int-snw-7347

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.922	5.20e-15	3.27e-03	4.89e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-7347 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
NEDD8	4738	2	0.572	0.936	119	Yes	-
UBA1	7317	4	0.555	0.971	207	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
[ UCHL3 ]	7347	1	0.113	0.922	25	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (12)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
NEDD8	4738	RBX1	9978	pp	--	int.I2D: BioGrid
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PGD	5226	UCHL3	7347	pp	--	int.I2D: Krogan_NonCore
PGD	5226	UBA1	7317	pp	--	int.I2D: YeastLow
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	UCHL3	7347	pp	--	int.I2D: Krogan_NonCore
UBA1	7317	UCHL3	7347	pp	--	int.I2D: BioGrid_Yeast
NEDD8	4738	UCHL3	7347	pp	--	int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro, yeast 2-hybrid

Related GO terms (151)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0070062	extracellular vesicular exosome	4.47e-06	6.44e-02	2.417	8	104	2400
GO:0005829	cytosol	6.07e-06	8.76e-02	2.361	8	132	2496
GO:0045116	protein neddylation	9.67e-06	1.40e-01	8.646	2	2	8
GO:0006511	ubiquitin-dependent protein catabolic process	5.26e-05	7.59e-01	5.254	3	5	126
GO:0016032	viral process	2.02e-04	1.00e+00	3.585	4	55	534
GO:0016071	mRNA metabolic process	2.86e-04	1.00e+00	4.430	3	31	223
GO:0016070	RNA metabolic process	3.86e-04	1.00e+00	4.283	3	32	247
GO:0006521	regulation of cellular amino acid metabolic process	4.17e-04	1.00e+00	6.002	2	17	50
GO:0000502	proteasome complex	5.62e-04	1.00e+00	5.788	2	17	58
GO:0019521	D-gluconate metabolic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.84e-04	1.00e+00	5.646	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.05e-04	1.00e+00	5.624	2	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.18e-04	1.00e+00	5.517	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	8.65e-04	1.00e+00	5.476	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.13e-04	1.00e+00	5.437	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	9.38e-04	1.00e+00	5.417	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.04e-03	1.00e+00	5.342	2	23	79
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0019322	pentose biosynthetic process	1.25e-03	1.00e+00	9.646	1	2	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.41e-03	1.00e+00	5.123	2	21	92
GO:0009051	pentose-phosphate shunt, oxidative branch	1.87e-03	1.00e+00	9.061	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0000209	protein polyubiquitination	2.23e-03	1.00e+00	4.788	2	20	116
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	4
GO:0004839	ubiquitin activating enzyme activity	2.49e-03	1.00e+00	8.646	1	1	4
GO:0019788	NEDD8 ligase activity	2.49e-03	1.00e+00	8.646	1	1	4
GO:0005654	nucleoplasm	2.92e-03	1.00e+00	2.567	4	76	1082
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043248	proteasome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030891	VCB complex	3.12e-03	1.00e+00	8.324	1	2	5
GO:0019941	modification-dependent protein catabolic process	3.12e-03	1.00e+00	8.324	1	1	5
GO:0000082	G1/S transition of mitotic cell cycle	3.64e-03	1.00e+00	4.427	2	32	149
GO:0042981	regulation of apoptotic process	3.69e-03	1.00e+00	4.417	2	24	150
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0030867	rough endoplasmic reticulum membrane	4.36e-03	1.00e+00	7.839	1	2	7
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	4.36e-03	1.00e+00	7.839	1	2	7
GO:0034641	cellular nitrogen compound metabolic process	4.76e-03	1.00e+00	4.228	2	20	171
GO:0019773	proteasome core complex, alpha-subunit complex	4.98e-03	1.00e+00	7.646	1	4	8
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	2	8
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0031625	ubiquitin protein ligase binding	5.15e-03	1.00e+00	4.170	2	14	178
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	184	6024
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	136	4559
GO:0006098	pentose-phosphate shunt	6.22e-03	1.00e+00	7.324	1	4	10
GO:0010467	gene expression	6.76e-03	1.00e+00	2.845	3	59	669
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	7	12
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0004842	ubiquitin-protein transferase activity	1.03e-02	1.00e+00	3.652	2	6	255
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	8	17
GO:0005839	proteasome core complex	1.12e-02	1.00e+00	6.476	1	8	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.18e-02	1.00e+00	6.398	1	1	19
GO:0048863	stem cell differentiation	1.18e-02	1.00e+00	6.398	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.18e-02	1.00e+00	6.398	1	8	19
GO:0030163	protein catabolic process	1.36e-02	1.00e+00	6.187	1	1	22
GO:0000792	heterochromatin	1.36e-02	1.00e+00	6.187	1	2	22
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0016567	protein ubiquitination	1.37e-02	1.00e+00	3.442	2	5	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0030057	desmosome	1.43e-02	1.00e+00	6.123	1	1	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.43e-02	1.00e+00	6.123	1	3	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0006513	protein monoubiquitination	1.43e-02	1.00e+00	6.123	1	1	23
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.61e-02	1.00e+00	5.946	1	3	26
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0050661	NADP binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.80e-02	1.00e+00	5.788	1	1	29
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0004221	ubiquitin thiolesterase activity	2.22e-02	1.00e+00	5.476	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0000278	mitotic cell cycle	2.33e-02	1.00e+00	3.035	2	48	391
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0014070	response to organic cyclic compound	2.65e-02	1.00e+00	5.220	1	4	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0043066	negative regulation of apoptotic process	2.71e-02	1.00e+00	2.918	2	31	424
GO:0043130	ubiquitin binding	2.77e-02	1.00e+00	5.154	1	1	45
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0008233	peptidase activity	3.32e-02	1.00e+00	4.891	1	2	54
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0000932	cytoplasmic mRNA processing body	3.32e-02	1.00e+00	4.891	1	3	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0044281	small molecule metabolic process	3.38e-02	1.00e+00	1.989	3	58	1211
GO:0008104	protein localization	3.44e-02	1.00e+00	4.839	1	3	56
GO:0004843	ubiquitin-specific protease activity	3.92e-02	1.00e+00	4.646	1	1	64
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0006915	apoptotic process	4.45e-02	1.00e+00	2.530	2	33	555
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	2	75
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0009653	anatomical structure morphogenesis	5.06e-02	1.00e+00	4.271	1	3	83
GO:0006464	cellular protein modification process	5.12e-02	1.00e+00	4.254	1	2	84
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0071456	cellular response to hypoxia	5.60e-02	1.00e+00	4.123	1	6	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0007219	Notch signaling pathway	7.25e-02	1.00e+00	3.739	1	5	120
GO:0009615	response to virus	7.60e-02	1.00e+00	3.669	1	5	126
GO:0007179	transforming growth factor beta receptor signaling pathway	7.71e-02	1.00e+00	3.646	1	4	128
GO:0016020	membrane	7.75e-02	1.00e+00	1.516	3	90	1681
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0061024	membrane organization	8.69e-02	1.00e+00	3.466	1	7	145
GO:0010008	endosome membrane	9.04e-02	1.00e+00	3.408	1	7	151
GO:0006974	cellular response to DNA damage stimulus	9.04e-02	1.00e+00	3.408	1	8	151
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0032403	protein complex binding	1.09e-01	1.00e+00	3.130	1	10	183
GO:0005765	lysosomal membrane	1.20e-01	1.00e+00	2.981	1	5	203
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0044822	poly(A) RNA binding	1.37e-01	1.00e+00	1.602	2	49	1056
GO:0005975	carbohydrate metabolic process	1.47e-01	1.00e+00	2.663	1	9	253
GO:0006281	DNA repair	1.52e-01	1.00e+00	2.618	1	18	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.53e-01	1.00e+00	2.602	1	8	264
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0043234	protein complex	1.70e-01	1.00e+00	2.442	1	18	295
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	21	317
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	110	3767
GO:0005524	ATP binding	1.91e-01	1.00e+00	1.304	2	60	1298
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0006508	proteolysis	2.13e-01	1.00e+00	2.084	1	9	378
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	12	420
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	12	997
GO:0005739	mitochondrion	4.76e-01	1.00e+00	0.683	1	28	998
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-7347

Statistics

Genes (9)

Interactions (12)

Related GO terms (151)