int-snw-6610

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.974	4.78e-17	1.03e-03	2.11e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-6610 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
PCNA	5111	5	0.553	0.974	294	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
SEC22B	9554	2	0.560	0.974	143	-	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-
[ SMPD2 ]	6610	1	0.321	0.974	60	-	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PCNA	5111	SEC22B	9554	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PCNA	5111	SMPD2	6610	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
ACTB	60	SEC22B	9554	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	SMPD2	6610	pp	--	int.I2D: BioGrid_Yeast
PSMD11	5717	SMPD2	6610	pp	--	int.I2D: BioGrid_Yeast
SMPD2	6610	SEC22B	9554	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PCNA	5111	pp	--	int.I2D: MINT, BioGrid; int.Mint: MI:0915(physical association)

Related GO terms (199)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000082	G1/S transition of mitotic cell cycle	2.19e-06	3.16e-02	5.275	4	32	149
GO:0005654	nucleoplasm	2.84e-05	4.09e-01	3.000	6	76	1082
GO:0006298	mismatch repair	8.17e-05	1.00e+00	7.172	2	3	20
GO:0032201	telomere maintenance via semi-conservative replication	9.02e-05	1.00e+00	7.102	2	5	21
GO:0000278	mitotic cell cycle	9.81e-05	1.00e+00	3.883	4	48	391
GO:0006297	nucleotide-excision repair, DNA gap filling	9.92e-05	1.00e+00	7.035	2	3	22
GO:0000722	telomere maintenance via recombination	1.29e-04	1.00e+00	6.850	2	5	25
GO:0006271	DNA strand elongation involved in DNA replication	1.86e-04	1.00e+00	6.587	2	7	30
GO:0006284	base-excision repair	2.84e-04	1.00e+00	6.285	2	3	37
GO:0016032	viral process	3.27e-04	1.00e+00	3.433	4	55	534
GO:0016071	mRNA metabolic process	4.04e-04	1.00e+00	4.278	3	31	223
GO:0006283	transcription-coupled nucleotide-excision repair	4.41e-04	1.00e+00	5.971	2	7	46
GO:0006521	regulation of cellular amino acid metabolic process	5.21e-04	1.00e+00	5.850	2	17	50
GO:0016070	RNA metabolic process	5.45e-04	1.00e+00	4.131	3	32	247
GO:0006281	DNA repair	6.40e-04	1.00e+00	4.051	3	18	261
GO:0000723	telomere maintenance	6.53e-04	1.00e+00	5.687	2	6	56
GO:0043626	PCNA complex	6.93e-04	1.00e+00	10.494	1	1	1
GO:0032077	positive regulation of deoxyribonuclease activity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0019521	D-gluconate metabolic process	6.93e-04	1.00e+00	10.494	1	1	1
GO:0000502	proteasome complex	7.01e-04	1.00e+00	5.636	2	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	8.52e-04	1.00e+00	5.494	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.79e-04	1.00e+00	5.472	2	22	65
GO:0006289	nucleotide-excision repair	9.62e-04	1.00e+00	5.407	2	11	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.02e-03	1.00e+00	5.365	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.08e-03	1.00e+00	5.324	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.14e-03	1.00e+00	5.285	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.17e-03	1.00e+00	5.265	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.30e-03	1.00e+00	5.190	2	23	79
GO:0030337	DNA polymerase processivity factor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0070557	PCNA-p21 complex	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006272	leading strand elongation	1.39e-03	1.00e+00	9.494	1	2	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.39e-03	1.00e+00	9.494	1	1	2
GO:0019322	pentose biosynthetic process	1.39e-03	1.00e+00	9.494	1	2	2
GO:0005055	laminin receptor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006407	rRNA export from nucleus	1.39e-03	1.00e+00	9.494	1	1	2
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.75e-03	1.00e+00	4.971	2	21	92
GO:0009051	pentose-phosphate shunt, oxidative branch	2.08e-03	1.00e+00	8.909	1	2	3
GO:0032139	dinucleotide insertion or deletion binding	2.08e-03	1.00e+00	8.909	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.08e-03	1.00e+00	8.909	1	1	3
GO:0070062	extracellular vesicular exosome	2.41e-03	1.00e+00	1.850	6	104	2400
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030686	90S preribosome	2.77e-03	1.00e+00	8.494	1	1	4
GO:0000209	protein polyubiquitination	2.77e-03	1.00e+00	4.636	2	20	116
GO:0006684	sphingomyelin metabolic process	2.77e-03	1.00e+00	8.494	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	4
GO:0019788	NEDD8 ligase activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0005829	cytosol	2.97e-03	1.00e+00	1.794	6	132	2496
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043248	proteasome assembly	3.46e-03	1.00e+00	8.172	1	1	5
GO:0030891	VCB complex	3.46e-03	1.00e+00	8.172	1	2	5
GO:0000730	DNA recombinase assembly	3.46e-03	1.00e+00	8.172	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.46e-03	1.00e+00	8.172	1	1	5
GO:0005663	DNA replication factor C complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0030957	Tat protein binding	4.15e-03	1.00e+00	7.909	1	3	6
GO:0032405	MutLalpha complex binding	4.15e-03	1.00e+00	7.909	1	1	6
GO:0033993	response to lipid	4.15e-03	1.00e+00	7.909	1	2	6
GO:0004767	sphingomyelin phosphodiesterase activity	4.15e-03	1.00e+00	7.909	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0042981	regulation of apoptotic process	4.58e-03	1.00e+00	4.265	2	24	150
GO:0000028	ribosomal small subunit assembly	4.84e-03	1.00e+00	7.687	1	1	7
GO:0043596	nuclear replication fork	4.84e-03	1.00e+00	7.687	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	4.84e-03	1.00e+00	7.687	1	2	7
GO:0019773	proteasome core complex, alpha-subunit complex	5.53e-03	1.00e+00	7.494	1	4	8
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	5.53e-03	1.00e+00	7.494	1	2	8
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0070182	DNA polymerase binding	5.53e-03	1.00e+00	7.494	1	2	8
GO:0045116	protein neddylation	5.53e-03	1.00e+00	7.494	1	2	8
GO:0034641	cellular nitrogen compound metabolic process	5.91e-03	1.00e+00	4.076	2	20	171
GO:0031625	ubiquitin protein ligase binding	6.39e-03	1.00e+00	4.018	2	14	178
GO:0044281	small molecule metabolic process	6.88e-03	1.00e+00	2.252	4	58	1211
GO:0006098	pentose-phosphate shunt	6.91e-03	1.00e+00	7.172	1	4	10
GO:0010569	regulation of double-strand break repair via homologous recombination	6.91e-03	1.00e+00	7.172	1	1	10
GO:0019985	translesion synthesis	7.60e-03	1.00e+00	7.035	1	2	11
GO:0031571	mitotic G1 DNA damage checkpoint	7.60e-03	1.00e+00	7.035	1	4	11
GO:0006275	regulation of DNA replication	8.29e-03	1.00e+00	6.909	1	2	12
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	7	12
GO:0005662	DNA replication factor A complex	8.98e-03	1.00e+00	6.794	1	1	13
GO:0010467	gene expression	9.33e-03	1.00e+00	2.693	3	59	669
GO:0035267	NuA4 histone acetyltransferase complex	9.67e-03	1.00e+00	6.687	1	4	14
GO:0050998	nitric-oxide synthase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0046513	ceramide biosynthetic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	8	17
GO:0035861	site of double-strand break	1.24e-02	1.00e+00	6.324	1	1	18
GO:0005839	proteasome core complex	1.24e-02	1.00e+00	6.324	1	8	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.31e-02	1.00e+00	6.246	1	1	19
GO:0048863	stem cell differentiation	1.31e-02	1.00e+00	6.246	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.31e-02	1.00e+00	6.246	1	8	19
GO:0000718	nucleotide-excision repair, DNA damage removal	1.45e-02	1.00e+00	6.102	1	4	21
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle	1.52e-02	1.00e+00	6.035	1	2	22
GO:0046686	response to cadmium ion	1.52e-02	1.00e+00	6.035	1	2	22
GO:0030863	cortical cytoskeleton	1.52e-02	1.00e+00	6.035	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.58e-02	1.00e+00	5.971	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.58e-02	1.00e+00	5.971	1	3	23
GO:0043236	laminin binding	1.58e-02	1.00e+00	5.971	1	1	23
GO:0006513	protein monoubiquitination	1.58e-02	1.00e+00	5.971	1	1	23
GO:0005515	protein binding	1.65e-02	1.00e+00	0.938	8	184	6024
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.79e-02	1.00e+00	5.794	1	3	26
GO:0043022	ribosome binding	1.86e-02	1.00e+00	5.739	1	3	27
GO:0050661	NADP binding	1.86e-02	1.00e+00	5.739	1	2	27
GO:0031492	nucleosomal DNA binding	1.86e-02	1.00e+00	5.739	1	4	27
GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane	1.86e-02	1.00e+00	5.739	1	1	27
GO:0019894	kinesin binding	1.93e-02	1.00e+00	5.687	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.99e-02	1.00e+00	5.636	1	1	29
GO:0006687	glycosphingolipid metabolic process	2.20e-02	1.00e+00	5.494	1	1	32
GO:0030971	receptor tyrosine kinase binding	2.27e-02	1.00e+00	5.450	1	2	33
GO:0001895	retina homeostasis	2.33e-02	1.00e+00	5.407	1	1	34
GO:0034332	adherens junction organization	2.47e-02	1.00e+00	5.324	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.54e-02	1.00e+00	5.285	1	4	37
GO:0070527	platelet aggregation	2.60e-02	1.00e+00	5.246	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.67e-02	1.00e+00	5.209	1	4	39
GO:0000781	chromosome, telomeric region	2.67e-02	1.00e+00	5.209	1	3	39
GO:0021762	substantia nigra development	3.01e-02	1.00e+00	5.035	1	2	44
GO:0043066	negative regulation of apoptotic process	3.32e-02	1.00e+00	2.766	2	31	424
GO:0003684	damaged DNA binding	3.35e-02	1.00e+00	4.879	1	7	49
GO:0009612	response to mechanical stimulus	3.41e-02	1.00e+00	4.850	1	2	50
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.62e-02	1.00e+00	4.766	1	5	53
GO:0006888	ER to Golgi vesicle-mediated transport	3.62e-02	1.00e+00	4.766	1	2	53
GO:0045216	cell-cell junction organization	3.68e-02	1.00e+00	4.739	1	2	54
GO:0000932	cytoplasmic mRNA processing body	3.68e-02	1.00e+00	4.739	1	3	54
GO:0000724	double-strand break repair via homologous recombination	3.75e-02	1.00e+00	4.713	1	3	55
GO:0005793	endoplasmic reticulum-Golgi intermediate compartment	3.82e-02	1.00e+00	4.687	1	1	56
GO:0044267	cellular protein metabolic process	4.07e-02	1.00e+00	2.605	2	29	474
GO:0006665	sphingolipid metabolic process	4.08e-02	1.00e+00	4.587	1	3	60
GO:0030855	epithelial cell differentiation	4.15e-02	1.00e+00	4.563	1	4	61
GO:0019903	protein phosphatase binding	4.22e-02	1.00e+00	4.540	1	4	62
GO:0005901	caveola	4.22e-02	1.00e+00	4.540	1	5	62
GO:0006302	double-strand break repair	4.22e-02	1.00e+00	4.540	1	4	62
GO:0034329	cell junction assembly	4.62e-02	1.00e+00	4.407	1	1	68
GO:0003697	single-stranded DNA binding	4.62e-02	1.00e+00	4.407	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.02e-02	1.00e+00	4.285	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	2	75
GO:0006915	apoptotic process	5.42e-02	1.00e+00	2.378	2	33	555
GO:0019083	viral transcription	5.48e-02	1.00e+00	4.154	1	10	81
GO:0047485	protein N-terminus binding	5.81e-02	1.00e+00	4.068	1	5	86
GO:0006415	translational termination	5.87e-02	1.00e+00	4.051	1	10	87
GO:0016605	PML body	5.94e-02	1.00e+00	4.035	1	3	88
GO:0005634	nucleus	6.02e-02	1.00e+00	0.925	6	136	4559
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	9	91
GO:0006928	cellular component movement	6.14e-02	1.00e+00	3.986	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.14e-02	1.00e+00	3.986	1	8	91
GO:0071456	cellular response to hypoxia	6.20e-02	1.00e+00	3.971	1	6	92
GO:0006414	translational elongation	6.27e-02	1.00e+00	3.955	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.98e-02	1.00e+00	3.794	1	10	104
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	3	105
GO:0072562	blood microparticle	7.44e-02	1.00e+00	3.700	1	3	111
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	8	112
GO:0097190	apoptotic signaling pathway	7.57e-02	1.00e+00	3.674	1	6	113
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7.63e-02	1.00e+00	3.661	1	11	114
GO:0019058	viral life cycle	7.70e-02	1.00e+00	3.649	1	13	115
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	5	118
GO:0007219	Notch signaling pathway	8.02e-02	1.00e+00	3.587	1	5	120
GO:0006260	DNA replication	8.08e-02	1.00e+00	3.575	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	8.40e-02	1.00e+00	3.517	1	5	126
GO:0009615	response to virus	8.40e-02	1.00e+00	3.517	1	5	126
GO:0000790	nuclear chromatin	8.60e-02	1.00e+00	3.483	1	9	129
GO:0006413	translational initiation	8.72e-02	1.00e+00	3.461	1	17	131
GO:0003735	structural constituent of ribosome	9.11e-02	1.00e+00	3.396	1	10	137
GO:0007507	heart development	9.23e-02	1.00e+00	3.375	1	7	139
GO:0006457	protein folding	9.49e-02	1.00e+00	3.334	1	7	143
GO:0061024	membrane organization	9.61e-02	1.00e+00	3.314	1	7	145
GO:0016020	membrane	1.01e-01	1.00e+00	1.364	3	90	1681
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.09e-01	1.00e+00	3.128	1	7	165
GO:0030424	axon	1.09e-01	1.00e+00	3.119	1	4	166
GO:0032403	protein complex binding	1.20e-01	1.00e+00	2.978	1	10	183
GO:0006412	translation	1.49e-01	1.00e+00	2.649	1	20	230
GO:0005975	carbohydrate metabolic process	1.62e-01	1.00e+00	2.511	1	9	253
GO:0004842	ubiquitin-protein transferase activity	1.63e-01	1.00e+00	2.500	1	6	255
GO:0048011	neurotrophin TRK receptor signaling pathway	1.72e-01	1.00e+00	2.423	1	15	269
GO:0019899	enzyme binding	1.76e-01	1.00e+00	2.380	1	12	277
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	12	291
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	18	295
GO:0016567	protein ubiquitination	1.87e-01	1.00e+00	2.290	1	5	295
GO:0035556	intracellular signal transduction	1.91e-01	1.00e+00	2.251	1	9	303
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	21	317
GO:0007411	axon guidance	2.00e-01	1.00e+00	2.177	1	13	319
GO:0005813	centrosome	2.04e-01	1.00e+00	2.145	1	14	326
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0015031	protein transport	2.13e-01	1.00e+00	2.081	1	5	341
GO:0005925	focal adhesion	2.27e-01	1.00e+00	1.978	1	19	366
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	6	369
GO:0055114	oxidation-reduction process	2.56e-01	1.00e+00	1.780	1	12	420
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	18	455
GO:0042802	identical protein binding	2.89e-01	1.00e+00	1.575	1	20	484
GO:0005730	nucleolus	3.18e-01	1.00e+00	0.814	2	69	1641
GO:0005789	endoplasmic reticulum membrane	3.32e-01	1.00e+00	1.339	1	16	570
GO:0045087	innate immune response	3.44e-01	1.00e+00	1.275	1	24	596
GO:0005794	Golgi apparatus	3.51e-01	1.00e+00	1.241	1	15	610
GO:0005887	integral component of plasma membrane	4.70e-01	1.00e+00	0.700	1	6	888
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	17	957
GO:0005737	cytoplasm	5.08e-01	1.00e+00	0.200	3	110	3767
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	12	997
GO:0044822	poly(A) RNA binding	5.33e-01	1.00e+00	0.450	1	49	1056
GO:0005886	plasma membrane	5.58e-01	1.00e+00	0.160	2	45	2582
GO:0005524	ATP binding	6.11e-01	1.00e+00	0.152	1	60	1298
GO:0046872	metal ion binding	6.13e-01	1.00e+00	0.142	1	25	1307
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-6610

Statistics

Genes (10)

Interactions (14)

Related GO terms (199)