int-snw-5298

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.994	7.35e-18	6.46e-04	1.48e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-5298 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
[ PI4KB ]	5298	1	-0.340	0.994	59	-	Yes
RBX1	9978	97	1.185	1.151	139	Yes	-
RPS11	6205	36	0.993	1.113	175	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
PPP3R1	5534	3	-0.462	0.994	76	-	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (14)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	PI4KB	5298	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
PI4KB	5298	PPP3R1	5534	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
PI4KB	5298	RPS11	6205	pp	--	int.I2D: BioGrid_Yeast
ATP6V1B2	526	PPP3R1	5534	pp	--	int.I2D: BioGrid_Yeast
ATP6V1B2	526	PI4KB	5298	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
RPS11	6205	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (192)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0005829	cytosol	1.16e-06	1.68e-02	2.379	9	132	2496
GO:0016071	mRNA metabolic process	1.09e-05	1.57e-01	4.693	4	31	223
GO:0016032	viral process	1.47e-05	2.13e-01	3.755	5	55	534
GO:0016070	RNA metabolic process	1.63e-05	2.34e-01	4.546	4	32	247
GO:0019083	viral transcription	1.99e-05	2.87e-01	5.739	3	10	81
GO:0006415	translational termination	2.47e-05	3.56e-01	5.636	3	10	87
GO:0006414	translational elongation	3.01e-05	4.35e-01	5.540	3	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	4.21e-05	6.08e-01	5.379	3	10	104
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	5.54e-05	7.99e-01	5.246	3	11	114
GO:0019058	viral life cycle	5.69e-05	8.21e-01	5.234	3	13	115
GO:0006413	translational initiation	8.39e-05	1.00e+00	5.046	3	17	131
GO:0003735	structural constituent of ribosome	9.58e-05	1.00e+00	4.981	3	10	137
GO:0044267	cellular protein metabolic process	2.07e-04	1.00e+00	3.605	4	29	474
GO:0022627	cytosolic small ribosomal subunit	3.16e-04	1.00e+00	6.209	2	4	39
GO:0005654	nucleoplasm	4.31e-04	1.00e+00	2.737	5	76	1082
GO:0006412	translation	4.42e-04	1.00e+00	4.234	3	20	230
GO:0010467	gene expression	7.70e-04	1.00e+00	3.108	4	59	669
GO:0004723	calcium-dependent protein serine/threonine phosphatase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.39e-03	1.00e+00	9.494	1	1	2
GO:0005055	laminin receptor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006407	rRNA export from nucleus	1.39e-03	1.00e+00	9.494	1	1	2
GO:0070062	extracellular vesicular exosome	2.41e-03	1.00e+00	1.850	6	104	2400
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	184	6024
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030686	90S preribosome	2.77e-03	1.00e+00	8.494	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	4
GO:0019788	NEDD8 ligase activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0004430	1-phosphatidylinositol 4-kinase activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0005955	calcineurin complex	2.77e-03	1.00e+00	8.494	1	2	4
GO:0016020	membrane	3.25e-03	1.00e+00	2.101	5	90	1681
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043248	proteasome assembly	3.46e-03	1.00e+00	8.172	1	1	5
GO:0030891	VCB complex	3.46e-03	1.00e+00	8.172	1	2	5
GO:0000730	DNA recombinase assembly	3.46e-03	1.00e+00	8.172	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.46e-03	1.00e+00	8.172	1	1	5
GO:0030957	Tat protein binding	4.15e-03	1.00e+00	7.909	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0000082	G1/S transition of mitotic cell cycle	4.52e-03	1.00e+00	4.275	2	32	149
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.84e-03	1.00e+00	7.687	1	2	7
GO:0030867	rough endoplasmic reticulum membrane	4.84e-03	1.00e+00	7.687	1	2	7
GO:0000028	ribosomal small subunit assembly	4.84e-03	1.00e+00	7.687	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	4.84e-03	1.00e+00	7.687	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	5.53e-03	1.00e+00	7.494	1	2	8
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0045116	protein neddylation	5.53e-03	1.00e+00	7.494	1	2	8
GO:0031625	ubiquitin protein ligase binding	6.39e-03	1.00e+00	4.018	2	14	178
GO:0010569	regulation of double-strand break repair via homologous recombination	6.91e-03	1.00e+00	7.172	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	7.60e-03	1.00e+00	7.035	1	4	11
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	7	12
GO:0042273	ribosomal large subunit biogenesis	8.98e-03	1.00e+00	6.794	1	4	13
GO:0005662	DNA replication factor A complex	8.98e-03	1.00e+00	6.794	1	1	13
GO:0035267	NuA4 histone acetyltransferase complex	9.67e-03	1.00e+00	6.687	1	4	14
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1.04e-02	1.00e+00	6.587	1	3	15
GO:0046034	ATP metabolic process	1.04e-02	1.00e+00	6.587	1	1	15
GO:0050998	nitric-oxide synthase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	8	17
GO:0035861	site of double-strand break	1.24e-02	1.00e+00	6.324	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.31e-02	1.00e+00	6.246	1	3	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.31e-02	1.00e+00	6.246	1	1	19
GO:0048863	stem cell differentiation	1.31e-02	1.00e+00	6.246	1	1	19
GO:0006281	DNA repair	1.33e-02	1.00e+00	3.466	2	18	261
GO:0006298	mismatch repair	1.38e-02	1.00e+00	6.172	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.45e-02	1.00e+00	6.102	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.45e-02	1.00e+00	6.102	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.52e-02	1.00e+00	6.035	1	3	22
GO:0030863	cortical cytoskeleton	1.52e-02	1.00e+00	6.035	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.58e-02	1.00e+00	5.971	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.58e-02	1.00e+00	5.971	1	3	23
GO:0043236	laminin binding	1.58e-02	1.00e+00	5.971	1	1	23
GO:0006513	protein monoubiquitination	1.58e-02	1.00e+00	5.971	1	1	23
GO:0000722	telomere maintenance via recombination	1.72e-02	1.00e+00	5.850	1	5	25
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	1.79e-02	1.00e+00	5.794	1	4	26
GO:0015991	ATP hydrolysis coupled proton transport	1.79e-02	1.00e+00	5.794	1	4	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.79e-02	1.00e+00	5.794	1	3	26
GO:0019843	rRNA binding	1.86e-02	1.00e+00	5.739	1	3	27
GO:0043022	ribosome binding	1.86e-02	1.00e+00	5.739	1	3	27
GO:0031492	nucleosomal DNA binding	1.86e-02	1.00e+00	5.739	1	4	27
GO:0046854	phosphatidylinositol phosphorylation	1.93e-02	1.00e+00	5.687	1	1	28
GO:0019894	kinesin binding	1.93e-02	1.00e+00	5.687	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.99e-02	1.00e+00	5.636	1	1	29
GO:0015992	proton transport	1.99e-02	1.00e+00	5.636	1	3	29
GO:0033572	transferrin transport	2.06e-02	1.00e+00	5.587	1	5	30
GO:0006271	DNA strand elongation involved in DNA replication	2.06e-02	1.00e+00	5.587	1	7	30
GO:0051701	interaction with host	2.20e-02	1.00e+00	5.494	1	4	32
GO:0001895	retina homeostasis	2.33e-02	1.00e+00	5.407	1	1	34
GO:0034332	adherens junction organization	2.47e-02	1.00e+00	5.324	1	1	36
GO:0090382	phagosome maturation	2.47e-02	1.00e+00	5.324	1	5	36
GO:0005925	focal adhesion	2.53e-02	1.00e+00	2.978	2	19	366
GO:0051084	'de novo' posttranslational protein folding	2.54e-02	1.00e+00	5.285	1	4	37
GO:0006284	base-excision repair	2.54e-02	1.00e+00	5.285	1	3	37
GO:0005902	microvillus	2.60e-02	1.00e+00	5.246	1	2	38
GO:0070527	platelet aggregation	2.60e-02	1.00e+00	5.246	1	2	38
GO:0000781	chromosome, telomeric region	2.67e-02	1.00e+00	5.209	1	3	39
GO:0000278	mitotic cell cycle	2.86e-02	1.00e+00	2.883	2	48	391
GO:0021762	substantia nigra development	3.01e-02	1.00e+00	5.035	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	3.14e-02	1.00e+00	4.971	1	7	46
GO:0044822	poly(A) RNA binding	3.18e-02	1.00e+00	2.035	3	49	1056
GO:0022625	cytosolic large ribosomal subunit	3.35e-02	1.00e+00	4.879	1	6	49
GO:0003684	damaged DNA binding	3.35e-02	1.00e+00	4.879	1	7	49
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	17	50
GO:0006879	cellular iron ion homeostasis	3.48e-02	1.00e+00	4.822	1	4	51
GO:0006661	phosphatidylinositol biosynthetic process	3.55e-02	1.00e+00	4.794	1	2	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.62e-02	1.00e+00	4.766	1	5	53
GO:0045216	cell-cell junction organization	3.68e-02	1.00e+00	4.739	1	2	54
GO:0097193	intrinsic apoptotic signaling pathway	3.75e-02	1.00e+00	4.713	1	6	55
GO:0000724	double-strand break repair via homologous recombination	3.75e-02	1.00e+00	4.713	1	3	55
GO:0000723	telomere maintenance	3.82e-02	1.00e+00	4.687	1	6	56
GO:0012505	endomembrane system	3.82e-02	1.00e+00	4.687	1	2	56
GO:0005840	ribosome	3.95e-02	1.00e+00	4.636	1	1	58
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	17	58
GO:0019903	protein phosphatase binding	4.22e-02	1.00e+00	4.540	1	4	62
GO:0006302	double-strand break repair	4.22e-02	1.00e+00	4.540	1	4	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	22	65
GO:0006289	nucleotide-excision repair	4.62e-02	1.00e+00	4.407	1	11	68
GO:0034329	cell junction assembly	4.62e-02	1.00e+00	4.407	1	1	68
GO:0003697	single-stranded DNA binding	4.62e-02	1.00e+00	4.407	1	5	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	22	70
GO:0042383	sarcolemma	4.82e-02	1.00e+00	4.344	1	3	71
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.02e-02	1.00e+00	4.285	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	22	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	2	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	23	79
GO:0005524	ATP binding	5.40e-02	1.00e+00	1.737	3	60	1298
GO:0001726	ruffle	5.41e-02	1.00e+00	4.172	1	4	80
GO:0006915	apoptotic process	5.42e-02	1.00e+00	2.378	2	33	555
GO:0006898	receptor-mediated endocytosis	5.68e-02	1.00e+00	4.102	1	3	84
GO:0016311	dephosphorylation	5.74e-02	1.00e+00	4.085	1	3	85
GO:0047485	protein N-terminus binding	5.81e-02	1.00e+00	4.068	1	5	86
GO:0016605	PML body	5.94e-02	1.00e+00	4.035	1	3	88
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	9	91
GO:0006928	cellular component movement	6.14e-02	1.00e+00	3.986	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.14e-02	1.00e+00	3.986	1	8	91
GO:0045087	innate immune response	6.16e-02	1.00e+00	2.275	2	24	596
GO:0001649	osteoblast differentiation	6.20e-02	1.00e+00	3.971	1	6	92
GO:0071456	cellular response to hypoxia	6.20e-02	1.00e+00	3.971	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	21	92
GO:0006364	rRNA processing	6.33e-02	1.00e+00	3.940	1	6	94
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	3	105
GO:0005741	mitochondrial outer membrane	7.05e-02	1.00e+00	3.780	1	7	105
GO:0072562	blood microparticle	7.44e-02	1.00e+00	3.700	1	3	111
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	8	112
GO:0048015	phosphatidylinositol-mediated signaling	7.63e-02	1.00e+00	3.661	1	7	114
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	20	116
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	5	118
GO:0007219	Notch signaling pathway	8.02e-02	1.00e+00	3.587	1	5	120
GO:0006260	DNA replication	8.08e-02	1.00e+00	3.575	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	8.40e-02	1.00e+00	3.517	1	5	126
GO:0006644	phospholipid metabolic process	8.60e-02	1.00e+00	3.483	1	5	129
GO:0000790	nuclear chromatin	8.60e-02	1.00e+00	3.483	1	9	129
GO:0008286	insulin receptor signaling pathway	9.42e-02	1.00e+00	3.344	1	7	142
GO:0006457	protein folding	9.49e-02	1.00e+00	3.334	1	7	143
GO:0061024	membrane organization	9.61e-02	1.00e+00	3.314	1	7	145
GO:0042981	regulation of apoptotic process	9.93e-02	1.00e+00	3.265	1	24	150
GO:0005516	calmodulin binding	1.06e-01	1.00e+00	3.172	1	3	160
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.09e-01	1.00e+00	3.128	1	7	165
GO:0030424	axon	1.09e-01	1.00e+00	3.119	1	4	166
GO:0005768	endosome	1.11e-01	1.00e+00	3.093	1	6	169
GO:0038095	Fc-epsilon receptor signaling pathway	1.11e-01	1.00e+00	3.102	1	12	168
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	20	171
GO:0019904	protein domain specific binding	1.17e-01	1.00e+00	3.010	1	6	179
GO:0032403	protein complex binding	1.20e-01	1.00e+00	2.978	1	10	183
GO:0005765	lysosomal membrane	1.32e-01	1.00e+00	2.829	1	5	203
GO:0004842	ubiquitin-protein transferase activity	1.63e-01	1.00e+00	2.500	1	6	255
GO:0019899	enzyme binding	1.76e-01	1.00e+00	2.380	1	12	277
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	12	291
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	18	295
GO:0016567	protein ubiquitination	1.87e-01	1.00e+00	2.290	1	5	295
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	21	317
GO:0043231	intracellular membrane-bounded organelle	2.00e-01	1.00e+00	2.181	1	9	318
GO:0007411	axon guidance	2.00e-01	1.00e+00	2.177	1	13	319
GO:0044281	small molecule metabolic process	2.03e-01	1.00e+00	1.252	2	58	1211
GO:0003723	RNA binding	2.13e-01	1.00e+00	2.076	1	20	342
GO:0000139	Golgi membrane	2.24e-01	1.00e+00	1.998	1	3	361
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	6	369
GO:0005737	cytoplasm	2.51e-01	1.00e+00	0.615	4	110	3767
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	31	424
GO:0005886	plasma membrane	2.60e-01	1.00e+00	0.745	3	45	2582
GO:0055085	transmembrane transport	2.64e-01	1.00e+00	1.729	1	10	435
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	18	455
GO:0048471	perinuclear region of cytoplasm	2.98e-01	1.00e+00	1.523	1	13	502
GO:0005509	calcium ion binding	3.13e-01	1.00e+00	1.442	1	5	531
GO:0007165	signal transduction	4.78e-01	1.00e+00	0.669	1	24	907
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	17	957
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	12	997
GO:0005634	nucleus	6.59e-01	1.00e+00	-0.075	3	136	4559
GO:0005730	nucleolus	7.01e-01	1.00e+00	-0.186	1	69	1641
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-5298

Statistics

Genes (10)

Interactions (14)

Related GO terms (192)