Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.938 | 1.18e-15 | 2.28e-03 | 3.78e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - |
PSMA2 | 5683 | 60 | 1.093 | 1.106 | 89 | Yes | - |
PSMB7 | 5695 | 48 | 0.982 | 1.052 | 57 | Yes | - |
PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
PGD | 5226 | 75 | 1.201 | 1.106 | 138 | Yes | - |
RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - |
EIF6 | 3692 | 14 | 0.700 | 1.013 | 267 | Yes | - |
ACO2 | 50 | 50 | 1.000 | 1.076 | 191 | Yes | - |
RSL24D1 | 51187 | 36 | 1.300 | 1.020 | 59 | Yes | - |
CDC16 | 8881 | 25 | 0.950 | 1.020 | 80 | Yes | - |
PCNA | 5111 | 5 | 0.553 | 0.974 | 294 | Yes | - |
PSMD3 | 5709 | 57 | 0.986 | 1.106 | 146 | Yes | - |
HNRNPK | 3190 | 2 | 0.488 | 0.938 | 252 | Yes | - |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
[ ANXA2 ] | 302 | 1 | 0.241 | 0.938 | 88 | - | - |
VCL | 7414 | 1 | -0.393 | 0.938 | 140 | - | Yes |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
ACTB | 60 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
PGD | 5226 | PSMD3 | 5709 | pp | -- | int.I2D: YeastLow |
PSMB7 | 5695 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
PSMB7 | 5695 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast |
EIF6 | 3692 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
HNRNPK | 3190 | RPSA | 3921 | pp | -- | int.I2D: IntAct_Rat |
ANXA2 | 302 | HNRNPK | 3190 | pp | -- | int.I2D: IntAct_Rat |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
RPSA | 3921 | VCL | 7414 | pp | -- | int.I2D: BIND |
PSMA1 | 5682 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastMedium |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
PSMA1 | 5682 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast |
ACTB | 60 | HNRNPK | 3190 | pp | -- | int.I2D: IntAct_Rat |
ACTB | 60 | PSMB7 | 5695 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACO2 | 50 | PGD | 5226 | pp | -- | int.I2D: YeastLow |
PSMA2 | 5683 | PSMD3 | 5709 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
PSMA2 | 5683 | VCL | 7414 | pp | -- | int.I2D: BIND |
PSMD3 | 5709 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG |
PSMA2 | 5683 | PSMB7 | 5695 | pp | -- | int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast |
PGD | 5226 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ANXA2 | 302 | PCNA | 5111 | pp | -- | int.I2D: MINT, BioGrid; int.Mint: MI:0915(physical association) |
EIF6 | 3692 | RSL24D1 | 51187 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
ANXA2 | 302 | EIF6 | 3692 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACTB | 60 | ANXA2 | 302 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ANXA2 | 302 | VCL | 7414 | pp | -- | int.I2D: BIND |
HNRNPK | 3190 | VCL | 7414 | pp | -- | int.I2D: BIND |
RPSA | 3921 | PCNA | 5111 | pp | -- | int.I2D: MINT, BioGrid; int.Mint: MI:0915(physical association) |
PSMA1 | 5682 | PSMA2 | 5683 | pp | -- | int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid |
ACTB | 60 | CDC16 | 8881 | pp | -- | int.I2D: YeastLow |
ACO2 | 50 | EIF6 | 3692 | pp | -- | int.I2D: YeastLow |
ACO2 | 50 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.18e-10 | 1.70e-06 | 6.209 | 6 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.86e-10 | 2.69e-06 | 6.102 | 6 | 22 | 70 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 2.62e-10 | 3.78e-06 | 6.022 | 6 | 22 | 74 |
GO:0000082 | G1/S transition of mitotic cell cycle | 3.15e-10 | 4.55e-06 | 5.234 | 7 | 32 | 149 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 3.92e-10 | 5.66e-06 | 5.927 | 6 | 23 | 79 |
GO:0006521 | regulation of cellular amino acid metabolic process | 3.38e-09 | 4.87e-05 | 6.324 | 5 | 17 | 50 |
GO:0000502 | proteasome complex | 7.26e-09 | 1.05e-04 | 6.110 | 5 | 17 | 58 |
GO:0005654 | nucleoplasm | 7.85e-09 | 1.13e-04 | 3.026 | 11 | 76 | 1082 |
GO:0000278 | mitotic cell cycle | 9.37e-09 | 1.35e-04 | 4.035 | 8 | 48 | 391 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 1.20e-08 | 1.73e-04 | 5.968 | 5 | 19 | 64 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 2.19e-08 | 3.16e-04 | 5.798 | 5 | 20 | 72 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 2.70e-08 | 3.89e-04 | 5.739 | 5 | 20 | 75 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 7.59e-08 | 1.10e-03 | 5.445 | 5 | 21 | 92 |
GO:0016032 | viral process | 1.06e-07 | 1.52e-03 | 3.585 | 8 | 55 | 534 |
GO:0016071 | mRNA metabolic process | 2.03e-07 | 2.93e-03 | 4.430 | 6 | 31 | 223 |
GO:0000209 | protein polyubiquitination | 2.43e-07 | 3.51e-03 | 5.110 | 5 | 20 | 116 |
GO:0070062 | extracellular vesicular exosome | 2.72e-07 | 3.92e-03 | 2.118 | 13 | 104 | 2400 |
GO:0016070 | RNA metabolic process | 3.71e-07 | 5.35e-03 | 4.283 | 6 | 32 | 247 |
GO:0042981 | regulation of apoptotic process | 8.74e-07 | 1.26e-02 | 4.739 | 5 | 24 | 150 |
GO:0005839 | proteasome core complex | 1.32e-06 | 1.90e-02 | 7.061 | 3 | 8 | 18 |
GO:0004298 | threonine-type endopeptidase activity | 1.56e-06 | 2.25e-02 | 6.983 | 3 | 8 | 19 |
GO:0034641 | cellular nitrogen compound metabolic process | 1.67e-06 | 2.41e-02 | 4.550 | 5 | 20 | 171 |
GO:0010467 | gene expression | 9.10e-06 | 1.31e-01 | 3.068 | 7 | 59 | 669 |
GO:0005829 | cytosol | 3.93e-05 | 5.66e-01 | 1.820 | 11 | 132 | 2496 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 4.10e-05 | 5.91e-01 | 7.646 | 2 | 4 | 8 |
GO:0005838 | proteasome regulatory particle | 9.64e-05 | 1.00e+00 | 7.061 | 2 | 7 | 12 |
GO:0043066 | negative regulation of apoptotic process | 1.34e-04 | 1.00e+00 | 3.240 | 5 | 31 | 424 |
GO:0022624 | proteasome accessory complex | 1.98e-04 | 1.00e+00 | 6.559 | 2 | 8 | 17 |
GO:0006298 | mismatch repair | 2.76e-04 | 1.00e+00 | 6.324 | 2 | 3 | 20 |
GO:0032201 | telomere maintenance via semi-conservative replication | 3.05e-04 | 1.00e+00 | 6.254 | 2 | 5 | 21 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 3.35e-04 | 1.00e+00 | 6.187 | 2 | 3 | 22 |
GO:0044281 | small molecule metabolic process | 4.02e-04 | 1.00e+00 | 2.212 | 7 | 58 | 1211 |
GO:0005730 | nucleolus | 4.22e-04 | 1.00e+00 | 1.966 | 8 | 69 | 1641 |
GO:0000722 | telomere maintenance via recombination | 4.34e-04 | 1.00e+00 | 6.002 | 2 | 5 | 25 |
GO:0006915 | apoptotic process | 4.68e-04 | 1.00e+00 | 2.852 | 5 | 33 | 555 |
GO:0005634 | nucleus | 4.75e-04 | 1.00e+00 | 1.192 | 13 | 136 | 4559 |
GO:0043022 | ribosome binding | 5.07e-04 | 1.00e+00 | 5.891 | 2 | 3 | 27 |
GO:0006271 | DNA strand elongation involved in DNA replication | 6.27e-04 | 1.00e+00 | 5.739 | 2 | 7 | 30 |
GO:0006284 | base-excision repair | 9.55e-04 | 1.00e+00 | 5.437 | 2 | 3 | 37 |
GO:0070527 | platelet aggregation | 1.01e-03 | 1.00e+00 | 5.398 | 2 | 2 | 38 |
GO:0032077 | positive regulation of deoxyribonuclease activity | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0000701 | purine-specific mismatch base pair DNA N-glycosylase activity | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0043626 | PCNA complex | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0030055 | cell-substrate junction | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0019521 | D-gluconate metabolic process | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0000054 | ribosomal subunit export from nucleus | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 1 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 1.47e-03 | 1.00e+00 | 5.123 | 2 | 7 | 46 |
GO:0005515 | protein binding | 2.10e-03 | 1.00e+00 | 0.897 | 14 | 184 | 6024 |
GO:0000723 | telomere maintenance | 2.18e-03 | 1.00e+00 | 4.839 | 2 | 6 | 56 |
GO:0030337 | DNA polymerase processivity factor activity | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0006272 | leading strand elongation | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 2 |
GO:0051538 | 3 iron, 4 sulfur cluster binding | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0003994 | aconitate hydratase activity | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0006407 | rRNA export from nucleus | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0036035 | osteoclast development | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 2 |
GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0070557 | PCNA-p21 complex | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0019322 | pentose biosynthetic process | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 2 |
GO:0005055 | laminin receptor activity | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 2 |
GO:0006289 | nucleotide-excision repair | 3.19e-03 | 1.00e+00 | 4.559 | 2 | 11 | 68 |
GO:0003697 | single-stranded DNA binding | 3.19e-03 | 1.00e+00 | 4.559 | 2 | 5 | 68 |
GO:0010988 | regulation of low-density lipoprotein particle clearance | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 3 |
GO:0032139 | dinucleotide insertion or deletion binding | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 3 |
GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 3 |
GO:0044354 | macropinosome | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 3 |
GO:0001765 | membrane raft assembly | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 3 |
GO:0009051 | pentose-phosphate shunt, oxidative branch | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 2 | 3 |
GO:0006281 | DNA repair | 3.91e-03 | 1.00e+00 | 3.203 | 3 | 18 | 261 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0045716 | positive regulation of low-density lipoprotein particle receptor biosynthetic process | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0019834 | phospholipase A2 inhibitor activity | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 4 |
GO:0043234 | protein complex | 5.50e-03 | 1.00e+00 | 3.027 | 3 | 18 | 295 |
GO:0006928 | cellular component movement | 5.64e-03 | 1.00e+00 | 4.138 | 2 | 7 | 91 |
GO:0035749 | myelin sheath adaxonal region | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 2 | 5 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 3 | 5 |
GO:0042256 | mature ribosome assembly | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0071229 | cellular response to acid chemical | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0043023 | ribosomal large subunit binding | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0006102 | isocitrate metabolic process | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 2 | 5 |
GO:0006900 | membrane budding | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0000730 | DNA recombinase assembly | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0005638 | lamin filament | 6.23e-03 | 1.00e+00 | 7.324 | 1 | 1 | 5 |
GO:0005813 | centrosome | 7.26e-03 | 1.00e+00 | 2.882 | 3 | 14 | 326 |
GO:0005663 | DNA replication factor C complex | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 6 |
GO:0006101 | citrate metabolic process | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 6 |
GO:0033993 | response to lipid | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 2 | 6 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 3 | 6 |
GO:0032405 | MutLalpha complex binding | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 1 | 6 |
GO:0051099 | positive regulation of binding | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0000028 | ribosomal small subunit assembly | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0002162 | dystroglycan binding | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 2 | 7 |
GO:0043297 | apical junction assembly | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0043596 | nuclear replication fork | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0034333 | adherens junction assembly | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0031340 | positive regulation of vesicle fusion | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 7 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 2 | 8 |
GO:0070688 | MLL5-L complex | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 8 |
GO:0045294 | alpha-catenin binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 8 |
GO:0070182 | DNA polymerase binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 2 | 8 |
GO:0045116 | protein neddylation | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 2 | 8 |
GO:0005925 | focal adhesion | 9.96e-03 | 1.00e+00 | 2.715 | 3 | 19 | 366 |
GO:0000790 | nuclear chromatin | 1.11e-02 | 1.00e+00 | 3.635 | 2 | 9 | 129 |
GO:0090136 | epithelial cell-cell adhesion | 1.12e-02 | 1.00e+00 | 6.476 | 1 | 1 | 9 |
GO:0006413 | translational initiation | 1.14e-02 | 1.00e+00 | 3.613 | 2 | 17 | 131 |
GO:0031982 | vesicle | 1.14e-02 | 1.00e+00 | 3.613 | 2 | 9 | 131 |
GO:0006098 | pentose-phosphate shunt | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 4 | 10 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 10 |
GO:0007589 | body fluid secretion | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 10 |
GO:0043220 | Schmidt-Lanterman incisure | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 10 |
GO:0016020 | membrane | 1.33e-02 | 1.00e+00 | 1.516 | 6 | 90 | 1681 |
GO:0019985 | translesion synthesis | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 2 | 11 |
GO:0044548 | S100 protein binding | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 1 | 11 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 4 | 11 |
GO:0051290 | protein heterotetramerization | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 2 | 11 |
GO:0002009 | morphogenesis of an epithelium | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 1 | 12 |
GO:0006275 | regulation of DNA replication | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 2 | 12 |
GO:0042273 | ribosomal large subunit biogenesis | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 4 | 13 |
GO:0005662 | DNA replication factor A complex | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 13 |
GO:0005916 | fascia adherens | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 13 |
GO:0030234 | enzyme regulator activity | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 3 | 13 |
GO:0048260 | positive regulation of receptor-mediated endocytosis | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 2 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 4 | 14 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.76e-02 | 1.00e+00 | 3.280 | 2 | 7 | 165 |
GO:0042176 | regulation of protein catabolic process | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 3 | 16 |
GO:0050998 | nitric-oxide synthase binding | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 1 | 16 |
GO:0002102 | podosome | 1.98e-02 | 1.00e+00 | 5.646 | 1 | 2 | 16 |
GO:0031625 | ubiquitin protein ligase binding | 2.04e-02 | 1.00e+00 | 3.170 | 2 | 14 | 178 |
GO:0042730 | fibrinolysis | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 18 |
GO:0035861 | site of double-strand break | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 18 |
GO:0034394 | protein localization to cell surface | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 18 |
GO:0007088 | regulation of mitosis | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 18 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 1 | 19 |
GO:0072661 | protein targeting to plasma membrane | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 1 | 19 |
GO:0019897 | extrinsic component of plasma membrane | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 2 | 20 |
GO:0005680 | anaphase-promoting complex | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 4 | 20 |
GO:0043034 | costamere | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 1 | 20 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 4 | 21 |
GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 2 | 22 |
GO:0046686 | response to cadmium ion | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 2 | 22 |
GO:0030863 | cortical cytoskeleton | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 4 | 22 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 3 | 23 |
GO:0043236 | laminin binding | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 1 | 23 |
GO:0043044 | ATP-dependent chromatin remodeling | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 4 | 23 |
GO:0005844 | polysome | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 4 | 23 |
GO:0045296 | cadherin binding | 2.95e-02 | 1.00e+00 | 5.061 | 1 | 1 | 24 |
GO:0070979 | protein K11-linked ubiquitination | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 6 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 3 | 26 |
GO:0050661 | NADP binding | 3.32e-02 | 1.00e+00 | 4.891 | 1 | 2 | 27 |
GO:0031492 | nucleosomal DNA binding | 3.32e-02 | 1.00e+00 | 4.891 | 1 | 4 | 27 |
GO:0006099 | tricarboxylic acid cycle | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 4 | 28 |
GO:0019894 | kinesin binding | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 3.56e-02 | 1.00e+00 | 4.788 | 1 | 1 | 29 |
GO:0005913 | cell-cell adherens junction | 3.56e-02 | 1.00e+00 | 4.788 | 1 | 1 | 29 |
GO:0030032 | lamellipodium assembly | 3.56e-02 | 1.00e+00 | 4.788 | 1 | 2 | 29 |
GO:0042254 | ribosome biogenesis | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 1 | 30 |
GO:0005544 | calcium-dependent phospholipid binding | 3.68e-02 | 1.00e+00 | 4.739 | 1 | 2 | 30 |
GO:0007094 | mitotic spindle assembly checkpoint | 3.80e-02 | 1.00e+00 | 4.692 | 1 | 4 | 31 |
GO:0030971 | receptor tyrosine kinase binding | 4.04e-02 | 1.00e+00 | 4.602 | 1 | 2 | 33 |
GO:0001895 | retina homeostasis | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 1 | 34 |
GO:0005876 | spindle microtubule | 4.16e-02 | 1.00e+00 | 4.559 | 1 | 2 | 34 |
GO:0005912 | adherens junction | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 2 | 35 |
GO:0051539 | 4 iron, 4 sulfur cluster binding | 4.28e-02 | 1.00e+00 | 4.517 | 1 | 3 | 35 |
GO:0034332 | adherens junction organization | 4.40e-02 | 1.00e+00 | 4.476 | 1 | 1 | 36 |
GO:0030199 | collagen fibril organization | 4.52e-02 | 1.00e+00 | 4.437 | 1 | 1 | 37 |
GO:0051084 | 'de novo' posttranslational protein folding | 4.52e-02 | 1.00e+00 | 4.437 | 1 | 4 | 37 |
GO:0000781 | chromosome, telomeric region | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 3 | 39 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 2 | 39 |
GO:0022627 | cytosolic small ribosomal subunit | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 4 | 39 |
GO:0005856 | cytoskeleton | 5.02e-02 | 1.00e+00 | 2.461 | 2 | 12 | 291 |
GO:0021762 | substantia nigra development | 5.35e-02 | 1.00e+00 | 4.187 | 1 | 2 | 44 |
GO:0048146 | positive regulation of fibroblast proliferation | 5.35e-02 | 1.00e+00 | 4.187 | 1 | 2 | 44 |
GO:0008092 | cytoskeletal protein binding | 5.71e-02 | 1.00e+00 | 4.092 | 1 | 1 | 47 |
GO:0005811 | lipid particle | 5.71e-02 | 1.00e+00 | 4.092 | 1 | 2 | 47 |
GO:0003743 | translation initiation factor activity | 5.95e-02 | 1.00e+00 | 4.031 | 1 | 8 | 49 |
GO:0003684 | damaged DNA binding | 5.95e-02 | 1.00e+00 | 4.031 | 1 | 7 | 49 |
GO:0006091 | generation of precursor metabolites and energy | 6.06e-02 | 1.00e+00 | 4.002 | 1 | 3 | 50 |
GO:0008283 | cell proliferation | 6.21e-02 | 1.00e+00 | 2.289 | 2 | 14 | 328 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 6.42e-02 | 1.00e+00 | 3.918 | 1 | 5 | 53 |
GO:0045216 | cell-cell junction organization | 6.53e-02 | 1.00e+00 | 3.891 | 1 | 2 | 54 |
GO:0000932 | cytoplasmic mRNA processing body | 6.53e-02 | 1.00e+00 | 3.891 | 1 | 3 | 54 |
GO:0000724 | double-strand break repair via homologous recombination | 6.65e-02 | 1.00e+00 | 3.865 | 1 | 3 | 55 |
GO:0003723 | RNA binding | 6.68e-02 | 1.00e+00 | 2.228 | 2 | 20 | 342 |
GO:0048306 | calcium-dependent protein binding | 6.77e-02 | 1.00e+00 | 3.839 | 1 | 1 | 56 |
GO:0006396 | RNA processing | 7.12e-02 | 1.00e+00 | 3.764 | 1 | 1 | 59 |
GO:0042995 | cell projection | 7.23e-02 | 1.00e+00 | 3.739 | 1 | 6 | 60 |
GO:0008013 | beta-catenin binding | 7.23e-02 | 1.00e+00 | 3.739 | 1 | 3 | 60 |
GO:0030855 | epithelial cell differentiation | 7.35e-02 | 1.00e+00 | 3.715 | 1 | 4 | 61 |
GO:0006302 | double-strand break repair | 7.47e-02 | 1.00e+00 | 3.692 | 1 | 4 | 62 |
GO:0019903 | protein phosphatase binding | 7.47e-02 | 1.00e+00 | 3.692 | 1 | 4 | 62 |
GO:0007155 | cell adhesion | 7.63e-02 | 1.00e+00 | 2.119 | 2 | 6 | 369 |
GO:0005604 | basement membrane | 7.93e-02 | 1.00e+00 | 3.602 | 1 | 1 | 66 |
GO:0034329 | cell junction assembly | 8.16e-02 | 1.00e+00 | 3.559 | 1 | 1 | 68 |
GO:0042383 | sarcolemma | 8.50e-02 | 1.00e+00 | 3.496 | 1 | 3 | 71 |
GO:0043086 | negative regulation of catalytic activity | 8.62e-02 | 1.00e+00 | 3.476 | 1 | 2 | 72 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 8.85e-02 | 1.00e+00 | 3.437 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 8.96e-02 | 1.00e+00 | 3.417 | 1 | 2 | 75 |
GO:0017137 | Rab GTPase binding | 9.08e-02 | 1.00e+00 | 3.398 | 1 | 2 | 76 |
GO:0031902 | late endosome membrane | 9.19e-02 | 1.00e+00 | 3.379 | 1 | 1 | 77 |
GO:0030336 | negative regulation of cell migration | 9.30e-02 | 1.00e+00 | 3.361 | 1 | 1 | 78 |
GO:0071013 | catalytic step 2 spliceosome | 9.30e-02 | 1.00e+00 | 3.361 | 1 | 4 | 78 |
GO:0001726 | ruffle | 9.53e-02 | 1.00e+00 | 3.324 | 1 | 4 | 80 |
GO:0019083 | viral transcription | 9.65e-02 | 1.00e+00 | 3.306 | 1 | 10 | 81 |
GO:0007160 | cell-matrix adhesion | 9.76e-02 | 1.00e+00 | 3.289 | 1 | 3 | 82 |
GO:0002576 | platelet degranulation | 9.76e-02 | 1.00e+00 | 3.289 | 1 | 4 | 82 |
GO:0047485 | protein N-terminus binding | 1.02e-01 | 1.00e+00 | 3.220 | 1 | 5 | 86 |
GO:0006415 | translational termination | 1.03e-01 | 1.00e+00 | 3.203 | 1 | 10 | 87 |
GO:0006936 | muscle contraction | 1.03e-01 | 1.00e+00 | 3.203 | 1 | 2 | 87 |
GO:0016605 | PML body | 1.04e-01 | 1.00e+00 | 3.187 | 1 | 3 | 88 |
GO:0042470 | melanosome | 1.08e-01 | 1.00e+00 | 3.138 | 1 | 9 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 1.08e-01 | 1.00e+00 | 3.138 | 1 | 8 | 91 |
GO:0007596 | blood coagulation | 1.09e-01 | 1.00e+00 | 1.816 | 2 | 18 | 455 |
GO:0071456 | cellular response to hypoxia | 1.09e-01 | 1.00e+00 | 3.123 | 1 | 6 | 92 |
GO:0006414 | translational elongation | 1.10e-01 | 1.00e+00 | 3.107 | 1 | 13 | 93 |
GO:0044267 | cellular protein metabolic process | 1.17e-01 | 1.00e+00 | 1.757 | 2 | 29 | 474 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 1.22e-01 | 1.00e+00 | 2.946 | 1 | 10 | 104 |
GO:0001934 | positive regulation of protein phosphorylation | 1.22e-01 | 1.00e+00 | 2.946 | 1 | 6 | 104 |
GO:0005938 | cell cortex | 1.22e-01 | 1.00e+00 | 2.946 | 1 | 3 | 104 |
GO:0014069 | postsynaptic density | 1.23e-01 | 1.00e+00 | 2.932 | 1 | 3 | 105 |
GO:0005506 | iron ion binding | 1.23e-01 | 1.00e+00 | 2.932 | 1 | 4 | 105 |
GO:0030496 | midbody | 1.27e-01 | 1.00e+00 | 2.891 | 1 | 5 | 108 |
GO:0015630 | microtubule cytoskeleton | 1.29e-01 | 1.00e+00 | 2.865 | 1 | 4 | 110 |
GO:0072562 | blood microparticle | 1.30e-01 | 1.00e+00 | 2.852 | 1 | 3 | 111 |
GO:0030529 | ribonucleoprotein complex | 1.31e-01 | 1.00e+00 | 2.839 | 1 | 8 | 112 |
GO:0005819 | spindle | 1.31e-01 | 1.00e+00 | 2.839 | 1 | 7 | 112 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 1.33e-01 | 1.00e+00 | 2.813 | 1 | 11 | 114 |
GO:0019058 | viral life cycle | 1.34e-01 | 1.00e+00 | 2.801 | 1 | 13 | 115 |
GO:0044237 | cellular metabolic process | 1.36e-01 | 1.00e+00 | 2.776 | 1 | 5 | 117 |
GO:0006325 | chromatin organization | 1.38e-01 | 1.00e+00 | 2.764 | 1 | 5 | 118 |
GO:0007219 | Notch signaling pathway | 1.40e-01 | 1.00e+00 | 2.739 | 1 | 5 | 120 |
GO:0006260 | DNA replication | 1.41e-01 | 1.00e+00 | 2.727 | 1 | 9 | 121 |
GO:0044822 | poly(A) RNA binding | 1.41e-01 | 1.00e+00 | 1.187 | 3 | 49 | 1056 |
GO:0009615 | response to virus | 1.46e-01 | 1.00e+00 | 2.669 | 1 | 5 | 126 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 1.46e-01 | 1.00e+00 | 2.669 | 1 | 5 | 126 |
GO:0005911 | cell-cell junction | 1.57e-01 | 1.00e+00 | 2.559 | 1 | 4 | 136 |
GO:0003735 | structural constituent of ribosome | 1.58e-01 | 1.00e+00 | 2.548 | 1 | 10 | 137 |
GO:0007507 | heart development | 1.60e-01 | 1.00e+00 | 2.527 | 1 | 7 | 139 |
GO:0006457 | protein folding | 1.64e-01 | 1.00e+00 | 2.486 | 1 | 7 | 143 |
GO:0005737 | cytoplasm | 1.66e-01 | 1.00e+00 | 0.574 | 7 | 110 | 3767 |
GO:0061024 | membrane organization | 1.66e-01 | 1.00e+00 | 2.466 | 1 | 7 | 145 |
GO:0001077 | RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription | 1.68e-01 | 1.00e+00 | 2.446 | 1 | 3 | 147 |
GO:0005198 | structural molecule activity | 1.72e-01 | 1.00e+00 | 2.417 | 1 | 5 | 150 |
GO:0005769 | early endosome | 1.74e-01 | 1.00e+00 | 2.398 | 1 | 2 | 152 |
GO:0031012 | extracellular matrix | 1.76e-01 | 1.00e+00 | 2.379 | 1 | 2 | 154 |
GO:0045121 | membrane raft | 1.78e-01 | 1.00e+00 | 2.361 | 1 | 8 | 156 |
GO:0000398 | mRNA splicing, via spliceosome | 1.86e-01 | 1.00e+00 | 2.289 | 1 | 8 | 164 |
GO:0030424 | axon | 1.88e-01 | 1.00e+00 | 2.271 | 1 | 4 | 166 |
GO:0005768 | endosome | 1.91e-01 | 1.00e+00 | 2.245 | 1 | 6 | 169 |
GO:0015629 | actin cytoskeleton | 1.99e-01 | 1.00e+00 | 2.179 | 1 | 3 | 177 |
GO:0032403 | protein complex binding | 2.05e-01 | 1.00e+00 | 2.130 | 1 | 10 | 183 |
GO:0001525 | angiogenesis | 2.13e-01 | 1.00e+00 | 2.069 | 1 | 4 | 191 |
GO:0005765 | lysosomal membrane | 2.25e-01 | 1.00e+00 | 1.981 | 1 | 5 | 203 |
GO:0030168 | platelet activation | 2.27e-01 | 1.00e+00 | 1.967 | 1 | 10 | 205 |
GO:0007067 | mitotic nuclear division | 2.49e-01 | 1.00e+00 | 1.820 | 1 | 14 | 227 |
GO:0005759 | mitochondrial matrix | 2.49e-01 | 1.00e+00 | 1.813 | 1 | 14 | 228 |
GO:0008380 | RNA splicing | 2.49e-01 | 1.00e+00 | 1.813 | 1 | 11 | 228 |
GO:0006412 | translation | 2.51e-01 | 1.00e+00 | 1.801 | 1 | 20 | 230 |
GO:0005975 | carbohydrate metabolic process | 2.73e-01 | 1.00e+00 | 1.663 | 1 | 9 | 253 |
GO:0004842 | ubiquitin-protein transferase activity | 2.75e-01 | 1.00e+00 | 1.652 | 1 | 6 | 255 |
GO:0003779 | actin binding | 2.85e-01 | 1.00e+00 | 1.591 | 1 | 12 | 266 |
GO:0019899 | enzyme binding | 2.95e-01 | 1.00e+00 | 1.532 | 1 | 12 | 277 |
GO:0016567 | protein ubiquitination | 3.11e-01 | 1.00e+00 | 1.442 | 1 | 5 | 295 |
GO:0019901 | protein kinase binding | 3.30e-01 | 1.00e+00 | 1.338 | 1 | 21 | 317 |
GO:0007411 | axon guidance | 3.32e-01 | 1.00e+00 | 1.329 | 1 | 13 | 319 |
GO:0005615 | extracellular space | 3.38e-01 | 1.00e+00 | 0.744 | 2 | 17 | 957 |
GO:0009986 | cell surface | 3.99e-01 | 1.00e+00 | 0.995 | 1 | 11 | 402 |
GO:0055114 | oxidation-reduction process | 4.13e-01 | 1.00e+00 | 0.932 | 1 | 12 | 420 |
GO:0042802 | identical protein binding | 4.59e-01 | 1.00e+00 | 0.727 | 1 | 20 | 484 |
GO:0048471 | perinuclear region of cytoplasm | 4.72e-01 | 1.00e+00 | 0.675 | 1 | 13 | 502 |
GO:0005509 | calcium ion binding | 4.91e-01 | 1.00e+00 | 0.594 | 1 | 5 | 531 |
GO:0045087 | innate immune response | 5.32e-01 | 1.00e+00 | 0.427 | 1 | 24 | 596 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 6.37e-01 | 1.00e+00 | 0.022 | 1 | 19 | 789 |
GO:0005886 | plasma membrane | 6.50e-01 | 1.00e+00 | -0.103 | 3 | 45 | 2582 |
GO:0007165 | signal transduction | 6.90e-01 | 1.00e+00 | -0.179 | 1 | 24 | 907 |
GO:0005576 | extracellular region | 7.04e-01 | 1.00e+00 | -0.233 | 1 | 4 | 942 |
GO:0008270 | zinc ion binding | 7.25e-01 | 1.00e+00 | -0.315 | 1 | 12 | 997 |
GO:0005739 | mitochondrion | 7.25e-01 | 1.00e+00 | -0.317 | 1 | 28 | 998 |
GO:0005524 | ATP binding | 8.17e-01 | 1.00e+00 | -0.696 | 1 | 60 | 1298 |
GO:0006351 | transcription, DNA-templated | 8.51e-01 | 1.00e+00 | -0.852 | 1 | 31 | 1446 |