Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.962 | 1.44e-16 | 1.36e-03 | 2.59e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - |
DDX18 | 8886 | 9 | 0.660 | 1.013 | 173 | Yes | - |
PSMB7 | 5695 | 48 | 0.982 | 1.052 | 57 | Yes | - |
PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
PGD | 5226 | 75 | 1.201 | 1.106 | 138 | Yes | - |
[ TP73 ] | 7161 | 1 | -0.081 | 0.962 | 101 | - | - |
ADH5 | 128 | 5 | 0.633 | 0.994 | 43 | Yes | - |
RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - |
ACO2 | 50 | 50 | 1.000 | 1.076 | 191 | Yes | - |
RSL24D1 | 51187 | 36 | 1.300 | 1.020 | 59 | Yes | - |
CDC16 | 8881 | 25 | 0.950 | 1.020 | 80 | Yes | - |
PSMD3 | 5709 | 57 | 0.986 | 1.106 | 146 | Yes | - |
RPS11 | 6205 | 36 | 0.993 | 1.113 | 175 | Yes | - |
LRPPRC | 10128 | 3 | -0.558 | 1.095 | 61 | - | Yes |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
ACTB | 60 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
PGD | 5226 | PSMD3 | 5709 | pp | -- | int.I2D: YeastLow |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
TP73 | 7161 | LRPPRC | 10128 | pp | -- | int.I2D: BioGrid |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMA1 | 5682 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastMedium |
ACO2 | 50 | DDX18 | 8886 | pp | -- | int.I2D: YeastLow |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast |
RPS11 | 6205 | DDX18 | 8886 | pp | -- | int.I2D: BioGrid_Yeast |
ADH5 | 128 | TP73 | 7161 | pp | -- | int.I2D: BioGrid |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACO2 | 50 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
PSMD3 | 5709 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG |
RPSA | 3921 | RPS11 | 6205 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast |
PGD | 5226 | DDX18 | 8886 | pp | -- | int.I2D: YeastLow |
PSMD11 | 5717 | DDX18 | 8886 | pp | -- | int.I2D: YeastLow |
PGD | 5226 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
DDX18 | 8886 | RSL24D1 | 51187 | pp | -- | int.I2D: YeastLow, BioGrid_Yeast |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
ADH5 | 128 | DDX18 | 8886 | pp | -- | int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast |
ACTB | 60 | LRPPRC | 10128 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | CDC16 | 8881 | pp | -- | int.I2D: YeastLow |
ACO2 | 50 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 9.43e-09 | 1.36e-04 | 6.028 | 5 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.38e-08 | 1.99e-04 | 5.921 | 5 | 22 | 70 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.83e-08 | 2.64e-04 | 5.841 | 5 | 22 | 74 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.55e-08 | 3.68e-04 | 5.747 | 5 | 23 | 79 |
GO:0016071 | mRNA metabolic process | 1.37e-07 | 1.98e-03 | 4.513 | 6 | 31 | 223 |
GO:0016070 | RNA metabolic process | 2.51e-07 | 3.62e-03 | 4.365 | 6 | 32 | 247 |
GO:0006521 | regulation of cellular amino acid metabolic process | 2.94e-07 | 4.24e-03 | 6.085 | 4 | 17 | 50 |
GO:0000502 | proteasome complex | 5.39e-07 | 7.77e-03 | 5.871 | 4 | 17 | 58 |
GO:0000082 | G1/S transition of mitotic cell cycle | 6.16e-07 | 8.88e-03 | 4.831 | 5 | 32 | 149 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 8.03e-07 | 1.16e-02 | 5.729 | 4 | 19 | 64 |
GO:0005654 | nucleoplasm | 1.02e-06 | 1.47e-02 | 2.819 | 9 | 76 | 1082 |
GO:0016032 | viral process | 1.29e-06 | 1.86e-02 | 3.475 | 7 | 55 | 534 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.29e-06 | 1.87e-02 | 5.559 | 4 | 20 | 72 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 1.52e-06 | 2.20e-02 | 5.500 | 4 | 20 | 75 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 3.46e-06 | 4.99e-02 | 5.205 | 4 | 21 | 92 |
GO:0000278 | mitotic cell cycle | 3.67e-06 | 5.29e-02 | 3.703 | 6 | 48 | 391 |
GO:0000209 | protein polyubiquitination | 8.72e-06 | 1.26e-01 | 4.871 | 4 | 20 | 116 |
GO:0005829 | cytosol | 1.81e-05 | 2.61e-01 | 1.903 | 11 | 132 | 2496 |
GO:0042981 | regulation of apoptotic process | 2.41e-05 | 3.47e-01 | 4.500 | 4 | 24 | 150 |
GO:0034641 | cellular nitrogen compound metabolic process | 4.02e-05 | 5.80e-01 | 4.311 | 4 | 20 | 171 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 7.15e-05 | 1.00e+00 | 7.269 | 2 | 4 | 11 |
GO:0010467 | gene expression | 7.77e-05 | 1.00e+00 | 2.928 | 6 | 59 | 669 |
GO:0005838 | proteasome regulatory particle | 8.57e-05 | 1.00e+00 | 7.144 | 2 | 7 | 12 |
GO:0022624 | proteasome accessory complex | 1.76e-04 | 1.00e+00 | 6.641 | 2 | 8 | 17 |
GO:0005839 | proteasome core complex | 1.98e-04 | 1.00e+00 | 6.559 | 2 | 8 | 18 |
GO:0004298 | threonine-type endopeptidase activity | 2.21e-04 | 1.00e+00 | 6.481 | 2 | 8 | 19 |
GO:0006298 | mismatch repair | 2.45e-04 | 1.00e+00 | 6.407 | 2 | 3 | 20 |
GO:0070062 | extracellular vesicular exosome | 6.50e-04 | 1.00e+00 | 1.670 | 9 | 104 | 2400 |
GO:0022627 | cytosolic small ribosomal subunit | 9.44e-04 | 1.00e+00 | 5.443 | 2 | 4 | 39 |
GO:0018467 | formaldehyde dehydrogenase activity | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0051903 | S-(hydroxymethyl)glutathione dehydrogenase activity | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0019521 | D-gluconate metabolic process | 1.18e-03 | 1.00e+00 | 9.729 | 1 | 1 | 1 |
GO:0043066 | negative regulation of apoptotic process | 1.29e-03 | 1.00e+00 | 3.001 | 4 | 31 | 424 |
GO:0003684 | damaged DNA binding | 1.49e-03 | 1.00e+00 | 5.114 | 2 | 7 | 49 |
GO:0044281 | small molecule metabolic process | 1.91e-03 | 1.00e+00 | 2.072 | 6 | 58 | 1211 |
GO:0016020 | membrane | 1.94e-03 | 1.00e+00 | 1.821 | 7 | 90 | 1681 |
GO:0051538 | 3 iron, 4 sulfur cluster binding | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0003994 | aconitate hydratase activity | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0046294 | formaldehyde catabolic process | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 2 | 2 |
GO:1902167 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0000961 | negative regulation of mitochondrial RNA catabolic process | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0019322 | pentose biosynthetic process | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 2 | 2 |
GO:0005055 | laminin receptor activity | 2.36e-03 | 1.00e+00 | 8.729 | 1 | 1 | 2 |
GO:0003697 | single-stranded DNA binding | 2.85e-03 | 1.00e+00 | 4.641 | 2 | 5 | 68 |
GO:0006915 | apoptotic process | 3.46e-03 | 1.00e+00 | 2.612 | 4 | 33 | 555 |
GO:0018119 | peptidyl-cysteine S-nitrosylation | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 2 | 3 |
GO:0070129 | regulation of mitochondrial translation | 3.53e-03 | 1.00e+00 | 8.144 | 1 | 1 | 3 |
GO:0019083 | viral transcription | 4.01e-03 | 1.00e+00 | 4.389 | 2 | 10 | 81 |
GO:0006415 | translational termination | 4.61e-03 | 1.00e+00 | 4.286 | 2 | 10 | 87 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0051409 | response to nitrosative stress | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0006068 | ethanol catabolic process | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0033326 | cerebrospinal fluid secretion | 4.71e-03 | 1.00e+00 | 7.729 | 1 | 1 | 4 |
GO:0005634 | nucleus | 5.07e-03 | 1.00e+00 | 1.034 | 11 | 136 | 4559 |
GO:0006414 | translational elongation | 5.25e-03 | 1.00e+00 | 4.189 | 2 | 13 | 93 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 3 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0004022 | alcohol dehydrogenase (NAD) activity | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0006102 | isocitrate metabolic process | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 2 | 5 |
GO:0000730 | DNA recombinase assembly | 5.88e-03 | 1.00e+00 | 7.407 | 1 | 1 | 5 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 6.53e-03 | 1.00e+00 | 4.028 | 2 | 10 | 104 |
GO:0006101 | citrate metabolic process | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 1 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 7.05e-03 | 1.00e+00 | 7.144 | 1 | 3 | 6 |
GO:0030529 | ribonucleoprotein complex | 7.53e-03 | 1.00e+00 | 3.921 | 2 | 8 | 112 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 7.79e-03 | 1.00e+00 | 3.896 | 2 | 11 | 114 |
GO:0019058 | viral life cycle | 7.93e-03 | 1.00e+00 | 3.883 | 2 | 13 | 115 |
GO:0000028 | ribosomal small subunit assembly | 8.22e-03 | 1.00e+00 | 6.921 | 1 | 1 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 8.22e-03 | 1.00e+00 | 6.921 | 1 | 2 | 7 |
GO:0005730 | nucleolus | 8.77e-03 | 1.00e+00 | 1.633 | 6 | 69 | 1641 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 2 | 8 |
GO:0003016 | respiratory system process | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 1 | 8 |
GO:0060044 | negative regulation of cardiac muscle cell proliferation | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 2 | 8 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 9.39e-03 | 1.00e+00 | 6.729 | 1 | 4 | 8 |
GO:0006413 | translational initiation | 1.02e-02 | 1.00e+00 | 3.695 | 2 | 17 | 131 |
GO:0045793 | positive regulation of cell size | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 2 | 9 |
GO:0047497 | mitochondrion transport along microtubule | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 3 | 9 |
GO:0003735 | structural constituent of ribosome | 1.11e-02 | 1.00e+00 | 3.631 | 2 | 10 | 137 |
GO:0006098 | pentose-phosphate shunt | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 4 | 10 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0006069 | ethanol oxidation | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0051775 | response to redox state | 1.17e-02 | 1.00e+00 | 6.407 | 1 | 1 | 10 |
GO:0048714 | positive regulation of oligodendrocyte differentiation | 1.29e-02 | 1.00e+00 | 6.269 | 1 | 2 | 11 |
GO:0043508 | negative regulation of JUN kinase activity | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 13 |
GO:0005504 | fatty acid binding | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 13 |
GO:0005662 | DNA replication factor A complex | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 3 | 13 |
GO:0005515 | protein binding | 1.56e-02 | 1.00e+00 | 0.757 | 12 | 184 | 6024 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 4 | 14 |
GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 2 | 14 |
GO:0048546 | digestive tract morphogenesis | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 14 |
GO:0044267 | cellular protein metabolic process | 1.70e-02 | 1.00e+00 | 2.425 | 3 | 29 | 474 |
GO:0031625 | ubiquitin protein ligase binding | 1.82e-02 | 1.00e+00 | 3.253 | 2 | 14 | 178 |
GO:0042176 | regulation of protein catabolic process | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 3 | 16 |
GO:0050998 | nitric-oxide synthase binding | 1.87e-02 | 1.00e+00 | 5.729 | 1 | 1 | 16 |
GO:0010243 | response to organonitrogen compound | 1.99e-02 | 1.00e+00 | 5.641 | 1 | 3 | 17 |
GO:0045777 | positive regulation of blood pressure | 1.99e-02 | 1.00e+00 | 5.641 | 1 | 1 | 17 |
GO:0035861 | site of double-strand break | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 1 | 18 |
GO:0004004 | ATP-dependent RNA helicase activity | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 2 | 18 |
GO:0007088 | regulation of mitosis | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 1 | 18 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 1 | 19 |
GO:0010165 | response to X-ray | 2.22e-02 | 1.00e+00 | 5.481 | 1 | 3 | 19 |
GO:0005680 | anaphase-promoting complex | 2.33e-02 | 1.00e+00 | 5.407 | 1 | 4 | 20 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 2.45e-02 | 1.00e+00 | 5.336 | 1 | 4 | 21 |
GO:0032201 | telomere maintenance via semi-conservative replication | 2.45e-02 | 1.00e+00 | 5.336 | 1 | 5 | 21 |
GO:0005640 | nuclear outer membrane | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 1 | 22 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 3 | 22 |
GO:0030863 | cortical cytoskeleton | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.56e-02 | 1.00e+00 | 5.269 | 1 | 4 | 22 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 3 | 23 |
GO:0043236 | laminin binding | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 1 | 23 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 4 | 23 |
GO:0005844 | polysome | 2.68e-02 | 1.00e+00 | 5.205 | 1 | 4 | 23 |
GO:0001836 | release of cytochrome c from mitochondria | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 3 | 24 |
GO:0000794 | condensed nuclear chromosome | 2.79e-02 | 1.00e+00 | 5.144 | 1 | 2 | 24 |
GO:0000722 | telomere maintenance via recombination | 2.91e-02 | 1.00e+00 | 5.085 | 1 | 5 | 25 |
GO:0005637 | nuclear inner membrane | 2.91e-02 | 1.00e+00 | 5.085 | 1 | 2 | 25 |
GO:0006412 | translation | 2.94e-02 | 1.00e+00 | 2.883 | 2 | 20 | 230 |
GO:0070979 | protein K11-linked ubiquitination | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 6 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 3 | 26 |
GO:0050661 | NADP binding | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 2 | 27 |
GO:0019843 | rRNA binding | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 3 | 27 |
GO:0043022 | ribosome binding | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 3 | 27 |
GO:0031492 | nucleosomal DNA binding | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 4 | 27 |
GO:0044822 | poly(A) RNA binding | 3.15e-02 | 1.00e+00 | 1.684 | 4 | 49 | 1056 |
GO:0006099 | tricarboxylic acid cycle | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 4 | 28 |
GO:0010332 | response to gamma radiation | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 3 | 28 |
GO:0019894 | kinesin binding | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 3.37e-02 | 1.00e+00 | 4.871 | 1 | 1 | 29 |
GO:0007346 | regulation of mitotic cell cycle | 3.37e-02 | 1.00e+00 | 4.871 | 1 | 1 | 29 |
GO:0051262 | protein tetramerization | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 2 | 30 |
GO:0034644 | cellular response to UV | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 5 | 30 |
GO:0048487 | beta-tubulin binding | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 2 | 30 |
GO:0042254 | ribosome biogenesis | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 1 | 30 |
GO:0006271 | DNA strand elongation involved in DNA replication | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 7 | 30 |
GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator | 3.48e-02 | 1.00e+00 | 4.822 | 1 | 2 | 30 |
GO:0007094 | mitotic spindle assembly checkpoint | 3.59e-02 | 1.00e+00 | 4.774 | 1 | 4 | 31 |
GO:0006281 | DNA repair | 3.71e-02 | 1.00e+00 | 2.701 | 2 | 18 | 261 |
GO:0048666 | neuron development | 3.93e-02 | 1.00e+00 | 4.641 | 1 | 2 | 34 |
GO:0001895 | retina homeostasis | 3.93e-02 | 1.00e+00 | 4.641 | 1 | 1 | 34 |
GO:0005876 | spindle microtubule | 3.93e-02 | 1.00e+00 | 4.641 | 1 | 2 | 34 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 4.05e-02 | 1.00e+00 | 4.599 | 1 | 3 | 35 |
GO:0034332 | adherens junction organization | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 1 | 36 |
GO:0051084 | 'de novo' posttranslational protein folding | 4.28e-02 | 1.00e+00 | 4.519 | 1 | 4 | 37 |
GO:0006284 | base-excision repair | 4.28e-02 | 1.00e+00 | 4.519 | 1 | 3 | 37 |
GO:0042645 | mitochondrial nucleoid | 4.28e-02 | 1.00e+00 | 4.519 | 1 | 1 | 37 |
GO:0021766 | hippocampus development | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 4 | 38 |
GO:0070527 | platelet aggregation | 4.39e-02 | 1.00e+00 | 4.481 | 1 | 2 | 38 |
GO:0000781 | chromosome, telomeric region | 4.50e-02 | 1.00e+00 | 4.443 | 1 | 3 | 39 |
GO:0005856 | cytoskeleton | 4.52e-02 | 1.00e+00 | 2.544 | 2 | 12 | 291 |
GO:0021762 | substantia nigra development | 5.06e-02 | 1.00e+00 | 4.269 | 1 | 2 | 44 |
GO:0045665 | negative regulation of neuron differentiation | 5.06e-02 | 1.00e+00 | 4.269 | 1 | 2 | 44 |
GO:0019901 | protein kinase binding | 5.27e-02 | 1.00e+00 | 2.420 | 2 | 21 | 317 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 5.29e-02 | 1.00e+00 | 4.205 | 1 | 7 | 46 |
GO:0001523 | retinoid metabolic process | 5.51e-02 | 1.00e+00 | 4.144 | 1 | 2 | 48 |
GO:0005813 | centrosome | 5.54e-02 | 1.00e+00 | 2.380 | 2 | 14 | 326 |
GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 5.62e-02 | 1.00e+00 | 4.114 | 1 | 5 | 49 |
GO:0006091 | generation of precursor metabolites and energy | 5.74e-02 | 1.00e+00 | 4.085 | 1 | 3 | 50 |
GO:0051028 | mRNA transport | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 2 | 52 |
GO:0003723 | RNA binding | 6.03e-02 | 1.00e+00 | 2.311 | 2 | 20 | 342 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.07e-02 | 1.00e+00 | 4.001 | 1 | 5 | 53 |
GO:0045216 | cell-cell junction organization | 6.18e-02 | 1.00e+00 | 3.974 | 1 | 2 | 54 |
GO:0002039 | p53 binding | 6.29e-02 | 1.00e+00 | 3.947 | 1 | 7 | 55 |
GO:0000724 | double-strand break repair via homologous recombination | 6.29e-02 | 1.00e+00 | 3.947 | 1 | 3 | 55 |
GO:0000723 | telomere maintenance | 6.40e-02 | 1.00e+00 | 3.921 | 1 | 6 | 56 |
GO:0005840 | ribosome | 6.62e-02 | 1.00e+00 | 3.871 | 1 | 1 | 58 |
GO:0005925 | focal adhesion | 6.80e-02 | 1.00e+00 | 2.213 | 2 | 19 | 366 |
GO:0006302 | double-strand break repair | 7.07e-02 | 1.00e+00 | 3.774 | 1 | 4 | 62 |
GO:0019903 | protein phosphatase binding | 7.07e-02 | 1.00e+00 | 3.774 | 1 | 4 | 62 |
GO:0009055 | electron carrier activity | 7.40e-02 | 1.00e+00 | 3.706 | 1 | 1 | 65 |
GO:0006289 | nucleotide-excision repair | 7.72e-02 | 1.00e+00 | 3.641 | 1 | 11 | 68 |
GO:0010468 | regulation of gene expression | 7.72e-02 | 1.00e+00 | 3.641 | 1 | 1 | 68 |
GO:0034329 | cell junction assembly | 7.72e-02 | 1.00e+00 | 3.641 | 1 | 1 | 68 |
GO:0009791 | post-embryonic development | 8.27e-02 | 1.00e+00 | 3.539 | 1 | 2 | 73 |
GO:0000785 | chromatin | 8.27e-02 | 1.00e+00 | 3.539 | 1 | 4 | 73 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 8.38e-02 | 1.00e+00 | 3.519 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 8.49e-02 | 1.00e+00 | 3.500 | 1 | 2 | 75 |
GO:0001822 | kidney development | 8.81e-02 | 1.00e+00 | 3.443 | 1 | 2 | 78 |
GO:0047485 | protein N-terminus binding | 9.67e-02 | 1.00e+00 | 3.302 | 1 | 5 | 86 |
GO:0003690 | double-stranded DNA binding | 9.67e-02 | 1.00e+00 | 3.302 | 1 | 1 | 86 |
GO:0016605 | PML body | 9.89e-02 | 1.00e+00 | 3.269 | 1 | 3 | 88 |
GO:0000187 | activation of MAPK activity | 1.01e-01 | 1.00e+00 | 3.237 | 1 | 5 | 90 |
GO:0006928 | cellular component movement | 1.02e-01 | 1.00e+00 | 3.221 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 1.02e-01 | 1.00e+00 | 3.221 | 1 | 8 | 91 |
GO:0051015 | actin filament binding | 1.03e-01 | 1.00e+00 | 3.205 | 1 | 2 | 92 |
GO:0001649 | osteoblast differentiation | 1.03e-01 | 1.00e+00 | 3.205 | 1 | 6 | 92 |
GO:0071456 | cellular response to hypoxia | 1.03e-01 | 1.00e+00 | 3.205 | 1 | 6 | 92 |
GO:0005739 | mitochondrion | 1.09e-01 | 1.00e+00 | 1.351 | 3 | 28 | 998 |
GO:0014069 | postsynaptic density | 1.17e-01 | 1.00e+00 | 3.014 | 1 | 3 | 105 |
GO:0005506 | iron ion binding | 1.17e-01 | 1.00e+00 | 3.014 | 1 | 4 | 105 |
GO:0015630 | microtubule cytoskeleton | 1.22e-01 | 1.00e+00 | 2.947 | 1 | 4 | 110 |
GO:0072562 | blood microparticle | 1.23e-01 | 1.00e+00 | 2.934 | 1 | 3 | 111 |
GO:0005819 | spindle | 1.24e-01 | 1.00e+00 | 2.921 | 1 | 7 | 112 |
GO:0044237 | cellular metabolic process | 1.29e-01 | 1.00e+00 | 2.858 | 1 | 5 | 117 |
GO:0043524 | negative regulation of neuron apoptotic process | 1.29e-01 | 1.00e+00 | 2.858 | 1 | 2 | 117 |
GO:0007568 | aging | 1.29e-01 | 1.00e+00 | 2.858 | 1 | 3 | 117 |
GO:0006325 | chromatin organization | 1.30e-01 | 1.00e+00 | 2.846 | 1 | 5 | 118 |
GO:0007219 | Notch signaling pathway | 1.32e-01 | 1.00e+00 | 2.822 | 1 | 5 | 120 |
GO:0032496 | response to lipopolysaccharide | 1.34e-01 | 1.00e+00 | 2.810 | 1 | 4 | 121 |
GO:0006260 | DNA replication | 1.34e-01 | 1.00e+00 | 2.810 | 1 | 9 | 121 |
GO:0007050 | cell cycle arrest | 1.37e-01 | 1.00e+00 | 2.774 | 1 | 9 | 124 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.39e-01 | 1.00e+00 | 2.751 | 1 | 5 | 126 |
GO:0000790 | nuclear chromatin | 1.42e-01 | 1.00e+00 | 2.717 | 1 | 9 | 129 |
GO:0006457 | protein folding | 1.56e-01 | 1.00e+00 | 2.569 | 1 | 7 | 143 |
GO:0061024 | membrane organization | 1.58e-01 | 1.00e+00 | 2.549 | 1 | 7 | 145 |
GO:0008017 | microtubule binding | 1.60e-01 | 1.00e+00 | 2.529 | 1 | 6 | 147 |
GO:0006974 | cellular response to DNA damage stimulus | 1.64e-01 | 1.00e+00 | 2.490 | 1 | 8 | 151 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.78e-01 | 1.00e+00 | 2.362 | 1 | 7 | 165 |
GO:0030424 | axon | 1.79e-01 | 1.00e+00 | 2.354 | 1 | 4 | 166 |
GO:0044212 | transcription regulatory region DNA binding | 1.81e-01 | 1.00e+00 | 2.336 | 1 | 6 | 168 |
GO:0005667 | transcription factor complex | 1.88e-01 | 1.00e+00 | 2.277 | 1 | 4 | 175 |
GO:0032403 | protein complex binding | 1.95e-01 | 1.00e+00 | 2.213 | 1 | 10 | 183 |
GO:0007067 | mitotic nuclear division | 2.36e-01 | 1.00e+00 | 1.902 | 1 | 14 | 227 |
GO:0005759 | mitochondrial matrix | 2.37e-01 | 1.00e+00 | 1.896 | 1 | 14 | 228 |
GO:0008134 | transcription factor binding | 2.50e-01 | 1.00e+00 | 1.810 | 1 | 8 | 242 |
GO:0005874 | microtubule | 2.56e-01 | 1.00e+00 | 1.769 | 1 | 7 | 249 |
GO:0005975 | carbohydrate metabolic process | 2.60e-01 | 1.00e+00 | 1.746 | 1 | 9 | 253 |
GO:0004842 | ubiquitin-protein transferase activity | 2.62e-01 | 1.00e+00 | 1.734 | 1 | 6 | 255 |
GO:0006954 | inflammatory response | 2.81e-01 | 1.00e+00 | 1.615 | 1 | 7 | 277 |
GO:0019899 | enzyme binding | 2.81e-01 | 1.00e+00 | 1.615 | 1 | 12 | 277 |
GO:0006200 | ATP catabolic process | 2.94e-01 | 1.00e+00 | 1.539 | 1 | 15 | 292 |
GO:0016567 | protein ubiquitination | 2.96e-01 | 1.00e+00 | 1.524 | 1 | 5 | 295 |
GO:0043234 | protein complex | 2.96e-01 | 1.00e+00 | 1.524 | 1 | 18 | 295 |
GO:0007411 | axon guidance | 3.16e-01 | 1.00e+00 | 1.411 | 1 | 13 | 319 |
GO:0003682 | chromatin binding | 3.23e-01 | 1.00e+00 | 1.375 | 1 | 11 | 327 |
GO:0008283 | cell proliferation | 3.24e-01 | 1.00e+00 | 1.371 | 1 | 14 | 328 |
GO:0008270 | zinc ion binding | 3.31e-01 | 1.00e+00 | 0.767 | 2 | 12 | 997 |
GO:0043565 | sequence-specific DNA binding | 3.38e-01 | 1.00e+00 | 1.294 | 1 | 6 | 346 |
GO:0007155 | cell adhesion | 3.57e-01 | 1.00e+00 | 1.201 | 1 | 6 | 369 |
GO:0055114 | oxidation-reduction process | 3.95e-01 | 1.00e+00 | 1.014 | 1 | 12 | 420 |
GO:0007596 | blood coagulation | 4.20e-01 | 1.00e+00 | 0.899 | 1 | 18 | 455 |
GO:0045893 | positive regulation of transcription, DNA-templated | 4.36e-01 | 1.00e+00 | 0.828 | 1 | 13 | 478 |
GO:0042802 | identical protein binding | 4.40e-01 | 1.00e+00 | 0.810 | 1 | 20 | 484 |
GO:0048471 | perinuclear region of cytoplasm | 4.53e-01 | 1.00e+00 | 0.757 | 1 | 13 | 502 |
GO:0005524 | ATP binding | 4.60e-01 | 1.00e+00 | 0.387 | 2 | 60 | 1298 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 4.96e-01 | 1.00e+00 | 0.574 | 1 | 16 | 570 |
GO:0042803 | protein homodimerization activity | 5.12e-01 | 1.00e+00 | 0.512 | 1 | 12 | 595 |
GO:0045087 | innate immune response | 5.12e-01 | 1.00e+00 | 0.509 | 1 | 24 | 596 |
GO:0006351 | transcription, DNA-templated | 5.20e-01 | 1.00e+00 | 0.231 | 2 | 31 | 1446 |
GO:0003700 | sequence-specific DNA binding transcription factor activity | 5.70e-01 | 1.00e+00 | 0.279 | 1 | 11 | 699 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 6.16e-01 | 1.00e+00 | 0.105 | 1 | 19 | 789 |
GO:0005737 | cytoplasm | 6.85e-01 | 1.00e+00 | -0.151 | 4 | 110 | 3767 |
GO:0005615 | extracellular space | 6.89e-01 | 1.00e+00 | -0.174 | 1 | 17 | 957 |
GO:0006355 | regulation of transcription, DNA-templated | 7.04e-01 | 1.00e+00 | -0.233 | 1 | 18 | 997 |
GO:0046872 | metal ion binding | 8.01e-01 | 1.00e+00 | -0.623 | 1 | 25 | 1307 |
GO:0005886 | plasma membrane | 9.65e-01 | 1.00e+00 | -1.606 | 1 | 45 | 2582 |