int-snw-1455

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.994 6.85e-18 6.35e-04 1.46e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-1455 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ADH5 128 50.6330.99443Yes-
RPA2 6118 981.2501.15169Yes-
[ CSNK1G2 ] 1455 1-0.0840.99490--
RSL24D1 51187 361.3001.02059Yes-
PSMA3 5684 120.5331.026218Yes-
EIF2S2 8894 271.0751.13881Yes-
RBX1 9978 971.1851.151139Yes-
DDX18 8886 90.6601.013173Yes-
PSMA2 5683 601.0931.10689Yes-
CLTC 1213 350.8841.138247Yes-
HNRNPC 3183 201.8121.026119Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
LPIN3 64900 1-0.6250.99439-Yes
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (23)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CLTC 1213 EIF2S2 8894 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA2 5683 PSMA3 5684 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BIND_Yeast, HPRD;
int.HPRD: yeast 2-hybrid
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
CSNK1G2 1455 PSMA3 5684 pp -- int.I2D: BioGrid_Yeast, Yeast_Kinome
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMA3 5684 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ADH5 128 DDX18 8886 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast
ACTB 60 CLTC 1213 pp -- int.I2D: IntAct_Yeast
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CSNK1G2 1455 pp -- int.I2D: BioGrid_Yeast
CSNK1G2 1455 LPIN3 64900 pp -- int.I2D: BioGrid_Yeast, Yeast_Kinome
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CLTC 1213 CSNK1G2 1455 pp -- int.I2D: BioGrid_Yeast
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
ADH5 128 CSNK1G2 1455 pp -- int.I2D: BioGrid_Yeast
PSMD11 5717 DDX18 8886 pp -- int.I2D: YeastLow
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
CSNK1G2 1455 DDX18 8886 pp -- int.I2D: BioGrid_Yeast, Yeast_Kinome
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast

Related GO terms (238)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005829cytosol7.58e-061.09e-011.990111322496
GO:0000082G1/S transition of mitotic cell cycle1.81e-052.61e-014.597432149
GO:0006521regulation of cellular amino acid metabolic process2.13e-053.07e-015.75731750
GO:0019773proteasome core complex, alpha-subunit complex3.22e-054.64e-017.816248
GO:0000502proteasome complex3.33e-054.80e-015.54331758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.48e-056.46e-015.40131964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.69e-056.77e-015.37932265
GO:0010467gene expression5.23e-057.54e-013.015659669
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.86e-058.45e-015.27232270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.38e-059.20e-015.23132072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.92e-059.98e-015.19232274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.20e-051.00e+005.17232075
GO:0005654nucleoplasm8.21e-051.00e+002.5447761082
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.41e-051.00e+005.09732379
GO:0016071mRNA metabolic process8.75e-051.00e+004.015431223
GO:0016070RNA metabolic process1.30e-041.00e+003.868432247
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.32e-041.00e+004.87732192
GO:0005839proteasome core complex1.75e-041.00e+006.6462818
GO:0004298threonine-type endopeptidase activity1.95e-041.00e+006.5682819
GO:0016032viral process2.12e-041.00e+003.077555534
GO:0000209protein polyubiquitination2.63e-041.00e+004.543320116
GO:0043044ATP-dependent chromatin remodeling2.88e-041.00e+006.2932423
GO:0070062extracellular vesicular exosome3.59e-041.00e+001.75791042400
GO:0031492nucleosomal DNA binding3.98e-041.00e+006.0612427
GO:0042981regulation of apoptotic process5.59e-041.00e+004.172324150
GO:0000278mitotic cell cycle7.47e-041.00e+003.205448391
GO:0034641cellular nitrogen compound metabolic process8.19e-041.00e+003.983320171
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity1.11e-031.00e+009.816111
GO:0018467formaldehyde dehydrogenase activity1.11e-031.00e+009.816111
GO:0019521D-gluconate metabolic process1.11e-031.00e+009.816111
GO:0016020membrane1.27e-031.00e+001.9087901681
GO:0044281small molecule metabolic process1.33e-031.00e+002.1596581211
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.54e-031.00e+005.0882553
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816112
GO:0002176male germ cell proliferation2.22e-031.00e+008.816112
GO:0019322pentose biosynthetic process2.22e-031.00e+008.816122
GO:0005055laminin receptor activity2.22e-031.00e+008.816112
GO:0006407rRNA export from nucleus2.22e-031.00e+008.816112
GO:0046294formaldehyde catabolic process2.22e-031.00e+008.816122
GO:0005850eukaryotic translation initiation factor 2 complex3.32e-031.00e+008.231113
GO:1900126negative regulation of hyaluronan biosynthetic process3.32e-031.00e+008.231123
GO:0018119peptidyl-cysteine S-nitrosylation3.32e-031.00e+008.231113
GO:0009051pentose-phosphate shunt, oxidative branch3.32e-031.00e+008.231123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity3.32e-031.00e+008.231113
GO:0071439clathrin complex3.32e-031.00e+008.231123
GO:0043234protein complex3.89e-031.00e+003.196318295
GO:0006068ethanol catabolic process4.43e-031.00e+007.816114
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.43e-031.00e+007.816114
GO:003068690S preribosome4.43e-031.00e+007.816114
GO:0032051clathrin light chain binding4.43e-031.00e+007.816114
GO:0031467Cul7-RING ubiquitin ligase complex4.43e-031.00e+007.816114
GO:0019788NEDD8 ligase activity4.43e-031.00e+007.816114
GO:0051409response to nitrosative stress4.43e-031.00e+007.816114
GO:1903077negative regulation of protein localization to plasma membrane4.43e-031.00e+007.816114
GO:0001649osteoblast differentiation4.56e-031.00e+004.2932692
GO:0044822poly(A) RNA binding4.60e-031.00e+002.0945491056
GO:0031465Cul4B-RING E3 ubiquitin ligase complex5.54e-031.00e+007.494135
GO:0031461cullin-RING ubiquitin ligase complex5.54e-031.00e+007.494115
GO:0043248proteasome assembly5.54e-031.00e+007.494115
GO:0004022alcohol dehydrogenase (NAD) activity5.54e-031.00e+007.494115
GO:0030891VCB complex5.54e-031.00e+007.494125
GO:0000730DNA recombinase assembly5.54e-031.00e+007.494115
GO:2000001regulation of DNA damage checkpoint5.54e-031.00e+007.494115
GO:0030130clathrin coat of trans-Golgi network vesicle6.64e-031.00e+007.231136
GO:0030957Tat protein binding6.64e-031.00e+007.231136
GO:0030118clathrin coat6.64e-031.00e+007.231126
GO:0031466Cul5-RING ubiquitin ligase complex6.64e-031.00e+007.231116
GO:0005515protein binding7.39e-031.00e+000.845121846024
GO:0030132clathrin coat of coated pit7.74e-031.00e+007.009127
GO:0000028ribosomal small subunit assembly7.74e-031.00e+007.009117
GO:0031462Cul2-RING ubiquitin ligase complex7.74e-031.00e+007.009127
GO:0000790nuclear chromatin8.78e-031.00e+003.80529129
GO:0031464Cul4A-RING E3 ubiquitin ligase complex8.84e-031.00e+006.816128
GO:0003016respiratory system process8.84e-031.00e+006.816118
GO:0070688MLL5-L complex8.84e-031.00e+006.816118
GO:0045116protein neddylation8.84e-031.00e+006.816128
GO:0006413translational initiation9.04e-031.00e+003.783217131
GO:0008195phosphatidate phosphatase activity9.94e-031.00e+006.646119
GO:0043066negative regulation of apoptotic process1.06e-021.00e+002.673331424
GO:0006098pentose-phosphate shunt1.10e-021.00e+006.4941410
GO:0061024membrane organization1.10e-021.00e+003.63627145
GO:0010569regulation of double-strand break repair via homologous recombination1.10e-021.00e+006.4941110
GO:0006069ethanol oxidation1.10e-021.00e+006.4941110
GO:0051775response to redox state1.10e-021.00e+006.4941110
GO:0031571mitotic G1 DNA damage checkpoint1.21e-021.00e+006.3571411
GO:0045120pronucleus1.21e-021.00e+006.3571211
GO:0006646phosphatidylethanolamine biosynthetic process1.32e-021.00e+006.2311212
GO:00709353'-UTR-mediated mRNA stabilization1.32e-021.00e+006.2311212
GO:0005838proteasome regulatory particle1.32e-021.00e+006.2311712
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.41e-021.00e+003.45027165
GO:0005662DNA replication factor A complex1.43e-021.00e+006.1161113
GO:0005504fatty acid binding1.43e-021.00e+006.1161113
GO:0008266poly(U) RNA binding1.43e-021.00e+006.1161113
GO:0044267cellular protein metabolic process1.44e-021.00e+002.512329474
GO:0035267NuA4 histone acetyltransferase complex1.54e-021.00e+006.0091414
GO:0031625ubiquitin protein ligase binding1.62e-021.00e+003.340214178
GO:0050998nitric-oxide synthase binding1.76e-021.00e+005.8161116
GO:0045777positive regulation of blood pressure1.87e-021.00e+005.7291117
GO:0022624proteasome accessory complex1.87e-021.00e+005.7291817
GO:0035861site of double-strand break1.98e-021.00e+005.6461118
GO:0004004ATP-dependent RNA helicase activity1.98e-021.00e+005.6461218
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.09e-021.00e+005.5681119
GO:0048863stem cell differentiation2.09e-021.00e+005.5681119
GO:0006915apoptotic process2.18e-021.00e+002.285333555
GO:0006298mismatch repair2.20e-021.00e+005.4941320
GO:0032201telomere maintenance via semi-conservative replication2.31e-021.00e+005.4241521
GO:0000718nucleotide-excision repair, DNA damage removal2.31e-021.00e+005.4241421
GO:0006297nucleotide-excision repair, DNA gap filling2.41e-021.00e+005.3571322
GO:0006656phosphatidylcholine biosynthetic process2.41e-021.00e+005.3571222
GO:0030863cortical cytoskeleton2.41e-021.00e+005.3571122
GO:0036464cytoplasmic ribonucleoprotein granule2.41e-021.00e+005.3571422
GO:0031463Cul3-RING ubiquitin ligase complex2.52e-021.00e+005.2931323
GO:0043236laminin binding2.52e-021.00e+005.2931123
GO:0006513protein monoubiquitination2.52e-021.00e+005.2931123
GO:0006412translation2.62e-021.00e+002.971220230
GO:0008135translation factor activity, nucleic acid binding2.63e-021.00e+005.2311724
GO:0000722telomere maintenance via recombination2.74e-021.00e+005.1721525
GO:0030148sphingolipid biosynthetic process2.85e-021.00e+005.1161226
GO:0003730mRNA 3'-UTR binding2.85e-021.00e+005.1161226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.85e-021.00e+005.1161326
GO:0043022ribosome binding2.96e-021.00e+005.0611327
GO:0050661NADP binding2.96e-021.00e+005.0611227
GO:0030669clathrin-coated endocytic vesicle membrane3.06e-021.00e+005.0091428
GO:0019894kinesin binding3.06e-021.00e+005.0091128
GO:0019005SCF ubiquitin ligase complex3.17e-021.00e+004.9581129
GO:0042254ribosome biogenesis3.28e-021.00e+004.9091130
GO:0033572transferrin transport3.28e-021.00e+004.9091530
GO:0006271DNA strand elongation involved in DNA replication3.28e-021.00e+004.9091730
GO:0006281DNA repair3.31e-021.00e+002.788218261
GO:0031623receptor internalization3.39e-021.00e+004.8621231
GO:0051219phosphoprotein binding3.49e-021.00e+004.8161232
GO:0005634nucleus3.58e-021.00e+000.83291364559
GO:0032588trans-Golgi network membrane3.71e-021.00e+004.7291234
GO:0001895retina homeostasis3.71e-021.00e+004.7291134
GO:0042277peptide binding3.81e-021.00e+004.6871335
GO:0034332adherens junction organization3.92e-021.00e+004.6461136
GO:0051084'de novo' posttranslational protein folding4.03e-021.00e+004.6071437
GO:0006284base-excision repair4.03e-021.00e+004.6071337
GO:0070527platelet aggregation4.14e-021.00e+004.5681238
GO:0022627cytosolic small ribosomal subunit4.24e-021.00e+004.5311439
GO:0000781chromosome, telomeric region4.24e-021.00e+004.5311339
GO:0006631fatty acid metabolic process4.35e-021.00e+004.4941140
GO:0030136clathrin-coated vesicle4.56e-021.00e+004.4241442
GO:0006892post-Golgi vesicle-mediated transport4.67e-021.00e+004.3901343
GO:0019901protein kinase binding4.72e-021.00e+002.508221317
GO:0021762substantia nigra development4.77e-021.00e+004.3571244
GO:0006283transcription-coupled nucleotide-excision repair4.99e-021.00e+004.2931746
GO:0001523retinoid metabolic process5.20e-021.00e+004.2311248
GO:0003743translation initiation factor activity5.30e-021.00e+004.2011849
GO:0003684damaged DNA binding5.30e-021.00e+004.2011749
GO:0003723RNA binding5.41e-021.00e+002.398220342
GO:0001948glycoprotein binding5.41e-021.00e+004.1721350
GO:0003725double-stranded RNA binding5.62e-021.00e+004.1161552
GO:0045216cell-cell junction organization5.83e-021.00e+004.0611254
GO:0000932cytoplasmic mRNA processing body5.83e-021.00e+004.0611354
GO:0000724double-strand break repair via homologous recombination5.93e-021.00e+004.0351355
GO:0000723telomere maintenance6.04e-021.00e+004.0091656
GO:0005925focal adhesion6.10e-021.00e+002.300219366
GO:0006665sphingolipid metabolic process6.46e-021.00e+003.9091360
GO:0019903protein phosphatase binding6.66e-021.00e+003.8621462
GO:0006302double-strand break repair6.66e-021.00e+003.8621462
GO:0009055electron carrier activity6.98e-021.00e+003.7941165
GO:0006289nucleotide-excision repair7.29e-021.00e+003.72911168
GO:0034329cell junction assembly7.29e-021.00e+003.7291168
GO:0003697single-stranded DNA binding7.29e-021.00e+003.7291568
GO:0046474glycerophospholipid biosynthetic process7.49e-021.00e+003.6871470
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis7.90e-021.00e+003.6071674
GO:0008584male gonad development8.01e-021.00e+003.5871375
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process8.01e-021.00e+003.5871275
GO:0071013catalytic step 2 spliceosome8.31e-021.00e+003.5311478
GO:0019083viral transcription8.62e-021.00e+003.47611081
GO:0005681spliceosomal complex8.82e-021.00e+003.4411483
GO:0006898receptor-mediated endocytosis8.93e-021.00e+003.4241384
GO:0016311dephosphorylation9.03e-021.00e+003.4071385
GO:0047485protein N-terminus binding9.13e-021.00e+003.3901586
GO:0006415translational termination9.23e-021.00e+003.37311087
GO:0016605PML body9.33e-021.00e+003.3571388
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II9.53e-021.00e+003.3241790
GO:0042470melanosome9.64e-021.00e+003.3081991
GO:0006928cellular component movement9.64e-021.00e+003.3081791
GO:0005200structural constituent of cytoskeleton9.64e-021.00e+003.3081891
GO:0071456cellular response to hypoxia9.74e-021.00e+003.2931692
GO:0006414translational elongation9.84e-021.00e+003.27711393
GO:0005730nucleolus9.98e-021.00e+001.1364691641
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.09e-011.00e+003.116110104
GO:0014069postsynaptic density1.10e-011.00e+003.10213105
GO:0072562blood microparticle1.16e-011.00e+003.02213111
GO:0030529ribonucleoprotein complex1.17e-011.00e+003.00918112
GO:0005819spindle1.17e-011.00e+003.00917112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.19e-011.00e+002.983111114
GO:0019058viral life cycle1.20e-011.00e+002.971113115
GO:0007568aging1.22e-011.00e+002.94613117
GO:0006325chromatin organization1.23e-011.00e+002.93315118
GO:0007219Notch signaling pathway1.25e-011.00e+002.90915120
GO:0006260DNA replication1.26e-011.00e+002.89719121
GO:0032496response to lipopolysaccharide1.26e-011.00e+002.89714121
GO:0006511ubiquitin-dependent protein catabolic process1.31e-011.00e+002.83915126
GO:0009615response to virus1.31e-011.00e+002.83915126
GO:0006644phospholipid metabolic process1.34e-011.00e+002.80515129
GO:0031982vesicle1.36e-011.00e+002.78319131
GO:0003735structural constituent of ribosome1.42e-011.00e+002.718110137
GO:0016055Wnt signaling pathway1.43e-011.00e+002.70817138
GO:0006457protein folding1.47e-011.00e+002.65617143
GO:0005198structural molecule activity1.54e-011.00e+002.58715150
GO:0046777protein autophosphorylation1.62e-011.00e+002.51217158
GO:0000287magnesium ion binding1.67e-011.00e+002.45914164
GO:0000398mRNA splicing, via spliceosome1.67e-011.00e+002.45918164
GO:0005524ATP binding1.69e-011.00e+001.0593601298
GO:0030424axon1.69e-011.00e+002.44114166
GO:0006886intracellular protein transport1.74e-011.00e+002.39815171
GO:0032403protein complex binding1.85e-011.00e+002.300110183
GO:0001701in utero embryonic development2.01e-011.00e+002.16518201
GO:0007067mitotic nuclear division2.24e-011.00e+001.990114227
GO:0008380RNA splicing2.25e-011.00e+001.983111228
GO:0005975carbohydrate metabolic process2.47e-011.00e+001.83319253
GO:0004842ubiquitin-protein transferase activity2.48e-011.00e+001.82216255
GO:0000166nucleotide binding2.52e-011.00e+001.79915259
GO:0019899enzyme binding2.67e-011.00e+001.702112277
GO:0005856cytoskeleton2.78e-011.00e+001.631112291
GO:0006200ATP catabolic process2.79e-011.00e+001.626115292
GO:0016567protein ubiquitination2.82e-011.00e+001.61215295
GO:0004674protein serine/threonine kinase activity2.92e-011.00e+001.549112308
GO:0007411axon guidance3.01e-011.00e+001.499113319
GO:0008270zinc ion binding3.04e-011.00e+000.855212997
GO:0007155cell adhesion3.40e-011.00e+001.28916369
GO:0055114oxidation-reduction process3.77e-011.00e+001.102112420
GO:0007596blood coagulation4.01e-011.00e+000.986118455
GO:0006468protein phosphorylation4.05e-011.00e+000.971118460
GO:0042802identical protein binding4.21e-011.00e+000.897120484
GO:0005789endoplasmic reticulum membrane4.76e-011.00e+000.661116570
GO:0042803protein homodimerization activity4.91e-011.00e+000.599112595
GO:0045087innate immune response4.91e-011.00e+000.597124596
GO:0005737cytoplasm6.34e-011.00e+00-0.06341103767
GO:0007165signal transduction6.46e-011.00e+00-0.009124907
GO:0005615extracellular space6.67e-011.00e+00-0.086117957
GO:0005739mitochondrion6.83e-011.00e+00-0.147128998
GO:0046872metal ion binding7.81e-011.00e+00-0.5361251307
GO:0005886plasma membrane8.09e-011.00e+00-0.5182452582