int-snw-9554

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.961 1.51e-16 1.38e-03 2.61e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-9554 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RUVBL1 8607 170.7201.013343Yes-
RBX1 9978 971.1851.151139Yes-
NAA10 8260 50.6680.983136Yes-
[ SEC22B ] 9554 20.5600.974143--
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
RUVBL2 10856 50.6931.003345Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (17)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RUVBL1 8607 RUVBL2 10856 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid, BioGrid_Mouse, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct, IntAct_Fly, IntAct_Worm, IntAct_Yeast, INTEROLOG, MINT_Worm, MINT_Yeast, BCI, BioGrid_Fly, BIND_Fly, BIND_Worm, FlyHigh, INNATEDB, Krogan_Core, MIPS, YeastHigh, Yu_GoldStd;
int.Ravasi: -;
int.HPRD: in vitro, in vivo, yeast 2-hybrid;
int.DIP: MI:0915(physical association)
ACTB 60 NAA10 8260 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow, BioGrid
NAA10 8260 SEC22B 9554 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 NAA10 8260 pp -- int.I2D: IntAct_Yeast
PSMD11 5717 RUVBL2 10856 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 SEC22B 9554 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
RUVBL1 8607 SEC22B 9554 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
SEC22B 9554 RUVBL2 10856 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (195)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0035267NuA4 histone acetyltransferase complex6.09e-088.79e-048.4243414
GO:0000812Swr1 complex9.67e-061.40e-018.646238
GO:0005654nucleoplasm1.21e-051.75e-013.1526761082
GO:0006281DNA repair1.23e-051.77e-014.618418261
GO:0043968histone H2A acetylation2.28e-053.28e-018.0612312
GO:0031011Ino80 complex3.14e-054.53e-017.8392314
GO:0030529ribonucleoprotein complex3.70e-055.34e-015.42438112
GO:0006325chromatin organization4.33e-056.24e-015.34835118
GO:0003678DNA helicase activity4.68e-056.76e-017.5592317
GO:0043022ribosome binding1.21e-041.00e+006.8912327
GO:0071339MLL1 complex1.21e-041.00e+006.8912327
GO:0043967histone H4 acetylation1.21e-041.00e+006.8912327
GO:0016020membrane1.53e-041.00e+002.5166901681
GO:0032508DNA duplex unwinding2.80e-041.00e+006.2892341
GO:0005515protein binding3.85e-041.00e+001.26091846024
GO:0003684damaged DNA binding4.01e-041.00e+006.0312749
GO:0040008regulation of growth4.17e-041.00e+006.0022550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.69e-041.00e+005.9182553
GO:0006310DNA recombination7.05e-041.00e+005.6242265
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0016363nuclear matrix1.38e-031.00e+005.13821291
GO:0071733transcriptional activation by promoter-enhancer looping1.87e-031.00e+009.061113
GO:0071899negative regulation of estrogen receptor binding1.87e-031.00e+009.061113
GO:0043141ATP-dependent 5'-3' DNA helicase activity2.49e-031.00e+008.646114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0071169establishment of protein localization to chromatin3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:0006323DNA packaging3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0004596peptide alpha-N-acetyltransferase activity3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0031415NatA complex3.12e-031.00e+008.324115
GO:0016887ATPase activity3.22e-031.00e+004.51727140
GO:0006457protein folding3.36e-031.00e+004.48627143
GO:0016032viral process3.59e-031.00e+003.170355534
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0006474N-terminal protein amino acid acetylation3.74e-031.00e+008.061116
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0006475internal protein amino acid acetylation4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0008080N-acetyltransferase activity4.98e-031.00e+007.646118
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0016407acetyltransferase activity6.22e-031.00e+007.3241110
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0005622intracellular6.91e-031.00e+003.95326207
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0016071mRNA metabolic process7.98e-031.00e+003.845231223
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0070062extracellular vesicular exosome8.87e-031.00e+001.73951042400
GO:0035066positive regulation of histone acetylation9.32e-031.00e+006.7391115
GO:0016070RNA metabolic process9.71e-031.00e+003.698232247
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0071392cellular response to estradiol stimulus1.12e-021.00e+006.4761118
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0005719nuclear euchromatin1.18e-021.00e+006.3981219
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0005730nucleolus1.31e-021.00e+001.9664691641
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0034080CENP-A containing nucleosome assembly1.55e-021.00e+006.0021125
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0004003ATP-dependent DNA helicase activity1.67e-021.00e+005.8911227
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0033116endoplasmic reticulum-Golgi intermediate compartment membrane1.67e-021.00e+005.8911127
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0034644cellular response to UV1.86e-021.00e+005.7391530
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0000278mitotic cell cycle2.33e-021.00e+003.035248391
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0031490chromatin DNA binding2.35e-021.00e+005.3981338
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding2.71e-021.00e+005.1871244
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0006521regulation of cellular amino acid metabolic process3.08e-021.00e+005.00211750
GO:0006888ER to Golgi vesicle-mediated transport3.26e-021.00e+004.9181253
GO:0005634nucleus3.27e-021.00e+001.07761364559
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0005793endoplasmic reticulum-Golgi intermediate compartment3.44e-021.00e+004.8391156
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0000502proteasome complex3.56e-021.00e+004.78811758
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.98e-021.00e+004.62412265
GO:0005524ATP binding4.04e-021.00e+001.8893601298
GO:0006338chromatin remodeling4.04e-021.00e+004.6021566
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.29e-021.00e+004.51712270
GO:0006334nucleosome assembly4.41e-021.00e+004.4761272
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.53e-021.00e+004.43712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.82e-021.00e+004.34212379
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0005794Golgi apparatus5.28e-021.00e+002.393215610
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0005829cytosol5.42e-021.00e+001.36141322496
GO:0042470melanosome5.54e-021.00e+004.1381991
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0051082unfolded protein binding5.66e-021.00e+004.1071593
GO:0005737cytoplasm5.81e-021.00e+001.08951103767
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0005815microtubule organizing center6.60e-021.00e+003.87815109
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0034641cellular nitrogen compound metabolic process1.02e-011.00e+003.228120171
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0007067mitotic nuclear division1.33e-011.00e+002.820114227
GO:0006412translation1.35e-011.00e+002.801120230
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0007283spermatogenesis1.52e-011.00e+002.61318262
GO:0006357regulation of transcription from RNA polymerase II promoter1.53e-011.00e+002.60218264
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0006200ATP catabolic process1.68e-011.00e+002.456115292
GO:0043234protein complex1.70e-011.00e+002.442118295
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0015031protein transport1.94e-011.00e+002.23315341
GO:0005925focal adhesion2.07e-011.00e+002.130119366
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0006351transcription, DNA-templated2.26e-011.00e+001.1482311446
GO:0043066negative regulation of apoptotic process2.36e-011.00e+001.918131424
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0042802identical protein binding2.65e-011.00e+001.727120484
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0005789endoplasmic reticulum membrane3.04e-011.00e+001.491116570
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.97e-011.00e+001.022119789
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0008270zinc ion binding4.75e-011.00e+000.685112997
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021491056
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041581211
GO:0016021integral component of membrane7.36e-011.00e+00-0.3071271982
GO:0005886plasma membrane8.31e-011.00e+00-0.6881452582