int-snw-4331

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.947	5.59e-16	1.90e-03	3.31e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-4331 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
[ MNAT1 ]	4331	1	0.082	0.947	76	-	-
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
ACO2	50	50	1.000	1.076	191	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMD7	5713	5	0.640	0.958	133	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (17)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACO2	50	PSMD7	5713	pp	--	int.I2D: YeastLow
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	PSMD7	5713	pp	--	int.I2D: YeastLow
MNAT1	4331	PSMD7	5713	pp	--	int.I2D: YeastLow
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ATP6V1B2	526	MNAT1	4331	pp	--	int.I2D: IntAct_Yeast
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
MNAT1	4331	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	MNAT1	4331	pp	--	int.I2D: YeastLow
ACTB	60	PSMD7	5713	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	MNAT1	4331	pp	--	int.I2D: YeastLow
PSMD7	5713	RBX1	9978	pp	--	int.I2D: YeastLow, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACO2	50	EIF6	3692	pp	--	int.I2D: YeastLow
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow

Related GO terms (188)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0043022	ribosome binding	1.50e-04	1.00e+00	6.739	2	3	27
GO:0016032	viral process	3.27e-04	1.00e+00	3.433	4	55	534
GO:0000054	ribosomal subunit export from nucleus	6.93e-04	1.00e+00	10.494	1	1	1
GO:0019521	D-gluconate metabolic process	6.93e-04	1.00e+00	10.494	1	1	1
GO:0051538	3 iron, 4 sulfur cluster binding	1.39e-03	1.00e+00	9.494	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.39e-03	1.00e+00	9.494	1	1	2
GO:0019322	pentose biosynthetic process	1.39e-03	1.00e+00	9.494	1	2	2
GO:0003994	aconitate hydratase activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0005055	laminin receptor activity	1.39e-03	1.00e+00	9.494	1	1	2
GO:0006407	rRNA export from nucleus	1.39e-03	1.00e+00	9.494	1	1	2
GO:0009051	pentose-phosphate shunt, oxidative branch	2.08e-03	1.00e+00	8.909	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.08e-03	1.00e+00	8.909	1	1	3
GO:0070062	extracellular vesicular exosome	2.41e-03	1.00e+00	1.850	6	104	2400
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.77e-03	1.00e+00	8.494	1	1	4
GO:0030686	90S preribosome	2.77e-03	1.00e+00	8.494	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.77e-03	1.00e+00	8.494	1	1	4
GO:0019788	NEDD8 ligase activity	2.77e-03	1.00e+00	8.494	1	1	4
GO:0005829	cytosol	2.97e-03	1.00e+00	1.794	6	132	2496
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.46e-03	1.00e+00	8.172	1	1	5
GO:0042256	mature ribosome assembly	3.46e-03	1.00e+00	8.172	1	1	5
GO:0006102	isocitrate metabolic process	3.46e-03	1.00e+00	8.172	1	1	5
GO:0030891	VCB complex	3.46e-03	1.00e+00	8.172	1	2	5
GO:0005638	lamin filament	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043023	ribosomal large subunit binding	3.46e-03	1.00e+00	8.172	1	1	5
GO:0006413	translational initiation	3.51e-03	1.00e+00	4.461	2	17	131
GO:0030957	Tat protein binding	4.15e-03	1.00e+00	7.909	1	3	6
GO:0006101	citrate metabolic process	4.15e-03	1.00e+00	7.909	1	1	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	1	6
GO:0000082	G1/S transition of mitotic cell cycle	4.52e-03	1.00e+00	4.275	2	32	149
GO:0005654	nucleoplasm	4.58e-03	1.00e+00	2.415	4	76	1082
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.84e-03	1.00e+00	7.687	1	2	7
GO:0000028	ribosomal small subunit assembly	4.84e-03	1.00e+00	7.687	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	4.84e-03	1.00e+00	7.687	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	5.53e-03	1.00e+00	7.494	1	2	8
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0045116	protein neddylation	5.53e-03	1.00e+00	7.494	1	2	8
GO:0006098	pentose-phosphate shunt	6.91e-03	1.00e+00	7.172	1	4	10
GO:0005675	holo TFIIH complex	7.60e-03	1.00e+00	7.035	1	1	11
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	7	12
GO:0042273	ribosomal large subunit biogenesis	8.98e-03	1.00e+00	6.794	1	4	13
GO:0021591	ventricular system development	8.98e-03	1.00e+00	6.794	1	2	13
GO:0010467	gene expression	9.33e-03	1.00e+00	2.693	3	59	669
GO:0035267	NuA4 histone acetyltransferase complex	9.67e-03	1.00e+00	6.687	1	4	14
GO:0016071	mRNA metabolic process	9.87e-03	1.00e+00	3.693	2	31	223
GO:0046961	proton-transporting ATPase activity, rotational mechanism	1.04e-02	1.00e+00	6.587	1	3	15
GO:0046034	ATP metabolic process	1.04e-02	1.00e+00	6.587	1	1	15
GO:0050998	nitric-oxide synthase binding	1.10e-02	1.00e+00	6.494	1	1	16
GO:0007512	adult heart development	1.10e-02	1.00e+00	6.494	1	1	16
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	1.10e-02	1.00e+00	6.494	1	1	16
GO:0016070	RNA metabolic process	1.20e-02	1.00e+00	3.546	2	32	247
GO:0015078	hydrogen ion transmembrane transporter activity	1.31e-02	1.00e+00	6.246	1	3	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.31e-02	1.00e+00	6.246	1	1	19
GO:0006281	DNA repair	1.33e-02	1.00e+00	3.466	2	18	261
GO:0000718	nucleotide-excision repair, DNA damage removal	1.45e-02	1.00e+00	6.102	1	4	21
GO:0030863	cortical cytoskeleton	1.52e-02	1.00e+00	6.035	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.52e-02	1.00e+00	6.035	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.58e-02	1.00e+00	5.971	1	4	23
GO:0006362	transcription elongation from RNA polymerase I promoter	1.58e-02	1.00e+00	5.971	1	3	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.58e-02	1.00e+00	5.971	1	3	23
GO:0043236	laminin binding	1.58e-02	1.00e+00	5.971	1	1	23
GO:0006513	protein monoubiquitination	1.58e-02	1.00e+00	5.971	1	1	23
GO:0006363	termination of RNA polymerase I transcription	1.65e-02	1.00e+00	5.909	1	3	24
GO:0006361	transcription initiation from RNA polymerase I promoter	1.79e-02	1.00e+00	5.794	1	3	26
GO:0015991	ATP hydrolysis coupled proton transport	1.79e-02	1.00e+00	5.794	1	4	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.79e-02	1.00e+00	5.794	1	3	26
GO:0050661	NADP binding	1.86e-02	1.00e+00	5.739	1	2	27
GO:0031492	nucleosomal DNA binding	1.86e-02	1.00e+00	5.739	1	4	27
GO:0006099	tricarboxylic acid cycle	1.93e-02	1.00e+00	5.687	1	4	28
GO:0019894	kinesin binding	1.93e-02	1.00e+00	5.687	1	1	28
GO:0005730	nucleolus	1.99e-02	1.00e+00	1.814	4	69	1641
GO:0019005	SCF ubiquitin ligase complex	1.99e-02	1.00e+00	5.636	1	1	29
GO:0015992	proton transport	1.99e-02	1.00e+00	5.636	1	3	29
GO:0006360	transcription from RNA polymerase I promoter	2.06e-02	1.00e+00	5.587	1	5	30
GO:0042254	ribosome biogenesis	2.06e-02	1.00e+00	5.587	1	1	30
GO:0033572	transferrin transport	2.06e-02	1.00e+00	5.587	1	5	30
GO:0006370	7-methylguanosine mRNA capping	2.06e-02	1.00e+00	5.587	1	5	30
GO:0051701	interaction with host	2.20e-02	1.00e+00	5.494	1	4	32
GO:0008094	DNA-dependent ATPase activity	2.33e-02	1.00e+00	5.407	1	2	34
GO:0001895	retina homeostasis	2.33e-02	1.00e+00	5.407	1	1	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.40e-02	1.00e+00	5.365	1	3	35
GO:0034332	adherens junction organization	2.47e-02	1.00e+00	5.324	1	1	36
GO:0090382	phagosome maturation	2.47e-02	1.00e+00	5.324	1	5	36
GO:0051084	'de novo' posttranslational protein folding	2.54e-02	1.00e+00	5.285	1	4	37
GO:0005902	microvillus	2.60e-02	1.00e+00	5.246	1	2	38
GO:0070527	platelet aggregation	2.60e-02	1.00e+00	5.246	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.67e-02	1.00e+00	5.209	1	4	39
GO:0000278	mitotic cell cycle	2.86e-02	1.00e+00	2.883	2	48	391
GO:0021762	substantia nigra development	3.01e-02	1.00e+00	5.035	1	2	44
GO:0050434	positive regulation of viral transcription	3.01e-02	1.00e+00	5.035	1	6	44
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	3.08e-02	1.00e+00	5.002	1	2	45
GO:0006283	transcription-coupled nucleotide-excision repair	3.14e-02	1.00e+00	4.971	1	7	46
GO:0043066	negative regulation of apoptotic process	3.32e-02	1.00e+00	2.766	2	31	424
GO:0048661	positive regulation of smooth muscle cell proliferation	3.35e-02	1.00e+00	4.879	1	4	49
GO:0003743	translation initiation factor activity	3.35e-02	1.00e+00	4.879	1	8	49
GO:0006091	generation of precursor metabolites and energy	3.41e-02	1.00e+00	4.850	1	3	50
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	17	50
GO:0006879	cellular iron ion homeostasis	3.48e-02	1.00e+00	4.822	1	4	51
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.62e-02	1.00e+00	4.766	1	5	53
GO:0045216	cell-cell junction organization	3.68e-02	1.00e+00	4.739	1	2	54
GO:0051592	response to calcium ion	3.75e-02	1.00e+00	4.713	1	3	55
GO:0012505	endomembrane system	3.82e-02	1.00e+00	4.687	1	2	56
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	17	58
GO:0044267	cellular protein metabolic process	4.07e-02	1.00e+00	2.605	2	29	474
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	22	65
GO:0044281	small molecule metabolic process	4.53e-02	1.00e+00	1.837	3	58	1211
GO:0006368	transcription elongation from RNA polymerase II promoter	4.55e-02	1.00e+00	4.428	1	6	67
GO:0006289	nucleotide-excision repair	4.62e-02	1.00e+00	4.407	1	11	68
GO:0034329	cell junction assembly	4.62e-02	1.00e+00	4.407	1	1	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.02e-02	1.00e+00	4.285	1	6	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	22	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	2	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	23	79
GO:0001726	ruffle	5.41e-02	1.00e+00	4.172	1	4	80
GO:0019083	viral transcription	5.48e-02	1.00e+00	4.154	1	10	81
GO:0047485	protein N-terminus binding	5.81e-02	1.00e+00	4.068	1	5	86
GO:0006415	translational termination	5.87e-02	1.00e+00	4.051	1	10	87
GO:0005634	nucleus	6.02e-02	1.00e+00	0.925	6	136	4559
GO:0042470	melanosome	6.14e-02	1.00e+00	3.986	1	9	91
GO:0006928	cellular component movement	6.14e-02	1.00e+00	3.986	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.14e-02	1.00e+00	3.986	1	8	91
GO:0071456	cellular response to hypoxia	6.20e-02	1.00e+00	3.971	1	6	92
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	21	92
GO:0006414	translational elongation	6.27e-02	1.00e+00	3.955	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.98e-02	1.00e+00	3.794	1	10	104
GO:0014069	postsynaptic density	7.05e-02	1.00e+00	3.780	1	3	105
GO:0005506	iron ion binding	7.05e-02	1.00e+00	3.780	1	4	105
GO:0006461	protein complex assembly	7.44e-02	1.00e+00	3.700	1	6	111
GO:0072562	blood microparticle	7.44e-02	1.00e+00	3.700	1	3	111
GO:0030529	ribonucleoprotein complex	7.50e-02	1.00e+00	3.687	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	7.63e-02	1.00e+00	3.661	1	11	114
GO:0019058	viral life cycle	7.70e-02	1.00e+00	3.649	1	13	115
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	20	116
GO:0044237	cellular metabolic process	7.82e-02	1.00e+00	3.624	1	5	117
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	5	118
GO:0007219	Notch signaling pathway	8.02e-02	1.00e+00	3.587	1	5	120
GO:0000790	nuclear chromatin	8.60e-02	1.00e+00	3.483	1	9	129
GO:0000086	G2/M transition of mitotic cell cycle	9.04e-02	1.00e+00	3.407	1	9	136
GO:0003735	structural constituent of ribosome	9.11e-02	1.00e+00	3.396	1	10	137
GO:0008286	insulin receptor signaling pathway	9.42e-02	1.00e+00	3.344	1	7	142
GO:0006457	protein folding	9.49e-02	1.00e+00	3.334	1	7	143
GO:0061024	membrane organization	9.61e-02	1.00e+00	3.314	1	7	145
GO:0042981	regulation of apoptotic process	9.93e-02	1.00e+00	3.265	1	24	150
GO:0016020	membrane	1.01e-01	1.00e+00	1.364	3	90	1681
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.09e-01	1.00e+00	3.128	1	7	165
GO:0030424	axon	1.09e-01	1.00e+00	3.119	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	20	171
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	14	178
GO:0032403	protein complex binding	1.20e-01	1.00e+00	2.978	1	10	183
GO:0006367	transcription initiation from RNA polymerase II promoter	1.21e-01	1.00e+00	2.971	1	8	184
GO:0005765	lysosomal membrane	1.32e-01	1.00e+00	2.829	1	5	203
GO:0005759	mitochondrial matrix	1.47e-01	1.00e+00	2.661	1	14	228
GO:0006412	translation	1.49e-01	1.00e+00	2.649	1	20	230
GO:0008270	zinc ion binding	1.49e-01	1.00e+00	1.533	2	12	997
GO:0005975	carbohydrate metabolic process	1.62e-01	1.00e+00	2.511	1	9	253
GO:0004842	ubiquitin-protein transferase activity	1.63e-01	1.00e+00	2.500	1	6	255
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.69e-01	1.00e+00	2.450	1	8	264
GO:0005856	cytoskeleton	1.84e-01	1.00e+00	2.309	1	12	291
GO:0006200	ATP catabolic process	1.85e-01	1.00e+00	2.304	1	15	292
GO:0043234	protein complex	1.87e-01	1.00e+00	2.290	1	18	295
GO:0016567	protein ubiquitination	1.87e-01	1.00e+00	2.290	1	5	295
GO:0005515	protein binding	1.97e-01	1.00e+00	0.523	6	184	6024
GO:0019901	protein kinase binding	1.99e-01	1.00e+00	2.186	1	21	317
GO:0043231	intracellular membrane-bounded organelle	2.00e-01	1.00e+00	2.181	1	9	318
GO:0007411	axon guidance	2.00e-01	1.00e+00	2.177	1	13	319
GO:0008283	cell proliferation	2.06e-01	1.00e+00	2.137	1	14	328
GO:0005524	ATP binding	2.25e-01	1.00e+00	1.152	2	60	1298
GO:0005925	focal adhesion	2.27e-01	1.00e+00	1.978	1	19	366
GO:0007155	cell adhesion	2.28e-01	1.00e+00	1.967	1	6	369
GO:0005737	cytoplasm	2.51e-01	1.00e+00	0.615	4	110	3767
GO:0006366	transcription from RNA polymerase II promoter	2.55e-01	1.00e+00	1.783	1	10	419
GO:0055114	oxidation-reduction process	2.56e-01	1.00e+00	1.780	1	12	420
GO:0055085	transmembrane transport	2.64e-01	1.00e+00	1.729	1	10	435
GO:0007596	blood coagulation	2.74e-01	1.00e+00	1.664	1	18	455
GO:0006468	protein phosphorylation	2.77e-01	1.00e+00	1.649	1	18	460
GO:0006915	apoptotic process	3.25e-01	1.00e+00	1.378	1	33	555
GO:0042803	protein homodimerization activity	3.44e-01	1.00e+00	1.277	1	12	595
GO:0045087	innate immune response	3.44e-01	1.00e+00	1.275	1	24	596
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	4.30e-01	1.00e+00	0.870	1	19	789
GO:0005615	extracellular space	4.97e-01	1.00e+00	0.592	1	17	957
GO:0005739	mitochondrion	5.12e-01	1.00e+00	0.531	1	28	998
GO:0044822	poly(A) RNA binding	5.33e-01	1.00e+00	0.450	1	49	1056
GO:0005886	plasma membrane	5.58e-01	1.00e+00	0.160	2	45	2582
GO:0016021	integral component of membrane	7.72e-01	1.00e+00	-0.459	1	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-4331

Statistics

Genes (10)

Interactions (17)

Related GO terms (188)