int-snw-2023

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.930 2.50e-15 2.74e-03 4.31e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-2023 subnetwork

Genes (28)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PSMA3 5684 120.5331.026218Yes-
RBX1 9978 971.1851.151139Yes-
PHB2 11331 90.8291.076140Yes-
PSMA2 5683 601.0931.10689Yes-
HNRNPC 3183 201.8121.026119Yes-
RPL6 6128 110.8441.113164Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
ATP6V1B2 526 440.8811.076278--
RPSA 3921 1561.3271.151152Yes-
RPS3A 6189 110.8351.069166Yes-
RPA2 6118 981.2501.15169Yes-
CDC16 8881 250.9501.02080Yes-
PCNA 5111 50.5530.974294Yes-
PSMD1 5707 120.8361.057113Yes-
EEF2 1938 270.8901.043301Yes-
PSMD13 5719 160.8481.029104Yes-
PSMD3 5709 570.9861.106146Yes-
EFTUD2 9343 70.8830.96978Yes-
CLTC 1213 350.8841.138247Yes-
PSMB2 5690 180.8771.026117Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
FBL 2091 70.8391.15165Yes-
PSMD6 9861 110.8481.009131Yes-
HSPD1 3329 350.9131.035286Yes-
[ ENO1 ] 2023 1-0.0780.930121--
PSMC1 5700 140.8401.018137Yes-

Interactions (99)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PSMA2 5683 PSMA3 5684 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD;
int.HPRD: yeast 2-hybrid
PSMD3 5709 PSMD13 5719 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT_Yeast, YeastHigh, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
ACTB 60 FBL 2091 pp -- int.I2D: MINT
ENO1 2023 PCNA 5111 pp -- int.I2D: MINT, BioGrid;
int.Mint: MI:0407(direct interaction), MI:0915(physical association)
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMC1 5700 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, MINT_Yeast, BioGrid, IntAct_Yeast, Krogan_Core, YeastHigh
PSMA3 5684 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow
ATP6V1B2 526 PHB2 11331 pp -- int.I2D: IntAct_Yeast
PSMD1 5707 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast
PSMB7 5695 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct
PSMD11 5717 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BioGrid, INTEROLOG
PSMA1 5682 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastMedium
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
HSPD1 3329 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 ATP6V1B2 526 pp -- int.I2D: BioGrid_Yeast
ATP6V1B2 526 RPSA 3921 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastHigh, BioGrid, INTEROLOG
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
HSPD1 3329 PSMA3 5684 pp -- int.I2D: BioGrid
PSMB7 5695 PSMD1 5707 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct
RPL6 6128 RPS3A 6189 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMC1 5700 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct_Fly, YeastMedium, IntAct
PSMA3 5684 PSMD1 5707 pp -- int.I2D: BioGrid, BioGrid_Yeast
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
EEF2 1938 PSMD13 5719 pp -- int.I2D: YeastLow
PSMD1 5707 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, MINT_Yeast, BioGrid, BioGrid_Yeast, IntAct_Yeast, Krogan_Core
PSMA2 5683 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, YeastLow, BioGrid
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMC1 5700 PHB2 11331 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA1 5682 PSMA3 5684 pp -- int.Intact: MI:0914(association), MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, CE_DATA, HPRD, IntAct, IntAct_Fly, IntAct_Mouse, IntAct_Worm, IntAct_Yeast, MINT_Worm, BioGrid, BioGrid_Fly, BIND_Fly, BIND_Yeast, FlyHigh, Krogan_Core, MINT_Fly, MINT_Yeast, YeastHigh, Yu_GoldStd;
int.HPRD: in vitro
PSMB2 5690 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, IntAct_Fly, YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, IntAct, IntAct_Yeast, MINT_Worm, MINT_Yeast, YeastHigh, BioGrid, BIND_Yeast, IntAct_Worm, INTEROLOG, Krogan_Core, MIPS
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMB2 5690 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast, YeastMedium
ATP6V1B2 526 CDC16 8881 pp -- int.I2D: IntAct_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PSMC1 5700 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
RPSA 3921 PCNA 5111 pp -- int.I2D: MINT, BioGrid;
int.Mint: MI:0915(physical association)
PSMA2 5683 PSMD13 5719 pp -- int.I2D: YeastLow
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast
ENO1 2023 PSMA3 5684 pp -- int.I2D: BioGrid
PSMA3 5684 EFTUD2 9343 pp -- int.I2D: BioGrid
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
PSMD13 5719 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct, IntAct_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
PSMA3 5684 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
PSMD1 5707 PSMD6 9861 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, IntAct, Krogan_Core
PSMC1 5700 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, MINT_Yeast, YeastHigh, BioGrid, IntAct_Yeast, Krogan_Core
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMA2 5683 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
ACTB 60 RPS3A 6189 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
ATP6V1B2 526 CLTC 1213 pp -- int.I2D: IntAct_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
PSMC1 5700 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, IntAct, Krogan_Core, MINT_Yeast
RPS3A 6189 PSMD6 9861 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB7 5695 PSMC1 5700 pp -- int.I2D: BioGrid_Yeast
RPSA 3921 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 HSPD1 3329 pp -- int.I2D: YeastLow, YeastMedium
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
EEF2 1938 PSMA3 5684 pp -- int.I2D: BioGrid
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA3 5684 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, Krogan_Core
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
ACTB 60 ENO1 2023 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core
PSMA3 5684 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB2 5690 PSMD6 9861 pp -- int.I2D: BioGrid_Yeast, YeastMedium
ACTB 60 RPL6 6128 pp -- int.I2D: BioGrid_Yeast
EEF2 1938 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 PHB2 11331 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastMedium, BioGrid, BioGrid_Yeast, IntAct_Yeast
PSMA1 5682 PSMB2 5690 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.HPRD: yeast 2-hybrid
PSMA1 5682 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
ACTB 60 PSMD6 9861 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMD13 5719 pp -- int.Proteinpedia: Mass spectrometry;
int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid
PSMC1 5700 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, YeastHigh, Krogan_Core
RPS3A 6189 PHB2 11331 pp -- int.I2D: IntAct_Yeast
EEF2 1938 PSMD3 5709 pp -- int.I2D: Krogan_NonCore
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow
ACTB 60 PSMD13 5719 pp -- int.I2D: BioGrid_Yeast
PSMA3 5684 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast, IntAct_Mouse, MINT_Yeast, YeastLow, Krogan_Core

Related GO terms (318)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.89e-229.94e-186.571122265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.81e-212.61e-176.464122270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.72e-215.36e-176.384122274
GO:0006521regulation of cellular amino acid metabolic process5.48e-217.91e-176.824111750
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.64e-211.25e-166.290122379
GO:0000502proteasome complex3.31e-204.78e-166.610111758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.08e-191.55e-156.468111964
GO:0000082G1/S transition of mitotic cell cycle2.94e-194.24e-155.4901332149
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.33e-196.25e-156.298112072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.00e-191.01e-146.239112075
GO:0016071mRNA metabolic process9.81e-191.42e-145.0151431223
GO:0016070RNA metabolic process4.18e-186.03e-144.8681432247
GO:0002474antigen processing and presentation of peptide antigen via MHC class I7.54e-181.09e-135.945112192
GO:0000209protein polyubiquitination1.07e-161.55e-125.6101120116
GO:0016032viral process2.02e-162.91e-123.9481655534
GO:0010467gene expression2.33e-163.36e-123.7101759669
GO:0042981regulation of apoptotic process1.96e-152.83e-115.2391124150
GO:0000278mitotic cell cycle2.61e-153.77e-114.2051448391
GO:0034641cellular nitrogen compound metabolic process8.49e-151.22e-105.0501120171
GO:0005654nucleoplasm3.16e-144.55e-103.09918761082
GO:0005829cytosol1.11e-131.60e-092.247231322496
GO:0043066negative regulation of apoptotic process2.56e-133.69e-093.9811331424
GO:0022624proteasome accessory complex3.68e-135.31e-097.5066817
GO:0070062extracellular vesicular exosome9.10e-131.31e-082.239221042400
GO:0005838proteasome regulatory particle1.48e-112.14e-077.7465712
GO:0005839proteasome core complex1.59e-102.30e-067.1615818
GO:0004298threonine-type endopeptidase activity2.16e-103.11e-067.0835819
GO:0006915apoptotic process2.94e-094.24e-053.3521133555
GO:0016020membrane8.34e-091.20e-042.29416901681
GO:0019773proteasome core complex, alpha-subunit complex3.65e-075.26e-037.594348
GO:0044281small molecule metabolic process9.94e-071.43e-022.35212581211
GO:0044822poly(A) RNA binding2.07e-062.98e-022.42411491056
GO:0005634nucleus1.74e-052.52e-011.176201364559
GO:0006414translational elongation2.95e-054.25e-014.47041393
GO:0005515protein binding8.03e-051.00e+000.912221846024
GO:0005730nucleolus1.36e-041.00e+001.78811691641
GO:0043234protein complex2.31e-041.00e+003.126518295
GO:0030234enzyme regulator activity2.80e-041.00e+006.3082313
GO:0042176regulation of protein catabolic process4.29e-041.00e+006.0092316
GO:0003723RNA binding4.57e-041.00e+002.913520342
GO:0019083viral transcription5.05e-041.00e+004.25431081
GO:0006415translational termination6.23e-041.00e+004.15131087
GO:0006298mismatch repair6.76e-041.00e+005.6872320
GO:0001649osteoblast differentiation7.33e-041.00e+004.0703692
GO:0032201telomere maintenance via semi-conservative replication7.46e-041.00e+005.6162521
GO:0006297nucleotide-excision repair, DNA gap filling8.20e-041.00e+005.5492322
GO:0036464cytoplasmic ribonucleoprotein granule8.20e-041.00e+005.5492422
GO:0043044ATP-dependent chromatin remodeling8.97e-041.00e+005.4852423
GO:0005844polysome8.97e-041.00e+005.4852423
GO:0006412translation9.55e-041.00e+003.163420230
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.05e-031.00e+003.893310104
GO:0000722telomere maintenance via recombination1.06e-031.00e+005.3652525
GO:0031492nucleosomal DNA binding1.24e-031.00e+005.2542427
GO:0030529ribonucleoprotein complex1.30e-031.00e+003.78638112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.36e-031.00e+003.761311114
GO:0019058viral life cycle1.40e-031.00e+003.748313115
GO:0033572transferrin transport1.53e-031.00e+005.1022530
GO:0006271DNA strand elongation involved in DNA replication1.53e-031.00e+005.1022730
GO:0002842positive regulation of T cell mediated immune response to tumor cell1.94e-031.00e+009.009111
GO:0032077positive regulation of deoxyribonuclease activity1.94e-031.00e+009.009111
GO:0000701purine-specific mismatch base pair DNA N-glycosylase activity1.94e-031.00e+009.009111
GO:0048291isotype switching to IgG isotypes1.94e-031.00e+009.009111
GO:1990259histone-glutamine methyltransferase activity1.94e-031.00e+009.009111
GO:0043626PCNA complex1.94e-031.00e+009.009111
GO:1990258histone glutamine methylation1.94e-031.00e+009.009111
GO:0016074snoRNA metabolic process1.94e-031.00e+009.009111
GO:0002368B cell cytokine production1.94e-031.00e+009.009111
GO:0044267cellular protein metabolic process1.97e-031.00e+002.442529474
GO:0006413translational initiation2.03e-031.00e+003.560317131
GO:0003735structural constituent of ribosome2.31e-031.00e+003.496310137
GO:0006284base-excision repair2.32e-031.00e+004.7992337
GO:0016887ATPase activity2.45e-031.00e+003.46437140
GO:0022627cytosolic small ribosomal subunit2.58e-031.00e+004.7232439
GO:0015030Cajal body3.27e-031.00e+004.5492344
GO:0006283transcription-coupled nucleotide-excision repair3.57e-031.00e+004.4852746
GO:0030337DNA polymerase processivity factor activity3.88e-031.00e+008.009112
GO:0006272leading strand elongation3.88e-031.00e+008.009122
GO:0006407rRNA export from nucleus3.88e-031.00e+008.009112
GO:0070557PCNA-p21 complex3.88e-031.00e+008.009112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009112
GO:0005055laminin receptor activity3.88e-031.00e+008.009112
GO:0007127meiosis I3.88e-031.00e+008.009112
GO:0003725double-stranded RNA binding4.54e-031.00e+004.3082552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.71e-031.00e+004.2812553
GO:0005925focal adhesion5.16e-031.00e+002.493419366
GO:0000723telomere maintenance5.25e-031.00e+004.2012656
GO:0032139dinucleotide insertion or deletion binding5.81e-031.00e+007.424113
GO:0000015phosphopyruvate hydratase complex5.81e-031.00e+007.424123
GO:0004634phosphopyruvate hydratase activity5.81e-031.00e+007.424123
GO:1900126negative regulation of hyaluronan biosynthetic process5.81e-031.00e+007.424123
GO:0006458'de novo' protein folding5.81e-031.00e+007.424113
GO:0030135coated vesicle5.81e-031.00e+007.424113
GO:0071439clathrin complex5.81e-031.00e+007.424123
GO:0006289nucleotide-excision repair7.65e-031.00e+003.92121168
GO:0003697single-stranded DNA binding7.65e-031.00e+003.9212568
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)7.74e-031.00e+007.009114
GO:003068690S preribosome7.74e-031.00e+007.009114
GO:0032051clathrin light chain binding7.74e-031.00e+007.009114
GO:0019788NEDD8 ligase activity7.74e-031.00e+007.009114
GO:0001652granular component7.74e-031.00e+007.009114
GO:0031428box C/D snoRNP complex7.74e-031.00e+007.009114
GO:0031467Cul7-RING ubiquitin ligase complex7.74e-031.00e+007.009114
GO:1903077negative regulation of protein localization to plasma membrane7.74e-031.00e+007.009114
GO:0031465Cul4B-RING E3 ubiquitin ligase complex9.67e-031.00e+006.687135
GO:2000001regulation of DNA damage checkpoint9.67e-031.00e+006.687115
GO:0031461cullin-RING ubiquitin ligase complex9.67e-031.00e+006.687115
GO:0043248proteasome assembly9.67e-031.00e+006.687115
GO:0046696lipopolysaccharide receptor complex9.67e-031.00e+006.687115
GO:0030891VCB complex9.67e-031.00e+006.687125
GO:0033600negative regulation of mammary gland epithelial cell proliferation9.67e-031.00e+006.687115
GO:0000730DNA recombinase assembly9.67e-031.00e+006.687115
GO:0071013catalytic step 2 spliceosome9.96e-031.00e+003.7232478
GO:0005681spliceosomal complex1.12e-021.00e+003.6342483
GO:0002181cytoplasmic translation1.16e-021.00e+006.424116
GO:0003688DNA replication origin binding1.16e-021.00e+006.424126
GO:0005663DNA replication factor C complex1.16e-021.00e+006.424116
GO:0030130clathrin coat of trans-Golgi network vesicle1.16e-021.00e+006.424136
GO:0060744mammary gland branching involved in thelarche1.16e-021.00e+006.424116
GO:0030118clathrin coat1.16e-021.00e+006.424126
GO:0033993response to lipid1.16e-021.00e+006.424126
GO:0031466Cul5-RING ubiquitin ligase complex1.16e-021.00e+006.424116
GO:0030957Tat protein binding1.16e-021.00e+006.424136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex1.16e-021.00e+006.424116
GO:0032405MutLalpha complex binding1.16e-021.00e+006.424116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis1.16e-021.00e+006.424116
GO:0042470melanosome1.34e-021.00e+003.5012991
GO:0000028ribosomal small subunit assembly1.35e-021.00e+006.201117
GO:0031462Cul2-RING ubiquitin ligase complex1.35e-021.00e+006.201127
GO:0033180proton-transporting V-type ATPase, V1 domain1.35e-021.00e+006.201127
GO:0030132clathrin coat of coated pit1.35e-021.00e+006.201127
GO:0043596nuclear replication fork1.35e-021.00e+006.201117
GO:0006281DNA repair1.37e-021.00e+002.566318261
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.54e-021.00e+006.009128
GO:0070688MLL5-L complex1.54e-021.00e+006.009118
GO:0070182DNA polymerase binding1.54e-021.00e+006.009128
GO:0045116protein neddylation1.54e-021.00e+006.009128
GO:0051604protein maturation1.54e-021.00e+006.009118
GO:0008494translation activator activity1.73e-021.00e+005.839119
GO:0006200ATP catabolic process1.85e-021.00e+002.404315292
GO:0010569regulation of double-strand break repair via homologous recombination1.93e-021.00e+005.6871110
GO:0043032positive regulation of macrophage activation1.93e-021.00e+005.6871110
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway1.93e-021.00e+005.6871110
GO:0005819spindle1.98e-021.00e+003.20127112
GO:0019985translesion synthesis2.12e-021.00e+005.5491211
GO:0032727positive regulation of interferon-alpha production2.12e-021.00e+005.5491111
GO:0031571mitotic G1 DNA damage checkpoint2.12e-021.00e+005.5491411
GO:0045120pronucleus2.12e-021.00e+005.5491211
GO:0019901protein kinase binding2.30e-021.00e+002.285321317
GO:00709353'-UTR-mediated mRNA stabilization2.31e-021.00e+005.4241212
GO:0006275regulation of DNA replication2.31e-021.00e+005.4241212
GO:0009615response to virus2.47e-021.00e+003.03125126
GO:0005813centrosome2.47e-021.00e+002.245314326
GO:0005662DNA replication factor A complex2.50e-021.00e+005.3081113
GO:0001530lipopolysaccharide binding2.50e-021.00e+005.3081313
GO:0008266poly(U) RNA binding2.50e-021.00e+005.3081113
GO:0051131chaperone-mediated protein complex assembly2.50e-021.00e+005.3081113
GO:0000790nuclear chromatin2.58e-021.00e+002.99829129
GO:0035267NuA4 histone acetyltransferase complex2.69e-021.00e+005.2011414
GO:0042026protein refolding2.87e-021.00e+005.1021215
GO:0046034ATP metabolic process2.87e-021.00e+005.1021115
GO:0046961proton-transporting ATPase activity, rotational mechanism2.87e-021.00e+005.1021315
GO:0060749mammary gland alveolus development2.87e-021.00e+005.1021215
GO:0050998nitric-oxide synthase binding3.06e-021.00e+005.0091116
GO:0061024membrane organization3.20e-021.00e+002.82927145
GO:0010243response to organonitrogen compound3.25e-021.00e+004.9211317
GO:0017025TBP-class protein binding3.25e-021.00e+004.9211317
GO:0003746translation elongation factor activity3.25e-021.00e+004.9211317
GO:0050870positive regulation of T cell activation3.25e-021.00e+004.9211117
GO:0031430M band3.25e-021.00e+004.9211117
GO:0035861site of double-strand break3.44e-021.00e+004.8391118
GO:0007088regulation of mitosis3.44e-021.00e+004.8391118
GO:0015078hydrogen ion transmembrane transporter activity3.63e-021.00e+004.7611319
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process3.63e-021.00e+004.7611119
GO:0048863stem cell differentiation3.63e-021.00e+004.7611119
GO:0032733positive regulation of interleukin-10 production3.63e-021.00e+004.7611119
GO:0005680anaphase-promoting complex3.81e-021.00e+004.6871420
GO:0042100B cell proliferation4.00e-021.00e+004.6161121
GO:0000398mRNA splicing, via spliceosome4.00e-021.00e+002.65128164
GO:0000718nucleotide-excision repair, DNA damage removal4.00e-021.00e+004.6161421
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding4.05e-021.00e+002.64227165
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle4.19e-021.00e+004.5491222
GO:0046686response to cadmium ion4.19e-021.00e+004.5491222
GO:0030863cortical cytoskeleton4.19e-021.00e+004.5491122
GO:0031463Cul3-RING ubiquitin ligase complex4.37e-021.00e+004.4851323
GO:0043236laminin binding4.37e-021.00e+004.4851123
GO:0006513protein monoubiquitination4.37e-021.00e+004.4851123
GO:0031625ubiquitin protein ligase binding4.64e-021.00e+002.533214178
GO:0042113B cell activation4.75e-021.00e+004.3651225
GO:0032735positive regulation of interleukin-12 production4.75e-021.00e+004.3651125
GO:0070979protein K11-linked ubiquitination4.93e-021.00e+004.3081626
GO:0015991ATP hydrolysis coupled proton transport4.93e-021.00e+004.3081426
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia4.93e-021.00e+004.3081326
GO:0003730mRNA 3'-UTR binding4.93e-021.00e+004.3081226
GO:0030331estrogen receptor binding5.12e-021.00e+004.2541227
GO:0043022ribosome binding5.12e-021.00e+004.2541327
GO:0030669clathrin-coated endocytic vesicle membrane5.30e-021.00e+004.2011428
GO:0019894kinesin binding5.30e-021.00e+004.2011128
GO:0019005SCF ubiquitin ligase complex5.48e-021.00e+004.1511129
GO:0015992proton transport5.48e-021.00e+004.1511329
GO:0003924GTPase activity5.56e-021.00e+002.387212197
GO:0031623receptor internalization5.85e-021.00e+004.0551231
GO:0007094mitotic spindle assembly checkpoint5.85e-021.00e+004.0551431
GO:0051701interaction with host6.04e-021.00e+004.0091432
GO:0030971receptor tyrosine kinase binding6.22e-021.00e+003.9641233
GO:0032588trans-Golgi network membrane6.40e-021.00e+003.9211234
GO:0008033tRNA processing6.40e-021.00e+003.9211134
GO:0001895retina homeostasis6.40e-021.00e+003.9211134
GO:0005876spindle microtubule6.40e-021.00e+003.9211234
GO:0006184GTP catabolic process6.44e-021.00e+002.267212214
GO:0034332adherens junction organization6.76e-021.00e+003.8391136
GO:0090382phagosome maturation6.76e-021.00e+003.8391536
GO:0032755positive regulation of interleukin-6 production6.76e-021.00e+003.8391236
GO:0051084'de novo' posttranslational protein folding6.95e-021.00e+003.7991437
GO:0005902microvillus7.13e-021.00e+003.7611238
GO:0007067mitotic nuclear division7.13e-021.00e+002.182214227
GO:0006096glycolytic process7.13e-021.00e+003.7611438
GO:0070527platelet aggregation7.13e-021.00e+003.7611238
GO:0008380RNA splicing7.19e-021.00e+002.176211228
GO:0000781chromosome, telomeric region7.31e-021.00e+003.7231339
GO:0032729positive regulation of interferon-gamma production7.31e-021.00e+003.7231239
GO:0042110T cell activation7.85e-021.00e+003.6161342
GO:0030136clathrin-coated vesicle7.85e-021.00e+003.6161442
GO:0006094gluconeogenesis8.03e-021.00e+003.5821543
GO:0006892post-Golgi vesicle-mediated transport8.03e-021.00e+003.5821343
GO:0014070response to organic cyclic compound8.03e-021.00e+003.5821443
GO:0021762substantia nigra development8.21e-021.00e+003.5491244
GO:0045727positive regulation of translation8.21e-021.00e+003.5491344
GO:0005737cytoplasm8.85e-021.00e+000.589111103767
GO:0022625cytosolic large ribosomal subunit9.10e-021.00e+003.3941649
GO:0003684damaged DNA binding9.10e-021.00e+003.3941749
GO:0006986response to unfolded protein9.27e-021.00e+003.3651250
GO:0005905coated pit9.27e-021.00e+003.3651350
GO:0006879cellular iron ion homeostasis9.45e-021.00e+003.3361451
GO:0045216cell-cell junction organization9.98e-021.00e+003.2541254
GO:0000932cytoplasmic mRNA processing body9.98e-021.00e+003.2541354
GO:0002244hematopoietic progenitor cell differentiation9.98e-021.00e+003.2541154
GO:0005743mitochondrial inner membrane1.00e-011.00e+001.89528277
GO:0002039p53 binding1.02e-011.00e+003.2271755
GO:0000724double-strand break repair via homologous recombination1.02e-011.00e+003.2271355
GO:0012505endomembrane system1.03e-011.00e+003.2011256
GO:0051087chaperone binding1.09e-011.00e+003.1261659
GO:0030855epithelial cell differentiation1.12e-011.00e+003.0781461
GO:0006302double-strand break repair1.14e-011.00e+003.0551462
GO:0019903protein phosphatase binding1.14e-011.00e+003.0551462
GO:0030141secretory granule1.14e-011.00e+003.0551262
GO:0005525GTP binding1.21e-011.00e+001.733212310
GO:0034329cell junction assembly1.24e-011.00e+002.9211168
GO:0008283cell proliferation1.33e-011.00e+001.651214328
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.34e-011.00e+002.7991674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.36e-011.00e+002.7801275
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process1.39e-011.00e+002.7421777
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.44e-011.00e+002.6871380
GO:0001726ruffle1.44e-011.00e+002.6871480
GO:0006898receptor-mediated endocytosis1.51e-011.00e+002.6161384
GO:0047485protein N-terminus binding1.54e-011.00e+002.5821586
GO:0050821protein stabilization1.58e-011.00e+002.5491288
GO:0016605PML body1.58e-011.00e+002.5491388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II1.61e-011.00e+002.5171790
GO:0016363nuclear matrix1.63e-011.00e+002.50111291
GO:0006928cellular component movement1.63e-011.00e+002.5011791
GO:0005200structural constituent of cytoskeleton1.63e-011.00e+002.5011891
GO:0071456cellular response to hypoxia1.64e-011.00e+002.4851692
GO:0051082unfolded protein binding1.66e-011.00e+002.4701593
GO:0006364rRNA processing1.67e-011.00e+002.4541694
GO:0014069postsynaptic density1.85e-011.00e+002.29413105
GO:0045892negative regulation of transcription, DNA-templated1.91e-011.00e+001.319215413
GO:0030308negative regulation of cell growth1.93e-011.00e+002.22716110
GO:0015630microtubule cytoskeleton1.93e-011.00e+002.22714110
GO:0072562blood microparticle1.95e-011.00e+002.21413111
GO:0006006glucose metabolic process2.06e-011.00e+002.12617118
GO:0006325chromatin organization2.06e-011.00e+002.12615118
GO:0007219Notch signaling pathway2.09e-011.00e+002.10215120
GO:0006260DNA replication2.10e-011.00e+002.09019121
GO:0006511ubiquitin-dependent protein catabolic process2.18e-011.00e+002.03115126
GO:0031982vesicle2.26e-011.00e+001.97519131
GO:0007507heart development2.38e-011.00e+001.89017139
GO:0005524ATP binding2.41e-011.00e+000.6674601298
GO:0008286insulin receptor signaling pathway2.42e-011.00e+001.85917142
GO:0042802identical protein binding2.42e-011.00e+001.090220484
GO:0006457protein folding2.44e-011.00e+001.84917143
GO:0010628positive regulation of gene expression2.48e-011.00e+001.81915146
GO:0005198structural molecule activity2.54e-011.00e+001.78015150
GO:0005769early endosome2.57e-011.00e+001.76112152
GO:0006397mRNA processing2.68e-011.00e+001.68712160
GO:0000287magnesium ion binding2.74e-011.00e+001.65114164
GO:0030424axon2.77e-011.00e+001.63414166
GO:0005615extracellular space2.83e-011.00e+000.691317957
GO:0006886intracellular protein transport2.84e-011.00e+001.59115171
GO:0016607nuclear speck2.86e-011.00e+001.58213172
GO:0003714transcription corepressor activity2.94e-011.00e+001.53318178
GO:0032403protein complex binding3.01e-011.00e+001.493110183
GO:0005765lysosomal membrane3.28e-011.00e+001.34315203
GO:0005759mitochondrial matrix3.60e-011.00e+001.176114228
GO:0005975carbohydrate metabolic process3.91e-011.00e+001.02619253
GO:0004842ubiquitin-protein transferase activity3.93e-011.00e+001.01416255
GO:0000166nucleotide binding3.98e-011.00e+000.99215259
GO:0043065positive regulation of apoptotic process4.09e-011.00e+000.943110268
GO:0019899enzyme binding4.19e-011.00e+000.895112277
GO:0005856cytoskeleton4.35e-011.00e+000.824112291
GO:0016567protein ubiquitination4.40e-011.00e+000.80415295
GO:0030154cell differentiation4.46e-011.00e+000.77515301
GO:0043231intracellular membrane-bounded organelle4.65e-011.00e+000.69619318
GO:0007411axon guidance4.66e-011.00e+000.691113319
GO:0007155cell adhesion5.16e-011.00e+000.48116369
GO:0006508proteolysis5.25e-011.00e+000.44619378
GO:0009986cell surface5.47e-011.00e+000.358111402
GO:0055085transmembrane transport5.76e-011.00e+000.244110435
GO:0005886plasma membrane5.80e-011.00e+00-0.0045452582
GO:0005739mitochondrion5.86e-011.00e+000.046228998
GO:0007596blood coagulation5.93e-011.00e+000.179118455
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.77e-011.00e+00-0.146116570
GO:0045087innate immune response6.94e-011.00e+00-0.210124596
GO:0003677DNA binding6.97e-011.00e+00-0.2422281218
GO:0003700sequence-specific DNA binding transcription factor activity7.52e-011.00e+00-0.440111699
GO:0006351transcription, DNA-templated7.86e-011.00e+00-0.4892311446
GO:0006355regulation of transcription, DNA-templated8.66e-011.00e+00-0.953118997
GO:0008270zinc ion binding8.66e-011.00e+00-0.953112997
GO:0016021integral component of membrane9.84e-011.00e+00-1.9441271982