int-snw-5122

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.940 1.02e-15 2.20e-03 3.69e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-5122 subnetwork

Genes (11)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PSMD1 5707 120.8361.057113Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
[ PCSK1 ] 5122 1-0.0500.94052--
CLTC 1213 350.8841.138247Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
ATP6V1B2 526 440.8811.076278--
POLR2B 5431 30.5870.940146Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (18)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 PCSK1 5122 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 PCSK1 5122 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
PCSK1 5122 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ATP6V1B2 526 PCSK1 5122 pp -- int.I2D: IntAct_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 POLR2B 5431 pp -- int.I2D: IntAct_Yeast
PCSK1 5122 POLR2B 5431 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016032viral process9.88e-071.42e-023.881655534
GO:0005654nucleoplasm3.31e-064.77e-023.0857761082
GO:0000082G1/S transition of mitotic cell cycle3.41e-064.92e-025.137432149
GO:0006521regulation of cellular amino acid metabolic process6.34e-069.15e-026.29831750
GO:0000502proteasome complex9.95e-061.44e-016.08431758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.34e-051.93e-015.94231964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.40e-052.03e-015.91932265
GO:0016071mRNA metabolic process1.69e-052.43e-014.556431223
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.76e-052.53e-015.81232270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.91e-052.76e-015.77232072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.08e-053.00e-015.73232274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2.16e-053.12e-015.71332075
GO:0016070RNA metabolic process2.52e-053.64e-014.408432247
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2.53e-053.65e-015.63832379
GO:0005838proteasome regulatory particle3.48e-055.01e-017.7722712
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.99e-055.76e-015.41832192
GO:0022624proteasome accessory complex7.15e-051.00e+007.2692817
GO:0010467gene expression7.74e-051.00e+003.293559669
GO:0000209protein polyubiquitination7.98e-051.00e+005.084320116
GO:0005829cytosol7.99e-051.00e+002.07181322496
GO:0000278mitotic cell cycle1.51e-041.00e+003.746448391
GO:0042981regulation of apoptotic process1.71e-041.00e+004.713324150
GO:0033572transferrin transport2.27e-041.00e+006.4502530
GO:0034641cellular nitrogen compound metabolic process2.52e-041.00e+004.524320171
GO:0006283transcription-coupled nucleotide-excision repair5.37e-041.00e+005.8332746
GO:0070062extracellular vesicular exosome6.19e-041.00e+001.93571042400
GO:0016020membrane6.82e-041.00e+002.2276901681
GO:0006281DNA repair8.68e-041.00e+003.914318261
GO:0006289nucleotide-excision repair1.17e-031.00e+005.26921168
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.52e-031.00e+009.357112
GO:0005055laminin receptor activity1.52e-031.00e+009.357112
GO:0006407rRNA export from nucleus1.52e-031.00e+009.357112
GO:0042470melanosome2.09e-031.00e+004.8492991
GO:1900126negative regulation of hyaluronan biosynthetic process2.29e-031.00e+008.772123
GO:0071439clathrin complex2.29e-031.00e+008.772123
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.05e-031.00e+008.357114
GO:003068690S preribosome3.05e-031.00e+008.357114
GO:0032051clathrin light chain binding3.05e-031.00e+008.357114
GO:0031467Cul7-RING ubiquitin ligase complex3.05e-031.00e+008.357114
GO:0019788NEDD8 ligase activity3.05e-031.00e+008.357114
GO:1903077negative regulation of protein localization to plasma membrane3.05e-031.00e+008.357114
GO:0032549ribonucleoside binding3.05e-031.00e+008.357124
GO:0043066negative regulation of apoptotic process3.49e-031.00e+003.214331424
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.81e-031.00e+008.035135
GO:0031461cullin-RING ubiquitin ligase complex3.81e-031.00e+008.035115
GO:0043248proteasome assembly3.81e-031.00e+008.035115
GO:0030891VCB complex3.81e-031.00e+008.035125
GO:0043043peptide biosynthetic process3.81e-031.00e+008.035115
GO:0000730DNA recombinase assembly3.81e-031.00e+008.035115
GO:2000001regulation of DNA damage checkpoint3.81e-031.00e+008.035115
GO:0030130clathrin coat of trans-Golgi network vesicle4.57e-031.00e+007.772136
GO:0030957Tat protein binding4.57e-031.00e+007.772136
GO:0030118clathrin coat4.57e-031.00e+007.772126
GO:0031466Cul5-RING ubiquitin ligase complex4.57e-031.00e+007.772116
GO:0044267cellular protein metabolic process4.78e-031.00e+003.053329474
GO:0061024membrane organization5.20e-031.00e+004.17727145
GO:0033180proton-transporting V-type ATPase, V1 domain5.33e-031.00e+007.549127
GO:0030132clathrin coat of coated pit5.33e-031.00e+007.549127
GO:0000028ribosomal small subunit assembly5.33e-031.00e+007.549117
GO:0031462Cul2-RING ubiquitin ligase complex5.33e-031.00e+007.549127
GO:0019773proteasome core complex, alpha-subunit complex6.09e-031.00e+007.357148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.09e-031.00e+007.357128
GO:0070688MLL5-L complex6.09e-031.00e+007.357118
GO:0045116protein neddylation6.09e-031.00e+007.357128
GO:0006915apoptotic process7.42e-031.00e+002.825333555
GO:0010569regulation of double-strand break repair via homologous recombination7.60e-031.00e+007.0351110
GO:0031625ubiquitin protein ligase binding7.74e-031.00e+003.881214178
GO:0031571mitotic G1 DNA damage checkpoint8.36e-031.00e+006.8971411
GO:0034774secretory granule lumen9.12e-031.00e+006.7721112
GO:0005662DNA replication factor A complex9.87e-031.00e+006.6561113
GO:0030234enzyme regulator activity9.87e-031.00e+006.6561313
GO:0035267NuA4 histone acetyltransferase complex1.06e-021.00e+006.5491414
GO:0046961proton-transporting ATPase activity, rotational mechanism1.14e-021.00e+006.4501315
GO:0046034ATP metabolic process1.14e-021.00e+006.4501115
GO:0050998nitric-oxide synthase binding1.21e-021.00e+006.3571116
GO:0016486peptide hormone processing1.21e-021.00e+006.3571116
GO:0042176regulation of protein catabolic process1.21e-021.00e+006.3571316
GO:0005665DNA-directed RNA polymerase II, core complex1.21e-021.00e+006.3571416
GO:0035861site of double-strand break1.36e-021.00e+006.1871118
GO:0005839proteasome core complex1.36e-021.00e+006.1871818
GO:0015078hydrogen ion transmembrane transporter activity1.44e-021.00e+006.1091319
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.44e-021.00e+006.1091119
GO:0048863stem cell differentiation1.44e-021.00e+006.1091119
GO:0004298threonine-type endopeptidase activity1.44e-021.00e+006.1091819
GO:0006298mismatch repair1.52e-021.00e+006.0351320
GO:0032201telomere maintenance via semi-conservative replication1.59e-021.00e+005.9641521
GO:0000718nucleotide-excision repair, DNA damage removal1.59e-021.00e+005.9641421
GO:0006297nucleotide-excision repair, DNA gap filling1.67e-021.00e+005.8971322
GO:0030863cortical cytoskeleton1.67e-021.00e+005.8971122
GO:0036464cytoplasmic ribonucleoprotein granule1.67e-021.00e+005.8971422
GO:0043044ATP-dependent chromatin remodeling1.74e-021.00e+005.8331423
GO:0031463Cul3-RING ubiquitin ligase complex1.74e-021.00e+005.8331323
GO:0043236laminin binding1.74e-021.00e+005.8331123
GO:0006513protein monoubiquitination1.74e-021.00e+005.8331123
GO:0003899DNA-directed RNA polymerase activity1.89e-021.00e+005.7131325
GO:0000722telomere maintenance via recombination1.89e-021.00e+005.7131525
GO:0015991ATP hydrolysis coupled proton transport1.97e-021.00e+005.6561426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.97e-021.00e+005.6561326
GO:0043234protein complex2.03e-021.00e+003.152218295
GO:0043022ribosome binding2.04e-021.00e+005.6021327
GO:0031492nucleosomal DNA binding2.04e-021.00e+005.6021427
GO:0030669clathrin-coated endocytic vesicle membrane2.12e-021.00e+005.5491428
GO:0019894kinesin binding2.12e-021.00e+005.5491128
GO:0019005SCF ubiquitin ligase complex2.19e-021.00e+005.4991129
GO:0015992proton transport2.19e-021.00e+005.4991329
GO:0006271DNA strand elongation involved in DNA replication2.27e-021.00e+005.4501730
GO:00063707-methylguanosine mRNA capping2.27e-021.00e+005.4501530
GO:0019901protein kinase binding2.32e-021.00e+003.048221317
GO:0031623receptor internalization2.34e-021.00e+005.4021231
GO:0051701interaction with host2.41e-021.00e+005.3571432
GO:0032588trans-Golgi network membrane2.56e-021.00e+005.2691234
GO:0001895retina homeostasis2.56e-021.00e+005.2691134
GO:0034332adherens junction organization2.71e-021.00e+005.1871136
GO:0090382phagosome maturation2.71e-021.00e+005.1871536
GO:0051084'de novo' posttranslational protein folding2.79e-021.00e+005.1471437
GO:0006284base-excision repair2.79e-021.00e+005.1471337
GO:0005902microvillus2.86e-021.00e+005.1091238
GO:0070527platelet aggregation2.86e-021.00e+005.1091238
GO:0022627cytosolic small ribosomal subunit2.94e-021.00e+005.0711439
GO:0000781chromosome, telomeric region2.94e-021.00e+005.0711339
GO:0005925focal adhesion3.04e-021.00e+002.841219366
GO:0030136clathrin-coated vesicle3.16e-021.00e+004.9641442
GO:0006892post-Golgi vesicle-mediated transport3.23e-021.00e+004.9301343
GO:0030133transport vesicle3.23e-021.00e+004.9301143
GO:0021762substantia nigra development3.31e-021.00e+004.8971244
GO:0050434positive regulation of viral transcription3.31e-021.00e+004.8971644
GO:0003684damaged DNA binding3.68e-021.00e+004.7421749
GO:0006879cellular iron ion homeostasis3.82e-021.00e+004.6841451
GO:0005515protein binding3.84e-021.00e+000.80081846024
GO:0003725double-stranded RNA binding3.90e-021.00e+004.6561552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.97e-021.00e+004.6291553
GO:0045216cell-cell junction organization4.04e-021.00e+004.6021254
GO:0000932cytoplasmic mRNA processing body4.04e-021.00e+004.6021354
GO:0000724double-strand break repair via homologous recombination4.12e-021.00e+004.5751355
GO:0044822poly(A) RNA binding4.14e-021.00e+001.8973491056
GO:0000723telomere maintenance4.19e-021.00e+004.5491656
GO:0012505endomembrane system4.19e-021.00e+004.5491256
GO:0019903protein phosphatase binding4.63e-021.00e+004.4021462
GO:0006302double-strand break repair4.63e-021.00e+004.4021462
GO:0006368transcription elongation from RNA polymerase II promoter4.99e-021.00e+004.2911667
GO:0034329cell junction assembly5.07e-021.00e+004.2691168
GO:0003697single-stranded DNA binding5.07e-021.00e+004.2691568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.50e-021.00e+004.1471674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process5.58e-021.00e+004.1281275
GO:0044281small molecule metabolic process5.85e-021.00e+001.7003581211
GO:0001726ruffle5.94e-021.00e+004.0351480
GO:0050796regulation of insulin secretion6.01e-021.00e+004.0171481
GO:0019083viral transcription6.01e-021.00e+004.01711081
GO:0006898receptor-mediated endocytosis6.23e-021.00e+003.9641384
GO:0047485protein N-terminus binding6.37e-021.00e+003.9301586
GO:0006415translational termination6.44e-021.00e+003.91411087
GO:0016605PML body6.51e-021.00e+003.8971388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II6.66e-021.00e+003.8651790
GO:0006928cellular component movement6.73e-021.00e+003.8491791
GO:0005200structural constituent of cytoskeleton6.73e-021.00e+003.8491891
GO:0001649osteoblast differentiation6.80e-021.00e+003.8331692
GO:0071456cellular response to hypoxia6.80e-021.00e+003.8331692
GO:0006414translational elongation6.87e-021.00e+003.81711393
GO:0006614SRP-dependent cotranslational protein targeting to membrane7.65e-021.00e+003.656110104
GO:0014069postsynaptic density7.73e-021.00e+003.64213105
GO:0004252serine-type endopeptidase activity7.80e-021.00e+003.62911106
GO:0072562blood microparticle8.15e-021.00e+003.56213111
GO:0030529ribonucleoprotein complex8.22e-021.00e+003.54918112
GO:0005819spindle8.22e-021.00e+003.54917112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay8.36e-021.00e+003.524111114
GO:0019058viral life cycle8.43e-021.00e+003.511113115
GO:0006325chromatin organization8.64e-021.00e+003.47415118
GO:0007219Notch signaling pathway8.78e-021.00e+003.45015120
GO:0006260DNA replication8.85e-021.00e+003.43819121
GO:0006511ubiquitin-dependent protein catabolic process9.20e-021.00e+003.37915126
GO:0009615response to virus9.20e-021.00e+003.37915126
GO:0000790nuclear chromatin9.41e-021.00e+003.34519129
GO:0006413translational initiation9.55e-021.00e+003.323117131
GO:0031982vesicle9.55e-021.00e+003.32319131
GO:0003735structural constituent of ribosome9.97e-021.00e+003.259110137
GO:0008286insulin receptor signaling pathway1.03e-011.00e+003.20717142
GO:0006457protein folding1.04e-011.00e+003.19717143
GO:0005198structural molecule activity1.09e-011.00e+003.12815150
GO:0000398mRNA splicing, via spliceosome1.18e-011.00e+002.99918164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.19e-011.00e+002.99017165
GO:0030424axon1.20e-011.00e+002.98214166
GO:0006886intracellular protein transport1.23e-011.00e+002.93915171
GO:0032403protein complex binding1.31e-011.00e+002.841110183
GO:0006367transcription initiation from RNA polymerase II promoter1.32e-011.00e+002.83318184
GO:0005765lysosomal membrane1.44e-011.00e+002.69115203
GO:0007267cell-cell signaling1.55e-011.00e+002.58211219
GO:0007067mitotic nuclear division1.60e-011.00e+002.530114227
GO:0008380RNA splicing1.61e-011.00e+002.524111228
GO:0006412translation1.62e-011.00e+002.511120230
GO:0005615extracellular space1.63e-011.00e+001.454217957
GO:0004842ubiquitin-protein transferase activity1.78e-011.00e+002.36216255
GO:0008152metabolic process1.80e-011.00e+002.34513258
GO:0019899enzyme binding1.92e-011.00e+002.243112277
GO:0005856cytoskeleton2.01e-011.00e+002.172112291
GO:0016567protein ubiquitination2.03e-011.00e+002.15215295
GO:0043231intracellular membrane-bounded organelle2.18e-011.00e+002.04419318
GO:0007411axon guidance2.18e-011.00e+002.039113319
GO:0003682chromatin binding2.23e-011.00e+002.004111327
GO:0005634nucleus2.47e-011.00e+000.52451364559
GO:0007155cell adhesion2.48e-011.00e+001.82916369
GO:0006508proteolysis2.53e-011.00e+001.79419378
GO:0005524ATP binding2.60e-011.00e+001.0152601298
GO:0006366transcription from RNA polymerase II promoter2.77e-011.00e+001.646110419
GO:0055085transmembrane transport2.86e-011.00e+001.592110435
GO:0007596blood coagulation2.97e-011.00e+001.527118455
GO:0005886plasma membrane3.13e-011.00e+000.6073452582
GO:0005730nucleolus3.61e-011.00e+000.6762691641
GO:0045087innate immune response3.71e-011.00e+001.137124596
GO:0005794Golgi apparatus3.78e-011.00e+001.104115610
GO:0008270zinc ion binding5.45e-011.00e+000.395112997
GO:0003677DNA binding6.21e-011.00e+000.1061281218
GO:0046872metal ion binding6.48e-011.00e+000.0051251307
GO:0016021integral component of membrane8.03e-011.00e+00-0.5961271982
GO:0005737cytoplasm8.25e-011.00e+00-0.52321103767