int-snw-10393

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.971 6.41e-17 1.11e-03 2.23e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-10393 subnetwork

Genes (12)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ACO2 50 501.0001.076191Yes-
CDC16 8881 250.9501.02080Yes-
UBA1 7317 40.5550.971207Yes-
RBX1 9978 971.1851.151139Yes-
PSMA2 5683 601.0931.10689Yes-
PPP2R1A 5518 90.6440.985249Yes-
[ ANAPC10 ] 10393 10.1950.97146Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (20)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
UBA1 7317 ANAPC10 10393 pp -- int.I2D: IntAct_Yeast
PGD 5226 UBA1 7317 pp -- int.I2D: YeastLow
PPP2R1A 5518 PSMA2 5683 pp -- int.I2D: IntAct_Mouse
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 ANAPC10 10393 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow
ACO2 50 PSMD11 5717 pp -- int.I2D: YeastLow
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACO2 50 PGD 5226 pp -- int.I2D: YeastLow
PPP2R1A 5518 UBA1 7317 pp -- int.I2D: IntAct_Yeast, YeastLow
ACO2 50 UBA1 7317 pp -- int.I2D: YeastLow
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PPP2R1A 5518 ANAPC10 10393 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid, IntAct
CDC16 8881 ANAPC10 10393 pp -- int.Intact: MI:0915(physical association), MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, BIND_Yeast, HPRD, Krogan_Core, MINT_Yeast, MIPS, YeastLow;
int.HPRD: in vivo

Related GO terms (213)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.81e-072.61e-036.20942265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.45e-073.53e-036.10242270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.06e-074.42e-036.02242274
GO:0000278mitotic cell cycle3.07e-074.44e-034.205648391
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.99e-075.76e-035.92742379
GO:0005829cytosol1.11e-061.61e-022.268101322496
GO:0005654nucleoplasm7.43e-061.07e-012.9597761082
GO:0016071mRNA metabolic process2.50e-053.60e-014.430431223
GO:0016070RNA metabolic process3.73e-055.38e-014.283432247
GO:0005680anaphase-promoting complex1.20e-041.00e+006.9092420
GO:0070979protein K11-linked ubiquitination2.04e-041.00e+006.5312626
GO:0000082G1/S transition of mitotic cell cycle2.22e-041.00e+004.597332149
GO:0007094mitotic spindle assembly checkpoint2.91e-041.00e+006.2772431
GO:0016032viral process7.25e-041.00e+003.170455534
GO:0006521regulation of cellular amino acid metabolic process7.60e-041.00e+005.58721750
GO:0070262peptidyl-serine dephosphorylation8.32e-041.00e+0010.231111
GO:0019521D-gluconate metabolic process8.32e-041.00e+0010.231111
GO:0000502proteasome complex1.02e-031.00e+005.37321758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.24e-031.00e+005.23121964
GO:0070062extracellular vesicular exosome1.27e-031.00e+001.81071042400
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.57e-031.00e+005.06122072
GO:00515383 iron, 4 sulfur cluster binding1.66e-031.00e+009.231112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.66e-031.00e+009.231112
GO:0019322pentose biosynthetic process1.66e-031.00e+009.231122
GO:0003994aconitate hydratase activity1.66e-031.00e+009.231112
GO:0005055laminin receptor activity1.66e-031.00e+009.231112
GO:0006407rRNA export from nucleus1.66e-031.00e+009.231112
GO:0010467gene expression1.68e-031.00e+002.845459669
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.70e-031.00e+005.00222075
GO:0009051pentose-phosphate shunt, oxidative branch2.49e-031.00e+008.646123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity2.49e-031.00e+008.646113
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.55e-031.00e+004.70822192
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.32e-031.00e+008.231114
GO:003068690S preribosome3.32e-031.00e+008.231114
GO:0031467Cul7-RING ubiquitin ligase complex3.32e-031.00e+008.231114
GO:0004839ubiquitin activating enzyme activity3.32e-031.00e+008.231114
GO:0019788NEDD8 ligase activity3.32e-031.00e+008.231114
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.88e-031.00e+004.398211114
GO:0000209protein polyubiquitination4.02e-031.00e+004.373220116
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.15e-031.00e+007.909135
GO:0031461cullin-RING ubiquitin ligase complex4.15e-031.00e+007.909115
GO:0019932second-messenger-mediated signaling4.15e-031.00e+007.909115
GO:0043248proteasome assembly4.15e-031.00e+007.909115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein4.15e-031.00e+007.909115
GO:0006102isocitrate metabolic process4.15e-031.00e+007.909115
GO:0030891VCB complex4.15e-031.00e+007.909125
GO:0000730DNA recombinase assembly4.15e-031.00e+007.909115
GO:2000001regulation of DNA damage checkpoint4.15e-031.00e+007.909115
GO:0019941modification-dependent protein catabolic process4.15e-031.00e+007.909115
GO:0030957Tat protein binding4.98e-031.00e+007.646136
GO:0006101citrate metabolic process4.98e-031.00e+007.646116
GO:0031466Cul5-RING ubiquitin ligase complex4.98e-031.00e+007.646116
GO:0030867rough endoplasmic reticulum membrane5.81e-031.00e+007.424127
GO:0000028ribosomal small subunit assembly5.81e-031.00e+007.424117
GO:0031462Cul2-RING ubiquitin ligase complex5.81e-031.00e+007.424127
GO:0042981regulation of apoptotic process6.62e-031.00e+004.002224150
GO:0019773proteasome core complex, alpha-subunit complex6.64e-031.00e+007.231148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex6.64e-031.00e+007.231128
GO:0070688MLL5-L complex6.64e-031.00e+007.231118
GO:0045116protein neddylation6.64e-031.00e+007.231128
GO:0006098pentose-phosphate shunt8.29e-031.00e+006.9091410
GO:0010569regulation of double-strand break repair via homologous recombination8.29e-031.00e+006.9091110
GO:0007084mitotic nuclear envelope reassembly8.29e-031.00e+006.9091110
GO:0034641cellular nitrogen compound metabolic process8.53e-031.00e+003.813220171
GO:0031571mitotic G1 DNA damage checkpoint9.12e-031.00e+006.7721411
GO:0031625ubiquitin protein ligase binding9.22e-031.00e+003.755214178
GO:0006915apoptotic process9.61e-031.00e+002.700333555
GO:0006275regulation of DNA replication9.94e-031.00e+006.6461212
GO:0030111regulation of Wnt signaling pathway9.94e-031.00e+006.6461112
GO:0005838proteasome regulatory particle9.94e-031.00e+006.6461712
GO:0006672ceramide metabolic process1.08e-021.00e+006.5311113
GO:0005662DNA replication factor A complex1.08e-021.00e+006.5311113
GO:0035267NuA4 histone acetyltransferase complex1.16e-021.00e+006.4241414
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand1.24e-021.00e+006.3241215
GO:0050998nitric-oxide synthase binding1.32e-021.00e+006.2311116
GO:0005634nucleus1.33e-021.00e+001.07781364559
GO:0022624proteasome accessory complex1.41e-021.00e+006.1441817
GO:0044281small molecule metabolic process1.42e-021.00e+001.9894581211
GO:0007067mitotic nuclear division1.47e-021.00e+003.405214227
GO:0007088regulation of mitosis1.49e-021.00e+006.0611118
GO:0035861site of double-strand break1.49e-021.00e+006.0611118
GO:0005839proteasome core complex1.49e-021.00e+006.0611818
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.57e-021.00e+005.9831119
GO:0048863stem cell differentiation1.57e-021.00e+005.9831119
GO:0004298threonine-type endopeptidase activity1.57e-021.00e+005.9831819
GO:0008601protein phosphatase type 2A regulator activity1.65e-021.00e+005.9091220
GO:0006298mismatch repair1.65e-021.00e+005.9091320
GO:0000159protein phosphatase type 2A complex1.65e-021.00e+005.9091220
GO:0032201telomere maintenance via semi-conservative replication1.73e-021.00e+005.8391521
GO:0045595regulation of cell differentiation1.73e-021.00e+005.8391121
GO:0000718nucleotide-excision repair, DNA damage removal1.73e-021.00e+005.8391421
GO:0006297nucleotide-excision repair, DNA gap filling1.82e-021.00e+005.7721322
GO:0003823antigen binding1.82e-021.00e+005.7721122
GO:0000792heterochromatin1.82e-021.00e+005.7721222
GO:0030863cortical cytoskeleton1.82e-021.00e+005.7721122
GO:0036464cytoplasmic ribonucleoprotein granule1.82e-021.00e+005.7721422
GO:0004842ubiquitin-protein transferase activity1.83e-021.00e+003.23726255
GO:0043044ATP-dependent chromatin remodeling1.90e-021.00e+005.7081423
GO:0030057desmosome1.90e-021.00e+005.7081123
GO:0031463Cul3-RING ubiquitin ligase complex1.90e-021.00e+005.7081323
GO:0043236laminin binding1.90e-021.00e+005.7081123
GO:0006513protein monoubiquitination1.90e-021.00e+005.7081123
GO:0006281DNA repair1.91e-021.00e+003.203218261
GO:0000722telomere maintenance via recombination2.06e-021.00e+005.5871525
GO:0005515protein binding2.09e-021.00e+000.84591846024
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.14e-021.00e+005.5311326
GO:0010033response to organic substance2.22e-021.00e+005.4761227
GO:0043022ribosome binding2.22e-021.00e+005.4761327
GO:0050661NADP binding2.22e-021.00e+005.4761227
GO:0000188inactivation of MAPK activity2.22e-021.00e+005.4761127
GO:0031492nucleosomal DNA binding2.22e-021.00e+005.4761427
GO:0006099tricarboxylic acid cycle2.31e-021.00e+005.4241428
GO:0019894kinesin binding2.31e-021.00e+005.4241128
GO:0019005SCF ubiquitin ligase complex2.39e-021.00e+005.3731129
GO:0016567protein ubiquitination2.40e-021.00e+003.02725295
GO:0006271DNA strand elongation involved in DNA replication2.47e-021.00e+005.3241730
GO:0001895retina homeostasis2.79e-021.00e+005.1441134
GO:0005876spindle microtubule2.79e-021.00e+005.1441234
GO:00515394 iron, 4 sulfur cluster binding2.87e-021.00e+005.1021335
GO:0034332adherens junction organization2.96e-021.00e+005.0611136
GO:0051084'de novo' posttranslational protein folding3.04e-021.00e+005.0221437
GO:0006284base-excision repair3.04e-021.00e+005.0221337
GO:0070527platelet aggregation3.12e-021.00e+004.9831238
GO:0022627cytosolic small ribosomal subunit3.20e-021.00e+004.9461439
GO:0000781chromosome, telomeric region3.20e-021.00e+004.9461339
GO:0004722protein serine/threonine phosphatase activity3.44e-021.00e+004.8391142
GO:0030155regulation of cell adhesion3.44e-021.00e+004.8391242
GO:0021762substantia nigra development3.60e-021.00e+004.7721244
GO:0006283transcription-coupled nucleotide-excision repair3.76e-021.00e+004.7081746
GO:0003684damaged DNA binding4.00e-021.00e+004.6161749
GO:0006091generation of precursor metabolites and energy4.08e-021.00e+004.5871350
GO:0000775chromosome, centromeric region4.08e-021.00e+004.5871250
GO:0040008regulation of growth4.08e-021.00e+004.5871550
GO:0016020membrane4.22e-021.00e+001.5164901681
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding4.32e-021.00e+004.5031553
GO:0045216cell-cell junction organization4.40e-021.00e+004.4761254
GO:0000932cytoplasmic mRNA processing body4.40e-021.00e+004.4761354
GO:0000724double-strand break repair via homologous recombination4.48e-021.00e+004.4501355
GO:0005739mitochondrion4.54e-021.00e+001.853328998
GO:0000723telomere maintenance4.56e-021.00e+004.4241656
GO:0043066negative regulation of apoptotic process4.68e-021.00e+002.503231424
GO:0019903protein phosphatase binding5.04e-021.00e+004.2771462
GO:0007059chromosome segregation5.04e-021.00e+004.2771462
GO:0006302double-strand break repair5.04e-021.00e+004.2771462
GO:0006289nucleotide-excision repair5.52e-021.00e+004.14411168
GO:0034329cell junction assembly5.52e-021.00e+004.1441168
GO:0003697single-stranded DNA binding5.52e-021.00e+004.1441568
GO:0044267cellular protein metabolic process5.72e-021.00e+002.342229474
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis5.99e-021.00e+004.0221674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process6.07e-021.00e+004.0021275
GO:0019083viral transcription6.54e-021.00e+003.89111081
GO:0047485protein N-terminus binding6.93e-021.00e+003.8051586
GO:0006415translational termination7.01e-021.00e+003.78811087
GO:0016605PML body7.08e-021.00e+003.7721388
GO:0006928cellular component movement7.32e-021.00e+003.7231791
GO:0005200structural constituent of cytoskeleton7.32e-021.00e+003.7231891
GO:0071456cellular response to hypoxia7.39e-021.00e+003.7081692
GO:0006414translational elongation7.47e-021.00e+003.69211393
GO:0006470protein dephosphorylation7.86e-021.00e+003.6161198
GO:0006614SRP-dependent cotranslational protein targeting to membrane8.32e-021.00e+003.531110104
GO:0014069postsynaptic density8.40e-021.00e+003.51713105
GO:0005506iron ion binding8.40e-021.00e+003.51714105
GO:0030308negative regulation of cell growth8.78e-021.00e+003.45016110
GO:0015630microtubule cytoskeleton8.78e-021.00e+003.45014110
GO:0006461protein complex assembly8.86e-021.00e+003.43716111
GO:0072562blood microparticle8.86e-021.00e+003.43713111
GO:0030529ribonucleoprotein complex8.93e-021.00e+003.42418112
GO:0005819spindle8.93e-021.00e+003.42417112
GO:0019058viral life cycle9.16e-021.00e+003.386113115
GO:0044237cellular metabolic process9.32e-021.00e+003.36115117
GO:0006325chromatin organization9.39e-021.00e+003.34815118
GO:0007219Notch signaling pathway9.54e-021.00e+003.32415120
GO:0006260DNA replication9.62e-021.00e+003.31219121
GO:0006511ubiquitin-dependent protein catabolic process1.00e-011.00e+003.25415126
GO:0009615response to virus1.00e-011.00e+003.25415126
GO:0000790nuclear chromatin1.02e-011.00e+003.22019129
GO:0006413translational initiation1.04e-011.00e+003.198117131
GO:0003735structural constituent of ribosome1.08e-011.00e+003.133110137
GO:0000086G2/M transition of mitotic cell cycle1.08e-011.00e+003.14419136
GO:0006457protein folding1.13e-011.00e+003.07117143
GO:0061024membrane organization1.14e-011.00e+003.05117145
GO:0010008endosome membrane1.19e-011.00e+002.99317151
GO:0006974cellular response to DNA damage stimulus1.19e-011.00e+002.99318151
GO:0008543fibroblast growth factor receptor signaling pathway1.22e-011.00e+002.94619156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.29e-011.00e+002.86517165
GO:0030424axon1.30e-011.00e+002.85614166
GO:0032403protein complex binding1.42e-011.00e+002.715110183
GO:0005765lysosomal membrane1.56e-011.00e+002.56615203
GO:0008380RNA splicing1.74e-011.00e+002.398111228
GO:0005759mitochondrial matrix1.74e-011.00e+002.398114228
GO:0006412translation1.75e-011.00e+002.386120230
GO:0005975carbohydrate metabolic process1.91e-011.00e+002.24819253
GO:0019899enzyme binding2.08e-011.00e+002.117112277
GO:0005856cytoskeleton2.17e-011.00e+002.046112291
GO:0044822poly(A) RNA binding2.18e-011.00e+001.1872491056
GO:0043234protein complex2.20e-011.00e+002.027118295
GO:0019901protein kinase binding2.34e-011.00e+001.923121317
GO:0007411axon guidance2.35e-011.00e+001.914113319
GO:0005813centrosome2.40e-011.00e+001.882114326
GO:0008283cell proliferation2.41e-011.00e+001.874114328
GO:0005925focal adhesion2.65e-011.00e+001.715119366
GO:0007155cell adhesion2.67e-011.00e+001.70416369
GO:0046982protein heterodimerization activity2.74e-011.00e+001.661113380
GO:0005524ATP binding2.95e-011.00e+000.8892601298
GO:0055114oxidation-reduction process2.99e-011.00e+001.517112420
GO:0007596blood coagulation3.19e-011.00e+001.401118455
GO:0005737cytoplasm3.86e-011.00e+000.35241103767
GO:0045087innate immune response3.97e-011.00e+001.012124596
GO:0005615extracellular space5.61e-011.00e+000.329117957
GO:0006355regulation of transcription, DNA-templated5.77e-011.00e+000.270118997
GO:0008270zinc ion binding5.77e-011.00e+000.270112997
GO:0005730nucleolus7.65e-011.00e+00-0.4491691641
GO:0005886plasma membrane9.06e-011.00e+00-1.1031452582