int-snw-5159

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.942 8.86e-16 2.13e-03 3.60e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5159 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ATP6V0C 527 60.6601.07669Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
ATP6V1B2 526 440.8811.076278--
RBX1 9978 971.1851.151139Yes-
TYK2 7297 20.5430.95439Yes-
[ PDGFRB ] 5159 1-0.3820.94291--
RPSA 3921 1561.3271.151152Yes-

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ATP6V0C 527 PDGFRB 5159 pp -- int.I2D: MINT
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 ATP6V0C 527 pp -- int.I2D: BioGrid_Yeast
PDGFRB 5159 TYK2 7297 pp -- int.I2D: BCI, HPRD;
int.HPRD: in vitro, in vivo
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ATP6V1B2 526 ATP6V0C 527 pp -- int.I2D: YeastMedium, INTEROLOG
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast

Related GO terms (251)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0046961proton-transporting ATPase activity, rotational mechanism3.62e-055.22e-017.7392315
GO:0070062extracellular vesicular exosome9.23e-051.00e+002.22571042400
GO:0015991ATP hydrolysis coupled proton transport1.12e-041.00e+006.9462426
GO:0015992proton transport1.39e-041.00e+006.7882329
GO:0031625ubiquitin protein ligase binding1.47e-041.00e+004.755314178
GO:0033572transferrin transport1.49e-041.00e+006.7392530
GO:0051701interaction with host1.70e-041.00e+006.6462432
GO:0016032viral process2.02e-041.00e+003.585455534
GO:0090382phagosome maturation2.16e-041.00e+006.4762536
GO:0006879cellular iron ion homeostasis4.34e-041.00e+005.9742451
GO:0005019platelet-derived growth factor beta-receptor activity6.24e-041.00e+0010.646111
GO:0005017platelet-derived growth factor-activated receptor activity6.24e-041.00e+0010.646111
GO:0060981cell migration involved in coronary angiogenesis6.24e-041.00e+0010.646111
GO:0035789metanephric mesenchymal cell migration6.24e-041.00e+0010.646111
GO:0004713protein tyrosine kinase activity1.12e-031.00e+005.2892582
GO:0005925focal adhesion1.21e-031.00e+003.715319366
GO:0071670smooth muscle cell chemotaxis1.25e-031.00e+009.646112
GO:0035791platelet-derived growth factor receptor-beta signaling pathway1.25e-031.00e+009.646112
GO:0004992platelet activating factor receptor activity1.25e-031.00e+009.646122
GO:0035441cell migration involved in vasculogenesis1.25e-031.00e+009.646112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0072262metanephric glomerular mesangial cell proliferation involved in metanephros development1.25e-031.00e+009.646112
GO:0005829cytosol1.39e-031.00e+001.94661322496
GO:0016020membrane1.80e-031.00e+002.2535901681
GO:0072278metanephric comma-shaped body morphogenesis1.87e-031.00e+009.061113
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway1.87e-031.00e+009.061113
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway1.87e-031.00e+009.061113
GO:0072277metanephric glomerular capillary formation1.87e-031.00e+009.061113
GO:0038085vascular endothelial growth factor binding2.49e-031.00e+008.646114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0018108peptidyl-tyrosine phosphorylation2.87e-031.00e+004.60227132
GO:0005654nucleoplasm2.92e-031.00e+002.5674761082
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0033179proton-transporting V-type ATPase, V0 domain3.12e-031.00e+008.324115
GO:0005131growth hormone receptor binding3.12e-031.00e+008.324115
GO:0036120cellular response to platelet-derived growth factor stimulus3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0072284metanephric S-shaped body morphogenesis3.12e-031.00e+008.324115
GO:0008286insulin receptor signaling pathway3.31e-031.00e+004.49627142
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0033180proton-transporting V-type ATPase, V1 domain4.36e-031.00e+007.839127
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0061298retina vasculature development in camera-type eye4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0072075metanephric mesenchyme development4.98e-031.00e+007.646118
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0010863positive regulation of phospholipase C activity4.98e-031.00e+007.646118
GO:0034405response to fluid shear stress4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0005515protein binding5.23e-031.00e+001.09081846024
GO:0046933proton-transporting ATP synthase activity, rotational mechanism5.60e-031.00e+007.476119
GO:0031702type 1 angiotensin receptor binding5.60e-031.00e+007.476119
GO:0005524ATP binding5.68e-031.00e+002.3044601298
GO:0032516positive regulation of phosphoprotein phosphatase activity6.22e-031.00e+007.3241110
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0046488phosphatidylinositol metabolic process6.22e-031.00e+007.3241110
GO:0005765lysosomal membrane6.65e-031.00e+003.98125203
GO:0048407platelet-derived growth factor binding6.85e-031.00e+007.1871111
GO:0055003cardiac myofibril assembly6.85e-031.00e+007.1871111
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0048745smooth muscle tissue development6.85e-031.00e+007.1871111
GO:2000573positive regulation of DNA biosynthetic process6.85e-031.00e+007.1871111
GO:0035909aorta morphogenesis7.47e-031.00e+007.0611112
GO:0050730regulation of peptidyl-tyrosine phosphorylation7.47e-031.00e+007.0611112
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0016071mRNA metabolic process7.98e-031.00e+003.845231223
GO:0050921positive regulation of chemotaxis8.09e-031.00e+006.9461213
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0055093response to hyperoxia8.09e-031.00e+006.9461113
GO:0031226intrinsic component of plasma membrane8.09e-031.00e+006.9461113
GO:0090280positive regulation of calcium ion import8.09e-031.00e+006.9461113
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0005161platelet-derived growth factor receptor binding8.70e-031.00e+006.8391114
GO:0046034ATP metabolic process9.32e-031.00e+006.7391115
GO:0016070RNA metabolic process9.71e-031.00e+003.698232247
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0014911positive regulation of smooth muscle cell migration9.94e-031.00e+006.6461116
GO:0001894tissue homeostasis1.06e-021.00e+006.5591117
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0015078hydrogen ion transmembrane transporter activity1.18e-021.00e+006.3981319
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0030325adrenal gland development1.30e-021.00e+006.2541121
GO:0043548phosphatidylinositol 3-kinase binding1.30e-021.00e+006.2541221
GO:0060338regulation of type I interferon-mediated signaling pathway1.30e-021.00e+006.2541121
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0032967positive regulation of collagen biosynthetic process1.30e-021.00e+006.2541121
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0005856cytoskeleton1.33e-021.00e+003.461212291
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0006024glycosaminoglycan biosynthetic process1.43e-021.00e+006.1231123
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:2000379positive regulation of reactive oxygen species metabolic process1.43e-021.00e+006.1231223
GO:0048705skeletal system morphogenesis1.49e-021.00e+006.0611124
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0019901protein kinase binding1.57e-021.00e+003.338221317
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity1.61e-021.00e+005.9461226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0048008platelet-derived growth factor receptor signaling pathway1.67e-021.00e+005.8911227
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0030177positive regulation of Wnt signaling pathway1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0045840positive regulation of mitosis1.73e-021.00e+005.8391228
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0032956regulation of actin cytoskeleton organization1.86e-021.00e+005.7391130
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0048839inner ear development2.29e-021.00e+005.4371237
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0000278mitotic cell cycle2.33e-021.00e+003.035248391
GO:0005902microvillus2.35e-021.00e+005.3981238
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0042542response to hydrogen peroxide2.41e-021.00e+005.3611139
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0004715non-membrane spanning protein tyrosine kinase activity2.59e-021.00e+005.2541442
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0043066negative regulation of apoptotic process2.71e-021.00e+002.918231424
GO:0032526response to retinoic acid2.83e-021.00e+005.1231246
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0043406positive regulation of MAP kinase activity2.83e-021.00e+005.1231446
GO:0055085transmembrane transport2.84e-021.00e+002.881210435
GO:0030670phagocytic vesicle membrane2.90e-021.00e+005.0921347
GO:0048661positive regulation of smooth muscle cell proliferation3.02e-021.00e+005.0311449
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0006521regulation of cellular amino acid metabolic process3.08e-021.00e+005.00211750
GO:0060326cell chemotaxis3.08e-021.00e+005.0021250
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling3.14e-021.00e+004.9741151
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0012505endomembrane system3.44e-021.00e+004.8391256
GO:0000502proteasome complex3.56e-021.00e+004.78811758
GO:0060337type I interferon signaling pathway3.56e-021.00e+004.7881258
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0043202lysosomal lumen3.86e-021.00e+004.6691163
GO:0042060wound healing3.92e-021.00e+004.6461264
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.98e-021.00e+004.62412265
GO:0009636response to toxic substance3.98e-021.00e+004.6241365
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.29e-021.00e+004.51712270
GO:0032355response to estradiol4.35e-021.00e+004.4961571
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.53e-021.00e+004.43712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.82e-021.00e+004.34212379
GO:0001726ruffle4.88e-021.00e+004.3241480
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0045087innate immune response5.06e-021.00e+002.427224596
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0042470melanosome5.54e-021.00e+004.1381991
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0016023cytoplasmic membrane-bounded vesicle6.37e-021.00e+003.93215105
GO:0070374positive regulation of ERK1 and ERK2 cascade6.43e-021.00e+003.91812106
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0048015phosphatidylinositol-mediated signaling6.89e-021.00e+003.81317114
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0030335positive regulation of cell migration7.65e-021.00e+003.65717127
GO:0016477cell migration7.71e-021.00e+003.64615128
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0010008endosome membrane9.04e-021.00e+003.40817151
GO:0008543fibroblast growth factor receptor signaling pathway9.33e-021.00e+003.36119156
GO:0046777protein autophosphorylation9.44e-021.00e+003.34217158
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0038095Fc-epsilon receptor signaling pathway1.00e-011.00e+003.254112168
GO:0034641cellular nitrogen compound metabolic process1.02e-011.00e+003.228120171
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0007173epidermal growth factor receptor signaling pathway1.12e-011.00e+003.084112189
GO:0016021integral component of membrane1.15e-011.00e+001.2783271982
GO:0016324apical plasma membrane1.18e-011.00e+003.01015199
GO:0001701in utero embryonic development1.19e-011.00e+002.99518201
GO:0005634nucleus1.20e-011.00e+000.81451364559
GO:0019221cytokine-mediated signaling pathway1.30e-011.00e+002.85819221
GO:0006412translation1.35e-011.00e+002.801120230
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0005102receptor binding1.51e-011.00e+002.62416260
GO:0048011neurotrophin TRK receptor signaling pathway1.56e-011.00e+002.575115269
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0007186G-protein coupled receptor signaling pathway1.67e-011.00e+002.47117289
GO:0043234protein complex1.70e-011.00e+002.442118295
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0035556intracellular signal transduction1.74e-011.00e+002.40319303
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005737cytoplasm1.87e-011.00e+000.76741103767
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0005886plasma membrane2.08e-011.00e+000.8973452582
GO:0008284positive regulation of cell proliferation2.15e-011.00e+002.06918382
GO:0009986cell surface2.25e-011.00e+001.995111402
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0006468protein phosphorylation2.53e-011.00e+001.801118460
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0007165signal transduction4.43e-011.00e+000.821124907
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0008270zinc ion binding4.75e-011.00e+000.685112997
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021491056
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041581211
GO:0005730nucleolus6.63e-011.00e+00-0.0341691641