| Dataset | Score | p-value 1 | p-value 2 | p-value 3 | 
|---|---|---|---|---|
| wolf-screen-ratio-mammosphere-adherent | 0.978 | 3.10e-17 | 9.28e-04 | 1.95e-02 | 

| Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI | 
|---|---|---|---|---|---|---|---|
| ADH5 | 128 | 5 | 0.633 | 0.994 | 43 | Yes | - | 
| RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - | 
| RSL24D1 | 51187 | 36 | 1.300 | 1.020 | 59 | Yes | - | 
| EIF6 | 3692 | 14 | 0.700 | 1.013 | 267 | Yes | - | 
| EIF2S2 | 8894 | 27 | 1.075 | 1.138 | 81 | Yes | - | 
| RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - | 
| PSMA2 | 5683 | 60 | 1.093 | 1.106 | 89 | Yes | - | 
| PPP2R1A | 5518 | 9 | 0.644 | 0.985 | 249 | Yes | - | 
| PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - | 
| ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - | 
| [ CSNK2B ] | 1460 | 1 | -0.064 | 0.978 | 217 | - | - | 
| RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - | 
| PGD | 5226 | 75 | 1.201 | 1.106 | 138 | Yes | - | 
| Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources | 
|---|---|---|---|---|---|---|
| RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast | 
| ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct | 
| PGD | 5226 | PPP2R1A | 5518 | pp | -- | int.I2D: YeastLow | 
| PSMA2 | 5683 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow | 
| ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct | 
| CSNK2B | 1460 | PPP2R1A | 5518 | pp | -- | int.I2D: IntAct_Mouse | 
| EIF6 | 3692 | PGD | 5226 | pp | -- | int.I2D: YeastLow | 
| ACTB | 60 | PPP2R1A | 5518 | pp | -- | int.I2D: BioGrid_Yeast | 
| ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast | 
| PPP2R1A | 5518 | PSMA2 | 5683 | pp | -- | int.I2D: IntAct_Mouse | 
| ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast | 
| ACTB | 60 | CSNK2B | 1460 | pp | -- | int.Intact: MI:0915(physical association) | 
| PGD | 5226 | PSMD11 | 5717 | pp | -- | int.I2D: YeastLow | 
| CSNK2B | 1460 | EIF6 | 3692 | pp | -- | int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association) | 
| CSNK2B | 1460 | EIF2S2 | 8894 | pp | -- | int.I2D: BIND, BCI, HPRD; int.HPRD: in vitro | 
| EIF6 | 3692 | RSL24D1 | 51187 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow | 
| ADH5 | 128 | CSNK2B | 1460 | pp | -- | int.Intact: MI:0915(physical association) | 
| EIF6 | 3692 | PPP2R1A | 5518 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct | 
| Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes | 
|---|---|---|---|---|---|---|---|
| GO:0000278 | mitotic cell cycle | 1.54e-05 | 2.21e-01 | 3.827 | 5 | 48 | 391 | 
| GO:0016071 | mRNA metabolic process | 3.56e-05 | 5.14e-01 | 4.315 | 4 | 31 | 223 | 
| GO:0070062 | extracellular vesicular exosome | 3.62e-05 | 5.23e-01 | 2.057 | 9 | 104 | 2400 | 
| GO:0005829 | cytosol | 5.02e-05 | 7.24e-01 | 2.000 | 9 | 132 | 2496 | 
| GO:0016070 | RNA metabolic process | 5.32e-05 | 7.67e-01 | 4.167 | 4 | 32 | 247 | 
| GO:0006413 | translational initiation | 1.96e-04 | 1.00e+00 | 4.667 | 3 | 17 | 131 | 
| GO:0010467 | gene expression | 1.99e-04 | 1.00e+00 | 3.052 | 5 | 59 | 669 | 
| GO:0043022 | ribosome binding | 2.60e-04 | 1.00e+00 | 6.361 | 2 | 3 | 27 | 
| GO:0000082 | G1/S transition of mitotic cell cycle | 2.86e-04 | 1.00e+00 | 4.481 | 3 | 32 | 149 | 
| GO:0003743 | translation initiation factor activity | 8.61e-04 | 1.00e+00 | 5.501 | 2 | 8 | 49 | 
| GO:0006521 | regulation of cellular amino acid metabolic process | 8.97e-04 | 1.00e+00 | 5.472 | 2 | 17 | 50 | 
| GO:0051903 | S-(hydroxymethyl)glutathione dehydrogenase activity | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0018467 | formaldehyde dehydrogenase activity | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0005956 | protein kinase CK2 complex | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0070262 | peptidyl-serine dephosphorylation | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0000054 | ribosomal subunit export from nucleus | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0019521 | D-gluconate metabolic process | 9.01e-04 | 1.00e+00 | 10.116 | 1 | 1 | 1 | 
| GO:0016032 | viral process | 1.02e-03 | 1.00e+00 | 3.055 | 4 | 55 | 534 | 
| GO:0000502 | proteasome complex | 1.20e-03 | 1.00e+00 | 5.258 | 2 | 17 | 58 | 
| GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 1.47e-03 | 1.00e+00 | 5.116 | 2 | 19 | 64 | 
| GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.51e-03 | 1.00e+00 | 5.093 | 2 | 22 | 65 | 
| GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.75e-03 | 1.00e+00 | 4.986 | 2 | 22 | 70 | 
| GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0002176 | male germ cell proliferation | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0019322 | pentose biosynthetic process | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 2 | 2 | 
| GO:0005055 | laminin receptor activity | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0006407 | rRNA export from nucleus | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 1 | 2 | 
| GO:0046294 | formaldehyde catabolic process | 1.80e-03 | 1.00e+00 | 9.116 | 1 | 2 | 2 | 
| GO:0005654 | nucleoplasm | 1.82e-03 | 1.00e+00 | 2.358 | 5 | 76 | 1082 | 
| GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 1.85e-03 | 1.00e+00 | 4.946 | 2 | 20 | 72 | 
| GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 1.95e-03 | 1.00e+00 | 4.906 | 2 | 22 | 74 | 
| GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 2.01e-03 | 1.00e+00 | 4.887 | 2 | 20 | 75 | 
| GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 2.22e-03 | 1.00e+00 | 4.812 | 2 | 23 | 79 | 
| GO:0005850 | eukaryotic translation initiation factor 2 complex | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 | 
| GO:0018119 | peptidyl-cysteine S-nitrosylation | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 | 
| GO:0009051 | pentose-phosphate shunt, oxidative branch | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 2 | 3 | 
| GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity | 2.70e-03 | 1.00e+00 | 8.531 | 1 | 1 | 3 | 
| GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 3.00e-03 | 1.00e+00 | 4.592 | 2 | 21 | 92 | 
| GO:0006068 | ethanol catabolic process | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0030686 | 90S preribosome | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0031467 | Cul7-RING ubiquitin ligase complex | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0019788 | NEDD8 ligase activity | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0051409 | response to nitrosative stress | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0019887 | protein kinase regulator activity | 3.60e-03 | 1.00e+00 | 8.116 | 1 | 1 | 4 | 
| GO:0061154 | endothelial tube morphogenesis | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 3 | 5 | 
| GO:0031461 | cullin-RING ubiquitin ligase complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0019932 | second-messenger-mediated signaling | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0042256 | mature ribosome assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0043248 | proteasome assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0004022 | alcohol dehydrogenase (NAD) activity | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0030891 | VCB complex | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 2 | 5 | 
| GO:0000730 | DNA recombinase assembly | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:2000001 | regulation of DNA damage checkpoint | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0005638 | lamin filament | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0043023 | ribosomal large subunit binding | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0051101 | regulation of DNA binding | 4.50e-03 | 1.00e+00 | 7.794 | 1 | 1 | 5 | 
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 4.56e-03 | 1.00e+00 | 4.283 | 2 | 11 | 114 | 
| GO:0000209 | protein polyubiquitination | 4.72e-03 | 1.00e+00 | 4.258 | 2 | 20 | 116 | 
| GO:0030957 | Tat protein binding | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 3 | 6 | 
| GO:0032927 | positive regulation of activin receptor signaling pathway | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 | 
| GO:0033211 | adiponectin-activated signaling pathway | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 | 
| GO:0031466 | Cul5-RING ubiquitin ligase complex | 5.40e-03 | 1.00e+00 | 7.531 | 1 | 1 | 6 | 
| GO:0005634 | nucleus | 5.94e-03 | 1.00e+00 | 1.131 | 9 | 136 | 4559 | 
| GO:0000028 | ribosomal small subunit assembly | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 7 | 
| GO:0031462 | Cul2-RING ubiquitin ligase complex | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 2 | 7 | 
| GO:0019773 | proteasome core complex, alpha-subunit complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 4 | 8 | 
| GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 8 | 
| GO:0003016 | respiratory system process | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 | 
| GO:0070688 | MLL5-L complex | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 1 | 8 | 
| GO:0045116 | protein neddylation | 7.19e-03 | 1.00e+00 | 7.116 | 1 | 2 | 8 | 
| GO:0042981 | regulation of apoptotic process | 7.77e-03 | 1.00e+00 | 3.887 | 2 | 24 | 150 | 
| GO:0044267 | cellular protein metabolic process | 7.89e-03 | 1.00e+00 | 2.812 | 3 | 29 | 474 | 
| GO:0006098 | pentose-phosphate shunt | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 4 | 10 | 
| GO:0010569 | regulation of double-strand break repair via homologous recombination | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 | 
| GO:0007084 | mitotic nuclear envelope reassembly | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 | 
| GO:0006069 | ethanol oxidation | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 | 
| GO:0051775 | response to redox state | 8.98e-03 | 1.00e+00 | 6.794 | 1 | 1 | 10 | 
| GO:0031571 | mitotic G1 DNA damage checkpoint | 9.87e-03 | 1.00e+00 | 6.656 | 1 | 4 | 11 | 
| GO:0034641 | cellular nitrogen compound metabolic process | 1.00e-02 | 1.00e+00 | 3.698 | 2 | 20 | 171 | 
| GO:0031625 | ubiquitin protein ligase binding | 1.08e-02 | 1.00e+00 | 3.640 | 2 | 14 | 178 | 
| GO:0043537 | negative regulation of blood vessel endothelial cell migration | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 | 
| GO:0006275 | regulation of DNA replication | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 2 | 12 | 
| GO:0030111 | regulation of Wnt signaling pathway | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 1 | 12 | 
| GO:0005838 | proteasome regulatory particle | 1.08e-02 | 1.00e+00 | 6.531 | 1 | 7 | 12 | 
| GO:0005515 | protein binding | 1.11e-02 | 1.00e+00 | 0.881 | 10 | 184 | 6024 | 
| GO:0006672 | ceramide metabolic process | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 | 
| GO:0042273 | ribosomal large subunit biogenesis | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 4 | 13 | 
| GO:0005662 | DNA replication factor A complex | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 | 
| GO:0005504 | fatty acid binding | 1.17e-02 | 1.00e+00 | 6.415 | 1 | 1 | 13 | 
| GO:0006915 | apoptotic process | 1.21e-02 | 1.00e+00 | 2.584 | 3 | 33 | 555 | 
| GO:0035267 | NuA4 histone acetyltransferase complex | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 4 | 14 | 
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 2 | 15 | 
| GO:0043623 | cellular protein complex assembly | 1.34e-02 | 1.00e+00 | 6.209 | 1 | 1 | 15 | 
| GO:0050998 | nitric-oxide synthase binding | 1.43e-02 | 1.00e+00 | 6.116 | 1 | 1 | 16 | 
| GO:0045777 | positive regulation of blood pressure | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 1 | 17 | 
| GO:0022624 | proteasome accessory complex | 1.52e-02 | 1.00e+00 | 6.028 | 1 | 8 | 17 | 
| GO:0035861 | site of double-strand break | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 1 | 18 | 
| GO:0005839 | proteasome core complex | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 8 | 18 | 
| GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 | 
| GO:0048863 | stem cell differentiation | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 1 | 19 | 
| GO:0004298 | threonine-type endopeptidase activity | 1.70e-02 | 1.00e+00 | 5.868 | 1 | 8 | 19 | 
| GO:0006412 | translation | 1.76e-02 | 1.00e+00 | 3.270 | 2 | 20 | 230 | 
| GO:0008601 | protein phosphatase type 2A regulator activity | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 2 | 20 | 
| GO:0006298 | mismatch repair | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 3 | 20 | 
| GO:0000159 | protein phosphatase type 2A complex | 1.79e-02 | 1.00e+00 | 5.794 | 1 | 2 | 20 | 
| GO:0032201 | telomere maintenance via semi-conservative replication | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 5 | 21 | 
| GO:0045595 | regulation of cell differentiation | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 1 | 21 | 
| GO:0000718 | nucleotide-excision repair, DNA damage removal | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 4 | 21 | 
| GO:0006297 | nucleotide-excision repair, DNA gap filling | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 3 | 22 | 
| GO:0003823 | antigen binding | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 1 | 22 | 
| GO:0030863 | cortical cytoskeleton | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 1 | 22 | 
| GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.97e-02 | 1.00e+00 | 5.656 | 1 | 4 | 22 | 
| GO:0043044 | ATP-dependent chromatin remodeling | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 4 | 23 | 
| GO:0031463 | Cul3-RING ubiquitin ligase complex | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 3 | 23 | 
| GO:0043236 | laminin binding | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 | 
| GO:0006513 | protein monoubiquitination | 2.05e-02 | 1.00e+00 | 5.592 | 1 | 1 | 23 | 
| GO:0008135 | translation factor activity, nucleic acid binding | 2.14e-02 | 1.00e+00 | 5.531 | 1 | 7 | 24 | 
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 1 | 25 | 
| GO:0000722 | telomere maintenance via recombination | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 5 | 25 | 
| GO:0006281 | DNA repair | 2.23e-02 | 1.00e+00 | 3.088 | 2 | 18 | 261 | 
| GO:0031519 | PcG protein complex | 2.23e-02 | 1.00e+00 | 5.472 | 1 | 4 | 25 | 
| GO:0045859 | regulation of protein kinase activity | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 1 | 26 | 
| GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 2.32e-02 | 1.00e+00 | 5.415 | 1 | 3 | 26 | 
| GO:0010033 | response to organic substance | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 | 
| GO:0050661 | NADP binding | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 2 | 27 | 
| GO:0000188 | inactivation of MAPK activity | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 1 | 27 | 
| GO:0031492 | nucleosomal DNA binding | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 4 | 27 | 
| GO:0019894 | kinesin binding | 2.50e-02 | 1.00e+00 | 5.308 | 1 | 1 | 28 | 
| GO:0019005 | SCF ubiquitin ligase complex | 2.58e-02 | 1.00e+00 | 5.258 | 1 | 1 | 29 | 
| GO:0042254 | ribosome biogenesis | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 1 | 30 | 
| GO:0006271 | DNA strand elongation involved in DNA replication | 2.67e-02 | 1.00e+00 | 5.209 | 1 | 7 | 30 | 
| GO:0001895 | retina homeostasis | 3.02e-02 | 1.00e+00 | 5.028 | 1 | 1 | 34 | 
| GO:0034332 | adherens junction organization | 3.20e-02 | 1.00e+00 | 4.946 | 1 | 1 | 36 | 
| GO:0007411 | axon guidance | 3.24e-02 | 1.00e+00 | 2.798 | 2 | 13 | 319 | 
| GO:0051084 | 'de novo' posttranslational protein folding | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 4 | 37 | 
| GO:0006284 | base-excision repair | 3.29e-02 | 1.00e+00 | 4.906 | 1 | 3 | 37 | 
| GO:0070527 | platelet aggregation | 3.37e-02 | 1.00e+00 | 4.868 | 1 | 2 | 38 | 
| GO:0022627 | cytosolic small ribosomal subunit | 3.46e-02 | 1.00e+00 | 4.830 | 1 | 4 | 39 | 
| GO:0000781 | chromosome, telomeric region | 3.46e-02 | 1.00e+00 | 4.830 | 1 | 3 | 39 | 
| GO:0004722 | protein serine/threonine phosphatase activity | 3.72e-02 | 1.00e+00 | 4.723 | 1 | 1 | 42 | 
| GO:0030155 | regulation of cell adhesion | 3.72e-02 | 1.00e+00 | 4.723 | 1 | 2 | 42 | 
| GO:0021762 | substantia nigra development | 3.90e-02 | 1.00e+00 | 4.656 | 1 | 2 | 44 | 
| GO:0006283 | transcription-coupled nucleotide-excision repair | 4.07e-02 | 1.00e+00 | 4.592 | 1 | 7 | 46 | 
| GO:0001523 | retinoid metabolic process | 4.24e-02 | 1.00e+00 | 4.531 | 1 | 2 | 48 | 
| GO:0003684 | damaged DNA binding | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 7 | 49 | 
| GO:0000775 | chromosome, centromeric region | 4.42e-02 | 1.00e+00 | 4.472 | 1 | 2 | 50 | 
| GO:0040008 | regulation of growth | 4.42e-02 | 1.00e+00 | 4.472 | 1 | 5 | 50 | 
| GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 4.68e-02 | 1.00e+00 | 4.388 | 1 | 5 | 53 | 
| GO:0045216 | cell-cell junction organization | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 2 | 54 | 
| GO:0000932 | cytoplasmic mRNA processing body | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 3 | 54 | 
| GO:0000724 | double-strand break repair via homologous recombination | 4.85e-02 | 1.00e+00 | 4.334 | 1 | 3 | 55 | 
| GO:0000723 | telomere maintenance | 4.93e-02 | 1.00e+00 | 4.308 | 1 | 6 | 56 | 
| GO:0043066 | negative regulation of apoptotic process | 5.43e-02 | 1.00e+00 | 2.388 | 2 | 31 | 424 | 
| GO:0019903 | protein phosphatase binding | 5.45e-02 | 1.00e+00 | 4.161 | 1 | 4 | 62 | 
| GO:0007059 | chromosome segregation | 5.45e-02 | 1.00e+00 | 4.161 | 1 | 4 | 62 | 
| GO:0006302 | double-strand break repair | 5.45e-02 | 1.00e+00 | 4.161 | 1 | 4 | 62 | 
| GO:0016020 | membrane | 5.55e-02 | 1.00e+00 | 1.401 | 4 | 90 | 1681 | 
| GO:0009055 | electron carrier activity | 5.71e-02 | 1.00e+00 | 4.093 | 1 | 1 | 65 | 
| GO:0006289 | nucleotide-excision repair | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 11 | 68 | 
| GO:0034329 | cell junction assembly | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 1 | 68 | 
| GO:0003697 | single-stranded DNA binding | 5.96e-02 | 1.00e+00 | 4.028 | 1 | 5 | 68 | 
| GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 6.47e-02 | 1.00e+00 | 3.906 | 1 | 6 | 74 | 
| GO:0008584 | male gonad development | 6.56e-02 | 1.00e+00 | 3.887 | 1 | 3 | 75 | 
| GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 6.56e-02 | 1.00e+00 | 3.887 | 1 | 2 | 75 | 
| GO:0019083 | viral transcription | 7.06e-02 | 1.00e+00 | 3.776 | 1 | 10 | 81 | 
| GO:0047485 | protein N-terminus binding | 7.48e-02 | 1.00e+00 | 3.689 | 1 | 5 | 86 | 
| GO:0006415 | translational termination | 7.57e-02 | 1.00e+00 | 3.673 | 1 | 10 | 87 | 
| GO:0016605 | PML body | 7.65e-02 | 1.00e+00 | 3.656 | 1 | 3 | 88 | 
| GO:0006928 | cellular component movement | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 7 | 91 | 
| GO:0005200 | structural constituent of cytoskeleton | 7.90e-02 | 1.00e+00 | 3.608 | 1 | 8 | 91 | 
| GO:0071456 | cellular response to hypoxia | 7.99e-02 | 1.00e+00 | 3.592 | 1 | 6 | 92 | 
| GO:0006414 | translational elongation | 8.07e-02 | 1.00e+00 | 3.576 | 1 | 13 | 93 | 
| GO:0006470 | protein dephosphorylation | 8.49e-02 | 1.00e+00 | 3.501 | 1 | 1 | 98 | 
| GO:0044281 | small molecule metabolic process | 8.95e-02 | 1.00e+00 | 1.459 | 3 | 58 | 1211 | 
| GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 8.98e-02 | 1.00e+00 | 3.415 | 1 | 10 | 104 | 
| GO:0014069 | postsynaptic density | 9.07e-02 | 1.00e+00 | 3.401 | 1 | 3 | 105 | 
| GO:0030308 | negative regulation of cell growth | 9.48e-02 | 1.00e+00 | 3.334 | 1 | 6 | 110 | 
| GO:0015630 | microtubule cytoskeleton | 9.48e-02 | 1.00e+00 | 3.334 | 1 | 4 | 110 | 
| GO:0006461 | protein complex assembly | 9.56e-02 | 1.00e+00 | 3.321 | 1 | 6 | 111 | 
| GO:0072562 | blood microparticle | 9.56e-02 | 1.00e+00 | 3.321 | 1 | 3 | 111 | 
| GO:0030529 | ribonucleoprotein complex | 9.64e-02 | 1.00e+00 | 3.308 | 1 | 8 | 112 | 
| GO:0019058 | viral life cycle | 9.89e-02 | 1.00e+00 | 3.270 | 1 | 13 | 115 | 
| GO:0007568 | aging | 1.01e-01 | 1.00e+00 | 3.245 | 1 | 3 | 117 | 
| GO:0006325 | chromatin organization | 1.01e-01 | 1.00e+00 | 3.233 | 1 | 5 | 118 | 
| GO:0007219 | Notch signaling pathway | 1.03e-01 | 1.00e+00 | 3.209 | 1 | 5 | 120 | 
| GO:0006260 | DNA replication | 1.04e-01 | 1.00e+00 | 3.197 | 1 | 9 | 121 | 
| GO:0032496 | response to lipopolysaccharide | 1.04e-01 | 1.00e+00 | 3.197 | 1 | 4 | 121 | 
| GO:0006511 | ubiquitin-dependent protein catabolic process | 1.08e-01 | 1.00e+00 | 3.138 | 1 | 5 | 126 | 
| GO:0009615 | response to virus | 1.08e-01 | 1.00e+00 | 3.138 | 1 | 5 | 126 | 
| GO:0000790 | nuclear chromatin | 1.10e-01 | 1.00e+00 | 3.104 | 1 | 9 | 129 | 
| GO:0000086 | G2/M transition of mitotic cell cycle | 1.16e-01 | 1.00e+00 | 3.028 | 1 | 9 | 136 | 
| GO:0003735 | structural constituent of ribosome | 1.17e-01 | 1.00e+00 | 3.018 | 1 | 10 | 137 | 
| GO:0016055 | Wnt signaling pathway | 1.18e-01 | 1.00e+00 | 3.007 | 1 | 7 | 138 | 
| GO:0006457 | protein folding | 1.22e-01 | 1.00e+00 | 2.956 | 1 | 7 | 143 | 
| GO:0061024 | membrane organization | 1.23e-01 | 1.00e+00 | 2.936 | 1 | 7 | 145 | 
| GO:0008543 | fibroblast growth factor receptor signaling pathway | 1.32e-01 | 1.00e+00 | 2.830 | 1 | 9 | 156 | 
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 1.39e-01 | 1.00e+00 | 2.749 | 1 | 7 | 165 | 
| GO:0030424 | axon | 1.40e-01 | 1.00e+00 | 2.741 | 1 | 4 | 166 | 
| GO:0019904 | protein domain specific binding | 1.50e-01 | 1.00e+00 | 2.632 | 1 | 6 | 179 | 
| GO:0032403 | protein complex binding | 1.53e-01 | 1.00e+00 | 2.600 | 1 | 10 | 183 | 
| GO:0001701 | in utero embryonic development | 1.67e-01 | 1.00e+00 | 2.465 | 1 | 8 | 201 | 
| GO:0005730 | nucleolus | 1.77e-01 | 1.00e+00 | 1.020 | 3 | 69 | 1641 | 
| GO:0008380 | RNA splicing | 1.87e-01 | 1.00e+00 | 2.283 | 1 | 11 | 228 | 
| GO:0008134 | transcription factor binding | 1.98e-01 | 1.00e+00 | 2.197 | 1 | 8 | 242 | 
| GO:0005975 | carbohydrate metabolic process | 2.06e-01 | 1.00e+00 | 2.133 | 1 | 9 | 253 | 
| GO:0004842 | ubiquitin-protein transferase activity | 2.07e-01 | 1.00e+00 | 2.121 | 1 | 6 | 255 | 
| GO:0005102 | receptor binding | 2.11e-01 | 1.00e+00 | 2.093 | 1 | 6 | 260 | 
| GO:0019899 | enzyme binding | 2.23e-01 | 1.00e+00 | 2.002 | 1 | 12 | 277 | 
| GO:0008270 | zinc ion binding | 2.25e-01 | 1.00e+00 | 1.154 | 2 | 12 | 997 | 
| GO:0005739 | mitochondrion | 2.26e-01 | 1.00e+00 | 1.153 | 2 | 28 | 998 | 
| GO:0005856 | cytoskeleton | 2.33e-01 | 1.00e+00 | 1.931 | 1 | 12 | 291 | 
| GO:0043234 | protein complex | 2.36e-01 | 1.00e+00 | 1.911 | 1 | 18 | 295 | 
| GO:0016567 | protein ubiquitination | 2.36e-01 | 1.00e+00 | 1.911 | 1 | 5 | 295 | 
| GO:0004674 | protein serine/threonine kinase activity | 2.45e-01 | 1.00e+00 | 1.849 | 1 | 12 | 308 | 
| GO:0044822 | poly(A) RNA binding | 2.46e-01 | 1.00e+00 | 1.071 | 2 | 49 | 1056 | 
| GO:0019901 | protein kinase binding | 2.51e-01 | 1.00e+00 | 1.807 | 1 | 21 | 317 | 
| GO:0003723 | RNA binding | 2.68e-01 | 1.00e+00 | 1.698 | 1 | 20 | 342 | 
| GO:0008285 | negative regulation of cell proliferation | 2.75e-01 | 1.00e+00 | 1.652 | 1 | 11 | 353 | 
| GO:0005925 | focal adhesion | 2.84e-01 | 1.00e+00 | 1.600 | 1 | 19 | 366 | 
| GO:0007155 | cell adhesion | 2.86e-01 | 1.00e+00 | 1.588 | 1 | 6 | 369 | 
| GO:0046982 | protein heterodimerization activity | 2.93e-01 | 1.00e+00 | 1.546 | 1 | 13 | 380 | 
| GO:0055114 | oxidation-reduction process | 3.19e-01 | 1.00e+00 | 1.401 | 1 | 12 | 420 | 
| GO:0046872 | metal ion binding | 3.32e-01 | 1.00e+00 | 0.764 | 2 | 25 | 1307 | 
| GO:0007596 | blood coagulation | 3.41e-01 | 1.00e+00 | 1.286 | 1 | 18 | 455 | 
| GO:0006468 | protein phosphorylation | 3.44e-01 | 1.00e+00 | 1.270 | 1 | 18 | 460 | 
| GO:0042802 | identical protein binding | 3.58e-01 | 1.00e+00 | 1.197 | 1 | 20 | 484 | 
| GO:0042803 | protein homodimerization activity | 4.22e-01 | 1.00e+00 | 0.899 | 1 | 12 | 595 | 
| GO:0045087 | innate immune response | 4.22e-01 | 1.00e+00 | 0.896 | 1 | 24 | 596 | 
| GO:0005737 | cytoplasm | 4.53e-01 | 1.00e+00 | 0.236 | 4 | 110 | 3767 | 
| GO:0007165 | signal transduction | 5.70e-01 | 1.00e+00 | 0.291 | 1 | 24 | 907 | 
| GO:0005615 | extracellular space | 5.91e-01 | 1.00e+00 | 0.213 | 1 | 17 | 957 | 
| GO:0006355 | regulation of transcription, DNA-templated | 6.06e-01 | 1.00e+00 | 0.154 | 1 | 18 | 997 | 
| GO:0005886 | plasma membrane | 7.05e-01 | 1.00e+00 | -0.219 | 2 | 45 | 2582 | 
| GO:0005524 | ATP binding | 7.07e-01 | 1.00e+00 | -0.226 | 1 | 60 | 1298 |