int-snw-51706

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.007 2.05e-18 4.67e-04 1.16e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-51706 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
CAD 790 170.8071.007333--
RSL24D1 51187 361.3001.02059Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
DDX18 8886 90.6601.013173Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
[ CYB5R1 ] 51706 1-0.0151.00762--
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (19)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
PSMD11 5717 DDX18 8886 pp -- int.I2D: YeastLow
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 CYB5R1 51706 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
CAD 790 CYB5R1 51706 pp -- int.I2D: YeastMedium
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
DDX18 8886 CYB5R1 51706 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CYB5R1 51706 pp -- int.I2D: BioGrid_Yeast

Related GO terms (202)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000082G1/S transition of mitotic cell cycle5.08e-067.32e-025.012432149
GO:0006521regulation of cellular amino acid metabolic process8.44e-061.22e-016.17231750
GO:0000502proteasome complex1.32e-051.91e-015.95831758
GO:0019773proteasome core complex, alpha-subunit complex1.77e-052.56e-018.231248
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.78e-052.57e-015.81631964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.87e-052.69e-015.79432265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.33e-053.37e-015.68732270
GO:0016071mRNA metabolic process2.50e-053.60e-014.430431223
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.54e-053.66e-015.64632072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.76e-053.98e-015.60732274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2.87e-054.14e-015.58732075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.36e-054.84e-015.51232379
GO:0016070RNA metabolic process3.73e-055.38e-014.283432247
GO:0016032viral process4.36e-056.28e-013.492555534
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.30e-057.64e-015.29332192
GO:0005839proteasome core complex9.64e-051.00e+007.0612818
GO:0000209protein polyubiquitination1.06e-041.00e+004.958320116
GO:0004298threonine-type endopeptidase activity1.08e-041.00e+006.9832819
GO:0005654nucleoplasm1.10e-041.00e+002.7376761082
GO:0070062extracellular vesicular exosome1.53e-041.00e+002.00281042400
GO:0005829cytosol2.03e-041.00e+001.94681322496
GO:0000278mitotic cell cycle2.22e-041.00e+003.620448391
GO:0042981regulation of apoptotic process2.26e-041.00e+004.587324150
GO:0034641cellular nitrogen compound metabolic process3.33e-041.00e+004.398320171
GO:0004151dihydroorotase activity8.32e-041.00e+0010.231111
GO:0019521D-gluconate metabolic process8.32e-041.00e+0010.231111
GO:0004070aspartate carbamoyltransferase activity8.32e-041.00e+0010.231111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity8.32e-041.00e+0010.231111
GO:0070335aspartate binding8.32e-041.00e+0010.231111
GO:0016020membrane1.23e-031.00e+002.1016901681
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0019322pentose biosynthetic process1.66e-031.00e+009.231122
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0070409carbamoyl phosphate biosynthetic process1.66e-031.00e+009.231112
GO:0010467gene expression1.68e-031.00e+002.845459669
GO:0044281small molecule metabolic process1.98e-031.00e+002.3115581211
GO:0009051pentose-phosphate shunt, oxidative branch2.49e-031.00e+008.646123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.49e-031.00e+008.646113
GO:0044205'de novo' UMP biosynthetic process2.49e-031.00e+008.646113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process2.49e-031.00e+008.646113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0006543glutamine catabolic process3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0051414response to cortisol4.15e-031.00e+007.909115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0043066negative regulation of apoptotic process4.55e-031.00e+003.088331424
GO:0016126sterol biosynthetic process4.98e-031.00e+007.646126
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0046134pyrimidine nucleoside biosynthetic process4.98e-031.00e+007.646116
GO:0004128cytochrome-b5 reductase activity, acting on NAD(P)H4.98e-031.00e+007.646116
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0006228UTP biosynthetic process7.47e-031.00e+007.061119
GO:0014075response to amine7.47e-031.00e+007.061119
GO:0031000response to caffeine7.47e-031.00e+007.061129
GO:0006098pentose-phosphate shunt8.29e-031.00e+006.9091410
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0006915apoptotic process9.61e-031.00e+002.700333555
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461712
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0006541glutamine metabolic process1.41e-021.00e+006.1441117
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441817
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0004004ATP-dependent RNA helicase activity1.49e-021.00e+006.0611218
GO:0017144drug metabolic process1.49e-021.00e+006.0611118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0071364cellular response to epidermal growth factor stimulus1.73e-021.00e+005.8391121
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006206pyrimidine nucleobase metabolic process1.82e-021.00e+005.7721222
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0033574response to testosterone1.82e-021.00e+005.7721222
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0019899enzyme binding2.14e-021.00e+003.117212277
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0050661NADP binding2.22e-021.00e+005.4761227
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0043234protein complex2.40e-021.00e+003.027218295
GO:0042254ribosome biogenesis2.47e-021.00e+005.3241130
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0018107peptidyl-threonine phosphorylation3.04e-021.00e+005.0221437
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0007595lactation3.20e-021.00e+004.9461239
GO:0043195terminal bouton3.36e-021.00e+004.8741141
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0005730nucleolus3.91e-021.00e+001.5514691641
GO:0035690cellular response to drug4.00e-021.00e+004.6161249
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0031100organ regeneration4.08e-021.00e+004.5871450
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0000932cytoplasmic mRNA processing body4.40e-021.00e+004.4761354
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0055114oxidation-reduction process4.60e-021.00e+002.517212420
GO:0042995cell projection4.88e-021.00e+004.3241660
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0005634nucleus5.06e-021.00e+000.88471364559
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0055086nucleobase-containing small molecule metabolic process5.67e-021.00e+004.1021270
GO:0044267cellular protein metabolic process5.72e-021.00e+002.342229474
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0001889liver development6.22e-021.00e+003.9641477
GO:0007565female pregnancy6.30e-021.00e+003.9461178
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0016363nuclear matrix7.32e-021.00e+003.72311291
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0005515protein binding7.35e-021.00e+000.67581846024
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0005524ATP binding8.65e-021.00e+001.4743601298
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0009615response to virus1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0007507heart development1.10e-011.00e+003.11217139
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0046777protein autophosphorylation1.24e-011.00e+002.92717158
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0004672protein kinase activity1.38e-011.00e+002.76416177
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0006412translation1.75e-011.00e+002.386120230
GO:0043025neuronal cell body1.86e-011.00e+002.29419245
GO:0005975carbohydrate metabolic process1.91e-011.00e+002.24819253
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0008270zinc ion binding1.99e-011.00e+001.270212997
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0044822poly(A) RNA binding2.18e-011.00e+001.1872491056
GO:0006200ATP catabolic process2.18e-011.00e+002.041115292
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0019901protein kinase binding2.34e-011.00e+001.923121317
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0005813centrosome2.40e-011.00e+001.882114326
GO:0003723RNA binding2.50e-011.00e+001.813120342
GO:0005925focal adhesion2.65e-011.00e+001.715119366
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0008150biological_process2.80e-011.00e+001.62713389
GO:0003674molecular_function3.13e-011.00e+001.43714444
GO:0007596blood coagulation3.19e-011.00e+001.401118455
GO:0042802identical protein binding3.36e-011.00e+001.312120484
GO:0045087innate immune response3.97e-011.00e+001.012124596
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0005739mitochondrion5.77e-011.00e+000.268128998
GO:0016021integral component of membrane8.30e-011.00e+00-0.7221271982
GO:0005737cytoplasm8.61e-011.00e+00-0.64821103767
GO:0005886plasma membrane9.06e-011.00e+00-1.1031452582