int-snw-51004

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.960 1.71e-16 1.42e-03 2.67e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-51004 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
CAD 790 170.8071.007333--
RPA2 6118 981.2501.15169Yes-
RBX1 9978 971.1851.151139Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
HSPD1 3329 350.9131.035286Yes-
ATP6V1B2 526 440.8811.076278--
[ COQ6 ] 51004 1-0.0290.96022--
RPSA 3921 1561.3271.151152Yes-

Interactions (15)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HSPD1 3329 COQ6 51004 pp -- int.I2D: YeastLow, IntAct_Yeast
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 COQ6 51004 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
CAD 790 COQ6 51004 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CAD 790 RPSA 3921 pp -- int.I2D: IntAct_Yeast
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
ACTB 60 CAD 790 pp -- int.I2D: IntAct_Yeast
ATP6V1B2 526 COQ6 51004 pp -- int.I2D: IntAct_Yeast

Related GO terms (241)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005829cytosol1.20e-041.00e+002.16871322496
GO:0016032viral process2.02e-041.00e+003.585455534
GO:0042995cell projection6.01e-041.00e+005.7392660
GO:0002842positive regulation of T cell mediated immune response to tumor cell6.24e-041.00e+0010.646111
GO:0004151dihydroorotase activity6.24e-041.00e+0010.646111
GO:0048291isotype switching to IgG isotypes6.24e-041.00e+0010.646111
GO:0004070aspartate carbamoyltransferase activity6.24e-041.00e+0010.646111
GO:0004088carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity6.24e-041.00e+0010.646111
GO:0070335aspartate binding6.24e-041.00e+0010.646111
GO:0002368B cell cytokine production6.24e-041.00e+0010.646111
GO:0043234protein complex6.49e-041.00e+004.027318295
GO:0003697single-stranded DNA binding7.72e-041.00e+005.5592568
GO:0070062extracellular vesicular exosome1.12e-031.00e+002.00261042400
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0070409carbamoyl phosphate biosynthetic process1.25e-031.00e+009.646112
GO:0016020membrane1.80e-031.00e+002.2535901681
GO:0006458'de novo' protein folding1.87e-031.00e+009.061113
GO:0030135coated vesicle1.87e-031.00e+009.061113
GO:0044205'de novo' UMP biosynthetic process1.87e-031.00e+009.061113
GO:0006207'de novo' pyrimidine nucleobase biosynthetic process1.87e-031.00e+009.061113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0006543glutamine catabolic process2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0005654nucleoplasm2.92e-031.00e+002.5674761082
GO:0051414response to cortisol3.12e-031.00e+008.324115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:0046696lipopolysaccharide receptor complex3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0003688DNA replication origin binding3.74e-031.00e+008.061126
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0046134pyrimidine nucleoside biosynthetic process3.74e-031.00e+008.061116
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex3.74e-031.00e+008.061116
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0033180proton-transporting V-type ATPase, V1 domain4.36e-031.00e+007.839127
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0051604protein maturation4.98e-031.00e+007.646118
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0016709oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen5.60e-031.00e+007.476119
GO:0006228UTP biosynthetic process5.60e-031.00e+007.476119
GO:0014075response to amine5.60e-031.00e+007.476119
GO:0031000response to caffeine5.60e-031.00e+007.476129
GO:0005524ATP binding5.68e-031.00e+002.3044601298
GO:0006744ubiquinone biosynthetic process6.22e-031.00e+007.3241110
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0043032positive regulation of macrophage activation6.22e-031.00e+007.3241110
GO:0032727positive regulation of interferon-alpha production6.85e-031.00e+007.1871111
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0016071mRNA metabolic process7.98e-031.00e+003.845231223
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0001530lipopolysaccharide binding8.09e-031.00e+006.9461313
GO:0051131chaperone-mediated protein complex assembly8.09e-031.00e+006.9461113
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0046961proton-transporting ATPase activity, rotational mechanism9.32e-031.00e+006.7391315
GO:0042026protein refolding9.32e-031.00e+006.7391215
GO:0046034ATP metabolic process9.32e-031.00e+006.7391115
GO:0016070RNA metabolic process9.71e-031.00e+003.698232247
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0006541glutamine metabolic process1.06e-021.00e+006.5591117
GO:0050870positive regulation of T cell activation1.06e-021.00e+006.5591117
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0017144drug metabolic process1.12e-021.00e+006.4761118
GO:0015078hydrogen ion transmembrane transporter activity1.18e-021.00e+006.3981319
GO:0032733positive regulation of interleukin-10 production1.18e-021.00e+006.3981119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0019899enzyme binding1.21e-021.00e+003.532212277
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0071364cellular response to epidermal growth factor stimulus1.30e-021.00e+006.2541121
GO:0042100B cell proliferation1.30e-021.00e+006.2541121
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006206pyrimidine nucleobase metabolic process1.36e-021.00e+006.1871222
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0033574response to testosterone1.36e-021.00e+006.1871222
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0042113B cell activation1.55e-021.00e+006.0021225
GO:0032735positive regulation of interleukin-12 production1.55e-021.00e+006.0021125
GO:0015991ATP hydrolysis coupled proton transport1.61e-021.00e+005.9461426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0015992proton transport1.80e-021.00e+005.7881329
GO:0033572transferrin transport1.86e-021.00e+005.7391530
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0051701interaction with host1.98e-021.00e+005.6461432
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0090382phagosome maturation2.22e-021.00e+005.4761536
GO:0032755positive regulation of interleukin-6 production2.22e-021.00e+005.4761236
GO:0018107peptidyl-threonine phosphorylation2.29e-021.00e+005.4371437
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0000278mitotic cell cycle2.33e-021.00e+003.035248391
GO:0005902microvillus2.35e-021.00e+005.3981238
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0032729positive regulation of interferon-gamma production2.41e-021.00e+005.3611239
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0007595lactation2.41e-021.00e+005.3611239
GO:0043195terminal bouton2.53e-021.00e+005.2891141
GO:0042110T cell activation2.59e-021.00e+005.2541342
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0043066negative regulation of apoptotic process2.71e-021.00e+002.918231424
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0035690cellular response to drug3.02e-021.00e+005.0311249
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0006521regulation of cellular amino acid metabolic process3.08e-021.00e+005.00211750
GO:0006986response to unfolded protein3.08e-021.00e+005.0021250
GO:0031100organ regeneration3.08e-021.00e+005.0021450
GO:0005905coated pit3.08e-021.00e+005.0021350
GO:0006879cellular iron ion homeostasis3.14e-021.00e+004.9741451
GO:0003725double-stranded RNA binding3.20e-021.00e+004.9461552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0050660flavin adenine dinucleotide binding3.32e-021.00e+004.8911254
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0044281small molecule metabolic process3.38e-021.00e+001.9893581211
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0002039p53 binding3.38e-021.00e+004.8651755
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0012505endomembrane system3.44e-021.00e+004.8391256
GO:0000502proteasome complex3.56e-021.00e+004.78811758
GO:0051087chaperone binding3.62e-021.00e+004.7641659
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0030141secretory granule3.80e-021.00e+004.6921262
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.98e-021.00e+004.62412265
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0055086nucleobase-containing small molecule metabolic process4.29e-021.00e+004.5171270
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.29e-021.00e+004.51712270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.53e-021.00e+004.43712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process4.70e-021.00e+004.3791777
GO:0001889liver development4.70e-021.00e+004.3791477
GO:0007565female pregnancy4.76e-021.00e+004.3611178
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.82e-021.00e+004.34212379
GO:0002755MyD88-dependent toll-like receptor signaling pathway4.88e-021.00e+004.3241380
GO:0001726ruffle4.88e-021.00e+004.3241480
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0050821protein stabilization5.36e-021.00e+004.1871288
GO:0042470melanosome5.54e-021.00e+004.1381991
GO:0016363nuclear matrix5.54e-021.00e+004.13811291
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0051082unfolded protein binding5.66e-021.00e+004.1071593
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0007507heart development8.35e-021.00e+003.52717139
GO:0016887ATPase activity8.41e-021.00e+003.51717140
GO:0008286insulin receptor signaling pathway8.52e-021.00e+003.49617142
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0005769early endosome9.10e-021.00e+003.39812152
GO:0046777protein autophosphorylation9.44e-021.00e+003.34217158
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0030424axon9.90e-021.00e+003.27114166
GO:0034641cellular nitrogen compound metabolic process1.02e-011.00e+003.228120171
GO:0004672protein kinase activity1.05e-011.00e+003.17916177
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0005615extracellular space1.16e-011.00e+001.744217957
GO:0005765lysosomal membrane1.20e-011.00e+002.98115203
GO:0005515protein binding1.20e-011.00e+000.67561846024
GO:0008270zinc ion binding1.24e-011.00e+001.685212997
GO:0005739mitochondrion1.25e-011.00e+001.683228998
GO:0005759mitochondrial matrix1.34e-011.00e+002.813114228
GO:0006412translation1.35e-011.00e+002.801120230
GO:0044822poly(A) RNA binding1.37e-011.00e+001.6022491056
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0043065positive regulation of apoptotic process1.55e-011.00e+002.580110268
GO:0005743mitochondrial inner membrane1.60e-011.00e+002.53218277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0006200ATP catabolic process1.68e-011.00e+002.456115292
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0043231intracellular membrane-bounded organelle1.82e-011.00e+002.33319318
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005925focal adhesion2.07e-011.00e+002.130119366
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0005886plasma membrane2.08e-011.00e+000.8973452582
GO:0009986cell surface2.25e-011.00e+001.995111402
GO:0055114oxidation-reduction process2.34e-011.00e+001.932112420
GO:0055085transmembrane transport2.41e-011.00e+001.881110435
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0042802identical protein binding2.65e-011.00e+001.727120484
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0005634nucleus3.08e-011.00e+000.49241364559
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0005794Golgi apparatus3.22e-011.00e+001.393115610
GO:0005737cytoplasm4.31e-011.00e+000.35231103767
GO:0005730nucleolus6.63e-011.00e+00-0.0341691641
GO:0016021integral component of membrane7.36e-011.00e+00-0.3071271982