int-snw-6713

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.973 4.95e-17 1.04e-03 2.13e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-6713 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ACO2 50 501.0001.076191Yes-
CDC16 8881 250.9501.02080Yes-
RUVBL1 8607 170.7201.013343Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PSMD3 5709 570.9861.106146Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
[ SQLE ] 6713 1-0.0500.97345--
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
PSMC1 5700 140.8401.018137Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (34)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACO2 50 RUVBL1 8607 pp -- int.I2D: YeastLow
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 SQLE 6713 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
ACO2 50 PSMC1 5700 pp -- int.I2D: YeastLow
PSMA1 5682 PSMC1 5700 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA2 5683 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
SQLE 6713 RUVBL1 8607 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMC1 5700 SQLE 6713 pp -- int.I2D: YeastLow
ACTB 60 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
PSMB7 5695 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMC1 5700 RUVBL1 8607 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow

Related GO terms (204)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle9.06e-141.31e-096.79472265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.56e-132.25e-096.68772270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.33e-133.37e-096.60772274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.75e-135.41e-096.51272379
GO:0006521regulation of cellular amino acid metabolic process3.74e-125.40e-086.95061750
GO:0000502proteasome complex9.49e-121.37e-076.73661758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.75e-112.53e-076.59461964
GO:0000082G1/S transition of mitotic cell cycle3.52e-115.08e-075.597732149
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent3.64e-115.25e-076.42462072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.68e-116.76e-076.36562075
GO:0005654nucleoplasm1.19e-101.72e-063.38911761082
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.65e-102.37e-066.07062192
GO:0016071mRNA metabolic process6.02e-108.68e-065.015731223
GO:0000209protein polyubiquitination6.77e-109.76e-065.736620116
GO:0000278mitotic cell cycle7.08e-101.02e-054.398848391
GO:0016070RNA metabolic process1.23e-091.77e-054.868732247
GO:0042981regulation of apoptotic process3.21e-094.63e-055.365624150
GO:0034641cellular nitrogen compound metabolic process7.06e-091.02e-045.176620171
GO:0016032viral process8.27e-091.19e-043.948855534
GO:0005838proteasome regulatory particle1.59e-072.30e-038.0093712
GO:0022624proteasome accessory complex4.91e-077.08e-037.5063817
GO:0005839proteasome core complex5.89e-078.50e-037.4243818
GO:0004298threonine-type endopeptidase activity6.99e-071.01e-027.3463819
GO:0010467gene expression1.16e-061.67e-023.430759669
GO:0043066negative regulation of apoptotic process1.53e-062.21e-023.866631424
GO:0044281small molecule metabolic process4.58e-066.60e-022.7678581211
GO:0006915apoptotic process7.29e-061.05e-013.477633555
GO:0005829cytosol1.20e-051.74e-012.045101322496
GO:0019773proteasome core complex, alpha-subunit complex2.44e-053.52e-018.009248
GO:0035267NuA4 histone acetyltransferase complex7.91e-051.00e+007.2012414
GO:0070062extracellular vesicular exosome6.75e-041.00e+001.78081042400
GO:0004506squalene monooxygenase activity9.71e-041.00e+0010.009111
GO:0006281DNA repair1.84e-031.00e+003.566318261
GO:00515383 iron, 4 sulfur cluster binding1.94e-031.00e+009.009112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0003994aconitate hydratase activity1.94e-031.00e+009.009112
GO:0005055laminin receptor activity1.94e-031.00e+009.009112
GO:0006407rRNA export from nucleus1.94e-031.00e+009.009112
GO:0006725cellular aromatic compound metabolic process1.94e-031.00e+009.009112
GO:0005634nucleus2.58e-031.00e+001.176101364559
GO:0005730nucleolus2.87e-031.00e+001.9136691641
GO:0016020membrane3.25e-031.00e+001.8796901681
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009114
GO:003068690S preribosome3.88e-031.00e+008.009114
GO:0031467Cul7-RING ubiquitin ligase complex3.88e-031.00e+008.009114
GO:0019788NEDD8 ligase activity3.88e-031.00e+008.009114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.84e-031.00e+007.687135
GO:0031461cullin-RING ubiquitin ligase complex4.84e-031.00e+007.687115
GO:0043248proteasome assembly4.84e-031.00e+007.687115
GO:0006102isocitrate metabolic process4.84e-031.00e+007.687115
GO:0030891VCB complex4.84e-031.00e+007.687125
GO:0000730DNA recombinase assembly4.84e-031.00e+007.687115
GO:2000001regulation of DNA damage checkpoint4.84e-031.00e+007.687115
GO:0030529ribonucleoprotein complex5.12e-031.00e+004.20128112
GO:0006325chromatin organization5.66e-031.00e+004.12625118
GO:0005515protein binding5.80e-031.00e+000.912111846024
GO:0016126sterol biosynthetic process5.81e-031.00e+007.424126
GO:0030957Tat protein binding5.81e-031.00e+007.424136
GO:0006101citrate metabolic process5.81e-031.00e+007.424116
GO:0031466Cul5-RING ubiquitin ligase complex5.81e-031.00e+007.424116
GO:0000028ribosomal small subunit assembly6.78e-031.00e+007.201117
GO:0031462Cul2-RING ubiquitin ligase complex6.78e-031.00e+007.201127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.74e-031.00e+007.009128
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0000812Swr1 complex7.74e-031.00e+007.009138
GO:0045116protein neddylation7.74e-031.00e+007.009128
GO:0016887ATPase activity7.89e-031.00e+003.87927140
GO:0010569regulation of double-strand break repair via homologous recombination9.67e-031.00e+006.6871110
GO:0031571mitotic G1 DNA damage checkpoint1.06e-021.00e+006.5491411
GO:0043968histone H2A acetylation1.16e-021.00e+006.4241312
GO:0031625ubiquitin protein ligase binding1.25e-021.00e+003.533214178
GO:0005662DNA replication factor A complex1.26e-021.00e+006.3081113
GO:0030234enzyme regulator activity1.26e-021.00e+006.3081313
GO:0031011Ino80 complex1.35e-021.00e+006.2011314
GO:0050998nitric-oxide synthase binding1.54e-021.00e+006.0091116
GO:0042176regulation of protein catabolic process1.54e-021.00e+006.0091316
GO:0017025TBP-class protein binding1.64e-021.00e+005.9211317
GO:0003678DNA helicase activity1.64e-021.00e+005.9211317
GO:0007088regulation of mitosis1.73e-021.00e+005.8391118
GO:0035861site of double-strand break1.73e-021.00e+005.8391118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.83e-021.00e+005.7611119
GO:0048863stem cell differentiation1.83e-021.00e+005.7611119
GO:0005680anaphase-promoting complex1.92e-021.00e+005.6871420
GO:0006298mismatch repair1.92e-021.00e+005.6871320
GO:0007067mitotic nuclear division1.98e-021.00e+003.182214227
GO:0032201telomere maintenance via semi-conservative replication2.02e-021.00e+005.6161521
GO:0000718nucleotide-excision repair, DNA damage removal2.02e-021.00e+005.6161421
GO:0006297nucleotide-excision repair, DNA gap filling2.12e-021.00e+005.5491322
GO:0030863cortical cytoskeleton2.12e-021.00e+005.5491122
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491422
GO:0043044ATP-dependent chromatin remodeling2.21e-021.00e+005.4851423
GO:0005844polysome2.21e-021.00e+005.4851423
GO:0031463Cul3-RING ubiquitin ligase complex2.21e-021.00e+005.4851323
GO:0043236laminin binding2.21e-021.00e+005.4851123
GO:0006513protein monoubiquitination2.21e-021.00e+005.4851123
GO:0034080CENP-A containing nucleosome assembly2.40e-021.00e+005.3651125
GO:0000722telomere maintenance via recombination2.40e-021.00e+005.3651525
GO:0070979protein K11-linked ubiquitination2.50e-021.00e+005.3081626
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.50e-021.00e+005.3081326
GO:0010033response to organic substance2.59e-021.00e+005.2541227
GO:0043022ribosome binding2.59e-021.00e+005.2541327
GO:0071339MLL1 complex2.59e-021.00e+005.2541327
GO:0043967histone H4 acetylation2.59e-021.00e+005.2541327
GO:0031492nucleosomal DNA binding2.59e-021.00e+005.2541427
GO:0006099tricarboxylic acid cycle2.69e-021.00e+005.2011428
GO:0019894kinesin binding2.69e-021.00e+005.2011128
GO:0019005SCF ubiquitin ligase complex2.78e-021.00e+005.1511129
GO:0006271DNA strand elongation involved in DNA replication2.87e-021.00e+005.1021730
GO:0007094mitotic spindle assembly checkpoint2.97e-021.00e+005.0551431
GO:0001895retina homeostasis3.25e-021.00e+004.9211134
GO:0006695cholesterol biosynthetic process3.25e-021.00e+004.9211434
GO:0005876spindle microtubule3.25e-021.00e+004.9211234
GO:00515394 iron, 4 sulfur cluster binding3.35e-021.00e+004.8791335
GO:0034332adherens junction organization3.44e-021.00e+004.8391136
GO:0051084'de novo' posttranslational protein folding3.53e-021.00e+004.7991437
GO:0006284base-excision repair3.53e-021.00e+004.7991337
GO:0070527platelet aggregation3.63e-021.00e+004.7611238
GO:0022627cytosolic small ribosomal subunit3.72e-021.00e+004.7231439
GO:0000781chromosome, telomeric region3.72e-021.00e+004.7231339
GO:0005813centrosome3.87e-021.00e+002.660214326
GO:0032508DNA duplex unwinding3.91e-021.00e+004.6511341
GO:0021762substantia nigra development4.19e-021.00e+004.5491244
GO:0006283transcription-coupled nucleotide-excision repair4.38e-021.00e+004.4851746
GO:0003684damaged DNA binding4.65e-021.00e+004.3941749
GO:0006091generation of precursor metabolites and energy4.75e-021.00e+004.3651350
GO:0040008regulation of growth4.75e-021.00e+004.3651550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.03e-021.00e+004.2811553
GO:0050660flavin adenine dinucleotide binding5.12e-021.00e+004.2541254
GO:0045216cell-cell junction organization5.12e-021.00e+004.2541254
GO:0000932cytoplasmic mRNA processing body5.12e-021.00e+004.2541354
GO:0000724double-strand break repair via homologous recombination5.21e-021.00e+004.2271355
GO:0000723telomere maintenance5.30e-021.00e+004.2011656
GO:0019903protein phosphatase binding5.86e-021.00e+004.0551462
GO:0006302double-strand break repair5.86e-021.00e+004.0551462
GO:0006310DNA recombination6.13e-021.00e+003.9861265
GO:0006289nucleotide-excision repair6.40e-021.00e+003.92111168
GO:0034329cell junction assembly6.40e-021.00e+003.9211168
GO:0003697single-stranded DNA binding6.40e-021.00e+003.9211568
GO:0006334nucleosome assembly6.77e-021.00e+003.8391272
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.95e-021.00e+003.7991674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.04e-021.00e+003.7801275
GO:0044267cellular protein metabolic process7.56e-021.00e+002.120229474
GO:0019083viral transcription7.59e-021.00e+003.66911081
GO:0047485protein N-terminus binding8.04e-021.00e+003.5821586
GO:0006415translational termination8.13e-021.00e+003.56611087
GO:0016605PML body8.21e-021.00e+003.5491388
GO:0016363nuclear matrix8.48e-021.00e+003.50111291
GO:0006928cellular component movement8.48e-021.00e+003.5011791
GO:0005200structural constituent of cytoskeleton8.48e-021.00e+003.5011891
GO:0071456cellular response to hypoxia8.57e-021.00e+003.4851692
GO:0006414translational elongation8.66e-021.00e+003.47011393
GO:0006614SRP-dependent cotranslational protein targeting to membrane9.64e-021.00e+003.308110104
GO:0014069postsynaptic density9.73e-021.00e+003.29413105
GO:0005506iron ion binding9.73e-021.00e+003.29414105
GO:0005815microtubule organizing center1.01e-011.00e+003.24115109
GO:0015630microtubule cytoskeleton1.02e-011.00e+003.22714110
GO:0072562blood microparticle1.03e-011.00e+003.21413111
GO:0005819spindle1.03e-011.00e+003.20117112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.05e-011.00e+003.176111114
GO:0019058viral life cycle1.06e-011.00e+003.163113115
GO:0044237cellular metabolic process1.08e-011.00e+003.13815117
GO:0007219Notch signaling pathway1.10e-011.00e+003.10215120
GO:0006260DNA replication1.11e-011.00e+003.09019121
GO:0006511ubiquitin-dependent protein catabolic process1.16e-011.00e+003.03115126
GO:0009615response to virus1.16e-011.00e+003.03115126
GO:0000790nuclear chromatin1.18e-011.00e+002.99819129
GO:0006413translational initiation1.20e-011.00e+002.975117131
GO:0003735structural constituent of ribosome1.25e-011.00e+002.911110137
GO:0005524ATP binding1.25e-011.00e+001.2523601298
GO:0006457protein folding1.30e-011.00e+002.84917143
GO:0005737cytoplasm1.32e-011.00e+000.71461103767
GO:0061024membrane organization1.32e-011.00e+002.82917145
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.49e-011.00e+002.64217165
GO:0030424axon1.50e-011.00e+002.63414166
GO:0032403protein complex binding1.64e-011.00e+002.493110183
GO:0005759mitochondrial matrix2.00e-011.00e+002.176114228
GO:0006412translation2.02e-011.00e+002.163120230
GO:0004842ubiquitin-protein transferase activity2.21e-011.00e+002.01416255
GO:0007283spermatogenesis2.26e-011.00e+001.97518262
GO:0006357regulation of transcription from RNA polymerase II promoter2.28e-011.00e+001.96418264
GO:0019899enzyme binding2.38e-011.00e+001.895112277
GO:0005856cytoskeleton2.48e-011.00e+001.824112291
GO:0006200ATP catabolic process2.49e-011.00e+001.819115292
GO:0043234protein complex2.51e-011.00e+001.804118295
GO:0016567protein ubiquitination2.51e-011.00e+001.80415295
GO:0019901protein kinase binding2.67e-011.00e+001.700121317
GO:0043231intracellular membrane-bounded organelle2.68e-011.00e+001.69619318
GO:0007411axon guidance2.69e-011.00e+001.691113319
GO:0044822poly(A) RNA binding2.74e-011.00e+000.9642491056
GO:0008283cell proliferation2.75e-011.00e+001.651114328
GO:0003723RNA binding2.85e-011.00e+001.591120342
GO:0005925focal adhesion3.02e-011.00e+001.493119366
GO:0007155cell adhesion3.04e-011.00e+001.48116369
GO:0055114oxidation-reduction process3.39e-011.00e+001.294112420
GO:0007596blood coagulation3.62e-011.00e+001.179118455
GO:0005789endoplasmic reticulum membrane4.32e-011.00e+000.854116570
GO:0045087innate immune response4.46e-011.00e+000.790124596
GO:0005794Golgi apparatus4.54e-011.00e+000.756115610
GO:0005615extracellular space6.18e-011.00e+000.106117957
GO:0008270zinc ion binding6.33e-011.00e+000.047112997
GO:0005739mitochondrion6.34e-011.00e+000.046128998
GO:0006351transcription, DNA-templated7.72e-011.00e+00-0.4891311446
GO:0016021integral component of membrane8.74e-011.00e+00-0.9441271982
GO:0005886plasma membrane9.37e-011.00e+00-1.3261452582