int-snw-10202

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.020 5.78e-19 3.38e-04 8.99e-03
wolf-screen-ratio-mammosphere-adherent-int-snw-10202 subnetwork

Genes (14)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
CDC16 8881 250.9501.02080Yes-
RBX1 9978 971.1851.151139Yes-
PSMD3 5709 570.9861.106146Yes-
RPS11 6205 360.9931.113175Yes-
[ DHRS2 ] 10202 10.1601.02014--
PSMB7 5695 480.9821.05257Yes-
RPL14 9045 421.2501.113143Yes-
PSMA1 5682 610.9961.052123Yes-
ACTB 60 1671.1531.151587Yes-
PSMD11 5717 1211.0951.106183Yes-
SAP18 10284 81.1151.06957Yes-
RPSA 3921 1561.3271.151152Yes-
RPS3A 6189 110.8351.069166Yes-

Interactions (23)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPS3A 6189 DHRS2 10202 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPS11 6205 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 PSMA1 5682 pp -- int.I2D: BioGrid_Yeast
ACTB 60 DHRS2 10202 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA1 5682 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPS3A 6189 SAP18 10284 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid, HPRD, MINT;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
RPS3A 6189 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
PSMA1 5682 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
RPSA 3921 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
ACTB 60 RPS3A 6189 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 CDC16 8881 pp -- int.I2D: YeastLow

Related GO terms (192)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016071mRNA metabolic process7.99e-121.15e-075.208831223
GO:0016070RNA metabolic process1.82e-112.62e-075.060832247
GO:0016032viral process2.08e-102.99e-064.118955534
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.08e-094.45e-056.30852265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.51e-096.50e-056.20152270
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.99e-098.63e-056.12152274
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process8.35e-091.20e-046.02752379
GO:0010467gene expression4.82e-086.95e-043.623859669
GO:0006521regulation of cellular amino acid metabolic process1.25e-071.80e-036.36541750
GO:0000082G1/S transition of mitotic cell cycle2.04e-072.95e-035.111532149
GO:0000502proteasome complex2.29e-073.30e-036.15141758
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.41e-074.92e-036.00941964
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.50e-077.94e-035.83942072
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.49e-079.36e-035.78042075
GO:0019083viral transcription8.85e-071.28e-025.66941081
GO:0005829cytosol8.90e-071.28e-022.183111322496
GO:0000278mitotic cell cycle9.54e-071.38e-023.983648391
GO:0006415translational termination1.18e-061.70e-025.56641087
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.48e-062.13e-025.48542192
GO:0043066negative regulation of apoptotic process1.53e-062.21e-023.866631424
GO:0006414translational elongation1.54e-062.23e-025.47041393
GO:0005654nucleoplasm1.95e-062.81e-022.9298761082
GO:0006614SRP-dependent cotranslational protein targeting to membrane2.42e-063.48e-025.308410104
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay3.49e-065.03e-025.176411114
GO:0019058viral life cycle3.61e-065.21e-025.163413115
GO:0000209protein polyubiquitination3.74e-065.39e-025.151420116
GO:0006413translational initiation6.06e-068.75e-024.975417131
GO:0022627cytosolic small ribosomal subunit6.52e-069.40e-026.3083439
GO:0003735structural constituent of ribosome7.24e-061.04e-014.911410137
GO:0070062extracellular vesicular exosome8.36e-061.21e-012.102101042400
GO:0042981regulation of apoptotic process1.04e-051.50e-014.780424150
GO:0034641cellular nitrogen compound metabolic process1.74e-052.51e-014.591420171
GO:0006412translation5.56e-058.02e-014.163420230
GO:0005838proteasome regulatory particle5.74e-058.28e-017.4242712
GO:0044267cellular protein metabolic process5.88e-058.48e-013.442529474
GO:0022624proteasome accessory complex1.18e-041.00e+006.9212817
GO:0005839proteasome core complex1.33e-041.00e+006.8392818
GO:0004298threonine-type endopeptidase activity1.48e-041.00e+006.7612819
GO:0005515protein binding9.66e-041.00e+001.037121846024
GO:0008207C21-steroid hormone metabolic process9.71e-041.00e+0010.009111
GO:0006915apoptotic process1.60e-031.00e+002.892433555
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009112
GO:0005055laminin receptor activity1.94e-031.00e+009.009112
GO:0006407rRNA export from nucleus1.94e-031.00e+009.009112
GO:0044822poly(A) RNA binding2.39e-031.00e+002.2865491056
GO:0005730nucleolus2.87e-031.00e+001.9136691641
GO:0061574ASAP complex2.91e-031.00e+008.424113
GO:0016020membrane3.25e-031.00e+001.8796901681
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.88e-031.00e+008.009114
GO:003068690S preribosome3.88e-031.00e+008.009114
GO:0031467Cul7-RING ubiquitin ligase complex3.88e-031.00e+008.009114
GO:0004090carbonyl reductase (NADPH) activity3.88e-031.00e+008.009114
GO:0019788NEDD8 ligase activity3.88e-031.00e+008.009114
GO:0003723RNA binding3.96e-031.00e+003.176320342
GO:0005925focal adhesion4.79e-031.00e+003.078319366
GO:0031465Cul4B-RING E3 ubiquitin ligase complex4.84e-031.00e+007.687135
GO:0031461cullin-RING ubiquitin ligase complex4.84e-031.00e+007.687115
GO:0043248proteasome assembly4.84e-031.00e+007.687115
GO:0030891VCB complex4.84e-031.00e+007.687125
GO:0000730DNA recombinase assembly4.84e-031.00e+007.687115
GO:2000001regulation of DNA damage checkpoint4.84e-031.00e+007.687115
GO:0030529ribonucleoprotein complex5.12e-031.00e+004.20128112
GO:0002181cytoplasmic translation5.81e-031.00e+007.424116
GO:0030957Tat protein binding5.81e-031.00e+007.424136
GO:0031466Cul5-RING ubiquitin ligase complex5.81e-031.00e+007.424116
GO:0000028ribosomal small subunit assembly6.78e-031.00e+007.201117
GO:0031462Cul2-RING ubiquitin ligase complex6.78e-031.00e+007.201127
GO:0019773proteasome core complex, alpha-subunit complex7.74e-031.00e+007.009148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex7.74e-031.00e+007.009128
GO:0070688MLL5-L complex7.74e-031.00e+007.009118
GO:0045116protein neddylation7.74e-031.00e+007.009128
GO:0010569regulation of double-strand break repair via homologous recombination9.67e-031.00e+006.6871110
GO:0031571mitotic G1 DNA damage checkpoint1.06e-021.00e+006.5491411
GO:0005634nucleus1.20e-021.00e+001.02491364559
GO:0031625ubiquitin protein ligase binding1.25e-021.00e+003.533214178
GO:0042273ribosomal large subunit biogenesis1.26e-021.00e+006.3081413
GO:0005662DNA replication factor A complex1.26e-021.00e+006.3081113
GO:0030234enzyme regulator activity1.26e-021.00e+006.3081313
GO:0005737cytoplasm1.35e-021.00e+001.13081103767
GO:0035267NuA4 histone acetyltransferase complex1.35e-021.00e+006.2011414
GO:0043011myeloid dendritic cell differentiation1.45e-021.00e+006.1021115
GO:0048025negative regulation of mRNA splicing, via spliceosome1.45e-021.00e+006.1021115
GO:0050998nitric-oxide synthase binding1.54e-021.00e+006.0091116
GO:0042176regulation of protein catabolic process1.54e-021.00e+006.0091316
GO:0007088regulation of mitosis1.73e-021.00e+005.8391118
GO:0035861site of double-strand break1.73e-021.00e+005.8391118
GO:0035145exon-exon junction complex1.83e-021.00e+005.7611119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.83e-021.00e+005.7611119
GO:0048863stem cell differentiation1.83e-021.00e+005.7611119
GO:0005680anaphase-promoting complex1.92e-021.00e+005.6871420
GO:0006298mismatch repair1.92e-021.00e+005.6871320
GO:0032201telomere maintenance via semi-conservative replication2.02e-021.00e+005.6161521
GO:0000718nucleotide-excision repair, DNA damage removal2.02e-021.00e+005.6161421
GO:0006297nucleotide-excision repair, DNA gap filling2.12e-021.00e+005.5491322
GO:0030863cortical cytoskeleton2.12e-021.00e+005.5491122
GO:0036464cytoplasmic ribonucleoprotein granule2.12e-021.00e+005.5491422
GO:0043044ATP-dependent chromatin remodeling2.21e-021.00e+005.4851423
GO:0005844polysome2.21e-021.00e+005.4851423
GO:0031463Cul3-RING ubiquitin ligase complex2.21e-021.00e+005.4851323
GO:0043236laminin binding2.21e-021.00e+005.4851123
GO:0006513protein monoubiquitination2.21e-021.00e+005.4851123
GO:0000722telomere maintenance via recombination2.40e-021.00e+005.3651525
GO:0000381regulation of alternative mRNA splicing, via spliceosome2.50e-021.00e+005.3081126
GO:0044281small molecule metabolic process2.50e-021.00e+001.7674581211
GO:0070979protein K11-linked ubiquitination2.50e-021.00e+005.3081626
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.50e-021.00e+005.3081326
GO:0006281DNA repair2.57e-021.00e+002.981218261
GO:0019843rRNA binding2.59e-021.00e+005.2541327
GO:0043022ribosome binding2.59e-021.00e+005.2541327
GO:0031492nucleosomal DNA binding2.59e-021.00e+005.2541427
GO:0000118histone deacetylase complex2.69e-021.00e+005.2011128
GO:0019894kinesin binding2.69e-021.00e+005.2011128
GO:0019005SCF ubiquitin ligase complex2.78e-021.00e+005.1511129
GO:0006271DNA strand elongation involved in DNA replication2.87e-021.00e+005.1021730
GO:0007094mitotic spindle assembly checkpoint2.97e-021.00e+005.0551431
GO:1903507negative regulation of nucleic acid-templated transcription3.06e-021.00e+005.0091232
GO:0034599cellular response to oxidative stress3.16e-021.00e+004.9641233
GO:0001895retina homeostasis3.25e-021.00e+004.9211134
GO:0005876spindle microtubule3.25e-021.00e+004.9211234
GO:0034332adherens junction organization3.44e-021.00e+004.8391136
GO:0051084'de novo' posttranslational protein folding3.53e-021.00e+004.7991437
GO:0006284base-excision repair3.53e-021.00e+004.7991337
GO:0070527platelet aggregation3.63e-021.00e+004.7611238
GO:0000781chromosome, telomeric region3.72e-021.00e+004.7231339
GO:0005813centrosome3.87e-021.00e+002.660214326
GO:0021762substantia nigra development4.19e-021.00e+004.5491244
GO:0006283transcription-coupled nucleotide-excision repair4.38e-021.00e+004.4851746
GO:0022625cytosolic large ribosomal subunit4.65e-021.00e+004.3941649
GO:0003684damaged DNA binding4.65e-021.00e+004.3941749
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding5.03e-021.00e+004.2811553
GO:0045216cell-cell junction organization5.12e-021.00e+004.2541254
GO:0000724double-strand break repair via homologous recombination5.21e-021.00e+004.2271355
GO:0000723telomere maintenance5.30e-021.00e+004.2011656
GO:0005840ribosome5.49e-021.00e+004.1511158
GO:0019903protein phosphatase binding5.86e-021.00e+004.0551462
GO:0006302double-strand break repair5.86e-021.00e+004.0551462
GO:0009636response to toxic substance6.13e-021.00e+003.9861365
GO:0006289nucleotide-excision repair6.40e-021.00e+003.92111168
GO:0034329cell junction assembly6.40e-021.00e+003.9211168
GO:0003697single-stranded DNA binding6.40e-021.00e+003.9211568
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis6.95e-021.00e+003.7991674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process7.04e-021.00e+003.7801275
GO:0047485protein N-terminus binding8.04e-021.00e+003.5821586
GO:0016605PML body8.21e-021.00e+003.5491388
GO:0006928cellular component movement8.48e-021.00e+003.5011791
GO:0005200structural constituent of cytoskeleton8.48e-021.00e+003.5011891
GO:0001649osteoblast differentiation8.57e-021.00e+003.4851692
GO:0071456cellular response to hypoxia8.57e-021.00e+003.4851692
GO:0006364rRNA processing8.75e-021.00e+003.4541694
GO:0014069postsynaptic density9.73e-021.00e+003.29413105
GO:0015630microtubule cytoskeleton1.02e-011.00e+003.22714110
GO:0072562blood microparticle1.03e-011.00e+003.21413111
GO:0005819spindle1.03e-011.00e+003.20117112
GO:0005635nuclear envelope1.04e-011.00e+003.18916113
GO:0006325chromatin organization1.09e-011.00e+003.12615118
GO:0007219Notch signaling pathway1.10e-011.00e+003.10215120
GO:0006260DNA replication1.11e-011.00e+003.09019121
GO:0006511ubiquitin-dependent protein catabolic process1.16e-011.00e+003.03115126
GO:0000790nuclear chromatin1.18e-011.00e+002.99819129
GO:0006457protein folding1.30e-011.00e+002.84917143
GO:0061024membrane organization1.32e-011.00e+002.82917145
GO:0006397mRNA processing1.45e-011.00e+002.68712160
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.49e-011.00e+002.64217165
GO:0030424axon1.50e-011.00e+002.63414166
GO:0016607nuclear speck1.55e-011.00e+002.58213172
GO:0003714transcription corepressor activity1.60e-011.00e+002.53318178
GO:0032403protein complex binding1.64e-011.00e+002.493110183
GO:0007067mitotic nuclear division1.99e-011.00e+002.182114227
GO:0008380RNA splicing2.00e-011.00e+002.176111228
GO:0005759mitochondrial matrix2.00e-011.00e+002.176114228
GO:0004842ubiquitin-protein transferase activity2.21e-011.00e+002.01416255
GO:0006357regulation of transcription from RNA polymerase II promoter2.28e-011.00e+001.96418264
GO:0043065positive regulation of apoptotic process2.31e-011.00e+001.943110268
GO:0019899enzyme binding2.38e-011.00e+001.895112277
GO:0005856cytoskeleton2.48e-011.00e+001.824112291
GO:0043234protein complex2.51e-011.00e+001.804118295
GO:0016567protein ubiquitination2.51e-011.00e+001.80415295
GO:0030154cell differentiation2.56e-011.00e+001.77515301
GO:0019901protein kinase binding2.67e-011.00e+001.700121317
GO:0007411axon guidance2.69e-011.00e+001.691113319
GO:0008283cell proliferation2.75e-011.00e+001.651114328
GO:0008285negative regulation of cell proliferation2.93e-011.00e+001.545111353
GO:0007155cell adhesion3.04e-011.00e+001.48116369
GO:0055114oxidation-reduction process3.39e-011.00e+001.294112420
GO:0007596blood coagulation3.62e-011.00e+001.179118455
GO:0045087innate immune response4.46e-011.00e+000.790124596
GO:0005615extracellular space6.18e-011.00e+000.106117957
GO:0008270zinc ion binding6.33e-011.00e+000.047112997
GO:0005739mitochondrion6.34e-011.00e+000.046128998
GO:0005524ATP binding7.33e-011.00e+00-0.3331601298
GO:0006351transcription, DNA-templated7.72e-011.00e+00-0.4891311446
GO:0005886plasma membrane9.37e-011.00e+00-1.3261452582