int-snw-9232

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.978 3.18e-17 9.34e-04 1.96e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-9232 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
CAD 790 170.8071.007333--
CDC16 8881 250.9501.02080Yes-
RBX1 9978 971.1851.151139Yes-
[ PTTG1 ] 9232 1-0.1550.97832--
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
ATP6V1B2 526 440.8811.076278--
RPSA 3921 1561.3271.151152Yes-

Interactions (13)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 CDC16 8881 pp -- int.I2D: IntAct_Yeast
CDC16 8881 PTTG1 9232 pp -- int.I2D: BioGrid
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
CAD 790 CDC16 8881 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005829cytosol6.07e-068.76e-022.36181322496
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.30e-051.87e-015.92732379
GO:0000278mitotic cell cycle6.02e-058.68e-014.035448391
GO:0005654nucleoplasm2.30e-041.00e+002.8895761082
GO:0006281DNA repair4.54e-041.00e+004.203318261
GO:0004151dihydroorotase activity6.24e-041.00e+0010.646111
GO:0004070aspartate carbamoyltransferase activity6.24e-041.00e+0010.646111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity6.24e-041.00e+0010.646111
GO:0070335aspartate binding6.24e-041.00e+0010.646111
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle7.05e-041.00e+005.62422265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.18e-041.00e+005.51722270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.13e-041.00e+005.43722274
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0070409carbamoyl phosphate biosynthetic process1.25e-031.00e+009.646112
GO:0044205'de novo' UMP biosynthetic process1.87e-031.00e+009.061113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process1.87e-031.00e+009.061113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0006543glutamine catabolic process2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0051414response to cortisol3.12e-031.00e+008.324115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0016032viral process3.59e-031.00e+003.170355534
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0046134pyrimidine nucleoside biosynthetic process3.74e-031.00e+008.061116
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0033180proton-transporting V-type ATPase, V1 domain4.36e-031.00e+007.839127
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0006228UTP biosynthetic process5.60e-031.00e+007.476119
GO:0014075response to amine5.60e-031.00e+007.476119
GO:0031000response to caffeine5.60e-031.00e+007.476129
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0016071mRNA metabolic process7.98e-031.00e+003.845231223
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0007067mitotic nuclear division8.25e-031.00e+003.820214227
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0070062extracellular vesicular exosome8.87e-031.00e+001.73951042400
GO:0046961proton-transporting ATPase activity, rotational mechanism9.32e-031.00e+006.7391315
GO:0046034ATP metabolic process9.32e-031.00e+006.7391115
GO:0016070RNA metabolic process9.71e-031.00e+003.698232247
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0051276chromosome organization9.94e-031.00e+006.6461316
GO:0006541glutamine metabolic process1.06e-021.00e+006.5591117
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0007088regulation of mitosis1.12e-021.00e+006.4761118
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0017144drug metabolic process1.12e-021.00e+006.4761118
GO:0015078hydrogen ion transmembrane transporter activity1.18e-021.00e+006.3981319
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0019899enzyme binding1.21e-021.00e+003.532212277
GO:0005680anaphase-promoting complex1.24e-021.00e+006.3241420
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0071364cellular response to epidermal growth factor stimulus1.30e-021.00e+006.2541121
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006206pyrimidine nucleobase metabolic process1.36e-021.00e+006.1871222
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0033574response to testosterone1.36e-021.00e+006.1871222
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043234protein complex1.37e-021.00e+003.442218295
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0016020membrane1.43e-021.00e+001.9314901681
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0004869cysteine-type endopeptidase inhibitor activity1.43e-021.00e+006.1231123
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0070979protein K11-linked ubiquitination1.61e-021.00e+005.9461626
GO:0015991ATP hydrolysis coupled proton transport1.61e-021.00e+005.9461426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0015992proton transport1.80e-021.00e+005.7881329
GO:0033572transferrin transport1.86e-021.00e+005.7391530
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0007094mitotic spindle assembly checkpoint1.92e-021.00e+005.6921431
GO:0051701interaction with host1.98e-021.00e+005.6461432
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0005876spindle microtubule2.10e-021.00e+005.5591234
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0090382phagosome maturation2.22e-021.00e+005.4761536
GO:0018107peptidyl-threonine phosphorylation2.29e-021.00e+005.4371437
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0005902microvillus2.35e-021.00e+005.3981238
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0007595lactation2.41e-021.00e+005.3611239
GO:0043195terminal bouton2.53e-021.00e+005.2891141
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0035690cellular response to drug3.02e-021.00e+005.0311249
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0006521regulation of cellular amino acid metabolic process3.08e-021.00e+005.00211750
GO:0031100organ regeneration3.08e-021.00e+005.0021450
GO:0006879cellular iron ion homeostasis3.14e-021.00e+004.9741451
GO:0005515protein binding3.23e-021.00e+000.89771846024
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0012505endomembrane system3.44e-021.00e+004.8391256
GO:0000502proteasome complex3.56e-021.00e+004.78811758
GO:0042995cell projection3.68e-021.00e+004.7391660
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0007059chromosome segregation3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0005524ATP binding4.04e-021.00e+001.8893601298
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0055086nucleobase-containing small molecule metabolic process4.29e-021.00e+004.5171270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0001889liver development4.70e-021.00e+004.3791477
GO:0007565female pregnancy4.76e-021.00e+004.3611178
GO:0001726ruffle4.88e-021.00e+004.3241480
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0042470melanosome5.54e-021.00e+004.1381991
GO:0016363nuclear matrix5.54e-021.00e+004.13811291
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0010951negative regulation of endopeptidase activity6.31e-021.00e+003.94611104
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0005819spindle6.78e-021.00e+003.83917112
GO:0017124SH3 domain binding6.84e-021.00e+003.82613113
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0007507heart development8.35e-021.00e+003.52717139
GO:0008286insulin receptor signaling pathway8.52e-021.00e+003.49617142
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0046777protein autophosphorylation9.44e-021.00e+003.34217158
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0034641cellular nitrogen compound metabolic process1.02e-011.00e+003.228120171
GO:0004672protein kinase activity1.05e-011.00e+003.17916177
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0005765lysosomal membrane1.20e-011.00e+002.98115203
GO:0005634nucleus1.20e-011.00e+000.81451364559
GO:0008270zinc ion binding1.24e-011.00e+001.685212997
GO:0006412translation1.35e-011.00e+002.801120230
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0007283spermatogenesis1.52e-011.00e+002.61318262
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0044281small molecule metabolic process1.71e-011.00e+001.4042581211
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005813centrosome1.86e-011.00e+002.297114326
GO:0005737cytoplasm1.87e-011.00e+000.76741103767
GO:0008283cell proliferation1.87e-011.00e+002.289114328
GO:0005925focal adhesion2.07e-011.00e+002.130119366
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0006366transcription from RNA polymerase II promoter2.33e-011.00e+001.935110419
GO:0043066negative regulation of apoptotic process2.36e-011.00e+001.918131424
GO:0055085transmembrane transport2.41e-011.00e+001.881110435
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0042802identical protein binding2.65e-011.00e+001.727120484
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0003700sequence-specific DNA binding transcription factor activity3.61e-011.00e+001.197111699
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0006355regulation of transcription, DNA-templated4.75e-011.00e+000.685118997
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021491056
GO:0005886plasma membrane4.98e-011.00e+000.3122452582
GO:0005730nucleolus6.63e-011.00e+00-0.0341691641
GO:0016021integral component of membrane7.36e-011.00e+00-0.3071271982