int-snw-9026

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.017	7.93e-19	3.67e-04	9.58e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-9026 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
EIF2S2	8894	27	1.075	1.138	81	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RBX1	9978	97	1.185	1.151	139	Yes	-
[ HIP1R ]	9026	1	-0.300	1.017	59	-	-
CLTC	1213	35	0.884	1.138	247	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (13)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	HIP1R	9026	pp	--	int.I2D: BioGrid_Yeast
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
ATP6V1B2	526	HIP1R	9026	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
CLTC	1213	HIP1R	9026	pp	--	int.I2D: HPRD, IntAct_Yeast, BCI, BioGrid_Yeast, MINT_Yeast, Tarassov_PCA, YeastLow; int.HPRD: in vitro
ACTB	60	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
CLTC	1213	EIF2S2	8894	pp	--	int.I2D: YeastLow
ATP6V1B2	526	CLTC	1213	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (197)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	1.20e-04	1.00e+00	2.168	7	132	2496
GO:0033572	transferrin transport	1.49e-04	1.00e+00	6.739	2	5	30
GO:0030136	clathrin-coated vesicle	2.94e-04	1.00e+00	6.254	2	4	42
GO:0006898	receptor-mediated endocytosis	1.18e-03	1.00e+00	5.254	2	3	84
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002176	male germ cell proliferation	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0042470	melanosome	1.38e-03	1.00e+00	5.138	2	9	91
GO:0005850	eukaryotic translation initiation factor 2 complex	1.87e-03	1.00e+00	9.061	1	1	3
GO:1900126	negative regulation of hyaluronan biosynthetic process	1.87e-03	1.00e+00	9.061	1	2	3
GO:0071439	clathrin complex	1.87e-03	1.00e+00	9.061	1	2	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0032051	clathrin light chain binding	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	4
GO:0019788	NEDD8 ligase activity	2.49e-03	1.00e+00	8.646	1	1	4
GO:1903077	negative regulation of protein localization to plasma membrane	2.49e-03	1.00e+00	8.646	1	1	4
GO:0044267	cellular protein metabolic process	2.56e-03	1.00e+00	3.342	3	29	474
GO:0006413	translational initiation	2.83e-03	1.00e+00	4.613	2	17	131
GO:0005654	nucleoplasm	2.92e-03	1.00e+00	2.567	4	76	1082
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043248	proteasome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030891	VCB complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0000730	DNA recombinase assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.12e-03	1.00e+00	8.324	1	1	5
GO:0061024	membrane organization	3.45e-03	1.00e+00	4.466	2	7	145
GO:0016032	viral process	3.59e-03	1.00e+00	3.170	3	55	534
GO:0000082	G1/S transition of mitotic cell cycle	3.64e-03	1.00e+00	4.427	2	32	149
GO:0030130	clathrin coat of trans-Golgi network vesicle	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0030118	clathrin coat	3.74e-03	1.00e+00	8.061	1	2	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.36e-03	1.00e+00	7.839	1	2	7
GO:0030132	clathrin coat of coated pit	4.36e-03	1.00e+00	7.839	1	2	7
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	4.36e-03	1.00e+00	7.839	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	2	8
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0045116	protein neddylation	4.98e-03	1.00e+00	7.646	1	2	8
GO:0031625	ubiquitin protein ligase binding	5.15e-03	1.00e+00	4.170	2	14	178
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	184	6024
GO:0010569	regulation of double-strand break repair via homologous recombination	6.22e-03	1.00e+00	7.324	1	1	10
GO:0010467	gene expression	6.76e-03	1.00e+00	2.845	3	59	669
GO:0031571	mitotic G1 DNA damage checkpoint	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	7	12
GO:0016071	mRNA metabolic process	7.98e-03	1.00e+00	3.845	2	31	223
GO:0005662	DNA replication factor A complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0030665	clathrin-coated vesicle membrane	8.09e-03	1.00e+00	6.946	1	2	13
GO:0006412	translation	8.47e-03	1.00e+00	3.801	2	20	230
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0070062	extracellular vesicular exosome	8.87e-03	1.00e+00	1.739	5	104	2400
GO:0046961	proton-transporting ATPase activity, rotational mechanism	9.32e-03	1.00e+00	6.739	1	3	15
GO:0046034	ATP metabolic process	9.32e-03	1.00e+00	6.739	1	1	15
GO:0016070	RNA metabolic process	9.71e-03	1.00e+00	3.698	2	32	247
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	8	17
GO:0006281	DNA repair	1.08e-02	1.00e+00	3.618	2	18	261
GO:0035861	site of double-strand break	1.12e-02	1.00e+00	6.476	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.18e-02	1.00e+00	6.398	1	3	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.18e-02	1.00e+00	6.398	1	1	19
GO:0048863	stem cell differentiation	1.18e-02	1.00e+00	6.398	1	1	19
GO:0006298	mismatch repair	1.24e-02	1.00e+00	6.324	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.30e-02	1.00e+00	6.254	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.30e-02	1.00e+00	6.254	1	4	21
GO:0005856	cytoskeleton	1.33e-02	1.00e+00	3.461	2	12	291
GO:0006297	nucleotide-excision repair, DNA gap filling	1.36e-02	1.00e+00	6.187	1	3	22
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.43e-02	1.00e+00	6.123	1	3	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0016020	membrane	1.43e-02	1.00e+00	1.931	4	90	1681
GO:0006513	protein monoubiquitination	1.43e-02	1.00e+00	6.123	1	1	23
GO:0008135	translation factor activity, nucleic acid binding	1.49e-02	1.00e+00	6.061	1	7	24
GO:0000722	telomere maintenance via recombination	1.55e-02	1.00e+00	6.002	1	5	25
GO:0019901	protein kinase binding	1.57e-02	1.00e+00	3.338	2	21	317
GO:0043231	intracellular membrane-bounded organelle	1.57e-02	1.00e+00	3.333	2	9	318
GO:0015991	ATP hydrolysis coupled proton transport	1.61e-02	1.00e+00	5.946	1	4	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.61e-02	1.00e+00	5.946	1	3	26
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0030669	clathrin-coated endocytic vesicle membrane	1.73e-02	1.00e+00	5.839	1	4	28
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.80e-02	1.00e+00	5.788	1	1	29
GO:0015992	proton transport	1.80e-02	1.00e+00	5.788	1	3	29
GO:0006271	DNA strand elongation involved in DNA replication	1.86e-02	1.00e+00	5.739	1	7	30
GO:0031623	receptor internalization	1.92e-02	1.00e+00	5.692	1	2	31
GO:0051701	interaction with host	1.98e-02	1.00e+00	5.646	1	4	32
GO:0005925	focal adhesion	2.05e-02	1.00e+00	3.130	2	19	366
GO:0032588	trans-Golgi network membrane	2.10e-02	1.00e+00	5.559	1	2	34
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0090382	phagosome maturation	2.22e-02	1.00e+00	5.476	1	5	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0006284	base-excision repair	2.29e-02	1.00e+00	5.437	1	3	37
GO:0000278	mitotic cell cycle	2.33e-02	1.00e+00	3.035	2	48	391
GO:0005902	microvillus	2.35e-02	1.00e+00	5.398	1	2	38
GO:0044822	poly(A) RNA binding	2.35e-02	1.00e+00	2.187	3	49	1056
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0000781	chromosome, telomeric region	2.41e-02	1.00e+00	5.361	1	3	39
GO:0006892	post-Golgi vesicle-mediated transport	2.65e-02	1.00e+00	5.220	1	3	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.83e-02	1.00e+00	5.123	1	7	46
GO:0003743	translation initiation factor activity	3.02e-02	1.00e+00	5.031	1	8	49
GO:0003684	damaged DNA binding	3.02e-02	1.00e+00	5.031	1	7	49
GO:0006521	regulation of cellular amino acid metabolic process	3.08e-02	1.00e+00	5.002	1	17	50
GO:0005905	coated pit	3.08e-02	1.00e+00	5.002	1	3	50
GO:0006879	cellular iron ion homeostasis	3.14e-02	1.00e+00	4.974	1	4	51
GO:0003725	double-stranded RNA binding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0000724	double-strand break repair via homologous recombination	3.38e-02	1.00e+00	4.865	1	3	55
GO:0000723	telomere maintenance	3.44e-02	1.00e+00	4.839	1	6	56
GO:0012505	endomembrane system	3.44e-02	1.00e+00	4.839	1	2	56
GO:0000502	proteasome complex	3.56e-02	1.00e+00	4.788	1	17	58
GO:0035091	phosphatidylinositol binding	3.74e-02	1.00e+00	4.715	1	3	61
GO:0019903	protein phosphatase binding	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006302	double-strand break repair	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.92e-02	1.00e+00	4.646	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.98e-02	1.00e+00	4.624	1	22	65
GO:0006289	nucleotide-excision repair	4.17e-02	1.00e+00	4.559	1	11	68
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0003697	single-stranded DNA binding	4.17e-02	1.00e+00	4.559	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.29e-02	1.00e+00	4.517	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.41e-02	1.00e+00	4.476	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.53e-02	1.00e+00	4.437	1	22	74
GO:0008584	male gonad development	4.59e-02	1.00e+00	4.417	1	3	75
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	2	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.59e-02	1.00e+00	4.417	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.82e-02	1.00e+00	4.342	1	23	79
GO:0001726	ruffle	4.88e-02	1.00e+00	4.324	1	4	80
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0047485	protein N-terminus binding	5.24e-02	1.00e+00	4.220	1	5	86
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0016605	PML body	5.36e-02	1.00e+00	4.187	1	3	88
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	5.48e-02	1.00e+00	4.154	1	7	90
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0001649	osteoblast differentiation	5.60e-02	1.00e+00	4.123	1	6	92
GO:0071456	cellular response to hypoxia	5.60e-02	1.00e+00	4.123	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.60e-02	1.00e+00	4.123	1	21	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0005819	spindle	6.78e-02	1.00e+00	3.839	1	7	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	20	116
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0007219	Notch signaling pathway	7.25e-02	1.00e+00	3.739	1	5	120
GO:0006260	DNA replication	7.30e-02	1.00e+00	3.727	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0031982	vesicle	7.89e-02	1.00e+00	3.613	1	9	131
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0008286	insulin receptor signaling pathway	8.52e-02	1.00e+00	3.496	1	7	142
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0005198	structural molecule activity	8.98e-02	1.00e+00	3.417	1	5	150
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	24	150
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0006886	intracellular protein transport	1.02e-01	1.00e+00	3.228	1	5	171
GO:0034641	cellular nitrogen compound metabolic process	1.02e-01	1.00e+00	3.228	1	20	171
GO:0032403	protein complex binding	1.09e-01	1.00e+00	3.130	1	10	183
GO:0001701	in utero embryonic development	1.19e-01	1.00e+00	2.995	1	8	201
GO:0005765	lysosomal membrane	1.20e-01	1.00e+00	2.981	1	5	203
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	14	227
GO:0004842	ubiquitin-protein transferase activity	1.48e-01	1.00e+00	2.652	1	6	255
GO:0003779	actin binding	1.54e-01	1.00e+00	2.591	1	12	266
GO:0019899	enzyme binding	1.60e-01	1.00e+00	2.532	1	12	277
GO:0016567	protein ubiquitination	1.70e-01	1.00e+00	2.442	1	5	295
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005524	ATP binding	1.91e-01	1.00e+00	1.304	2	60	1298
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0005886	plasma membrane	2.08e-01	1.00e+00	0.897	3	45	2582
GO:0043066	negative regulation of apoptotic process	2.36e-01	1.00e+00	1.918	1	31	424
GO:0055085	transmembrane transport	2.41e-01	1.00e+00	1.881	1	10	435
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0048471	perinuclear region of cytoplasm	2.73e-01	1.00e+00	1.675	1	13	502
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	33	555
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0005737	cytoplasm	4.31e-01	1.00e+00	0.352	3	110	3767
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	12	997
GO:0044281	small molecule metabolic process	5.46e-01	1.00e+00	0.404	1	58	1211
GO:0046872	metal ion binding	5.75e-01	1.00e+00	0.294	1	25	1307
GO:0005634	nucleus	5.79e-01	1.00e+00	0.077	3	136	4559
GO:0005730	nucleolus	6.63e-01	1.00e+00	-0.034	1	69	1641
GO:0016021	integral component of membrane	7.36e-01	1.00e+00	-0.307	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-9026

Statistics

Genes (9)

Interactions (13)

Related GO terms (197)