e-03 | 1.00e+00 | 4.432 | 2 | 4 | 63 |
GO:0006310 | DNA recombination | 4.32e-03 | 1.00e+00 | 4.343 | 2 | 4 | 67 |
GO:0009263 | deoxyribonucleotide biosynthetic process | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0035794 | positive regulation of mitochondrial membrane permeability | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0071899 | negative regulation of estrogen receptor binding | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0051097 | negative regulation of helicase activity | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0005850 | eukaryotic translation initiation factor 2 complex | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0071733 | transcriptional activation by promoter-enhancer looping | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0035033 | histone deacetylase regulator activity | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0002360 | T cell lineage commitment | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0034103 | regulation of tissue remodeling | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0004748 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | 4.41e-03 | 1.00e+00 | 7.825 | 1 | 1 | 3 |
GO:0006289 | nucleotide-excision repair | 4.58e-03 | 1.00e+00 | 4.301 | 2 | 12 | 69 |
GO:0008380 | RNA splicing | 4.60e-03 | 1.00e+00 | 3.136 | 3 | 13 | 232 |
GO:0000785 | chromatin | 5.11e-03 | 1.00e+00 | 4.220 | 2 | 5 | 73 |
GO:0007265 | Ras protein signal transduction | 5.39e-03 | 1.00e+00 | 4.181 | 2 | 3 | 75 |
GO:0008584 | male gonad development | 5.67e-03 | 1.00e+00 | 4.143 | 2 | 2 | 77 |
GO:0000212 | meiotic spindle organization | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0005658 | alpha DNA polymerase:primase complex | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0043137 | DNA replication, removal of RNA primer | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0090403 | oxidative stress-induced premature senescence | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0043141 | ATP-dependent 5'-3' DNA helicase activity | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0002326 | B cell lineage commitment | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0006610 | ribosomal protein import into nucleus | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0006273 | lagging strand elongation | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0003896 | DNA primase activity | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 2 | 4 |
GO:0016602 | CCAAT-binding factor complex | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0071782 | endoplasmic reticulum tubular network | 5.87e-03 | 1.00e+00 | 7.409 | 1 | 1 | 4 |
GO:0071013 | catalytic step 2 spliceosome | 5.96e-03 | 1.00e+00 | 4.106 | 2 | 7 | 79 |
GO:0005681 | spliceosomal complex | 6.56e-03 | 1.00e+00 | 4.034 | 2 | 3 | 83 |
GO:0047485 | protein N-terminus binding | 7.03e-03 | 1.00e+00 | 3.983 | 2 | 4 | 86 |
GO:0000166 | nucleotide binding | 7.15e-03 | 1.00e+00 | 2.907 | 3 | 6 | 272 |
GO:0001940 | male pronucleus | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0001882 | nucleoside binding | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0097371 | MDM2/MDM4 family protein binding | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0006269 | DNA replication, synthesis of RNA primer | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 2 | 5 |
GO:0071169 | establishment of protein localization to chromatin | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0017108 | 5'-flap endonuclease activity | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0005827 | polar microtubule | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0000730 | DNA recombinase assembly | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 3 | 5 |
GO:0004523 | RNA-DNA hybrid ribonuclease activity | 7.33e-03 | 1.00e+00 | 7.088 | 1 | 1 | 5 |
GO:0016605 | PML body | 8.00e-03 | 1.00e+00 | 3.886 | 2 | 5 | 92 |
GO:0005200 | structural constituent of cytoskeleton | 8.17e-03 | 1.00e+00 | 3.870 | 2 | 7 | 93 |
GO:0019899 | enzyme binding | 8.37e-03 | 1.00e+00 | 2.825 | 3 | 11 | 288 |
GO:0000018 | regulation of DNA recombination | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0001221 | transcription cofactor binding | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0002309 | T cell proliferation involved in immune response | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 4 | 6 |
GO:0070245 | positive regulation of thymocyte apoptotic process | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0007406 | negative regulation of neuroblast proliferation | 8.79e-03 | 1.00e+00 | 6.825 | 1 | 1 | 6 |
GO:0043234 | protein complex | 9.35e-03 | 1.00e+00 | 2.766 | 3 | 17 | 300 |
GO:0044281 | small molecule metabolic process | 9.57e-03 | 1.00e+00 | 1.656 | 6 | 57 | 1295 |
GO:0001939 | female pronucleus | 1.03e-02 | 1.00e+00 | 6.602 | 1 | 1 | 7 |
GO:0030157 | pancreatic juice secretion | 1.03e-02 | 1.00e+00 | 6.602 | 1 | 1 | 7 |
GO:0031497 | chromatin assembly | 1.03e-02 | 1.00e+00 | 6.602 | 1 | 1 | 7 |
GO:0000930 | gamma-tubulin complex | 1.03e-02 | 1.00e+00 | 6.602 | 1 | 1 | 7 |
GO:0000733 | DNA strand renaturation | 1.17e-02 | 1.00e+00 | 6.409 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 1.17e-02 | 1.00e+00 | 6.409 | 1 | 1 | 8 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 1.17e-02 | 1.00e+00 | 6.409 | 1 | 5 | 8 |
GO:0005524 | ATP binding | 1.18e-02 | 1.00e+00 | 1.591 | 6 | 46 | 1354 |
GO:0019058 | viral life cycle | 1.23e-02 | 1.00e+00 | 3.564 | 2 | 10 | 115 |
GO:0008409 | 5'-3' exonuclease activity | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0032609 | interferon-gamma production | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0010389 | regulation of G2/M transition of mitotic cell cycle | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0006983 | ER overload response | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 2 | 9 |
GO:0031065 | positive regulation of histone deacetylation | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 1 | 9 |
GO:0000075 | cell cycle checkpoint | 1.32e-02 | 1.00e+00 | 6.240 | 1 | 2 | 9 |
GO:0006379 | mRNA cleavage | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 10 |
GO:0090399 | replicative senescence | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 10 |
GO:2000648 | positive regulation of stem cell proliferation | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 10 |
GO:0000731 | DNA synthesis involved in DNA repair | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 10 |
GO:0046902 | regulation of mitochondrial membrane permeability | 1.46e-02 | 1.00e+00 | 6.088 | 1 | 1 | 10 |
GO:0006413 | translational initiation | 1.57e-02 | 1.00e+00 | 3.376 | 2 | 12 | 131 |
GO:0021846 | cell proliferation in forebrain | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:0008340 | determination of adult lifespan | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:0071850 | mitotic cell cycle arrest | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:0045120 | pronucleus | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:0033762 | response to glucagon | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 1 | 11 |
GO:2000036 | regulation of stem cell maintenance | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 2 | 11 |
GO:0051290 | protein heterotetramerization | 1.61e-02 | 1.00e+00 | 5.950 | 1 | 2 | 11 |
GO:0000086 | G2/M transition of mitotic cell cycle | 1.71e-02 | 1.00e+00 | 3.311 | 2 | 7 | 137 |
GO:0019985 | translesion synthesis | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 2 | 12 |
GO:0009650 | UV protection | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 1 | 12 |
GO:0070935 | 3'-UTR-mediated mRNA stabilization | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 2 | 12 |
GO:0070266 | necroptotic process | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 1 | 12 |
GO:0032461 | positive regulation of protein oligomerization | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 1 | 12 |
GO:0009303 | rRNA transcription | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 1.75e-02 | 1.00e+00 | 5.825 | 1 | 7 | 12 |
GO:0016887 | ATPase activity | 1.88e-02 | 1.00e+00 | 3.240 | 2 | 7 | 144 |
GO:0042273 | ribosomal large subunit biogenesis | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 4 | 13 |
GO:0005662 | DNA replication factor A complex | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 3 | 13 |
GO:0048205 | COPI coating of Golgi vesicle | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 1 | 13 |
GO:0000738 | DNA catabolic process, exonucleolytic | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 2 | 13 |
GO:0030126 | COPI vesicle coat | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 1 | 13 |
GO:0008266 | poly(U) RNA binding | 1.90e-02 | 1.00e+00 | 5.709 | 1 | 1 | 13 |
GO:0061024 | membrane organization | 1.93e-02 | 1.00e+00 | 3.220 | 2 | 5 | 146 |
GO:0006457 | protein folding | 2.00e-02 | 1.00e+00 | 3.190 | 2 | 8 | 149 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 2 | 14 |
GO:2000378 | negative regulation of reactive oxygen species metabolic process | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0004527 | exonuclease activity | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0007020 | microtubule nucleation | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0007095 | mitotic G2 DNA damage checkpoint | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0009651 | response to salt stress | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 2 | 14 |
GO:0048568 | embryonic organ development | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 1 | 14 |
GO:0035066 | positive regulation of histone acetylation | 2.18e-02 | 1.00e+00 | 5.503 | 1 | 1 | 15 |
GO:0050998 | nitric-oxide synthase binding | 2.33e-02 | 1.00e+00 | 5.409 | 1 | 1 | 16 |
GO:0008408 | 3'-5' exonuclease activity | 2.33e-02 | 1.00e+00 | 5.409 | 1 | 2 | 16 |
GO:0010243 | response to organonitrogen compound | 2.47e-02 | 1.00e+00 | 5.322 | 1 | 2 | 17 |
GO:0042149 | cellular response to glucose starvation | 2.47e-02 | 1.00e+00 | 5.322 | 1 | 1 | 17 |
GO:0075733 | intracellular transport of virus | 2.47e-02 | 1.00e+00 | 5.322 | 1 | 2 | 17 |
GO:0006309 | apoptotic DNA fragmentation | 2.47e-02 | 1.00e+00 | 5.322 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 2.47e-02 | 1.00e+00 | 5.322 | 1 | 9 | 17 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 2.51e-02 | 1.00e+00 | 3.017 | 2 | 5 | 168 |
GO:0071392 | cellular response to estradiol stimulus | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 1 | 18 |
GO:0031122 | cytoplasmic microtubule organization | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 2 | 18 |
GO:0035861 | site of double-strand break | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 1 | 18 |
GO:0051721 | protein phosphatase 2A binding | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 1 | 18 |
GO:0006303 | double-strand break repair via nonhomologous end joining | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 3 | 18 |
GO:0015949 | nucleobase-containing small molecule interconversion | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 2 | 18 |
GO:0005657 | replication fork | 2.62e-02 | 1.00e+00 | 5.240 | 1 | 3 | 18 |
GO:0006259 | DNA metabolic process | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 3 | 19 |
GO:0048863 | stem cell differentiation | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 1 | 19 |
GO:0035035 | histone acetyltransferase binding | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 1 | 19 |
GO:0071158 | positive regulation of cell cycle arrest | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 1 | 19 |
GO:0010165 | response to X-ray | 2.76e-02 | 1.00e+00 | 5.162 | 1 | 2 | 19 |
GO:0031625 | ubiquitin protein ligase binding | 2.85e-02 | 1.00e+00 | 2.918 | 2 | 13 | 180 |
GO:0005719 | nuclear euchromatin | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 2 | 20 |
GO:0002931 | response to ischemia | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 1 | 20 |
GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 1 | 20 |
GO:0006298 | mismatch repair | 2.90e-02 | 1.00e+00 | 5.088 | 1 | 6 | 20 |
GO:0008156 | negative regulation of DNA replication | 3.04e-02 | 1.00e+00 | 5.017 | 1 | 1 | 21 |
GO:0007369 | gastrulation | 3.04e-02 | 1.00e+00 | 5.017 | 1 | 1 | 21 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 3.04e-02 | 1.00e+00 | 5.017 | 1 | 5 | 21 |
GO:0005669 | transcription factor TFIID complex | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 1 | 22 |
GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 1 | 22 |
GO:0006378 | mRNA polyadenylation | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 1 | 22 |
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 3 | 22 |
GO:0030863 | cortical cytoskeleton | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 3.19e-02 | 1.00e+00 | 4.950 | 1 | 4 | 22 |
GO:0045893 | positive regulation of transcription, DNA-templated | 3.36e-02 | 1.00e+00 | 2.067 | 3 | 17 | 487 |
GO:0042802 | identical protein binding | 3.43e-02 | 1.00e+00 | 2.055 | 3 | 18 | 491 |
GO:0008135 | translation factor activity, nucleic acid binding | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 4 | 24 |
GO:0001836 | release of cytochrome c from mitochondria | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 2 | 24 |
GO:0000794 | condensed nuclear chromosome | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 2 | 24 |
GO:0006206 | pyrimidine nucleobase metabolic process | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 2 | 24 |
GO:0048147 | negative regulation of fibroblast proliferation | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 1 | 24 |
GO:2000379 | positive regulation of reactive oxygen species metabolic process | 3.47e-02 | 1.00e+00 | 4.825 | 1 | 1 | 24 |
GO:0044267 | cellular protein metabolic process | 3.50e-02 | 1.00e+00 | 2.043 | 3 | 24 | 495 |
GO:0003924 | GTPase activity | 3.55e-02 | 1.00e+00 | 2.744 | 2 | 9 | 203 |
GO:0001816 | cytokine production | 3.61e-02 | 1.00e+00 | 4.766 | 1 | 1 | 25 |
GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 3.61e-02 | 1.00e+00 | 4.766 | 1 | 1 | 25 |
GO:0008536 | Ran GTPase binding | 3.61e-02 | 1.00e+00 | 4.766 | 1 | 2 | 25 |
GO:0007569 | cell aging | 3.61e-02 | 1.00e+00 | 4.766 | 1 | 2 | 25 |
GO:0071479 | cellular response to ionizing radiation | 3.61e-02 | 1.00e+00 | 4.766 | 1 | 1 | 25 |
GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 3.76e-02 | 1.00e+00 | 4.709 | 1 | 3 | 26 |
GO:0004519 | endonuclease activity | 3.76e-02 | 1.00e+00 | 4.709 | 1 | 1 | 26 |
GO:0001701 | in utero embryonic development | 3.78e-02 | 1.00e+00 | 2.695 | 2 | 6 | 210 |
GO:0004003 | ATP-dependent DNA helicase activity | 3.90e-02 | 1.00e+00 | 4.655 | 1 | 3 | 27 |
GO:0034080 | CENP-A containing nucleosome assembly | 3.90e-02 | 1.00e+00 | 4.655 | 1 | 2 | 27 |
GO:0001046 | core promoter sequence-specific DNA binding | 4.04e-02 | 1.00e+00 | 4.602 | 1 | 1 | 28 |
GO:0019894 | kinesin binding | 4.04e-02 | 1.00e+00 | 4.602 | 1 | 1 | 28 |
GO:0006184 | GTP catabolic process | 4.11e-02 | 1.00e+00 | 2.628 | 2 | 9 | 220 |
GO:0010332 | response to gamma radiation | 4.18e-02 | 1.00e+00 | 4.551 | 1 | 2 | 29 |
GO:0003730 | mRNA 3'-UTR binding | 4.18e-02 | 1.00e+00 | 4.551 | 1 | 2 | 29 |
GO:0003887 | DNA-directed DNA polymerase activity | 4.18e-02 | 1.00e+00 | 4.551 | 1 | 3 | 29 |
GO:0006606 | protein import into nucleus | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 1 | 30 |
GO:0051262 | protein tetramerization | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 3 | 30 |
GO:0021549 | cerebellum development | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 1 | 30 |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 4.32e-02 | 1.00e+00 | 4.503 | 1 | 2 | 30 |
GO:0019221 | cytokine-mediated signaling pathway | 4.45e-02 | 1.00e+00 | 2.564 | 2 | 3 | 230 |
GO:0046677 | response to antibiotic | 4.46e-02 | 1.00e+00 | 4.455 | 1 | 2 | 31 |
GO:0016604 | nuclear body | 4.46e-02 | 1.00e+00 | 4.455 | 1 | 2 | 31 |
GO:0007067 | mitotic nuclear division | 4.49e-02 | 1.00e+00 | 2.558 | 2 | 13 | 231 |
GO:0090502 | RNA phosphodiester bond hydrolysis, endonucleolytic | 4.60e-02 | 1.00e+00 | 4.409 | 1 | 1 | 32 |
GO:0002250 | adaptive immune response | 4.60e-02 | 1.00e+00 | 4.409 | 1 | 1 | 32 |
GO:0006412 | translation | 4.63e-02 | 1.00e+00 | 2.533 | 2 | 15 | 235 |
GO:0030971 | receptor tyrosine kinase binding | 4.74e-02 | 1.00e+00 | 4.365 | 1 | 2 | 33 |
GO:0033077 | T cell differentiation in thymus | 4.74e-02 | 1.00e+00 | 4.365 | 1 | 2 | 33 |
GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 4.74e-02 | 1.00e+00 | 4.365 | 1 | 1 | 33 |
GO:0001085 | RNA polymerase II transcription factor binding | 4.89e-02 | 1.00e+00 | 4.322 | 1 | 2 | 34 |
GO:0034332 | adherens junction organization | 5.17e-02 | 1.00e+00 | 4.240 | 1 | 1 | 36 |
GO:0051402 | neuron apoptotic process | 5.17e-02 | 1.00e+00 | 4.240 | 1 | 2 | 36 |
GO:0001895 | retina homeostasis | 5.17e-02 | 1.00e+00 | 4.240 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 5.30e-02 | 1.00e+00 | 4.200 | 1 | 4 | 37 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 5.30e-02 | 1.00e+00 | 4.200 | 1 | 3 | 37 |
GO:0001756 | somitogenesis | 5.44e-02 | 1.00e+00 | 4.162 | 1 | 1 | 38 |
GO:0070527 | platelet aggregation | 5.44e-02 | 1.00e+00 | 4.162 | 1 | 2 | 38 |
GO:0000737 | DNA catabolic process, endonucleolytic | 5.58e-02 | 1.00e+00 | 4.124 | 1 | 2 | 39 |
GO:0031490 | chromatin DNA binding | 5.58e-02 | 1.00e+00 | 4.124 | 1 | 2 | 39 |
GO:0000781 | chromosome, telomeric region | 5.72e-02 | 1.00e+00 | 4.088 | 1 | 2 | 40 |
GO:0001228 | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 5.72e-02 | 1.00e+00 | 4.088 | 1 | 2 | 40 |
GO:0030145 | manganese ion binding | 5.86e-02 | 1.00e+00 | 4.052 | 1 | 1 | 41 |
GO:0031124 | mRNA 3'-end processing | 6.00e-02 | 1.00e+00 | 4.017 | 1 | 2 | 42 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 6.00e-02 | 1.00e+00 | 4.017 | 1 | 1 | 42 |
GO:0042110 | T cell activation | 6.14e-02 | 1.00e+00 | 3.983 | 1 | 3 | 43 |
GO:0014070 | response to organic cyclic compound | 6.14e-02 | 1.00e+00 | 3.983 | 1 | 3 | 43 |
GO:0010212 | response to ionizing radiation | 6.14e-02 | 1.00e+00 | 3.983 | 1 | 1 | 43 |
GO:0048146 | positive regulation of fibroblast proliferation | 6.28e-02 | 1.00e+00 | 3.950 | 1 | 2 | 44 |
GO:0034613 | cellular protein localization | 6.28e-02 | 1.00e+00 | 3.950 | 1 | 1 | 44 |
GO:0015030 | Cajal body | 6.42e-02 | 1.00e+00 | 3.918 | 1 | 2 | 45 |
GO:0006369 | termination of RNA polymerase II transcription | 6.42e-02 | 1.00e+00 | 3.918 | 1 | 2 | 45 |
GO:0021762 | substantia nigra development | 6.55e-02 | 1.00e+00 | 3.886 | 1 | 1 | 46 |
GO:0043525 | positive regulation of neuron apoptotic process | 6.55e-02 | 1.00e+00 | 3.886 | 1 | 2 | 46 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 6.55e-02 | 1.00e+00 | 3.886 | 1 | 8 | 46 |
GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 6.69e-02 | 1.00e+00 | 3.855 | 1 | 5 | 47 |
GO:0048511 | rhythmic process | 6.69e-02 | 1.00e+00 | 3.855 | 1 | 2 | 47 |
GO:0005507 | copper ion binding | 6.83e-02 | 1.00e+00 | 3.825 | 1 | 2 | 48 |
GO:0003743 | translation initiation factor activity | 6.97e-02 | 1.00e+00 | 3.795 | 1 | 4 | 49 |
GO:0022625 | cytosolic large ribosomal subunit | 6.97e-02 | 1.00e+00 | 3.795 | 1 | 5 | 49 |
GO:0031100 | organ regeneration | 7.10e-02 | 1.00e+00 | 3.766 | 1 | 4 | 50 |
GO:0035690 | cellular response to drug | 7.10e-02 | 1.00e+00 | 3.766 | 1 | 2 | 50 |
GO:0060041 | retina development in camera-type eye | 7.51e-02 | 1.00e+00 | 3.682 | 1 | 3 | 53 |
GO:0090305 | nucleic acid phosphodiester bond hydrolysis | 7.65e-02 | 1.00e+00 | 3.655 | 1 | 2 | 54 |
GO:0000226 | microtubule cytoskeleton organization | 7.79e-02 | 1.00e+00 | 3.628 | 1 | 3 | 55 |
GO:0097193 | intrinsic apoptotic signaling pathway | 7.79e-02 | 1.00e+00 | 3.628 | 1 | 4 | 55 |
GO:0002039 | p53 binding | 7.79e-02 | 1.00e+00 | 3.628 | 1 | 7 | 55 |
GO:0000932 | cytoplasmic mRNA processing body | 7.92e-02 | 1.00e+00 | 3.602 | 1 | 3 | 56 |
GO:0008104 | protein localization | 7.92e-02 | 1.00e+00 | 3.602 | 1 | 3 | 56 |
GO:0007613 | memory | 7.92e-02 | 1.00e+00 | 3.602 | 1 | 2 | 56 |
GO:0006968 | cellular defense response | 7.92e-02 | 1.00e+00 | 3.602 | 1 | 1 | 56 |
GO:0000724 | double-strand break repair via homologous recombination | 8.06e-02 | 1.00e+00 | 3.577 | 1 | 6 | 57 |
GO:0007202 | activation of phospholipase C activity | 8.19e-02 | 1.00e+00 | 3.551 | 1 | 1 | 58 |
GO:0005525 | GTP binding | 8.32e-02 | 1.00e+00 | 2.052 | 2 | 11 | 328 |
GO:0051087 | chaperone binding | 8.33e-02 | 1.00e+00 | 3.527 | 1 | 6 | 59 |
GO:0045216 | cell-cell junction organization | 8.33e-02 | 1.00e+00 | 3.527 | 1 | 2 | 59 |
GO:0005643 | nuclear pore | 8.33e-02 | 1.00e+00 | 3.527 | 1 | 4 | 59 |
GO:0008283 | cell proliferation | 8.45e-02 | 1.00e+00 | 2.039 | 2 | 12 | 331 |
GO:0003682 | chromatin binding | 8.58e-02 | 1.00e+00 | 2.026 | 2 | 12 | 334 |
GO:0042995 | cell projection | 8.87e-02 | 1.00e+00 | 3.432 | 1 | 6 | 63 |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 9.00e-02 | 1.00e+00 | 3.409 | 1 | 1 | 64 |
GO:0006338 | chromatin remodeling | 9.54e-02 | 1.00e+00 | 3.322 | 1 | 4 | 68 |
GO:0003697 | single-stranded DNA binding | 9.67e-02 | 1.00e+00 | 3.301 | 1 | 9 | 69 |
GO:0035264 | multicellular organism growth | 9.81e-02 | 1.00e+00 | 3.280 | 1 | 1 | 70 |
GO:0034329 | cell junction assembly | 9.94e-02 | 1.00e+00 | 3.260 | 1 | 1 | 71 |
GO:0032355 | response to estradiol | 1.02e-01 | 1.00e+00 | 3.220 | 1 | 5 | 73 |
GO:0055086 | nucleobase-containing small molecule metabolic process | 1.02e-01 | 1.00e+00 | 3.220 | 1 | 5 | 73 |
GO:0002020 | protease binding | 1.03e-01 | 1.00e+00 | 3.200 | 1 | 4 | 74 |
GO:0042826 | histone deacetylase binding | 1.03e-01 | 1.00e+00 | 3.200 | 1 | 1 | 74 |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 1.05e-01 | 1.00e+00 | 3.181 | 1 | 1 | 75 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 1.07e-01 | 1.00e+00 | 3.143 | 1 | 5 | 77 |
GO:0006334 | nucleosome assembly | 1.10e-01 | 1.00e+00 | 3.106 | 1 | 4 | 79 |
GO:0019083 | viral transcription | 1.13e-01 | 1.00e+00 | 3.070 | 1 | 8 | 81 |
GO:0051301 | cell division | 1.13e-01 | 1.00e+00 | 3.070 | 1 | 6 | 81 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 1.14e-01 | 1.00e+00 | 1.331 | 3 | 19 | 811 |
GO:0046982 | protein heterodimerization activity | 1.16e-01 | 1.00e+00 | 1.769 | 2 | 11 | 399 |
GO:0005179 | hormone activity | 1.17e-01 | 1.00e+00 | 3.017 | 1 | 1 | 84 |
GO:0006415 | translational termination | 1.20e-01 | 1.00e+00 | 2.967 | 1 | 8 | 87 |
GO:0050852 | T cell receptor signaling pathway | 1.22e-01 | 1.00e+00 | 2.950 | 1 | 2 | 88 |
GO:0003690 | double-stranded DNA binding | 1.26e-01 | 1.00e+00 | 2.902 | 1 | 4 | 91 |
GO:0006928 | cellular component movement | 1.27e-01 | 1.00e+00 | 2.886 | 1 | 7 | 92 |
GO:0006414 | translational elongation | 1.28e-01 | 1.00e+00 | 2.870 | 1 | 11 | 93 |
GO:0006366 | transcription from RNA polymerase II promoter | 1.28e-01 | 1.00e+00 | 1.678 | 2 | 12 | 425 |
GO:0051082 | unfolded protein binding | 1.31e-01 | 1.00e+00 | 2.840 | 1 | 6 | 95 |
GO:0001649 | osteoblast differentiation | 1.31e-01 | 1.00e+00 | 2.840 | 1 | 6 | 95 |
GO:0003677 | DNA binding | 1.32e-01 | 1.00e+00 | 1.010 | 4 | 26 | 1351 |
GO:0006364 | rRNA processing | 1.32e-01 | 1.00e+00 | 2.825 | 1 | 5 | 96 |
GO:0071456 | cellular response to hypoxia | 1.35e-01 | 1.00e+00 | 2.795 | 1 | 4 | 98 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 1.42e-01 | 1.00e+00 | 2.709 | 1 | 8 | 104 |
GO:0014069 | postsynaptic density | 1.45e-01 | 1.00e+00 | 2.682 | 1 | 1 | 106 |
GO:0007596 | blood coagulation | 1.48e-01 | 1.00e+00 | 1.551 | 2 | 14 | 464 |
GO:0005815 | microtubule organizing center | 1.50e-01 | 1.00e+00 | 2.628 | 1 | 4 | 110 |
GO:0006461 | protein complex assembly | 1.51e-01 | 1.00e+00 | 2.615 | 1 | 6 | 111 |
GO:0030308 | negative regulation of cell growth | 1.54e-01 | 1.00e+00 | 2.589 | 1 | 6 | 113 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1.55e-01 | 1.00e+00 | 2.577 | 1 | 10 | 114 |
GO:0072562 | blood microparticle | 1.57e-01 | 1.00e+00 | 2.551 | 1 | 4 | 116 |
GO:0007219 | Notch signaling pathway | 1.69e-01 | 1.00e+00 | 2.444 | 1 | 4 | 125 |
GO:0007050 | cell cycle arrest | 1.70e-01 | 1.00e+00 | 2.432 | 1 | 7 | 126 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.71e-01 | 1.00e+00 | 2.421 | 1 | 5 | 127 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 1.75e-01 | 1.00e+00 | 2.387 | 1 | 3 | 130 |
GO:0009615 | response to virus | 1.77e-01 | 1.00e+00 | 2.365 | 1 | 6 | 132 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 1.78e-01 | 1.00e+00 | 2.354 | 1 | 3 | 133 |
GO:0044255 | cellular lipid metabolic process | 1.87e-01 | 1.00e+00 | 2.280 | 1 | 4 | 140 |
GO:0003735 | structural constituent of ribosome | 1.88e-01 | 1.00e+00 | 2.270 | 1 | 8 | 141 |
GO:0005911 | cell-cell junction | 1.89e-01 | 1.00e+00 | 2.260 | 1 | 3 | 142 |
GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 2.00e-01 | 1.00e+00 | 2.171 | 1 | 2 | 151 |
GO:0006974 | cellular response to DNA damage stimulus | 2.08e-01 | 1.00e+00 | 2.106 | 1 | 8 | 158 |
GO:0005198 | structural molecule activity | 2.10e-01 | 1.00e+00 | 2.097 | 1 | 4 | 159 |
GO:0006397 | mRNA processing | 2.21e-01 | 1.00e+00 | 2.009 | 1 | 3 | 169 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 2.24e-01 | 1.00e+00 | 1.992 | 1 | 7 | 171 |
GO:0044212 | transcription regulatory region DNA binding | 2.24e-01 | 1.00e+00 | 1.992 | 1 | 6 | 171 |
GO:0030424 | axon | 2.25e-01 | 1.00e+00 | 1.983 | 1 | 3 | 172 |
GO:0006886 | intracellular protein transport | 2.26e-01 | 1.00e+00 | 1.975 | 1 | 4 | 173 |
GO:0000287 | magnesium ion binding | 2.27e-01 | 1.00e+00 | 1.967 | 1 | 5 | 174 |
GO:0016607 | nuclear speck | 2.28e-01 | 1.00e+00 | 1.958 | 1 | 4 | 175 |
GO:0045087 | innate immune response | 2.29e-01 | 1.00e+00 | 1.143 | 2 | 20 | 616 |
GO:0031965 | nuclear membrane | 2.29e-01 | 1.00e+00 | 1.950 | 1 | 4 | 176 |
GO:0019904 | protein domain specific binding | 2.35e-01 | 1.00e+00 | 1.910 | 1 | 6 | 181 |
GO:0005622 | intracellular | 2.85e-01 | 1.00e+00 | 1.589 | 1 | 5 | 226 |
GO:0005759 | mitochondrial matrix | 2.92e-01 | 1.00e+00 | 1.545 | 1 | 12 | 233 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 3.02e-01 | 1.00e+00 | 0.863 | 2 | 11 | 748 |
GO:0008134 | transcription factor binding | 3.06e-01 | 1.00e+00 | 1.467 | 1 | 8 | 246 |
GO:0043025 | neuronal cell body | 3.14e-01 | 1.00e+00 | 1.421 | 1 | 4 | 254 |
GO:0043065 | positive regulation of apoptotic process | 3.34e-01 | 1.00e+00 | 1.311 | 1 | 8 | 274 |
GO:0006357 | regulation of transcription from RNA polymerase II promoter | 3.35e-01 | 1.00e+00 | 1.306 | 1 | 6 | 275 |
GO:0007283 | spermatogenesis | 3.36e-01 | 1.00e+00 | 1.301 | 1 | 6 | 276 |
GO:0006200 | ATP catabolic process | 3.62e-01 | 1.00e+00 | 1.166 | 1 | 14 | 303 |
GO:0046872 | metal ion binding | 3.67e-01 | 1.00e+00 | 0.478 | 3 | 24 | 1465 |
GO:0005856 | cytoskeleton | 3.70e-01 | 1.00e+00 | 1.129 | 1 | 8 | 311 |
GO:0035556 | intracellular signal transduction | 3.76e-01 | 1.00e+00 | 1.101 | 1 | 6 | 317 |
GO:0030154 | cell differentiation | 3.83e-01 | 1.00e+00 | 1.065 | 1 | 5 | 325 |
GO:0007411 | axon guidance | 3.85e-01 | 1.00e+00 | 1.056 | 1 | 9 | 327 |
GO:0043231 | intracellular membrane-bounded organelle | 3.90e-01 | 1.00e+00 | 1.034 | 1 | 8 | 332 |
GO:0005813 | centrosome | 3.96e-01 | 1.00e+00 | 1.004 | 1 | 12 | 339 |
GO:0007275 | multicellular organismal development | 4.00e-01 | 1.00e+00 | 0.983 | 1 | 5 | 344 |
GO:0008285 | negative regulation of cell proliferation | 4.21e-01 | 1.00e+00 | 0.890 | 1 | 11 | 367 |
GO:0005925 | focal adhesion | 4.23e-01 | 1.00e+00 | 0.878 | 1 | 18 | 370 |
GO:0005615 | extracellular space | 4.43e-01 | 1.00e+00 | 0.429 | 2 | 17 | 1010 |
GO:0005739 | mitochondrion | 4.61e-01 | 1.00e+00 | 0.379 | 2 | 24 | 1046 |
GO:0045892 | negative regulation of transcription, DNA-templated | 4.69e-01 | 1.00e+00 | 0.682 | 1 | 14 | 424 |
GO:0008270 | zinc ion binding | 4.71e-01 | 1.00e+00 | 0.350 | 2 | 12 | 1067 |
GO:0006355 | regulation of transcription, DNA-templated | 4.90e-01 | 1.00e+00 | 0.301 | 2 | 17 | 1104 |
GO:0055114 | oxidation-reduction process | 5.12e-01 | 1.00e+00 | 0.500 | 1 | 11 | 481 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 5.86e-01 | 1.00e+00 | 0.207 | 1 | 12 | 589 |
GO:0005783 | endoplasmic reticulum | 5.99e-01 | 1.00e+00 | 0.157 | 1 | 9 | 610 |
GO:0005794 | Golgi apparatus | 6.23e-01 | 1.00e+00 | 0.065 | 1 | 14 | 650 |
GO:0006351 | transcription, DNA-templated | 6.92e-01 | 1.00e+00 | -0.221 | 2 | 25 | 1585 |
GO:0007165 | signal transduction | 7.63e-01 | 1.00e+00 | -0.482 | 1 | 17 | 950 |