int-snw-1460

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.978 3.10e-17 9.28e-04 1.95e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-1460 subnetwork

Genes (13)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ADH5 128 50.6330.99443Yes-
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
EIF6 3692 140.7001.013267Yes-
EIF2S2 8894 271.0751.13881Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PPP2R1A 5518 90.6440.985249Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
[ CSNK2B ] 1460 1-0.0640.978217--
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (18)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CSNK2B 1460 PPP2R1A 5518 pp -- int.I2D: IntAct_Mouse
EIF6 3692 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
PPP2R1A 5518 PSMA2 5683 pp -- int.I2D: IntAct_Mouse
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CSNK2B 1460 pp -- int.Intact: MI:0915(physical association)
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
CSNK2B 1460 EIF6 3692 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
CSNK2B 1460 EIF2S2 8894 pp -- int.I2D: BIND, BCI, HPRD;
int.HPRD: in vitro
EIF6 3692 RSL24D1 51187 pp -- int.I2D: BioGrid_Yeast, YeastLow
ADH5 128 CSNK2B 1460 pp -- int.Intact: MI:0915(physical association)
EIF6 3692 PPP2R1A 5518 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct

Related GO terms (237)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000278mitotic cell cycle1.54e-052.21e-013.827548391
GO:0016071mRNA metabolic process3.56e-055.14e-014.315431223
GO:0070062extracellular vesicular exosome3.62e-055.23e-012.05791042400
GO:0005829cytosol5.02e-057.24e-012.00091322496
GO:0016070RNA metabolic process5.32e-057.67e-014.167432247
GO:0006413translational initiation1.96e-041.00e+004.667317131
GO:0010467gene expression1.99e-041.00e+003.052559669
GO:0043022ribosome binding2.60e-041.00e+006.3612327
GO:0000082G1/S transition of mitotic cell cycle2.86e-041.00e+004.481332149
GO:0003743translation initiation factor activity8.61e-041.00e+005.5012849
GO:0006521regulation of cellular amino acid metabolic process8.97e-041.00e+005.47221750
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity9.01e-041.00e+0010.116111
GO:0018467formaldehyde dehydrogenase activity9.01e-041.00e+0010.116111
GO:0005956protein kinase CK2 complex9.01e-041.00e+0010.116111
GO:0070262peptidyl-serine dephosphorylation9.01e-041.00e+0010.116111
GO:0000054ribosomal subunit export from nucleus9.01e-041.00e+0010.116111
GO:0019521D-gluconate metabolic process9.01e-041.00e+0010.116111
GO:0016032viral process1.02e-031.00e+003.055455534
GO:0000502proteasome complex1.20e-031.00e+005.25821758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.47e-031.00e+005.11621964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.51e-031.00e+005.09322265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.75e-031.00e+004.98622270
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.80e-031.00e+009.116112
GO:0002176male germ cell proliferation1.80e-031.00e+009.116112
GO:0019322pentose biosynthetic process1.80e-031.00e+009.116122
GO:0005055laminin receptor activity1.80e-031.00e+009.116112
GO:0006407rRNA export from nucleus1.80e-031.00e+009.116112
GO:0046294formaldehyde catabolic process1.80e-031.00e+009.116122
GO:0005654nucleoplasm1.82e-031.00e+002.3585761082
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.85e-031.00e+004.94622072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.95e-031.00e+004.90622274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I2.01e-031.00e+004.88722075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2.22e-031.00e+004.81222379
GO:0005850eukaryotic translation initiation factor 2 complex2.70e-031.00e+008.531113
GO:0018119peptidyl-cysteine S-nitrosylation2.70e-031.00e+008.531113
GO:0009051pentose-phosphate shunt, oxidative branch2.70e-031.00e+008.531123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.70e-031.00e+008.531113
GO:0002474antigen processing and presentation of peptide antigen via MHC class I3.00e-031.00e+004.59222192
GO:0006068ethanol catabolic process3.60e-031.00e+008.116114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.60e-031.00e+008.116114
GO:003068690S preribosome3.60e-031.00e+008.116114
GO:0031467Cul7-RING ubiquitin ligase complex3.60e-031.00e+008.116114
GO:0019788NEDD8 ligase activity3.60e-031.00e+008.116114
GO:0051409response to nitrosative stress3.60e-031.00e+008.116114
GO:0019887protein kinase regulator activity3.60e-031.00e+008.116114
GO:0061154endothelial tube morphogenesis4.50e-031.00e+007.794115
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.50e-031.00e+007.794135
GO:0031461cullin-RING ubiquitin ligase complex4.50e-031.00e+007.794115
GO:0019932second-messenger-mediated signaling4.50e-031.00e+007.794115
GO:0042256mature ribosome assembly4.50e-031.00e+007.794115
GO:0043248proteasome assembly4.50e-031.00e+007.794115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein4.50e-031.00e+007.794115
GO:0004022alcohol dehydrogenase (NAD) activity4.50e-031.00e+007.794115
GO:0030891VCB complex4.50e-031.00e+007.794125
GO:0000730DNA recombinase assembly4.50e-031.00e+007.794115
GO:2000001regulation of DNA damage checkpoint4.50e-031.00e+007.794115
GO:0005638lamin filament4.50e-031.00e+007.794115
GO:0043023ribosomal large subunit binding4.50e-031.00e+007.794115
GO:0051101regulation of DNA binding4.50e-031.00e+007.794115
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay4.56e-031.00e+004.283211114
GO:0000209protein polyubiquitination4.72e-031.00e+004.258220116
GO:0030957Tat protein binding5.40e-031.00e+007.531136
GO:0032927positive regulation of activin receptor signaling pathway5.40e-031.00e+007.531116
GO:0033211adiponectin-activated signaling pathway5.40e-031.00e+007.531116
GO:0031466Cul5-RING ubiquitin ligase complex5.40e-031.00e+007.531116
GO:0005634nucleus5.94e-031.00e+001.13191364559
GO:0000028ribosomal small subunit assembly6.29e-031.00e+007.308117
GO:0031462Cul2-RING ubiquitin ligase complex6.29e-031.00e+007.308127
GO:0019773proteasome core complex, alpha-subunit complex7.19e-031.00e+007.116148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.19e-031.00e+007.116128
GO:0003016respiratory system process7.19e-031.00e+007.116118
GO:0070688MLL5-L complex7.19e-031.00e+007.116118
GO:0045116protein neddylation7.19e-031.00e+007.116128
GO:0042981regulation of apoptotic process7.77e-031.00e+003.887224150
GO:0044267cellular protein metabolic process7.89e-031.00e+002.812329474
GO:0006098pentose-phosphate shunt8.98e-031.00e+006.7941410
GO:0010569regulation of double-strand break repair via homologous recombination8.98e-031.00e+006.7941110
GO:0007084mitotic nuclear envelope reassembly8.98e-031.00e+006.7941110
GO:0006069ethanol oxidation8.98e-031.00e+006.7941110
GO:0051775response to redox state8.98e-031.00e+006.7941110
GO:0031571mitotic G1 DNA damage checkpoint9.87e-031.00e+006.6561411
GO:0034641cellular nitrogen compound metabolic process1.00e-021.00e+003.698220171
GO:0031625ubiquitin protein ligase binding1.08e-021.00e+003.640214178
GO:0043537negative regulation of blood vessel endothelial cell migration1.08e-021.00e+006.5311112
GO:0006275regulation of DNA replication1.08e-021.00e+006.5311212
GO:0030111regulation of Wnt signaling pathway1.08e-021.00e+006.5311112
GO:0005838proteasome regulatory particle1.08e-021.00e+006.5311712
GO:0005515protein binding1.11e-021.00e+000.881101846024
GO:0006672ceramide metabolic process1.17e-021.00e+006.4151113
GO:0042273ribosomal large subunit biogenesis1.17e-021.00e+006.4151413
GO:0005662DNA replication factor A complex1.17e-021.00e+006.4151113
GO:0005504fatty acid binding1.17e-021.00e+006.4151113
GO:0006915apoptotic process1.21e-021.00e+002.584333555
GO:0035267NuA4 histone acetyltransferase complex1.26e-021.00e+006.3081414
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.34e-021.00e+006.2091215
GO:0043623cellular protein complex assembly1.34e-021.00e+006.2091115
GO:0050998nitric-oxide synthase binding1.43e-021.00e+006.1161116
GO:0045777positive regulation of blood pressure1.52e-021.00e+006.0281117
GO:0022624proteasome accessory complex1.52e-021.00e+006.0281817
GO:0035861site of double-strand break1.61e-021.00e+005.9461118
GO:0005839proteasome core complex1.61e-021.00e+005.9461818
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.70e-021.00e+005.8681119
GO:0048863stem cell differentiation1.70e-021.00e+005.8681119
GO:0004298threonine-type endopeptidase activity1.70e-021.00e+005.8681819
GO:0006412translation1.76e-021.00e+003.270220230
GO:0008601protein phosphatase type 2A regulator activity1.79e-021.00e+005.7941220
GO:0006298mismatch repair1.79e-021.00e+005.7941320
GO:0000159protein phosphatase type 2A complex1.79e-021.00e+005.7941220
GO:0032201telomere maintenance via semi-conservative replication1.88e-021.00e+005.7231521
GO:0045595regulation of cell differentiation1.88e-021.00e+005.7231121
GO:0000718nucleotide-excision repair, DNA damage removal1.88e-021.00e+005.7231421
GO:0006297nucleotide-excision repair, DNA gap filling1.97e-021.00e+005.6561322
GO:0003823antigen binding1.97e-021.00e+005.6561122
GO:0030863cortical cytoskeleton1.97e-021.00e+005.6561122
GO:0036464cytoplasmic ribonucleoprotein granule1.97e-021.00e+005.6561422
GO:0043044ATP-dependent chromatin remodeling2.05e-021.00e+005.5921423
GO:0031463Cul3-RING ubiquitin ligase complex2.05e-021.00e+005.5921323
GO:0043236laminin binding2.05e-021.00e+005.5921123
GO:0006513protein monoubiquitination2.05e-021.00e+005.5921123
GO:0008135translation factor activity, nucleic acid binding2.14e-021.00e+005.5311724
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation2.23e-021.00e+005.4721125
GO:0000722telomere maintenance via recombination2.23e-021.00e+005.4721525
GO:0006281DNA repair2.23e-021.00e+003.088218261
GO:0031519PcG protein complex2.23e-021.00e+005.4721425
GO:0045859regulation of protein kinase activity2.32e-021.00e+005.4151126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.32e-021.00e+005.4151326
GO:0010033response to organic substance2.41e-021.00e+005.3611227
GO:0050661NADP binding2.41e-021.00e+005.3611227
GO:0000188inactivation of MAPK activity2.41e-021.00e+005.3611127
GO:0031492nucleosomal DNA binding2.41e-021.00e+005.3611427
GO:0019894kinesin binding2.50e-021.00e+005.3081128
GO:0019005SCF ubiquitin ligase complex2.58e-021.00e+005.2581129
GO:0042254ribosome biogenesis2.67e-021.00e+005.2091130
GO:0006271DNA strand elongation involved in DNA replication2.67e-021.00e+005.2091730
GO:0001895retina homeostasis3.02e-021.00e+005.0281134
GO:0034332adherens junction organization3.20e-021.00e+004.9461136
GO:0007411axon guidance3.24e-021.00e+002.798213319
GO:0051084'de novo' posttranslational protein folding3.29e-021.00e+004.9061437
GO:0006284base-excision repair3.29e-021.00e+004.9061337
GO:0070527platelet aggregation3.37e-021.00e+004.8681238
GO:0022627cytosolic small ribosomal subunit3.46e-021.00e+004.8301439
GO:0000781chromosome, telomeric region3.46e-021.00e+004.8301339
GO:0004722protein serine/threonine phosphatase activity3.72e-021.00e+004.7231142
GO:0030155regulation of cell adhesion3.72e-021.00e+004.7231242
GO:0021762substantia nigra development3.90e-021.00e+004.6561244
GO:0006283transcription-coupled nucleotide-excision repair4.07e-021.00e+004.5921746
GO:0001523retinoid metabolic process4.24e-021.00e+004.5311248
GO:0003684damaged DNA binding4.33e-021.00e+004.5011749
GO:0000775chromosome, centromeric region4.42e-021.00e+004.4721250
GO:0040008regulation of growth4.42e-021.00e+004.4721550
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.68e-021.00e+004.3881553
GO:0045216cell-cell junction organization4.76e-021.00e+004.3611254
GO:0000932cytoplasmic mRNA processing body4.76e-021.00e+004.3611354
GO:0000724double-strand break repair via homologous recombination4.85e-021.00e+004.3341355
GO:0000723telomere maintenance4.93e-021.00e+004.3081656
GO:0043066negative regulation of apoptotic process5.43e-021.00e+002.388231424
GO:0019903protein phosphatase binding5.45e-021.00e+004.1611462
GO:0007059chromosome segregation5.45e-021.00e+004.1611462
GO:0006302double-strand break repair5.45e-021.00e+004.1611462
GO:0016020membrane5.55e-021.00e+001.4014901681
GO:0009055electron carrier activity5.71e-021.00e+004.0931165
GO:0006289nucleotide-excision repair5.96e-021.00e+004.02811168
GO:0034329cell junction assembly5.96e-021.00e+004.0281168
GO:0003697single-stranded DNA binding5.96e-021.00e+004.0281568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.47e-021.00e+003.9061674
GO:0008584male gonad development6.56e-021.00e+003.8871375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.56e-021.00e+003.8871275
GO:0019083viral transcription7.06e-021.00e+003.77611081
GO:0047485protein N-terminus binding7.48e-021.00e+003.6891586
GO:0006415translational termination7.57e-021.00e+003.67311087
GO:0016605PML body7.65e-021.00e+003.6561388
GO:0006928cellular component movement7.90e-021.00e+003.6081791
GO:0005200structural constituent of cytoskeleton7.90e-021.00e+003.6081891
GO:0071456cellular response to hypoxia7.99e-021.00e+003.5921692
GO:0006414translational elongation8.07e-021.00e+003.57611393
GO:0006470protein dephosphorylation8.49e-021.00e+003.5011198
GO:0044281small molecule metabolic process8.95e-021.00e+001.4593581211
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.98e-021.00e+003.415110104
GO:0014069postsynaptic density9.07e-021.00e+003.40113105
GO:0030308negative regulation of cell growth9.48e-021.00e+003.33416110
GO:0015630microtubule cytoskeleton9.48e-021.00e+003.33414110
GO:0006461protein complex assembly9.56e-021.00e+003.32116111
GO:0072562blood microparticle9.56e-021.00e+003.32113111
GO:0030529ribonucleoprotein complex9.64e-021.00e+003.30818112
GO:0019058viral life cycle9.89e-021.00e+003.270113115
GO:0007568aging1.01e-011.00e+003.24513117
GO:0006325chromatin organization1.01e-011.00e+003.23315118
GO:0007219Notch signaling pathway1.03e-011.00e+003.20915120
GO:0006260DNA replication1.04e-011.00e+003.19719121
GO:0032496response to lipopolysaccharide1.04e-011.00e+003.19714121
GO:0006511ubiquitin-dependent protein catabolic process1.08e-011.00e+003.13815126
GO:0009615response to virus1.08e-011.00e+003.13815126
GO:0000790nuclear chromatin1.10e-011.00e+003.10419129
GO:0000086G2/M transition of mitotic cell cycle1.16e-011.00e+003.02819136
GO:0003735structural constituent of ribosome1.17e-011.00e+003.018110137
GO:0016055Wnt signaling pathway1.18e-011.00e+003.00717138
GO:0006457protein folding1.22e-011.00e+002.95617143
GO:0061024membrane organization1.23e-011.00e+002.93617145
GO:0008543fibroblast growth factor receptor signaling pathway1.32e-011.00e+002.83019156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.39e-011.00e+002.74917165
GO:0030424axon1.40e-011.00e+002.74114166
GO:0019904protein domain specific binding1.50e-011.00e+002.63216179
GO:0032403protein complex binding1.53e-011.00e+002.600110183
GO:0001701in utero embryonic development1.67e-011.00e+002.46518201
GO:0005730nucleolus1.77e-011.00e+001.0203691641
GO:0008380RNA splicing1.87e-011.00e+002.283111228
GO:0008134transcription factor binding1.98e-011.00e+002.19718242
GO:0005975carbohydrate metabolic process2.06e-011.00e+002.13319253
GO:0004842ubiquitin-protein transferase activity2.07e-011.00e+002.12116255
GO:0005102receptor binding2.11e-011.00e+002.09316260
GO:0019899enzyme binding2.23e-011.00e+002.002112277
GO:0008270zinc ion binding2.25e-011.00e+001.154212997
GO:0005739mitochondrion2.26e-011.00e+001.153228998
GO:0005856cytoskeleton2.33e-011.00e+001.931112291
GO:0043234protein complex2.36e-011.00e+001.911118295
GO:0016567protein ubiquitination2.36e-011.00e+001.91115295
GO:0004674protein serine/threonine kinase activity2.45e-011.00e+001.849112308
GO:0044822poly(A) RNA binding2.46e-011.00e+001.0712491056
GO:0019901protein kinase binding2.51e-011.00e+001.807121317
GO:0003723RNA binding2.68e-011.00e+001.698120342
GO:0008285negative regulation of cell proliferation2.75e-011.00e+001.652111353
GO:0005925focal adhesion2.84e-011.00e+001.600119366
GO:0007155cell adhesion2.86e-011.00e+001.58816369
GO:0046982protein heterodimerization activity2.93e-011.00e+001.546113380
GO:0055114oxidation-reduction process3.19e-011.00e+001.401112420
GO:0046872metal ion binding3.32e-011.00e+000.7642251307
GO:0007596blood coagulation3.41e-011.00e+001.286118455
GO:0006468protein phosphorylation3.44e-011.00e+001.270118460
GO:0042802identical protein binding3.58e-011.00e+001.197120484
GO:0042803protein homodimerization activity4.22e-011.00e+000.899112595
GO:0045087innate immune response4.22e-011.00e+000.896124596
GO:0005737cytoplasm4.53e-011.00e+000.23641103767
GO:0007165signal transduction5.70e-011.00e+000.291124907
GO:0005615extracellular space5.91e-011.00e+000.213117957
GO:0006355regulation of transcription, DNA-templated6.06e-011.00e+000.154118997
GO:0005886plasma membrane7.05e-011.00e+00-0.2192452582
GO:0005524ATP binding7.07e-011.00e+00-0.2261601298