Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.930 | 2.46e-15 | 2.73e-03 | 4.30e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - |
EIF2S2 | 8894 | 27 | 1.075 | 1.138 | 81 | Yes | - |
PSMA2 | 5683 | 60 | 1.093 | 1.106 | 89 | Yes | - |
HNRNPC | 3183 | 20 | 1.812 | 1.026 | 119 | Yes | - |
TP53 | 7157 | 2 | 0.432 | 0.944 | 564 | - | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
[ KPNA2 ] | 3838 | 1 | 0.176 | 0.930 | 141 | - | - |
KPNB1 | 3837 | 6 | 0.613 | 1.017 | 296 | Yes | - |
ITK | 3702 | 2 | 0.602 | 0.950 | 39 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
KPNB1 | 3837 | PSMA2 | 5683 | pp | -- | int.I2D: Krogan_NonCore, YeastLow |
ACTB | 60 | KPNB1 | 3837 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
KPNB1 | 3837 | KPNA2 | 3838 | pp | -- | int.I2D: BioGrid, BIND_Mouse, IntAct_Fly, HPRD, MINT; int.Mint: MI:0915(physical association); int.HPRD: in vitro, yeast 2-hybrid; int.DIP: MI:0407(direct interaction) |
KPNB1 | 3837 | PSMD11 | 5717 | pp | -- | int.I2D: Krogan_NonCore |
PSMD11 | 5717 | TP53 | 7157 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: BioGrid, MINT, StelzlHigh, HPRD, IntAct; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
KPNB1 | 3837 | TP53 | 7157 | pp | -- | int.I2D: BioGrid, HPRD; int.HPRD: in vivo |
RPA2 | 6118 | TP53 | 7157 | pp | -- | int.Transfac: - |
ITK | 3702 | KPNA2 | 3838 | pp | -- | int.I2D: BioGrid, HPRD, BIND; int.HPRD: in vitro, in vivo |
KPNA2 | 3838 | TP53 | 7157 | pp | -- | int.I2D: HPRD; int.HPRD: in vitro, in vivo, yeast 2-hybrid |
HNRNPC | 3183 | KPNA2 | 3838 | pp | -- | int.Intact: MI:0915(physical association) |
TP53 | 7157 | EIF2S2 | 8894 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: HPRD, IntAct, BioGrid, MINT, StelzlHigh; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005654 | nucleoplasm | 3.84e-08 | 5.54e-04 | 3.415 | 8 | 76 | 1082 |
GO:0005829 | cytosol | 1.16e-06 | 1.68e-02 | 2.379 | 9 | 132 | 2496 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 9.78e-06 | 1.41e-01 | 6.079 | 3 | 19 | 64 |
GO:0016032 | viral process | 1.47e-05 | 2.13e-01 | 3.755 | 5 | 55 | 534 |
GO:0008139 | nuclear localization sequence binding | 1.55e-05 | 2.24e-01 | 8.324 | 2 | 3 | 9 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 2.37e-05 | 3.42e-01 | 8.035 | 2 | 4 | 11 |
GO:0006607 | NLS-bearing protein import into nucleus | 3.92e-05 | 5.65e-01 | 7.687 | 2 | 3 | 14 |
GO:0000790 | nuclear chromatin | 8.01e-05 | 1.00e+00 | 5.068 | 3 | 9 | 129 |
GO:0043044 | ATP-dependent chromatin remodeling | 1.09e-04 | 1.00e+00 | 6.971 | 2 | 4 | 23 |
GO:0000060 | protein import into nucleus, translocation | 1.18e-04 | 1.00e+00 | 6.909 | 2 | 5 | 24 |
GO:0000082 | G1/S transition of mitotic cell cycle | 1.23e-04 | 1.00e+00 | 4.860 | 3 | 32 | 149 |
GO:0042981 | regulation of apoptotic process | 1.25e-04 | 1.00e+00 | 4.850 | 3 | 24 | 150 |
GO:0031492 | nucleosomal DNA binding | 1.50e-04 | 1.00e+00 | 6.739 | 2 | 4 | 27 |
GO:0005515 | protein binding | 1.61e-04 | 1.00e+00 | 1.260 | 10 | 184 | 6024 |
GO:0006284 | base-excision repair | 2.84e-04 | 1.00e+00 | 6.285 | 2 | 3 | 37 |
GO:0006915 | apoptotic process | 3.78e-04 | 1.00e+00 | 3.378 | 4 | 33 | 555 |
GO:0003684 | damaged DNA binding | 5.00e-04 | 1.00e+00 | 5.879 | 2 | 7 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 5.21e-04 | 1.00e+00 | 5.850 | 2 | 17 | 50 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 5.85e-04 | 1.00e+00 | 5.766 | 2 | 5 | 53 |
GO:0008565 | protein transporter activity | 6.53e-04 | 1.00e+00 | 5.687 | 2 | 5 | 56 |
GO:0000502 | proteasome complex | 7.01e-04 | 1.00e+00 | 5.636 | 2 | 17 | 58 |
GO:0019899 | enzyme binding | 7.61e-04 | 1.00e+00 | 3.965 | 3 | 12 | 277 |
GO:0010467 | gene expression | 7.70e-04 | 1.00e+00 | 3.108 | 4 | 59 | 669 |
GO:0006302 | double-strand break repair | 8.00e-04 | 1.00e+00 | 5.540 | 2 | 4 | 62 |
GO:0019903 | protein phosphatase binding | 8.00e-04 | 1.00e+00 | 5.540 | 2 | 4 | 62 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 8.79e-04 | 1.00e+00 | 5.472 | 2 | 22 | 65 |
GO:0043234 | protein complex | 9.14e-04 | 1.00e+00 | 3.875 | 3 | 18 | 295 |
GO:0006289 | nucleotide-excision repair | 9.62e-04 | 1.00e+00 | 5.407 | 2 | 11 | 68 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.02e-03 | 1.00e+00 | 5.365 | 2 | 22 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.08e-03 | 1.00e+00 | 5.324 | 2 | 20 | 72 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.14e-03 | 1.00e+00 | 5.285 | 2 | 22 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 1.17e-03 | 1.00e+00 | 5.265 | 2 | 20 | 75 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.30e-03 | 1.00e+00 | 5.190 | 2 | 23 | 79 |
GO:0097252 | oligodendrocyte apoptotic process | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:1901525 | negative regulation of macromitophagy | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:0002176 | male germ cell proliferation | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:0032633 | interleukin-4 production | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:0090343 | positive regulation of cell aging | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:0001865 | NK T cell differentiation | 1.39e-03 | 1.00e+00 | 9.494 | 1 | 1 | 2 |
GO:0047485 | protein N-terminus binding | 1.53e-03 | 1.00e+00 | 5.068 | 2 | 5 | 86 |
GO:0016605 | PML body | 1.60e-03 | 1.00e+00 | 5.035 | 2 | 3 | 88 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.75e-03 | 1.00e+00 | 4.971 | 2 | 21 | 92 |
GO:0000278 | mitotic cell cycle | 2.06e-03 | 1.00e+00 | 3.468 | 3 | 48 | 391 |
GO:0035794 | positive regulation of mitochondrial membrane permeability | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 3 |
GO:0051097 | negative regulation of helicase activity | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 3 |
GO:0005850 | eukaryotic translation initiation factor 2 complex | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 3 |
GO:0035033 | histone deacetylase regulator activity | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 3 |
GO:0002360 | T cell lineage commitment | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 2 | 3 |
GO:0034103 | regulation of tissue remodeling | 2.08e-03 | 1.00e+00 | 8.909 | 1 | 1 | 3 |
GO:0043066 | negative regulation of apoptotic process | 2.59e-03 | 1.00e+00 | 3.351 | 3 | 31 | 424 |
GO:0000209 | protein polyubiquitination | 2.77e-03 | 1.00e+00 | 4.636 | 2 | 20 | 116 |
GO:0090403 | oxidative stress-induced premature senescence | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 4 |
GO:0002326 | B cell lineage commitment | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 2 | 4 |
GO:0006610 | ribosomal protein import into nucleus | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 4 |
GO:0071782 | endoplasmic reticulum tubular network | 2.77e-03 | 1.00e+00 | 8.494 | 1 | 1 | 4 |
GO:0005730 | nucleolus | 2.92e-03 | 1.00e+00 | 2.136 | 5 | 69 | 1641 |
GO:0016020 | membrane | 3.25e-03 | 1.00e+00 | 2.101 | 5 | 90 | 1681 |
GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:0097371 | MDM2/MDM4 family protein binding | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:0070245 | positive regulation of thymocyte apoptotic process | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:0000730 | DNA recombinase assembly | 3.46e-03 | 1.00e+00 | 8.172 | 1 | 1 | 5 |
GO:0000018 | regulation of DNA recombination | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 6 |
GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 6 |
GO:0002309 | T cell proliferation involved in immune response | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 3 | 6 |
GO:0007406 | negative regulation of neuroblast proliferation | 4.15e-03 | 1.00e+00 | 7.909 | 1 | 1 | 6 |
GO:0044822 | poly(A) RNA binding | 4.19e-03 | 1.00e+00 | 2.450 | 4 | 49 | 1056 |
GO:0000733 | DNA strand renaturation | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 7 |
GO:0031497 | chromatin assembly | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 7 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 5.51e-03 | 1.00e+00 | 4.128 | 2 | 7 | 165 |
GO:0070688 | MLL5-L complex | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 1 | 8 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 5.53e-03 | 1.00e+00 | 7.494 | 1 | 4 | 8 |
GO:0034641 | cellular nitrogen compound metabolic process | 5.91e-03 | 1.00e+00 | 4.076 | 2 | 20 | 171 |
GO:0032609 | interferon-gamma production | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 9 |
GO:0006983 | ER overload response | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 2 | 9 |
GO:0031065 | positive regulation of histone deacetylation | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 9 |
GO:0031625 | ubiquitin protein ligase binding | 6.39e-03 | 1.00e+00 | 4.018 | 2 | 14 | 178 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 6.91e-03 | 1.00e+00 | 7.172 | 1 | 1 | 10 |
GO:0071850 | mitotic cell cycle arrest | 6.91e-03 | 1.00e+00 | 7.172 | 1 | 1 | 10 |
GO:0090399 | replicative senescence | 6.91e-03 | 1.00e+00 | 7.172 | 1 | 1 | 10 |
GO:0046902 | regulation of mitochondrial membrane permeability | 6.91e-03 | 1.00e+00 | 7.172 | 1 | 2 | 10 |
GO:0008340 | determination of adult lifespan | 7.60e-03 | 1.00e+00 | 7.035 | 1 | 1 | 11 |
GO:0045120 | pronucleus | 7.60e-03 | 1.00e+00 | 7.035 | 1 | 2 | 11 |
GO:0009303 | rRNA transcription | 7.60e-03 | 1.00e+00 | 7.035 | 1 | 1 | 11 |
GO:0001701 | in utero embryonic development | 8.08e-03 | 1.00e+00 | 3.843 | 2 | 8 | 201 |
GO:0070935 | 3'-UTR-mediated mRNA stabilization | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 2 | 12 |
GO:0070266 | necroptotic process | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 12 |
GO:0032461 | positive regulation of protein oligomerization | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 1 | 12 |
GO:0005838 | proteasome regulatory particle | 8.29e-03 | 1.00e+00 | 6.909 | 1 | 7 | 12 |
GO:0005662 | DNA replication factor A complex | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 13 |
GO:0008266 | poly(U) RNA binding | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 4 | 14 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 2 | 14 |
GO:2000378 | negative regulation of reactive oxygen species metabolic process | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 1 | 14 |
GO:0030330 | DNA damage response, signal transduction by p53 class mediator | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 1 | 14 |
GO:0009651 | response to salt stress | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 2 | 14 |
GO:0048568 | embryonic organ development | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 1 | 14 |
GO:0019221 | cytokine-mediated signaling pathway | 9.70e-03 | 1.00e+00 | 3.706 | 2 | 9 | 221 |
GO:0016071 | mRNA metabolic process | 9.87e-03 | 1.00e+00 | 3.693 | 2 | 31 | 223 |
GO:0050998 | nitric-oxide synthase binding | 1.10e-02 | 1.00e+00 | 6.494 | 1 | 1 | 16 |
GO:0042149 | cellular response to glucose starvation | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 17 |
GO:0051721 | protein phosphatase 2A binding | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 17 |
GO:0075733 | intracellular transport of virus | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 3 | 17 |
GO:0006309 | apoptotic DNA fragmentation | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 8 | 17 |
GO:0016070 | RNA metabolic process | 1.20e-02 | 1.00e+00 | 3.546 | 2 | 32 | 247 |
GO:0035861 | site of double-strand break | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 18 |
GO:0005839 | proteasome core complex | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 8 | 18 |
GO:0005657 | replication fork | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 3 | 18 |
GO:0006259 | DNA metabolic process | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 2 | 19 |
GO:0048863 | stem cell differentiation | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 19 |
GO:0035035 | histone acetyltransferase binding | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 19 |
GO:0007369 | gastrulation | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 1 | 19 |
GO:0004298 | threonine-type endopeptidase activity | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 8 | 19 |
GO:0071158 | positive regulation of cell cycle arrest | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 2 | 19 |
GO:0010165 | response to X-ray | 1.31e-02 | 1.00e+00 | 6.246 | 1 | 3 | 19 |
GO:0008156 | negative regulation of DNA replication | 1.38e-02 | 1.00e+00 | 6.172 | 1 | 1 | 20 |
GO:0002931 | response to ischemia | 1.38e-02 | 1.00e+00 | 6.172 | 1 | 1 | 20 |
GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator | 1.38e-02 | 1.00e+00 | 6.172 | 1 | 2 | 20 |
GO:0006298 | mismatch repair | 1.38e-02 | 1.00e+00 | 6.172 | 1 | 3 | 20 |
GO:0005634 | nucleus | 1.44e-02 | 1.00e+00 | 1.147 | 7 | 136 | 4559 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 4 | 21 |
GO:0032201 | telomere maintenance via semi-conservative replication | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 5 | 21 |
GO:0005669 | transcription factor TFIID complex | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 1 | 22 |
GO:0090200 | positive regulation of release of cytochrome c from mitochondria | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 1 | 22 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 3 | 22 |
GO:0048147 | negative regulation of fibroblast proliferation | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 1 | 22 |
GO:0030863 | cortical cytoskeleton | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.52e-02 | 1.00e+00 | 6.035 | 1 | 4 | 22 |
GO:0070062 | extracellular vesicular exosome | 1.53e-02 | 1.00e+00 | 1.587 | 5 | 104 | 2400 |
GO:0071479 | cellular response to ionizing radiation | 1.58e-02 | 1.00e+00 | 5.971 | 1 | 1 | 23 |
GO:2000379 | positive regulation of reactive oxygen species metabolic process | 1.58e-02 | 1.00e+00 | 5.971 | 1 | 2 | 23 |
GO:0008135 | translation factor activity, nucleic acid binding | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 7 | 24 |
GO:0001836 | release of cytochrome c from mitochondria | 1.65e-02 | 1.00e+00 | 5.909 | 1 | 3 | 24 |
GO:0001816 | cytokine production | 1.72e-02 | 1.00e+00 | 5.850 | 1 | 3 | 25 |
GO:0000722 | telomere maintenance via recombination | 1.72e-02 | 1.00e+00 | 5.850 | 1 | 5 | 25 |
GO:0008536 | Ran GTPase binding | 1.72e-02 | 1.00e+00 | 5.850 | 1 | 1 | 25 |
GO:0007569 | cell aging | 1.72e-02 | 1.00e+00 | 5.850 | 1 | 1 | 25 |
GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 4 | 26 |
GO:0003730 | mRNA 3'-UTR binding | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 2 | 26 |
GO:0019901 | protein kinase binding | 1.93e-02 | 1.00e+00 | 3.186 | 2 | 21 | 317 |
GO:0010332 | response to gamma radiation | 1.93e-02 | 1.00e+00 | 5.687 | 1 | 3 | 28 |
GO:0002250 | adaptive immune response | 1.93e-02 | 1.00e+00 | 5.687 | 1 | 1 | 28 |
GO:0019894 | kinesin binding | 1.93e-02 | 1.00e+00 | 5.687 | 1 | 1 | 28 |
GO:0021549 | cerebellum development | 1.99e-02 | 1.00e+00 | 5.636 | 1 | 1 | 29 |
GO:0006606 | protein import into nucleus | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 2 | 30 |
GO:0051262 | protein tetramerization | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 2 | 30 |
GO:0034644 | cellular response to UV | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 5 | 30 |
GO:0006271 | DNA strand elongation involved in DNA replication | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 7 | 30 |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.06e-02 | 1.00e+00 | 5.587 | 1 | 2 | 30 |
GO:0046677 | response to antibiotic | 2.13e-02 | 1.00e+00 | 5.540 | 1 | 2 | 31 |
GO:0016604 | nuclear body | 2.13e-02 | 1.00e+00 | 5.540 | 1 | 2 | 31 |
GO:0003723 | RNA binding | 2.22e-02 | 1.00e+00 | 3.076 | 2 | 20 | 342 |
GO:0001756 | somitogenesis | 2.27e-02 | 1.00e+00 | 5.450 | 1 | 2 | 33 |
GO:0030971 | receptor tyrosine kinase binding | 2.27e-02 | 1.00e+00 | 5.450 | 1 | 2 | 33 |
GO:0033077 | T cell differentiation in thymus | 2.27e-02 | 1.00e+00 | 5.450 | 1 | 2 | 33 |
GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 2.27e-02 | 1.00e+00 | 5.450 | 1 | 2 | 33 |
GO:0001085 | RNA polymerase II transcription factor binding | 2.27e-02 | 1.00e+00 | 5.450 | 1 | 2 | 33 |
GO:0001895 | retina homeostasis | 2.33e-02 | 1.00e+00 | 5.407 | 1 | 1 | 34 |
GO:0034332 | adherens junction organization | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 1 | 36 |
GO:0051402 | neuron apoptotic process | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 2 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 2.54e-02 | 1.00e+00 | 5.285 | 1 | 4 | 37 |
GO:0001228 | RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 2.54e-02 | 1.00e+00 | 5.285 | 1 | 2 | 37 |
GO:0070527 | platelet aggregation | 2.60e-02 | 1.00e+00 | 5.246 | 1 | 2 | 38 |
GO:0000781 | chromosome, telomeric region | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 3 | 39 |
GO:0042110 | T cell activation | 2.88e-02 | 1.00e+00 | 5.102 | 1 | 3 | 42 |
GO:0004715 | non-membrane spanning protein tyrosine kinase activity | 2.88e-02 | 1.00e+00 | 5.102 | 1 | 4 | 42 |
GO:0021762 | substantia nigra development | 3.01e-02 | 1.00e+00 | 5.035 | 1 | 2 | 44 |
GO:0034613 | cellular protein localization | 3.01e-02 | 1.00e+00 | 5.035 | 1 | 1 | 44 |
GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | 3.01e-02 | 1.00e+00 | 5.035 | 1 | 2 | 44 |
GO:0043525 | positive regulation of neuron apoptotic process | 3.14e-02 | 1.00e+00 | 4.971 | 1 | 2 | 46 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 3.14e-02 | 1.00e+00 | 4.971 | 1 | 7 | 46 |
GO:0005507 | copper ion binding | 3.14e-02 | 1.00e+00 | 4.971 | 1 | 2 | 46 |
GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 3.21e-02 | 1.00e+00 | 4.940 | 1 | 5 | 47 |
GO:0003743 | translation initiation factor activity | 3.35e-02 | 1.00e+00 | 4.879 | 1 | 8 | 49 |
GO:0035690 | cellular response to drug | 3.35e-02 | 1.00e+00 | 4.879 | 1 | 2 | 49 |
GO:0045216 | cell-cell junction organization | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 54 |
GO:0000932 | cytoplasmic mRNA processing body | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 3 | 54 |
GO:0006968 | cellular defense response | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 1 | 54 |
GO:0097193 | intrinsic apoptotic signaling pathway | 3.75e-02 | 1.00e+00 | 4.713 | 1 | 6 | 55 |
GO:0007202 | activation of phospholipase C activity | 3.75e-02 | 1.00e+00 | 4.713 | 1 | 3 | 55 |
GO:0002039 | p53 binding | 3.75e-02 | 1.00e+00 | 4.713 | 1 | 7 | 55 |
GO:0000724 | double-strand break repair via homologous recombination | 3.75e-02 | 1.00e+00 | 4.713 | 1 | 3 | 55 |
GO:0007596 | blood coagulation | 3.78e-02 | 1.00e+00 | 2.664 | 2 | 18 | 455 |
GO:0008104 | protein localization | 3.82e-02 | 1.00e+00 | 4.687 | 1 | 3 | 56 |
GO:0000723 | telomere maintenance | 3.82e-02 | 1.00e+00 | 4.687 | 1 | 6 | 56 |
GO:0005643 | nuclear pore | 3.88e-02 | 1.00e+00 | 4.661 | 1 | 4 | 57 |
GO:0051087 | chaperone binding | 4.02e-02 | 1.00e+00 | 4.612 | 1 | 6 | 59 |
GO:0044267 | cellular protein metabolic process | 4.07e-02 | 1.00e+00 | 2.605 | 2 | 29 | 474 |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 4.15e-02 | 1.00e+00 | 4.563 | 1 | 2 | 61 |
GO:0042802 | identical protein binding | 4.23e-02 | 1.00e+00 | 2.575 | 2 | 20 | 484 |
GO:0044281 | small molecule metabolic process | 4.53e-02 | 1.00e+00 | 1.837 | 3 | 58 | 1211 |
GO:0035264 | multicellular organism growth | 4.55e-02 | 1.00e+00 | 4.428 | 1 | 1 | 67 |
GO:0003697 | single-stranded DNA binding | 4.62e-02 | 1.00e+00 | 4.407 | 1 | 5 | 68 |
GO:0034329 | cell junction assembly | 4.62e-02 | 1.00e+00 | 4.407 | 1 | 1 | 68 |
GO:0042826 | histone deacetylase binding | 4.88e-02 | 1.00e+00 | 4.324 | 1 | 2 | 72 |
GO:0000785 | chromatin | 4.95e-02 | 1.00e+00 | 4.304 | 1 | 4 | 73 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 5.02e-02 | 1.00e+00 | 4.285 | 1 | 6 | 74 |
GO:0002020 | protease binding | 5.02e-02 | 1.00e+00 | 4.285 | 1 | 4 | 74 |
GO:0008584 | male gonad development | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 3 | 75 |
GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 3 | 75 |
GO:0007265 | Ras protein signal transduction | 5.08e-02 | 1.00e+00 | 4.265 | 1 | 2 | 75 |
GO:0071013 | catalytic step 2 spliceosome | 5.28e-02 | 1.00e+00 | 4.209 | 1 | 4 | 78 |
GO:0005524 | ATP binding | 5.40e-02 | 1.00e+00 | 1.737 | 3 | 60 | 1298 |
GO:0005681 | spliceosomal complex | 5.61e-02 | 1.00e+00 | 4.119 | 1 | 4 | 83 |
GO:0050852 | T cell receptor signaling pathway | 5.74e-02 | 1.00e+00 | 4.085 | 1 | 4 | 85 |
GO:0016363 | nuclear matrix | 6.14e-02 | 1.00e+00 | 3.986 | 1 | 12 | 91 |
GO:0006928 | cellular component movement | 6.14e-02 | 1.00e+00 | 3.986 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 6.14e-02 | 1.00e+00 | 3.986 | 1 | 8 | 91 |
GO:0045087 | innate immune response | 6.16e-02 | 1.00e+00 | 2.275 | 2 | 24 | 596 |
GO:0001649 | osteoblast differentiation | 6.20e-02 | 1.00e+00 | 3.971 | 1 | 6 | 92 |
GO:0071456 | cellular response to hypoxia | 6.20e-02 | 1.00e+00 | 3.971 | 1 | 6 | 92 |
GO:0014069 | postsynaptic density | 7.05e-02 | 1.00e+00 | 3.780 | 1 | 3 | 105 |
GO:0030308 | negative regulation of cell growth | 7.37e-02 | 1.00e+00 | 3.713 | 1 | 6 | 110 |
GO:0006461 | protein complex assembly | 7.44e-02 | 1.00e+00 | 3.700 | 1 | 6 | 111 |
GO:0072562 | blood microparticle | 7.44e-02 | 1.00e+00 | 3.700 | 1 | 3 | 111 |
GO:0030529 | ribonucleoprotein complex | 7.50e-02 | 1.00e+00 | 3.687 | 1 | 8 | 112 |
GO:0005635 | nuclear envelope | 7.57e-02 | 1.00e+00 | 3.674 | 1 | 6 | 113 |
GO:0019058 | viral life cycle | 7.70e-02 | 1.00e+00 | 3.649 | 1 | 13 | 115 |
GO:0006325 | chromatin organization | 7.89e-02 | 1.00e+00 | 3.612 | 1 | 5 | 118 |
GO:0007219 | Notch signaling pathway | 8.02e-02 | 1.00e+00 | 3.587 | 1 | 5 | 120 |
GO:0006260 | DNA replication | 8.08e-02 | 1.00e+00 | 3.575 | 1 | 9 | 121 |
GO:0007050 | cell cycle arrest | 8.27e-02 | 1.00e+00 | 3.540 | 1 | 9 | 124 |
GO:0009615 | response to virus | 8.40e-02 | 1.00e+00 | 3.517 | 1 | 5 | 126 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 8.40e-02 | 1.00e+00 | 3.517 | 1 | 5 | 126 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 8.53e-02 | 1.00e+00 | 3.494 | 1 | 4 | 128 |
GO:0006413 | translational initiation | 8.72e-02 | 1.00e+00 | 3.461 | 1 | 17 | 131 |
GO:0018108 | peptidyl-tyrosine phosphorylation | 8.79e-02 | 1.00e+00 | 3.450 | 1 | 7 | 132 |
GO:0005911 | cell-cell junction | 9.04e-02 | 1.00e+00 | 3.407 | 1 | 4 | 136 |
GO:0006457 | protein folding | 9.49e-02 | 1.00e+00 | 3.334 | 1 | 7 | 143 |
GO:0061024 | membrane organization | 9.61e-02 | 1.00e+00 | 3.314 | 1 | 7 | 145 |
GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 9.74e-02 | 1.00e+00 | 3.294 | 1 | 3 | 147 |
GO:0006974 | cellular response to DNA damage stimulus | 9.99e-02 | 1.00e+00 | 3.256 | 1 | 8 | 151 |
GO:0000398 | mRNA splicing, via spliceosome | 1.08e-01 | 1.00e+00 | 3.137 | 1 | 8 | 164 |
GO:0030424 | axon | 1.09e-01 | 1.00e+00 | 3.119 | 1 | 4 | 166 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 1.11e-01 | 1.00e+00 | 3.102 | 1 | 12 | 168 |
GO:0031965 | nuclear membrane | 1.11e-01 | 1.00e+00 | 3.102 | 1 | 3 | 168 |
GO:0044212 | transcription regulatory region DNA binding | 1.11e-01 | 1.00e+00 | 3.102 | 1 | 6 | 168 |
GO:0019904 | protein domain specific binding | 1.17e-01 | 1.00e+00 | 3.010 | 1 | 6 | 179 |
GO:0005759 | mitochondrial matrix | 1.47e-01 | 1.00e+00 | 2.661 | 1 | 14 | 228 |
GO:0008380 | RNA splicing | 1.47e-01 | 1.00e+00 | 2.661 | 1 | 11 | 228 |
GO:0008270 | zinc ion binding | 1.49e-01 | 1.00e+00 | 1.533 | 2 | 12 | 997 |
GO:0006412 | translation | 1.49e-01 | 1.00e+00 | 2.649 | 1 | 20 | 230 |
GO:0008134 | transcription factor binding | 1.56e-01 | 1.00e+00 | 2.575 | 1 | 8 | 242 |
GO:0000166 | nucleotide binding | 1.66e-01 | 1.00e+00 | 2.477 | 1 | 5 | 259 |
GO:0006281 | DNA repair | 1.67e-01 | 1.00e+00 | 2.466 | 1 | 18 | 261 |
GO:0043065 | positive regulation of apoptotic process | 1.71e-01 | 1.00e+00 | 2.428 | 1 | 10 | 268 |
GO:0005856 | cytoskeleton | 1.84e-01 | 1.00e+00 | 2.309 | 1 | 12 | 291 |
GO:0030154 | cell differentiation | 1.90e-01 | 1.00e+00 | 2.261 | 1 | 5 | 301 |
GO:0035556 | intracellular signal transduction | 1.91e-01 | 1.00e+00 | 2.251 | 1 | 9 | 303 |
GO:0007275 | multicellular organismal development | 1.99e-01 | 1.00e+00 | 2.190 | 1 | 5 | 316 |
GO:0007411 | axon guidance | 2.00e-01 | 1.00e+00 | 2.177 | 1 | 13 | 319 |
GO:0003682 | chromatin binding | 2.05e-01 | 1.00e+00 | 2.141 | 1 | 11 | 327 |
GO:0008283 | cell proliferation | 2.06e-01 | 1.00e+00 | 2.137 | 1 | 14 | 328 |
GO:0008285 | negative regulation of cell proliferation | 2.20e-01 | 1.00e+00 | 2.031 | 1 | 11 | 353 |
GO:0005925 | focal adhesion | 2.27e-01 | 1.00e+00 | 1.978 | 1 | 19 | 366 |
GO:0046872 | metal ion binding | 2.28e-01 | 1.00e+00 | 1.142 | 2 | 25 | 1307 |
GO:0046982 | protein heterodimerization activity | 2.34e-01 | 1.00e+00 | 1.924 | 1 | 13 | 380 |
GO:0005737 | cytoplasm | 2.51e-01 | 1.00e+00 | 0.615 | 4 | 110 | 3767 |
GO:0045892 | negative regulation of transcription, DNA-templated | 2.52e-01 | 1.00e+00 | 1.804 | 1 | 15 | 413 |
GO:0045893 | positive regulation of transcription, DNA-templated | 2.86e-01 | 1.00e+00 | 1.593 | 1 | 13 | 478 |
GO:0005783 | endoplasmic reticulum | 3.25e-01 | 1.00e+00 | 1.375 | 1 | 10 | 556 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 3.32e-01 | 1.00e+00 | 1.339 | 1 | 16 | 570 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 3.92e-01 | 1.00e+00 | 1.045 | 1 | 11 | 699 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 4.30e-01 | 1.00e+00 | 0.870 | 1 | 19 | 789 |
GO:0007165 | signal transduction | 4.78e-01 | 1.00e+00 | 0.669 | 1 | 24 | 907 |
GO:0005615 | extracellular space | 4.97e-01 | 1.00e+00 | 0.592 | 1 | 17 | 957 |
GO:0006355 | regulation of transcription, DNA-templated | 5.12e-01 | 1.00e+00 | 0.533 | 1 | 18 | 997 |
GO:0005739 | mitochondrion | 5.12e-01 | 1.00e+00 | 0.531 | 1 | 28 | 998 |
GO:0003677 | DNA binding | 5.86e-01 | 1.00e+00 | 0.244 | 1 | 28 | 1218 |