int-snw-10454

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.950 4.20e-16 1.77e-03 3.15e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-10454 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RSL24D1 51187 361.3001.02059Yes-
RUVBL1 8607 170.7201.013343Yes-
RPL10 6134 10.7480.950159Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PPP2R1A 5518 90.6440.985249Yes-
RPL14 9045 421.2501.113143Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
[ TAB1 ] 10454 10.3380.95090Yes-
CFL1 1072 120.6741.020203Yes-
PGD 5226 751.2011.106138Yes-

Interactions (20)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPL10 6134 TAB1 10454 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
PPP2R1A 5518 PSMA2 5683 pp -- int.I2D: IntAct_Mouse
PPP2R1A 5518 TAB1 10454 pp -- int.Intact: MI:0915(physical association)
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
RPL10 6134 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 RSL24D1 51187 pp -- int.I2D: YeastLow
PPP2R1A 5518 RUVBL1 8607 pp -- int.I2D: YeastLow
ACTB 60 CFL1 1072 pp -- int.Intact: MI:0915(physical association);
int.I2D: BioGrid_Yeast, MINT_Yeast, MIPS, BioGrid, BIND_Yeast, HPRD, IntAct, IntAct_Yeast, MINT, VidalHuman_core, YeastLow, Yu_GoldStd;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
RUVBL1 8607 TAB1 10454 pp -- int.Intact: MI:0915(physical association);
int.I2D: MINT, IntAct;
int.Mint: MI:0915(physical association)
ACTB 60 RUVBL1 8607 pp -- int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11 5717 RUVBL1 8607 pp -- int.I2D: YeastLow
CFL1 1072 TAB1 10454 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
CFL1 1072 PGD 5226 pp -- int.I2D: YeastLow
RBX1 9978 TAB1 10454 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
CFL1 1072 RUVBL1 8607 pp -- int.I2D: YeastLow

Related GO terms (225)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016071mRNA metabolic process6.13e-078.84e-034.752531223
GO:0016070RNA metabolic process1.02e-061.46e-024.605532247
GO:0005829cytosol1.83e-052.63e-012.11691322496
GO:0016032viral process4.36e-056.28e-013.492555534
GO:0035267NuA4 histone acetyltransferase complex5.74e-058.28e-017.4242414
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.00e-041.00e+004.983311114
GO:0010467gene expression1.28e-041.00e+003.167559669
GO:0016020membrane1.34e-041.00e+002.3237901681
GO:0070062extracellular vesicular exosome1.53e-041.00e+002.00281042400
GO:0022625cytosolic large ribosomal subunit7.30e-041.00e+005.6162649
GO:0006521regulation of cellular amino acid metabolic process7.60e-041.00e+005.58721750
GO:0040008regulation of growth7.60e-041.00e+005.5872550
GO:0070262peptidyl-serine dephosphorylation8.32e-041.00e+0010.231111
GO:0019521D-gluconate metabolic process8.32e-041.00e+0010.231111
GO:0000502proteasome complex1.02e-031.00e+005.37321758
GO:0005654nucleoplasm1.19e-031.00e+002.4745761082
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.24e-031.00e+005.23121964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.28e-031.00e+005.20922265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.49e-031.00e+005.10222270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.57e-031.00e+005.06122072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.66e-031.00e+005.0222674
GO:0019322pentose biosynthetic process1.66e-031.00e+009.231122
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.66e-031.00e+005.02222274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.70e-031.00e+005.00222075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process1.89e-031.00e+004.92722379
GO:0019083viral transcription1.98e-031.00e+004.89121081
GO:0006415translational termination2.28e-031.00e+004.78821087
GO:0001842neural fold formation2.49e-031.00e+008.646113
GO:0016363nuclear matrix2.49e-031.00e+004.72321291
GO:0009051pentose-phosphate shunt, oxidative branch2.49e-031.00e+008.646123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.49e-031.00e+008.646113
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.55e-031.00e+004.70822192
GO:0006414translational elongation2.60e-031.00e+004.69221393
GO:0006614SRP-dependent cotranslational protein targeting to membrane3.24e-031.00e+004.531210104
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0048273mitogen-activated protein kinase p38 binding3.32e-031.00e+008.231114
GO:0000278mitotic cell cycle3.62e-031.00e+003.205348391
GO:0030529ribonucleoprotein complex3.75e-031.00e+004.42428112
GO:0019058viral life cycle3.95e-031.00e+004.386213115
GO:0000209protein polyubiquitination4.02e-031.00e+004.373220116
GO:0005515protein binding4.10e-031.00e+000.997101846024
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0019932second-messenger-mediated signaling4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0006325chromatin organization4.15e-031.00e+004.34825118
GO:0043066negative regulation of apoptotic process4.55e-031.00e+003.088331424
GO:0009615response to virus4.72e-031.00e+004.25425126
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0030836positive regulation of actin filament depolymerization4.98e-031.00e+007.646126
GO:0019209kinase activator activity4.98e-031.00e+007.646116
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0006413translational initiation5.09e-031.00e+004.198217131
GO:0003735structural constituent of ribosome5.55e-031.00e+004.133210137
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0044267cellular protein metabolic process6.22e-031.00e+002.927329474
GO:0000082G1/S transition of mitotic cell cycle6.54e-031.00e+004.012232149
GO:0042981regulation of apoptotic process6.62e-031.00e+004.002224150
GO:0019773proteasome core complex, alpha-subunit complex6.64e-031.00e+007.231148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0030042actin filament depolymerization6.64e-031.00e+007.231128
GO:0000812Swr1 complex6.64e-031.00e+007.231138
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0000185activation of MAPKKK activity7.47e-031.00e+007.061129
GO:0006098pentose-phosphate shunt8.29e-031.00e+006.9091410
GO:0007084mitotic nuclear envelope reassembly8.29e-031.00e+006.9091110
GO:0034641cellular nitrogen compound metabolic process8.53e-031.00e+003.813220171
GO:0061001regulation of dendritic spine morphogenesis9.12e-031.00e+006.7721211
GO:0006915apoptotic process9.61e-031.00e+002.700333555
GO:0032403protein complex binding9.72e-031.00e+003.715210183
GO:0006275regulation of DNA replication9.94e-031.00e+006.6461212
GO:0030111regulation of Wnt signaling pathway9.94e-031.00e+006.6461112
GO:0043968histone H2A acetylation9.94e-031.00e+006.6461312
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461712
GO:0006672ceramide metabolic process1.08e-021.00e+006.5311113
GO:0042273ribosomal large subunit biogenesis1.08e-021.00e+006.5311413
GO:0031011Ino80 complex1.16e-021.00e+006.4241314
GO:0045087innate immune response1.17e-021.00e+002.597324596
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.24e-021.00e+006.3241215
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0031258lamellipodium membrane1.32e-021.00e+006.2311216
GO:0022604regulation of cell morphogenesis1.32e-021.00e+006.2311116
GO:0003678DNA helicase activity1.41e-021.00e+006.1441317
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441817
GO:0005839proteasome core complex1.49e-021.00e+006.0611818
GO:0006412translation1.50e-021.00e+003.386220230
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0004298threonine-type endopeptidase activity1.57e-021.00e+005.9831819
GO:0008601protein phosphatase type 2A regulator activity1.65e-021.00e+005.9091220
GO:0000159protein phosphatase type 2A complex1.65e-021.00e+005.9091220
GO:0030010establishment of cell polarity1.73e-021.00e+005.8391221
GO:0045595regulation of cell differentiation1.73e-021.00e+005.8391121
GO:0000281mitotic cytokinesis1.73e-021.00e+005.8391121
GO:0003823antigen binding1.82e-021.00e+005.7721122
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0030864cortical actin cytoskeleton1.90e-021.00e+005.7081123
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043200response to amino acid1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway2.06e-021.00e+005.5871325
GO:0034080CENP-A containing nucleosome assembly2.06e-021.00e+005.5871125
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0010033response to organic substance2.22e-021.00e+005.4761227
GO:0050661NADP binding2.22e-021.00e+005.4761227
GO:0000188inactivation of MAPK activity2.22e-021.00e+005.4761127
GO:0071339MLL1 complex2.22e-021.00e+005.4761327
GO:0043967histone H4 acetylation2.22e-021.00e+005.4761327
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0001755neural crest cell migration2.31e-021.00e+005.4241228
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0043234protein complex2.40e-021.00e+003.027218295
GO:0042254ribosome biogenesis2.47e-021.00e+005.3241130
GO:0007411axon guidance2.78e-021.00e+002.914213319
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0003007heart morphogenesis2.79e-021.00e+005.1441134
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0008047enzyme activator activity3.20e-021.00e+004.9461139
GO:0007249I-kappaB kinase/NF-kappaB signaling3.36e-021.00e+004.8741241
GO:0032508DNA duplex unwinding3.36e-021.00e+004.8741341
GO:0004722protein serine/threonine phosphatase activity3.44e-021.00e+004.8391142
GO:0030155regulation of cell adhesion3.44e-021.00e+004.8391242
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway3.52e-021.00e+004.8051443
GO:0005925focal adhesion3.58e-021.00e+002.715219366
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0007266Rho protein signal transduction3.84e-021.00e+004.6771247
GO:0007254JNK cascade4.00e-021.00e+004.6161349
GO:0003824catalytic activity4.08e-021.00e+004.5871150
GO:0000775chromosome, centromeric region4.08e-021.00e+004.5871250
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0000932cytoplasmic mRNA processing body4.40e-021.00e+004.4761354
GO:0051403stress-activated MAPK cascade4.40e-021.00e+004.4761254
GO:0007059chromosome segregation5.04e-021.00e+004.2771462
GO:0005634nucleus5.06e-021.00e+000.88471364559
GO:0006310DNA recombination5.28e-021.00e+004.2091265
GO:0034146toll-like receptor 5 signaling pathway5.28e-021.00e+004.2091265
GO:0034166toll-like receptor 10 signaling pathway5.28e-021.00e+004.2091265
GO:0007596blood coagulation5.32e-021.00e+002.401218455
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0032587ruffle membrane5.67e-021.00e+004.1021370
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway5.75e-021.00e+004.0811271
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway5.75e-021.00e+004.0811271
GO:0006334nucleosome assembly5.83e-021.00e+004.0611272
GO:0030324lung development5.83e-021.00e+004.0611172
GO:0034162toll-like receptor 9 signaling pathway5.83e-021.00e+004.0611272
GO:0034134toll-like receptor 2 signaling pathway5.91e-021.00e+004.0411273
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0035666TRIF-dependent toll-like receptor signaling pathway6.15e-021.00e+003.9831376
GO:0002756MyD88-independent toll-like receptor signaling pathway6.30e-021.00e+003.9461378
GO:0034138toll-like receptor 3 signaling pathway6.38e-021.00e+003.9271379
GO:0002755MyD88-dependent toll-like receptor signaling pathway6.46e-021.00e+003.9091380
GO:0002576platelet degranulation6.62e-021.00e+003.8741482
GO:0000187activation of MAPK activity7.24e-021.00e+003.7391590
GO:0007010cytoskeleton organization7.32e-021.00e+003.7231191
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0044281small molecule metabolic process7.33e-021.00e+001.5743581211
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006364rRNA processing7.55e-021.00e+003.6771694
GO:0034142toll-like receptor 4 signaling pathway7.70e-021.00e+003.6461396
GO:0006470protein dephosphorylation7.86e-021.00e+003.6161198
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0002224toll-like receptor signaling pathway8.70e-021.00e+003.46313109
GO:0005815microtubule organizing center8.70e-021.00e+003.46315109
GO:0030308negative regulation of cell growth8.78e-021.00e+003.45016110
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0006461protein complex assembly8.86e-021.00e+003.43716111
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0030036actin cytoskeleton organization9.77e-021.00e+003.28915123
GO:0051092positive regulation of NF-kappaB transcription factor activity9.85e-021.00e+003.27714124
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0007179transforming growth factor beta receptor signaling pathway1.01e-011.00e+003.23114128
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0031982vesicle1.04e-011.00e+003.19819131
GO:0000086G2/M transition of mitotic cell cycle1.08e-011.00e+003.14419136
GO:0005911cell-cell junction1.08e-011.00e+003.14414136
GO:0016887ATPase activity1.10e-011.00e+003.10217140
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0010008endosome membrane1.19e-011.00e+002.99317151
GO:0008543fibroblast growth factor receptor signaling pathway1.22e-011.00e+002.94619156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0038095Fc-epsilon receptor signaling pathway1.31e-011.00e+002.839112168
GO:0031625ubiquitin protein ligase binding1.38e-011.00e+002.755114178
GO:0005730nucleolus1.48e-011.00e+001.1363691641
GO:0001701in utero embryonic development1.55e-011.00e+002.58018201
GO:0030168platelet activation1.58e-011.00e+002.552110205
GO:0007067mitotic nuclear division1.73e-011.00e+002.405114227
GO:0008380RNA splicing1.74e-011.00e+002.398111228
GO:0005737cytoplasm1.81e-011.00e+000.67451103767
GO:0005615extracellular space1.87e-011.00e+001.329217957
GO:0005975carbohydrate metabolic process1.91e-011.00e+002.24819253
GO:0004842ubiquitin-protein transferase activity1.93e-011.00e+002.23716255
GO:0007283spermatogenesis1.98e-011.00e+002.19818262
GO:0006357regulation of transcription from RNA polymerase II promoter1.99e-011.00e+002.18718264
GO:0003779actin binding2.00e-011.00e+002.176112266
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0044822poly(A) RNA binding2.18e-011.00e+001.1872491056
GO:0016567protein ubiquitination2.20e-011.00e+002.02715295
GO:0019901protein kinase binding2.34e-011.00e+001.923121317
GO:0043231intracellular membrane-bounded organelle2.35e-011.00e+001.91819318
GO:0003723RNA binding2.50e-011.00e+001.813120342
GO:0046982protein heterodimerization activity2.74e-011.00e+001.661113380
GO:0005524ATP binding2.95e-011.00e+000.8892601298
GO:0055114oxidation-reduction process2.99e-011.00e+001.517112420
GO:0006468protein phosphorylation3.22e-011.00e+001.386118460
GO:0005783endoplasmic reticulum3.76e-011.00e+001.112110556
GO:0005794Golgi apparatus4.05e-011.00e+000.978115610
GO:0005739mitochondrion5.77e-011.00e+000.268128998
GO:0006355regulation of transcription, DNA-templated5.77e-011.00e+000.270118997
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0006351transcription, DNA-templated7.19e-011.00e+00-0.2671311446