int-snw-9296

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.930 2.48e-15 2.74e-03 4.31e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-9296 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RBX1 9978 971.1851.151139Yes-
[ ATP6V1F ] 9296 10.1840.93036--
PSMD3 5709 570.9861.106146Yes-
PPP3R1 5534 3-0.4620.99476--
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ATP6V0C 527 60.6601.07669Yes-
ACTB 60 1671.1531.151587Yes-
ATP6V1B2 526 440.8811.076278--
RPSA 3921 1561.3271.151152Yes-

Interactions (24)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ATP6V0C 527 ATP6V1F 9296 pp -- int.I2D: INTEROLOG, YeastMedium
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 PPP3R1 5534 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ATP6V1B2 526 ATP6V0C 527 pp -- int.I2D: YeastMedium, INTEROLOG
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PPP3R1 5534 ATP6V1F 9296 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 ATP6V1F 9296 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastMedium, IntAct_Yeast, INTEROLOG
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 ATP6V1F 9296 pp -- int.I2D: BioGrid_Yeast
ATP6V0C 527 PPP3R1 5534 pp -- int.I2D: BioGrid_Yeast
ACTB 60 ATP6V0C 527 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast

Related GO terms (191)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016032viral process6.18e-088.92e-043.978755534
GO:0006521regulation of cellular amino acid metabolic process6.20e-088.94e-046.58741750
GO:0000082G1/S transition of mitotic cell cycle8.22e-081.19e-035.334532149
GO:0000502proteasome complex1.14e-071.64e-036.37341758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.70e-072.45e-036.23141964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.81e-072.61e-036.20942265
GO:0046961proton-transporting ATPase activity, rotational mechanism1.99e-072.87e-037.9093315
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.45e-073.53e-036.10242270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.74e-073.95e-036.06142072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.06e-074.42e-036.02242274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.23e-074.67e-036.00242075
GO:0005654nucleoplasm3.69e-075.32e-033.1528761082
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.99e-075.76e-035.92742379
GO:0016071mRNA metabolic process6.13e-078.84e-034.752531223
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.38e-071.06e-025.70842192
GO:0016070RNA metabolic process1.02e-061.46e-024.605532247
GO:0005829cytosol1.11e-061.61e-022.268101322496
GO:0015991ATP hydrolysis coupled proton transport1.13e-061.63e-027.1163426
GO:0015992proton transport1.59e-062.29e-026.9583329
GO:0033572transferrin transport1.76e-062.54e-026.9093530
GO:0000209protein polyubiquitination1.87e-062.70e-025.373420116
GO:0051701interaction with host2.15e-063.11e-026.8163432
GO:0090382phagosome maturation3.09e-064.46e-026.6463536
GO:0042981regulation of apoptotic process5.21e-067.52e-025.002424150
GO:0034641cellular nitrogen compound metabolic process8.77e-061.26e-014.813420171
GO:0006879cellular iron ion homeostasis8.96e-061.29e-016.1443451
GO:0000278mitotic cell cycle9.66e-061.39e-013.942548391
GO:0070062extracellular vesicular exosome1.31e-051.89e-012.17291042400
GO:0033180proton-transporting V-type ATPase, V1 domain1.33e-051.92e-018.424227
GO:0005838proteasome regulatory particle4.17e-056.01e-017.6462712
GO:0006915apoptotic process5.24e-057.56e-013.437533555
GO:0022624proteasome accessory complex8.57e-051.00e+007.1442817
GO:0005839proteasome core complex9.64e-051.00e+007.0612818
GO:0015078hydrogen ion transmembrane transporter activity1.08e-041.00e+006.9832319
GO:0004298threonine-type endopeptidase activity1.08e-041.00e+006.9832819
GO:0010467gene expression1.28e-041.00e+003.167559669
GO:0008286insulin receptor signaling pathway1.93e-041.00e+004.66637142
GO:0043066negative regulation of apoptotic process3.02e-041.00e+003.503431424
GO:0031625ubiquitin protein ligase binding3.75e-041.00e+004.340314178
GO:0042624ATPase activity, uncoupled8.32e-041.00e+0010.231111
GO:0004723calcium-dependent protein serine/threonine phosphatase activity1.66e-031.00e+009.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0005955calcineurin complex3.32e-031.00e+008.231124
GO:0005515protein binding4.10e-031.00e+000.997101846024
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0033179proton-transporting V-type ATPase, V0 domain4.15e-031.00e+007.909115
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0016469proton-transporting two-sector ATPase complex4.15e-031.00e+007.909115
GO:0055085transmembrane transport4.89e-031.00e+003.051310435
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0016471vacuolar proton-transporting V-type ATPase complex5.81e-031.00e+007.424117
GO:0019773proteasome core complex, alpha-subunit complex6.64e-031.00e+007.231148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0046933proton-transporting ATP synthase activity, rotational mechanism7.47e-031.00e+007.061119
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0016020membrane8.36e-031.00e+001.8385901681
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0030234enzyme regulator activity1.08e-021.00e+006.5311313
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:0005765lysosomal membrane1.19e-021.00e+003.56625203
GO:0046034ATP metabolic process1.24e-021.00e+006.3241115
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0042176regulation of protein catabolic process1.32e-021.00e+006.2311316
GO:0044281small molecule metabolic process1.42e-021.00e+001.9894581211
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway2.14e-021.00e+005.5311426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0030177positive regulation of Wnt signaling pathway2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0005902microvillus3.12e-021.00e+004.9831238
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0005925focal adhesion3.58e-021.00e+002.715219366
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0030670phagocytic vesicle membrane3.84e-021.00e+004.6771347
GO:0005730nucleolus3.91e-021.00e+001.5514691641
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0097193intrinsic apoptotic signaling pathway4.48e-021.00e+004.4501655
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0012505endomembrane system4.56e-021.00e+004.4241256
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0044267cellular protein metabolic process5.72e-021.00e+002.342229474
GO:0042383sarcolemma5.75e-021.00e+004.0811371
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0001726ruffle6.46e-021.00e+003.9091480
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0016311dephosphorylation6.85e-021.00e+003.8221385
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0042470melanosome7.32e-021.00e+003.7231991
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0045087innate immune response8.56e-021.00e+002.012224596
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0010008endosome membrane1.19e-011.00e+002.99317151
GO:0005516calmodulin binding1.25e-011.00e+002.90913160
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0038095Fc-epsilon receptor signaling pathway1.31e-011.00e+002.839112168
GO:0019904protein domain specific binding1.39e-011.00e+002.74716179
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0005634nucleus1.45e-011.00e+000.66261364559
GO:0006412translation1.75e-011.00e+002.386120230
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0006200ATP catabolic process2.18e-011.00e+002.041115292
GO:0043234protein complex2.20e-011.00e+002.027118295
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0019901protein kinase binding2.34e-011.00e+001.923121317
GO:0043231intracellular membrane-bounded organelle2.35e-011.00e+001.91819318
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0005813centrosome2.40e-011.00e+001.882114326
GO:0003723RNA binding2.50e-011.00e+001.813120342
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0005524ATP binding2.95e-011.00e+000.8892601298
GO:0007596blood coagulation3.19e-011.00e+001.401118455
GO:0005509calcium ion binding3.63e-011.00e+001.17915531
GO:0016021integral component of membrane5.06e-011.00e+000.2782271982
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0044822poly(A) RNA binding5.99e-011.00e+000.1871491056
GO:0005737cytoplasm6.43e-011.00e+00-0.06331103767
GO:0005886plasma membrane6.61e-011.00e+00-0.1032452582