int-snw-1073

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.020 5.60e-19 3.35e-04 8.94e-03
wolf-screen-ratio-mammosphere-adherent-int-snw-1073 subnetwork

Genes (15)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
RSL24D1 51187 361.3001.02059Yes-
ACO2 50 501.0001.076191Yes-
CDC16 8881 250.9501.02080Yes-
RBX1 9978 971.1851.151139Yes-
PSMD3 5709 570.9861.106146Yes-
PSMB7 5695 480.9821.05257Yes-
PSMA1 5682 610.9961.052123Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
HSPD1 3329 350.9131.035286Yes-
CFL1 1072 120.6741.020203Yes-
[ CFL2 ] 1073 10.2901.0209Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (28)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CFL1 1072 CFL2 1073 pp -- int.I2D: MINT
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 CFL2 1073 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid, HPRD, IntAct, MINT, VidalHuman_core, INNATEDB;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACO2 50 CFL1 1072 pp -- int.I2D: YeastLow
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
HSPD1 3329 RPSA 3921 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
ACO2 50 HSPD1 3329 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 HSPD1 3329 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, YeastLow

Related GO terms (246)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.61e-096.65e-056.20952265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.73e-099.71e-056.10252270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle8.94e-091.29e-046.02252274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.25e-081.80e-045.92752379
GO:0006521regulation of cellular amino acid metabolic process1.70e-072.45e-036.26541750
GO:0000082G1/S transition of mitotic cell cycle3.04e-074.38e-035.012532149
GO:0000502proteasome complex3.11e-074.48e-036.05141758
GO:0016032viral process4.56e-076.57e-033.656755534
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.64e-076.69e-035.90941964
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent7.47e-071.08e-025.73942072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I8.81e-071.27e-025.68042075
GO:0000278mitotic cell cycle1.55e-062.24e-023.883648391
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.01e-062.89e-025.38642192
GO:0016071mRNA metabolic process2.24e-063.23e-024.430531223
GO:0043066negative regulation of apoptotic process2.49e-063.59e-023.766631424
GO:0016070RNA metabolic process3.69e-065.33e-024.283532247
GO:0005654nucleoplasm3.91e-065.63e-022.8308761082
GO:0000209protein polyubiquitination5.06e-067.30e-025.051420116
GO:0042981regulation of apoptotic process1.40e-052.02e-014.680424150
GO:0030836positive regulation of actin filament depolymerization1.51e-052.18e-018.324226
GO:0070062extracellular vesicular exosome2.13e-053.07e-012.002101042400
GO:0034641cellular nitrogen compound metabolic process2.35e-053.39e-014.491420171
GO:0030042actin filament depolymerization2.82e-054.06e-017.909228
GO:0005829cytosol3.05e-054.39e-011.946101322496
GO:0061001regulation of dendritic spine morphogenesis5.52e-057.97e-017.4502211
GO:0005838proteasome regulatory particle6.62e-059.55e-017.3242712
GO:0022624proteasome accessory complex1.36e-041.00e+006.8222817
GO:0005839proteasome core complex1.53e-041.00e+006.7392818
GO:0004298threonine-type endopeptidase activity1.71e-041.00e+006.6612819
GO:0010467gene expression4.31e-041.00e+002.845559669
GO:0044281small molecule metabolic process8.92e-041.00e+002.2526581211
GO:0002842positive regulation of T cell mediated immune response to tumor cell1.04e-031.00e+009.909111
GO:0048291isotype switching to IgG isotypes1.04e-031.00e+009.909111
GO:0019521D-gluconate metabolic process1.04e-031.00e+009.909111
GO:0002368B cell cytokine production1.04e-031.00e+009.909111
GO:00515383 iron, 4 sulfur cluster binding2.08e-031.00e+008.909112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.08e-031.00e+008.909112
GO:0019322pentose biosynthetic process2.08e-031.00e+008.909122
GO:0003994aconitate hydratase activity2.08e-031.00e+008.909112
GO:0005055laminin receptor activity2.08e-031.00e+008.909112
GO:0006407rRNA export from nucleus2.08e-031.00e+008.909112
GO:0006915apoptotic process2.11e-031.00e+002.793433555
GO:0003697single-stranded DNA binding2.21e-031.00e+004.8222568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis2.61e-031.00e+004.7002674
GO:0001842neural fold formation3.12e-031.00e+008.324113
GO:0006458'de novo' protein folding3.12e-031.00e+008.324113
GO:0009051pentose-phosphate shunt, oxidative branch3.12e-031.00e+008.324123
GO:0030135coated vesicle3.12e-031.00e+008.324113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity3.12e-031.00e+008.324113
GO:0016363nuclear matrix3.92e-031.00e+004.40121291
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.15e-031.00e+007.909114
GO:003068690S preribosome4.15e-031.00e+007.909114
GO:0031467Cul7-RING ubiquitin ligase complex4.15e-031.00e+007.909114
GO:0019788NEDD8 ligase activity4.15e-031.00e+007.909114
GO:0016020membrane4.89e-031.00e+001.7796901681
GO:0031465Cul4B-RING E3 ubiquitin ligase complex5.19e-031.00e+007.587135
GO:0031461cullin-RING ubiquitin ligase complex5.19e-031.00e+007.587115
GO:0043248proteasome assembly5.19e-031.00e+007.587115
GO:0046696lipopolysaccharide receptor complex5.19e-031.00e+007.587115
GO:0006102isocitrate metabolic process5.19e-031.00e+007.587115
GO:0030891VCB complex5.19e-031.00e+007.587125
GO:0000730DNA recombinase assembly5.19e-031.00e+007.587115
GO:2000001regulation of DNA damage checkpoint5.19e-031.00e+007.587115
GO:0003688DNA replication origin binding6.22e-031.00e+007.324126
GO:0030957Tat protein binding6.22e-031.00e+007.324136
GO:0019907cyclin-dependent protein kinase activating kinase holoenzyme complex6.22e-031.00e+007.324116
GO:0006101citrate metabolic process6.22e-031.00e+007.324116
GO:0031466Cul5-RING ubiquitin ligase complex6.22e-031.00e+007.324116
GO:0000028ribosomal small subunit assembly7.26e-031.00e+007.102117
GO:0031462Cul2-RING ubiquitin ligase complex7.26e-031.00e+007.102127
GO:0019773proteasome core complex, alpha-subunit complex8.29e-031.00e+006.909148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex8.29e-031.00e+006.909128
GO:0070688MLL5-L complex8.29e-031.00e+006.909118
GO:0045116protein neddylation8.29e-031.00e+006.909128
GO:0051604protein maturation8.29e-031.00e+006.909118
GO:0006098pentose-phosphate shunt1.04e-021.00e+006.5871410
GO:0010569regulation of double-strand break repair via homologous recombination1.04e-021.00e+006.5871110
GO:0043032positive regulation of macrophage activation1.04e-021.00e+006.5871110
GO:0032727positive regulation of interferon-alpha production1.14e-021.00e+006.4501111
GO:0031571mitotic G1 DNA damage checkpoint1.14e-021.00e+006.4501411
GO:0005662DNA replication factor A complex1.34e-021.00e+006.2091113
GO:0030234enzyme regulator activity1.34e-021.00e+006.2091313
GO:0001530lipopolysaccharide binding1.34e-021.00e+006.2091313
GO:0051131chaperone-mediated protein complex assembly1.34e-021.00e+006.2091113
GO:0005515protein binding1.35e-021.00e+000.812111846024
GO:0031625ubiquitin protein ligase binding1.43e-021.00e+003.433214178
GO:0035267NuA4 histone acetyltransferase complex1.45e-021.00e+006.1021414
GO:0005615extracellular space1.46e-021.00e+002.007417957
GO:0042026protein refolding1.55e-021.00e+006.0021215
GO:0050998nitric-oxide synthase binding1.65e-021.00e+005.9091116
GO:0046716muscle cell cellular homeostasis1.65e-021.00e+005.9091116
GO:0042176regulation of protein catabolic process1.65e-021.00e+005.9091316
GO:0031258lamellipodium membrane1.65e-021.00e+005.9091216
GO:0022604regulation of cell morphogenesis1.65e-021.00e+005.9091116
GO:0050870positive regulation of T cell activation1.75e-021.00e+005.8221117
GO:0031674I band1.86e-021.00e+005.7391118
GO:0007088regulation of mitosis1.86e-021.00e+005.7391118
GO:0035861site of double-strand break1.86e-021.00e+005.7391118
GO:0032733positive regulation of interleukin-10 production1.96e-021.00e+005.6611119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.96e-021.00e+005.6611119
GO:0048863stem cell differentiation1.96e-021.00e+005.6611119
GO:0005680anaphase-promoting complex2.06e-021.00e+005.5871420
GO:0006298mismatch repair2.06e-021.00e+005.5871320
GO:0005730nucleolus2.14e-021.00e+001.5515691641
GO:0042100B cell proliferation2.16e-021.00e+005.5171121
GO:0032201telomere maintenance via semi-conservative replication2.16e-021.00e+005.5171521
GO:0030010establishment of cell polarity2.16e-021.00e+005.5171221
GO:0000281mitotic cytokinesis2.16e-021.00e+005.5171121
GO:0000718nucleotide-excision repair, DNA damage removal2.16e-021.00e+005.5171421
GO:0005634nucleus2.17e-021.00e+000.92591364559
GO:0006297nucleotide-excision repair, DNA gap filling2.26e-021.00e+005.4501322
GO:0030863cortical cytoskeleton2.26e-021.00e+005.4501122
GO:0036464cytoplasmic ribonucleoprotein granule2.26e-021.00e+005.4501422
GO:0005759mitochondrial matrix2.28e-021.00e+003.076214228
GO:0043044ATP-dependent chromatin remodeling2.37e-021.00e+005.3861423
GO:0005844polysome2.37e-021.00e+005.3861423
GO:0030864cortical actin cytoskeleton2.37e-021.00e+005.3861123
GO:0031463Cul3-RING ubiquitin ligase complex2.37e-021.00e+005.3861323
GO:0043236laminin binding2.37e-021.00e+005.3861123
GO:0043200response to amino acid2.37e-021.00e+005.3861123
GO:0006513protein monoubiquitination2.37e-021.00e+005.3861123
GO:0000722telomere maintenance via recombination2.57e-021.00e+005.2651525
GO:0042113B cell activation2.57e-021.00e+005.2651225
GO:0032735positive regulation of interleukin-12 production2.57e-021.00e+005.2651125
GO:0070979protein K11-linked ubiquitination2.67e-021.00e+005.2091626
GO:0045214sarcomere organization2.67e-021.00e+005.2091126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.67e-021.00e+005.2091326
GO:0043022ribosome binding2.77e-021.00e+005.1541327
GO:0050661NADP binding2.77e-021.00e+005.1541227
GO:0031492nucleosomal DNA binding2.77e-021.00e+005.1541427
GO:0001755neural crest cell migration2.87e-021.00e+005.1021228
GO:0006099tricarboxylic acid cycle2.87e-021.00e+005.1021428
GO:0019894kinesin binding2.87e-021.00e+005.1021128
GO:0006281DNA repair2.93e-021.00e+002.881218261
GO:0019005SCF ubiquitin ligase complex2.98e-021.00e+005.0511129
GO:0003779actin binding3.04e-021.00e+002.854212266
GO:0042254ribosome biogenesis3.08e-021.00e+005.0021130
GO:0006271DNA strand elongation involved in DNA replication3.08e-021.00e+005.0021730
GO:0007094mitotic spindle assembly checkpoint3.18e-021.00e+004.9551431
GO:0001895retina homeostasis3.48e-021.00e+004.8221134
GO:0005876spindle microtubule3.48e-021.00e+004.8221234
GO:00515394 iron, 4 sulfur cluster binding3.58e-021.00e+004.7801335
GO:0043234protein complex3.67e-021.00e+002.705218295
GO:0034332adherens junction organization3.68e-021.00e+004.7391136
GO:0032755positive regulation of interleukin-6 production3.68e-021.00e+004.7391236
GO:0051084'de novo' posttranslational protein folding3.78e-021.00e+004.7001437
GO:0006284base-excision repair3.78e-021.00e+004.7001337
GO:0070527platelet aggregation3.88e-021.00e+004.6611238
GO:0032729positive regulation of interferon-gamma production3.98e-021.00e+004.6241239
GO:0022627cytosolic small ribosomal subunit3.98e-021.00e+004.6241439
GO:0000781chromosome, telomeric region3.98e-021.00e+004.6241339
GO:0007411axon guidance4.24e-021.00e+002.592213319
GO:0042110T cell activation4.28e-021.00e+004.5171342
GO:0005813centrosome4.41e-021.00e+002.560214326
GO:0021762substantia nigra development4.48e-021.00e+004.4501244
GO:0006283transcription-coupled nucleotide-excision repair4.68e-021.00e+004.3861746
GO:0007266Rho protein signal transduction4.78e-021.00e+004.3551247
GO:0003684damaged DNA binding4.98e-021.00e+004.2941749
GO:0006091generation of precursor metabolites and energy5.08e-021.00e+004.2651350
GO:0006986response to unfolded protein5.08e-021.00e+004.2651250
GO:0005905coated pit5.08e-021.00e+004.2651350
GO:0003725double-stranded RNA binding5.28e-021.00e+004.2091552
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.38e-021.00e+004.1811553
GO:0005925focal adhesion5.42e-021.00e+002.393219366
GO:0045216cell-cell junction organization5.47e-021.00e+004.1541254
GO:0000724double-strand break repair via homologous recombination5.57e-021.00e+004.1281355
GO:0002039p53 binding5.57e-021.00e+004.1281755
GO:0000723telomere maintenance5.67e-021.00e+004.1021656
GO:0051087chaperone binding5.97e-021.00e+004.0271659
GO:0019903protein phosphatase binding6.26e-021.00e+003.9551462
GO:0006302double-strand break repair6.26e-021.00e+003.9551462
GO:0030141secretory granule6.26e-021.00e+003.9551262
GO:0006289nucleotide-excision repair6.85e-021.00e+003.82211168
GO:0034329cell junction assembly6.85e-021.00e+003.8221168
GO:0032587ruffle membrane7.04e-021.00e+003.7801370
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.53e-021.00e+003.6801275
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process7.72e-021.00e+003.6421777
GO:0007596blood coagulation7.95e-021.00e+002.079218455
GO:0002755MyD88-dependent toll-like receptor signaling pathway8.01e-021.00e+003.5871380
GO:0019083viral transcription8.10e-021.00e+003.56911081
GO:0002576platelet degranulation8.20e-021.00e+003.5521482
GO:0044267cellular protein metabolic process8.54e-021.00e+002.020229474
GO:0047485protein N-terminus binding8.58e-021.00e+003.4831586
GO:0006415translational termination8.68e-021.00e+003.46611087
GO:0016605PML body8.78e-021.00e+003.4501388
GO:0050821protein stabilization8.78e-021.00e+003.4501288
GO:0007010cytoskeleton organization9.06e-021.00e+003.4011191
GO:0006928cellular component movement9.06e-021.00e+003.4011791
GO:0005200structural constituent of cytoskeleton9.06e-021.00e+003.4011891
GO:0071456cellular response to hypoxia9.16e-021.00e+003.3861692
GO:0006414translational elongation9.25e-021.00e+003.37011393
GO:0051082unfolded protein binding9.25e-021.00e+003.3701593
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.03e-011.00e+003.209110104
GO:0014069postsynaptic density1.04e-011.00e+003.19513105
GO:0005506iron ion binding1.04e-011.00e+003.19514105
GO:0072562blood microparticle1.09e-011.00e+003.11513111
GO:0015630microtubule cytoskeleton1.09e-011.00e+003.12814110
GO:0030529ribonucleoprotein complex1.10e-011.00e+003.10218112
GO:0005819spindle1.10e-011.00e+003.10217112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.12e-011.00e+003.076111114
GO:0019058viral life cycle1.13e-011.00e+003.064113115
GO:0044237cellular metabolic process1.15e-011.00e+003.03915117
GO:0006325chromatin organization1.16e-011.00e+003.02715118
GO:0007219Notch signaling pathway1.18e-011.00e+003.00215120
GO:0006260DNA replication1.19e-011.00e+002.99019121
GO:0030036actin cytoskeleton organization1.21e-011.00e+002.96715123
GO:0006511ubiquitin-dependent protein catabolic process1.23e-011.00e+002.93215126
GO:0009615response to virus1.23e-011.00e+002.93215126
GO:0000790nuclear chromatin1.26e-011.00e+002.89819129
GO:0045087innate immune response1.26e-011.00e+001.690224596
GO:0006413translational initiation1.28e-011.00e+002.876117131
GO:0031982vesicle1.28e-011.00e+002.87619131
GO:0003735structural constituent of ribosome1.33e-011.00e+002.811110137
GO:0005911cell-cell junction1.33e-011.00e+002.82214136
GO:0016887ATPase activity1.36e-011.00e+002.78017140
GO:0006457protein folding1.39e-011.00e+002.74917143
GO:0061024membrane organization1.41e-011.00e+002.72917145
GO:0005769early endosome1.47e-011.00e+002.66112152
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.59e-011.00e+002.54317165
GO:0030424axon1.59e-011.00e+002.53414166
GO:0015629actin cytoskeleton1.69e-011.00e+002.44213177
GO:0005737cytoplasm1.74e-011.00e+000.61561103767
GO:0032403protein complex binding1.74e-011.00e+002.393110183
GO:0030168platelet activation1.93e-011.00e+002.230110205
GO:0007067mitotic nuclear division2.12e-011.00e+002.083114227
GO:0006412translation2.14e-011.00e+002.064120230
GO:0005975carbohydrate metabolic process2.33e-011.00e+001.92619253
GO:0004842ubiquitin-protein transferase activity2.35e-011.00e+001.91516255
GO:0043065positive regulation of apoptotic process2.45e-011.00e+001.843110268
GO:0005743mitochondrial inner membrane2.53e-011.00e+001.79518277
GO:0019899enzyme binding2.53e-011.00e+001.795112277
GO:0005856cytoskeleton2.64e-011.00e+001.724112291
GO:0006200ATP catabolic process2.64e-011.00e+001.719115292
GO:0016567protein ubiquitination2.67e-011.00e+001.70515295
GO:0005739mitochondrion2.79e-011.00e+000.946228998
GO:0019901protein kinase binding2.84e-011.00e+001.601121317
GO:0008283cell proliferation2.92e-011.00e+001.552114328
GO:0044822poly(A) RNA binding3.02e-011.00e+000.8652491056
GO:0003723RNA binding3.02e-011.00e+001.491120342
GO:0007155cell adhesion3.22e-011.00e+001.38216369
GO:0009986cell surface3.46e-011.00e+001.258111402
GO:0055114oxidation-reduction process3.58e-011.00e+001.195112420
GO:0006468protein phosphorylation3.85e-011.00e+001.064118460
GO:0005524ATP binding3.97e-011.00e+000.5672601298
GO:0008270zinc ion binding6.59e-011.00e+00-0.052112997
GO:0005886plasma membrane7.79e-011.00e+00-0.4252452582