int-snw-1933

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.936 1.46e-15 2.41e-03 3.93e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-1933 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
RUVBL1 8607 170.7201.013343Yes-
EEF2 1938 270.8901.043301Yes-
RBX1 9978 971.1851.151139Yes-
DDX18 8886 90.6601.013173Yes-
ACTB 60 1671.1531.151587Yes-
OGDH 4967 130.8471.076113Yes-
CFL1 1072 120.6741.020203Yes-
RPSA 3921 1561.3271.151152Yes-
[ EEF1B2 ] 1933 1-0.0250.936134Yes-
PGD 5226 751.2011.106138Yes-

Interactions (25)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CFL1 1072 EEF1B2 1933 pp -- int.I2D: YeastLow
EEF2 1938 PGD 5226 pp -- int.I2D: BioGrid_Yeast
RUVBL1 8607 DDX18 8886 pp -- int.I2D: YeastLow
CFL1 1072 OGDH 4967 pp -- int.I2D: YeastLow
EEF1B2 1933 OGDH 4967 pp -- int.I2D: YeastLow
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CFL1 1072 DDX18 8886 pp -- int.I2D: YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
OGDH 4967 RUVBL1 8607 pp -- int.I2D: YeastLow
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
EEF1B2 1933 RUVBL1 8607 pp -- int.I2D: YeastLow
EEF2 1938 DDX18 8886 pp -- int.I2D: YeastLow
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 EEF1B2 1933 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
EEF1B2 1933 EEF2 1938 pp -- int.I2D: YeastLow
ACTB 60 EEF2 1938 pp -- int.I2D: YeastLow, IntAct_Yeast
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
EEF1B2 1933 DDX18 8886 pp -- int.I2D: YeastLow
CFL1 1072 RUVBL1 8607 pp -- int.I2D: YeastLow
OGDH 4967 DDX18 8886 pp -- int.I2D: YeastLow

Related GO terms (214)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0006414translational elongation5.47e-057.90e-015.27731393
GO:0035267NuA4 histone acetyltransferase complex5.74e-058.28e-017.4242414
GO:0003746translation elongation factor activity8.57e-051.00e+007.1442317
GO:0030529ribonucleoprotein complex9.53e-051.00e+005.00938112
GO:0044267cellular protein metabolic process4.62e-041.00e+003.342429474
GO:0006412translation7.92e-041.00e+003.971320230
GO:0019521D-gluconate metabolic process8.32e-041.00e+0010.231111
GO:0034602oxoglutarate dehydrogenase (NAD+) activity8.32e-041.00e+0010.231111
GO:0006281DNA repair1.14e-031.00e+003.788318261
GO:0016020membrane1.23e-031.00e+002.1016901681
GO:0061034olfactory bulb mitral cell layer development1.66e-031.00e+009.231112
GO:0045252oxoglutarate dehydrogenase complex1.66e-031.00e+009.231122
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.66e-031.00e+005.0222674
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0019322pentose biosynthetic process1.66e-031.00e+009.231122
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0001842neural fold formation2.49e-031.00e+008.646113
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity2.49e-031.00e+008.646113
GO:0016363nuclear matrix2.49e-031.00e+004.72321291
GO:0009051pentose-phosphate shunt, oxidative branch2.49e-031.00e+008.646123
GO:0022028tangential migration from the subventricular zone to the olfactory bulb2.49e-031.00e+008.646113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.49e-031.00e+008.646113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0006104succinyl-CoA metabolic process3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0006734NADH metabolic process3.32e-031.00e+008.231114
GO:0005853eukaryotic translation elongation factor 1 complex3.32e-031.00e+008.231124
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0006325chromatin organization4.15e-031.00e+004.34825118
GO:0030976thiamine pyrophosphate binding4.15e-031.00e+007.909115
GO:0021695cerebellar cortex development4.98e-031.00e+007.646126
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0030836positive regulation of actin filament depolymerization4.98e-031.00e+007.646126
GO:0021860pyramidal neuron development4.98e-031.00e+007.646116
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0030042actin filament depolymerization6.64e-031.00e+007.231128
GO:0006554lysine catabolic process6.64e-031.00e+007.231128
GO:0000812Swr1 complex6.64e-031.00e+007.231138
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0008494translation activator activity7.47e-031.00e+007.061119
GO:0070062extracellular vesicular exosome7.84e-031.00e+001.58761042400
GO:0006098pentose-phosphate shunt8.29e-031.00e+006.9091410
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0021756striatum development8.29e-031.00e+006.9091110
GO:0021794thalamus development9.12e-031.00e+006.7721111
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0061001regulation of dendritic spine morphogenesis9.12e-031.00e+006.7721211
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0005829cytosol9.54e-031.00e+001.53161322496
GO:0005654nucleoplasm9.57e-031.00e+002.1524761082
GO:0043968histone H2A acetylation9.94e-031.00e+006.6461312
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0031011Ino80 complex1.16e-021.00e+006.4241314
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:00061032-oxoglutarate metabolic process1.32e-021.00e+006.2311116
GO:0031258lamellipodium membrane1.32e-021.00e+006.2311216
GO:0022604regulation of cell morphogenesis1.32e-021.00e+006.2311116
GO:0003678DNA helicase activity1.41e-021.00e+006.1441317
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0004004ATP-dependent RNA helicase activity1.49e-021.00e+006.0611218
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0010467gene expression1.60e-021.00e+002.430359669
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0030010establishment of cell polarity1.73e-021.00e+005.8391221
GO:0000281mitotic cytokinesis1.73e-021.00e+005.8391121
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0005844polysome1.90e-021.00e+005.7081423
GO:0030864cortical actin cytoskeleton1.90e-021.00e+005.7081123
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0043200response to amino acid1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0034080CENP-A containing nucleosome assembly2.06e-021.00e+005.5871125
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0005515protein binding2.09e-021.00e+000.84591846024
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0050661NADP binding2.22e-021.00e+005.4761227
GO:0071339MLL1 complex2.22e-021.00e+005.4761327
GO:0043967histone H4 acetylation2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0001755neural crest cell migration2.31e-021.00e+005.4241228
GO:0006099tricarboxylic acid cycle2.31e-021.00e+005.4241428
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0042254ribosome biogenesis2.47e-021.00e+005.3241130
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0031072heat shock protein binding2.71e-021.00e+005.1871133
GO:0019901protein kinase binding2.75e-021.00e+002.923221317
GO:0007411axon guidance2.78e-021.00e+002.914213319
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0021766hippocampus development3.12e-021.00e+004.9831438
GO:0006096glycolytic process3.12e-021.00e+004.9831438
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0032508DNA duplex unwinding3.36e-021.00e+004.8741341
GO:0005925focal adhesion3.58e-021.00e+002.715219366
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0045727positive regulation of translation3.60e-021.00e+004.7721344
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0007266Rho protein signal transduction3.84e-021.00e+004.6771247
GO:0005730nucleolus3.91e-021.00e+001.5514691641
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0006091generation of precursor metabolites and energy4.08e-021.00e+004.5871350
GO:0040008regulation of growth4.08e-021.00e+004.5871550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0002244hematopoietic progenitor cell differentiation4.40e-021.00e+004.4761154
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0031966mitochondrial membrane4.48e-021.00e+004.4501155
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0051087chaperone binding4.80e-021.00e+004.3481659
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0044822poly(A) RNA binding5.23e-021.00e+001.7723491056
GO:0006310DNA recombination5.28e-021.00e+004.2091265
GO:0007596blood coagulation5.32e-021.00e+002.401218455
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0032587ruffle membrane5.67e-021.00e+004.1021370
GO:0006334nucleosome assembly5.83e-021.00e+004.0611272
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0002576platelet degranulation6.62e-021.00e+003.8741482
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016032viral process7.07e-021.00e+002.170255534
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0007010cytoskeleton organization7.32e-021.00e+003.7231191
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0045087innate immune response8.56e-021.00e+002.012224596
GO:0005524ATP binding8.65e-021.00e+001.4743601298
GO:0005815microtubule organizing center8.70e-021.00e+003.46315109
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay9.09e-021.00e+003.398111114
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0044237cellular metabolic process9.32e-021.00e+003.36115117
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0030036actin cytoskeleton organization9.77e-021.00e+003.28915123
GO:0009615response to virus1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0031982vesicle1.04e-011.00e+003.19819131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0005911cell-cell junction1.08e-011.00e+003.14414136
GO:0016887ATPase activity1.10e-011.00e+003.10217140
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0010628positive regulation of gene expression1.15e-011.00e+003.04115146
GO:0000082G1/S transition of mitotic cell cycle1.17e-011.00e+003.012132149
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0034641cellular nitrogen compound metabolic process1.33e-011.00e+002.813120171
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0005634nucleus1.45e-011.00e+000.66261364559
GO:0003924GTPase activity1.52e-011.00e+002.609112197
GO:0030168platelet activation1.58e-011.00e+002.552110205
GO:0006184GTP catabolic process1.64e-011.00e+002.490112214
GO:0016071mRNA metabolic process1.71e-011.00e+002.430131223
GO:0007067mitotic nuclear division1.73e-011.00e+002.405114227
GO:0005759mitochondrial matrix1.74e-011.00e+002.398114228
GO:0016070RNA metabolic process1.87e-011.00e+002.283132247
GO:0005615extracellular space1.87e-011.00e+001.329217957
GO:0005975carbohydrate metabolic process1.91e-011.00e+002.24819253
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0007283spermatogenesis1.98e-011.00e+002.19818262
GO:0006357regulation of transcription from RNA polymerase II promoter1.99e-011.00e+002.18718264
GO:0003779actin binding2.00e-011.00e+002.176112266
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0006200ATP catabolic process2.18e-011.00e+002.041115292
GO:0043234protein complex2.20e-011.00e+002.027118295
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0005525GTP binding2.30e-011.00e+001.955112310
GO:0043231intracellular membrane-bounded organelle2.35e-011.00e+001.91819318
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0044281small molecule metabolic process2.67e-011.00e+000.9892581211
GO:0000278mitotic cell cycle2.81e-011.00e+001.620148391
GO:0055114oxidation-reduction process2.99e-011.00e+001.517112420
GO:0043066negative regulation of apoptotic process3.01e-011.00e+001.503131424
GO:0006468protein phosphorylation3.22e-011.00e+001.386118460
GO:0005737cytoplasm3.86e-011.00e+000.35241103767
GO:0005794Golgi apparatus4.05e-011.00e+000.978115610
GO:0005739mitochondrion5.77e-011.00e+000.268128998
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0046872metal ion binding6.80e-011.00e+00-0.1211251307
GO:0006351transcription, DNA-templated7.19e-011.00e+00-0.2671311446
GO:0005886plasma membrane9.06e-011.00e+00-1.1031452582