meta-reg-snw-8394

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
int-snw-1120 tai-screen-luciferase 6.205 8.63e-128 1.09e-06 4.18e-03 23 17
reg-snw-8394 tai-screen-luciferase 4.751 5.99e-25 4.27e-04 7.04e-04 5 3
int-snw-56848 tai-screen-luciferase 6.375 2.94e-136 3.59e-07 2.58e-03 24 19
int-snw-5714 tai-screen-luciferase 6.408 6.16e-138 2.88e-07 2.35e-03 16 13
int-snw-5706 tai-screen-luciferase 6.189 4.80e-127 1.20e-06 4.35e-03 25 21
tai-screen-luciferase-meta-reg-snw-8394 subnetwork

Genes (37)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
RPS20 6224 22-4.7576.314153Yes-
RPS8 6202 33-5.5457.555234--
ZMAT1 84460 5-3.1824.75136--
CHMP2A 27243 33-9.0377.55541YesYes
RPS15 6209 30-5.0407.011116Yes-
COPA 1314 48-9.3955.672340YesYes
CHKB 1120 8-2.1946.20542--
COPB2 9276 48-13.1689.06341YesYes
RPS16 6217 38-5.4444.880205--
PSMD1 5707 16-3.6046.408113-Yes
CDC42 998 44-6.9604.707276YesYes
ARL1 400 18-4.1428.046110-Yes
RPS11 6205 44-6.5887.555175Yes-
RPS6 6194 44-5.6038.046217Yes-
MRPS12 6183 35-5.4215.516341Yes-
RAN 5901 38-3.8094.325258YesYes
COPB1 1315 39-6.2219.063118YesYes
RPS13 6207 43-6.5897.555174Yes-
SRPK2 6733 10-2.8274.940109--
PLK1 5347 14-3.6906.189217Yes-
RPS24 6229 46-7.0348.389217Yes-
PIP5K1A 8394 5-1.8204.75130--
RPS9 6203 45-7.1277.555140Yes-
RPS4X 6191 44-6.7477.555263Yes-
COPZ1 22818 48-8.3019.06313YesYes
ATP6V1D 51382 30-4.1317.286149--
RPS15A 6210 36-5.4137.555177Yes-
WDR46 9277 31-4.2904.226101YesYes
RPS27A 6233 45-5.6318.389344Yes-
PSMC6 5706 14-3.1696.408158--
PSMD8 5714 15-2.9164.418143--
PSMD3 5709 22-3.9356.408201-Yes
SKP1 6500 26-3.7506.413203--
SPHK2 56848 17-3.0106.37537--
RPS26 6231 43-7.4788.04660Yes-
ARCN1 372 48-8.2329.063118YesYes
SRPK1 6732 8-3.7337.13850--

Interactions (115)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
CDC42 998 RPS27A 6233 pp -- int.I2D: SOURAV_MAPK_HIGH
RPS20 6224 RPS26 6231 pp -- int.I2D: YeastLow
RPS4X 6191 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS27A 6233 SKP1 6500 pp -- int.I2D: BioGrid_Yeast, YeastLow
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
RPS11 6205 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS11 6205 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastMedium, Krogan_Core, MINT_Yeast
COPA 1314 PIP5K1A 8394 pd > reg.ITFP.txt: no annot
COPA 1314 PSMD8 5714 pp -- int.I2D: YeastLow
RPS13 6207 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
PLK1 5347 PSMC6 5706 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS11 6205 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
ARCN1 372 RAN 5901 pp -- int.I2D: YeastLow
PSMD3 5709 PIP5K1A 8394 pd > reg.ITFP.txt: no annot
RPS15 6209 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS9 6203 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS16 6217 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
MRPS12 6183 RPS20 6224 pp -- int.I2D: YeastMedium
SKP1 6500 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS13 6207 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS15 6209 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS11 6205 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RAN 5901 RPS11 6205 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
RPS13 6207 WDR46 9277 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
CHKB 1120 SRPK2 6733 pp -- int.I2D: BioGrid_Yeast, Yeast_Kinome
PLK1 5347 RPS27A 6233 pp -- int.I2D: YeastLow
RPS9 6203 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
CHKB 1120 PSMD3 5709 pp -- int.I2D: IntAct_Yeast
MRPS12 6183 RPS15 6209 pp -- int.I2D: YeastMedium
RPS8 6202 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
ARL1 400 CHKB 1120 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
RPS16 6217 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
RPS15A 6210 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastHigh, YeastMedium
ARL1 400 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
PSMD1 5707 SRPK2 6733 pp -- int.I2D: BioGrid_Yeast, Yeast_Kinome
RPS20 6224 RPS27A 6233 pp -- int.I2D: YeastLow
PSMD3 5709 PSMD8 5714 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, IntAct_Yeast, INTEROLOG, Krogan_Core, YeastHigh
RPS4X 6191 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
ARL1 400 COPA 1314 pp -- int.I2D: BioGrid_Yeast
RAN 5901 RPS15 6209 pp -- int.I2D: YeastLow
RPS4X 6191 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS8 6202 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
RPS8 6202 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
COPA 1314 COPB1 1315 pp -- int.I2D: BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct_Yeast, MINT_Yeast, Krogan_Core, YeastHigh
PSMC6 5706 SKP1 6500 pp -- int.I2D: YeastLow
PSMD8 5714 MRPS12 6183 pd < reg.ITFP.txt: no annot
RPS8 6202 CHMP2A 27243 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RAN 5901 WDR46 9277 pp -- int.I2D: YeastLow
PSMD8 5714 ATP6V1D 51382 pp -- int.I2D: YeastLow
PLK1 5347 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
PSMC6 5706 RAN 5901 pp -- int.I2D: YeastLow
PSMC6 5706 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
COPA 1314 SRPK2 6733 pd > reg.ITFP.txt: no annot
COPB1 1315 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastMedium;
int.DIP: MI:0915(physical association)
PLK1 5347 RPS8 6202 pp -- int.I2D: BioGrid_Fly, FlyEmbryo, IntAct_Fly
COPA 1314 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS15 6209 RPS16 6217 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS4X 6191 RPS8 6202 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 ARL1 400 pp -- int.I2D: BioGrid_Yeast
ARL1 400 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
RAN 5901 SPHK2 56848 pp -- int.I2D: IntAct_Yeast, BIND_Yeast, MINT_Yeast, MIPS, YeastLow
PIP5K1A 8394 ZMAT1 84460 pd < reg.ITFP.txt: no annot
RPS4X 6191 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
COPB1 1315 COPB2 9276 pp -- int.I2D: BioGrid
ARCN1 372 COPB1 1315 pp -- int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct_Yeast, INTEROLOG, MINT_Yeast, YeastHigh, BIND, BIND_Yeast, HPRD, Krogan_Core, MIPS;
int.HPRD: in vivo
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS15 6209 RPS15A 6210 pp -- int.I2D: YeastMedium, INTEROLOG
RPS6 6194 RPS16 6217 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 RPS27A 6233 pp -- int.I2D: YeastLow
SRPK1 6732 SRPK2 6733 pp -- int.I2D: BioGrid, MINT
RPS6 6194 RPS20 6224 pp -- int.I2D: YeastLow
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
PSMC6 5706 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid_Yeast, Krogan_Core, MINT_Yeast
RPS6 6194 RPS8 6202 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPS4X 6191 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
RPS8 6202 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS16 6217 RPS26 6231 pp -- int.I2D: BioGrid_Yeast
RAN 5901 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS15A 6210 RPS27A 6233 pp -- int.I2D: YeastLow
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
RAN 5901 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS20 6224 pp -- int.I2D: YeastMedium, INTEROLOG
PSMC6 5706 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS13 6207 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium
PSMD3 5709 MRPS12 6183 pd <> reg.ITFP.txt: no annot
RPS8 6202 RPS11 6205 pp -- int.I2D: BioGrid_Yeast

Related GO terms (396)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0022627cytosolic small ribosomal subunit3.00e-264.89e-227.200132139
GO:0016032viral process1.05e-231.71e-194.1682237540
GO:0019058viral life cycle1.68e-232.73e-195.8461525115
GO:0016071mRNA metabolic process1.36e-222.22e-185.0721729223
GO:0016070RNA metabolic process8.00e-221.31e-174.9241729247
GO:0019083viral transcription1.31e-212.13e-176.146132281
GO:0006415translational termination3.53e-215.77e-176.042132287
GO:0006414translational elongation8.89e-211.45e-165.946132293
GO:0003735structural constituent of ribosome3.44e-205.61e-165.4531424141
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.13e-206.74e-165.7851322104
GO:0005829cytosol8.82e-201.44e-152.41631742562
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.44e-192.35e-155.6531322114
GO:0006413translational initiation9.44e-191.54e-145.4521327131
GO:0006412translation5.08e-178.30e-134.7161429235
GO:0010467gene expression7.27e-161.19e-113.5691836669
GO:0015935small ribosomal subunit3.22e-155.26e-117.5057917
GO:0016020membrane3.89e-156.35e-112.60024481746
GO:0044822poly(A) RNA binding1.83e-132.99e-092.95919421078
GO:0044267cellular protein metabolic process2.88e-114.70e-073.5341329495
GO:0048205COPI coating of Golgi vesicle5.74e-119.37e-077.4065613
GO:0030126COPI vesicle coat5.74e-119.37e-077.4065613
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.82e-102.98e-065.4637870
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.72e-104.44e-065.3837874
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.35e-107.10e-065.2897879
GO:0006890retrograde vesicle-mediated transport, Golgi to ER2.32e-093.79e-056.4635625
GO:0070062extracellular vesicular exosome8.54e-091.39e-041.88021512516
GO:0042274ribosomal small subunit biogenesis1.09e-081.78e-047.2004612
GO:0061024membrane organization3.26e-085.33e-044.403711146
GO:0000082G1/S transition of mitotic cell cycle3.93e-086.42e-044.364711150
GO:0022624proteasome accessory complex5.21e-088.50e-046.6984417
GO:0005925focal adhesion1.02e-071.66e-033.424923370
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.38e-075.52e-035.0855665
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.38e-075.52e-035.0855665
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.07e-079.91e-034.9175673
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.94e-071.30e-024.8405677
GO:0002474antigen processing and presentation of peptide antigen via MHC class I2.14e-063.50e-024.5525794
GO:0005838proteasome regulatory particle2.33e-063.80e-026.7853312
GO:0043066negative regulation of apoptotic process4.52e-067.38e-023.027814433
GO:0006521regulation of cellular amino acid metabolic process4.78e-067.80e-025.1414550
GO:0042176regulation of protein catabolic process5.89e-069.61e-026.3703416
GO:0000209protein polyubiquitination6.05e-069.87e-024.24957116
GO:0006891intra-Golgi vesicle-mediated transport7.14e-061.16e-016.2823317
GO:0000502proteasome complex8.69e-061.42e-014.9274458
GO:0005840ribosome9.30e-061.52e-014.90241059
GO:0000056ribosomal small subunit export from nucleus1.50e-052.45e-018.200223
GO:0036464cytoplasmic ribonucleoprotein granule1.60e-052.62e-015.9113522
GO:0042981regulation of apoptotic process2.18e-053.55e-013.86957151
GO:0000278mitotic cell cycle2.66e-054.34e-012.956716398
GO:0019843rRNA binding3.02e-054.93e-015.6153427
GO:0006886intracellular protein transport4.18e-056.83e-013.67256173
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.98e-058.13e-017.463235
GO:0033119negative regulation of RNA splicing4.98e-058.13e-017.463225
GO:0006364rRNA processing6.40e-051.00e+004.2004896
GO:0048024regulation of mRNA splicing, via spliceosome7.46e-051.00e+007.200226
GO:0030529ribonucleoprotein complex1.25e-041.00e+003.95248114
GO:0030234enzyme regulator activity3.84e-041.00e+006.0852213
GO:0051233spindle midzone5.15e-041.00e+005.8782215
GO:0005654nucleoplasm5.98e-041.00e+001.8589261095
GO:0045070positive regulation of viral genome replication6.66e-041.00e+005.6982217
GO:0075733intracellular transport of virus6.66e-041.00e+005.6982317
GO:0034641cellular nitrogen compound metabolic process6.68e-041.00e+003.31745177
GO:0005737cytoplasm1.15e-031.00e+000.99818653976
GO:0045787positive regulation of cell cycle1.23e-031.00e+005.2612223
GO:0005844polysome1.45e-031.00e+005.1412225
GO:0045184establishment of protein localization1.69e-031.00e+005.0302227
GO:0008284positive regulation of cell proliferation1.80e-031.00e+002.49257392
GO:0044281small molecule metabolic process1.97e-031.00e+001.6169161295
GO:0006669sphinganine-1-phosphate biosynthetic process2.27e-031.00e+008.785111
GO:0022605oogenesis stage2.27e-031.00e+008.785111
GO:0035063nuclear speck organization2.27e-031.00e+008.785111
GO:0033176proton-transporting V-type ATPase complex2.27e-031.00e+008.785111
GO:0021691cerebellar Purkinje cell layer maturation2.27e-031.00e+008.785111
GO:0045071negative regulation of viral genome replication2.68e-031.00e+004.6982234
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway3.00e-031.00e+004.6152336
GO:0000086G2/M transition of mitotic cell cycle3.65e-031.00e+003.27236137
GO:0071338positive regulation of hair follicle cell proliferation4.53e-031.00e+007.785112
GO:0007092activation of mitotic anaphase-promoting complex activity4.53e-031.00e+007.785112
GO:0008481sphinganine kinase activity4.53e-031.00e+007.785112
GO:0004103choline kinase activity4.53e-031.00e+007.785112
GO:0060661submandibular salivary gland formation4.53e-031.00e+007.785112
GO:0017050D-erythro-sphingosine kinase activity4.53e-031.00e+007.785112
GO:0090135actin filament branching4.53e-031.00e+007.785112
GO:0006650glycerophospholipid metabolic process4.53e-031.00e+007.785112
GO:0043525positive regulation of neuron apoptotic process4.86e-031.00e+004.2612246
GO:0005198structural molecule activity5.53e-031.00e+003.05735159
GO:0007030Golgi organization5.72e-031.00e+004.1412350
GO:0051683establishment of Golgi localization6.79e-031.00e+007.200123
GO:0006670sphingosine metabolic process6.79e-031.00e+007.200113
GO:0003161cardiac conduction system development6.79e-031.00e+007.200113
GO:0010997anaphase-promoting complex binding6.79e-031.00e+007.200113
GO:0000942condensed nuclear chromosome outer kinetochore6.79e-031.00e+007.200113
GO:0016197endosomal transport7.63e-031.00e+003.9272358
GO:0019904protein domain specific binding7.90e-031.00e+002.87033181
GO:0006915apoptotic process8.90e-031.00e+001.95059571
GO:0034191apolipoprotein A-I receptor binding9.04e-031.00e+006.785114
GO:0004305ethanolamine kinase activity9.04e-031.00e+006.785114
GO:0048664neuron fate determination9.04e-031.00e+006.785114
GO:0040038polar body extrusion after meiotic divisions9.04e-031.00e+006.785114
GO:0035092sperm chromatin condensation9.04e-031.00e+006.785114
GO:0060684epithelial-mesenchymal cell signaling9.04e-031.00e+006.785114
GO:0051835positive regulation of synapse structural plasticity9.04e-031.00e+006.785114
GO:0031467Cul7-RING ubiquitin ligase complex9.04e-031.00e+006.785114
GO:0000055ribosomal large subunit export from nucleus9.04e-031.00e+006.785114
GO:0072384organelle transport along microtubule9.04e-031.00e+006.785124
GO:0003924GTPase activity1.08e-021.00e+002.70536203
GO:0005730nucleolus1.12e-021.00e+001.2379361684
GO:0031584activation of phospholipase D activity1.13e-021.00e+006.463115
GO:0036336dendritic cell migration1.13e-021.00e+006.463115
GO:0009404toxin metabolic process1.13e-021.00e+006.463115
GO:0030071regulation of mitotic metaphase/anaphase transition1.13e-021.00e+006.463115
GO:0035088establishment or maintenance of apical/basal cell polarity1.13e-021.00e+006.463115
GO:0050684regulation of mRNA processing1.13e-021.00e+006.463115
GO:1902188positive regulation of viral release from host cell1.13e-021.00e+006.463115
GO:0071168protein localization to chromatin1.13e-021.00e+006.463115
GO:0031256leading edge membrane1.13e-021.00e+006.463115
GO:0046834lipid phosphorylation1.13e-021.00e+006.463115
GO:0003729mRNA binding1.19e-021.00e+003.5952373
GO:0006184GTP catabolic process1.34e-021.00e+002.58936220
GO:0002309T cell proliferation involved in immune response1.35e-021.00e+006.200116
GO:0045182translation regulator activity1.35e-021.00e+006.200126
GO:0060789hair follicle placode formation1.35e-021.00e+006.200116
GO:0048554positive regulation of metalloenzyme activity1.35e-021.00e+006.200116
GO:0097178ruffle assembly1.35e-021.00e+006.200116
GO:0005515protein binding1.35e-021.00e+000.59621876127
GO:0006924activation-induced cell death of T cells1.35e-021.00e+006.200126
GO:0050792regulation of viral process1.35e-021.00e+006.200116
GO:0007067mitotic nuclear division1.53e-021.00e+002.51837231
GO:0007097nuclear migration1.58e-021.00e+005.978127
GO:0007091metaphase/anaphase transition of mitotic cell cycle1.58e-021.00e+005.978117
GO:00163081-phosphatidylinositol-4-phosphate 5-kinase activity1.58e-021.00e+005.978117
GO:0061512protein localization to cilium1.58e-021.00e+005.978117
GO:0003334keratinocyte development1.58e-021.00e+005.978117
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.58e-021.00e+005.978117
GO:0000028ribosomal small subunit assembly1.58e-021.00e+005.978137
GO:0034101erythrocyte homeostasis1.58e-021.00e+005.978117
GO:0048193Golgi vesicle transport1.58e-021.00e+005.978117
GO:0030157pancreatic juice secretion1.58e-021.00e+005.978117
GO:0006657CDP-choline pathway1.58e-021.00e+005.978117
GO:0043497regulation of protein heterodimerization activity1.58e-021.00e+005.978117
GO:0010761fibroblast migration1.80e-021.00e+005.785118
GO:0051489regulation of filopodium assembly1.80e-021.00e+005.785118
GO:0039702viral budding via host ESCRT complex1.80e-021.00e+005.785118
GO:0001649osteoblast differentiation1.96e-021.00e+003.2152395
GO:0005847mRNA cleavage and polyadenylation specificity factor complex2.02e-021.00e+005.615119
GO:0034067protein localization to Golgi apparatus2.02e-021.00e+005.615119
GO:0090136epithelial cell-cell adhesion2.02e-021.00e+005.615129
GO:0032863activation of Rac GTPase activity2.24e-021.00e+005.4631110
GO:0031274positive regulation of pseudopodium assembly2.24e-021.00e+005.4631210
GO:0005798Golgi-associated vesicle2.24e-021.00e+005.4631110
GO:0060047heart contraction2.24e-021.00e+005.4631110
GO:0035518histone H2A monoubiquitination2.47e-021.00e+005.3261211
GO:0030496midbody2.53e-021.00e+003.01724109
GO:1903543positive regulation of exosomal secretion2.69e-021.00e+005.2001112
GO:0019082viral protein processing2.69e-021.00e+005.2001212
GO:0007264small GTPase mediated signal transduction2.77e-021.00e+002.19037290
GO:0031929TOR signaling2.91e-021.00e+005.0851113
GO:0032479regulation of type I interferon production2.91e-021.00e+005.0851213
GO:0006646phosphatidylethanolamine biosynthetic process2.91e-021.00e+005.0851113
GO:0004143diacylglycerol kinase activity2.91e-021.00e+005.0851113
GO:0005524ATP binding3.03e-021.00e+001.1897191354
GO:0031333negative regulation of protein complex assembly3.13e-021.00e+004.9781114
GO:0031996thioesterase binding3.13e-021.00e+004.9781114
GO:0017016Ras GTPase binding3.13e-021.00e+004.9781114
GO:0007219Notch signaling pathway3.25e-021.00e+002.81924125
GO:0004674protein serine/threonine kinase activity3.33e-021.00e+002.08536312
GO:0051443positive regulation of ubiquitin-protein transferase activity3.35e-021.00e+004.8781115
GO:0048821erythrocyte development3.35e-021.00e+004.8781215
GO:0008654phospholipid biosynthetic process3.35e-021.00e+004.8781115
GO:0030131clathrin adaptor complex3.35e-021.00e+004.8781115
GO:0030225macrophage differentiation3.35e-021.00e+004.8781115
GO:0031369translation initiation factor binding3.35e-021.00e+004.8781215
GO:0003951NAD+ kinase activity3.35e-021.00e+004.8781115
GO:0019901protein kinase binding3.55e-021.00e+002.04839320
GO:0005525GTP binding3.78e-021.00e+002.01236328
GO:0030742GTP-dependent protein binding3.79e-021.00e+004.6981117
GO:0019068virion assembly3.79e-021.00e+004.6981217
GO:0006644phospholipid metabolic process3.85e-021.00e+002.68723137
GO:007188914-3-3 protein binding4.00e-021.00e+004.6151118
GO:0010800positive regulation of peptidyl-threonine phosphorylation4.00e-021.00e+004.6151118
GO:0090316positive regulation of intracellular protein transport4.00e-021.00e+004.6151118
GO:0008286insulin receptor signaling pathway4.21e-021.00e+002.61524144
GO:0006259DNA metabolic process4.22e-021.00e+004.5371119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process4.22e-021.00e+004.5371119
GO:0031572G2 DNA damage checkpoint4.22e-021.00e+004.5371119
GO:0000070mitotic sister chromatid segregation4.22e-021.00e+004.5371119
GO:0007088regulation of mitosis4.22e-021.00e+004.5371119
GO:0072661protein targeting to plasma membrane4.22e-021.00e+004.5371119
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity4.22e-021.00e+004.5371119
GO:0001578microtubule bundle formation4.44e-021.00e+004.4631120
GO:0043473pigmentation4.44e-021.00e+004.4631220
GO:0043393regulation of protein binding4.44e-021.00e+004.4631220
GO:0010628positive regulation of gene expression4.48e-021.00e+002.56624149
GO:0046847filopodium assembly4.66e-021.00e+004.3931121
GO:0000245spliceosomal complex assembly4.66e-021.00e+004.3931121
GO:0007369gastrulation4.66e-021.00e+004.3931121
GO:0045862positive regulation of proteolysis4.66e-021.00e+004.3931121
GO:0031648protein destabilization4.66e-021.00e+004.3931121
GO:0000281mitotic cytokinesis4.66e-021.00e+004.3931121
GO:0031435mitogen-activated protein kinase kinase kinase binding4.87e-021.00e+004.3261122
GO:0007220Notch receptor processing4.87e-021.00e+004.3261222
GO:0006656phosphatidylcholine biosynthetic process4.87e-021.00e+004.3261122
GO:0007052mitotic spindle organization4.87e-021.00e+004.3261122
GO:0045087innate immune response4.97e-021.00e+001.518411616
GO:1900026positive regulation of substrate adhesion-dependent cell spreading5.09e-021.00e+004.2611123
GO:0051297centrosome organization5.09e-021.00e+004.2611223
GO:0048041focal adhesion assembly5.09e-021.00e+004.2611123
GO:0002040sprouting angiogenesis5.09e-021.00e+004.2611123
GO:0051017actin filament bundle assembly5.09e-021.00e+004.2611123
GO:0005761mitochondrial ribosome5.30e-021.00e+004.2001124
GO:0007163establishment or maintenance of cell polarity5.30e-021.00e+004.2001224
GO:0006611protein export from nucleus5.52e-021.00e+004.1411125
GO:0031519PcG protein complex5.52e-021.00e+004.1411125
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway5.52e-021.00e+004.1411225
GO:0005978glycogen biosynthetic process5.73e-021.00e+004.0851226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia5.73e-021.00e+004.0851226
GO:0030148sphingolipid biosynthetic process5.73e-021.00e+004.0851126
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity5.73e-021.00e+004.0851226
GO:0045859regulation of protein kinase activity5.73e-021.00e+004.0851126
GO:0000287magnesium ion binding5.90e-021.00e+002.34222174
GO:0031424keratinization5.95e-021.00e+004.0301127
GO:0051149positive regulation of muscle cell differentiation5.95e-021.00e+004.0301227
GO:0031069hair follicle morphogenesis5.95e-021.00e+004.0301127
GO:0004672protein kinase activity6.14e-021.00e+002.30924178
GO:0032467positive regulation of cytokinesis6.16e-021.00e+003.9781128
GO:0046854phosphatidylinositol phosphorylation6.16e-021.00e+003.9781128
GO:0042626ATPase activity, coupled to transmembrane movement of substances6.16e-021.00e+003.9781128
GO:0019005SCF ubiquitin ligase complex6.38e-021.00e+003.9271129
GO:0072686mitotic spindle6.38e-021.00e+003.9271129
GO:0000139Golgi membrane6.45e-021.00e+001.69837408
GO:0031647regulation of protein stability6.59e-021.00e+003.8781130
GO:0007346regulation of mitotic cell cycle6.59e-021.00e+003.8781330
GO:0046677response to antibiotic6.80e-021.00e+003.8311131
GO:0007093mitotic cell cycle checkpoint6.80e-021.00e+003.8311231
GO:0006909phagocytosis6.80e-021.00e+003.8311131
GO:0007094mitotic spindle assembly checkpoint6.80e-021.00e+003.8311131
GO:0007173epidermal growth factor receptor signaling pathway6.95e-021.00e+002.20825191
GO:0015992proton transport7.01e-021.00e+003.7851132
GO:0032480negative regulation of type I interferon production7.01e-021.00e+003.7851232
GO:0033572transferrin transport7.01e-021.00e+003.7851132
GO:0033077T cell differentiation in thymus7.22e-021.00e+003.7411133
GO:0042692muscle cell differentiation7.43e-021.00e+003.6981234
GO:0001890placenta development7.43e-021.00e+003.6981134
GO:0051701interaction with host7.43e-021.00e+003.6981134
GO:0005876spindle microtubule7.43e-021.00e+003.6981134
GO:0007205protein kinase C-activating G-protein coupled receptor signaling pathway7.64e-021.00e+003.6561135
GO:0034332adherens junction organization7.85e-021.00e+003.6151436
GO:0007077mitotic nuclear envelope disassembly8.06e-021.00e+003.5761137
GO:0016301kinase activity8.06e-021.00e+003.5761237
GO:0001568blood vessel development8.27e-021.00e+003.5371238
GO:0045740positive regulation of DNA replication8.27e-021.00e+003.5371138
GO:0050681androgen receptor binding8.27e-021.00e+003.5371238
GO:0090382phagosome maturation8.27e-021.00e+003.5371138
GO:0008047enzyme activator activity8.48e-021.00e+003.5001139
GO:0032092positive regulation of protein binding8.48e-021.00e+003.5001139
GO:0005765lysosomal membrane8.72e-021.00e+002.01722218
GO:0006468protein phosphorylation8.85e-021.00e+001.50336467
GO:0007249I-kappaB kinase/NF-kappaB signaling8.90e-021.00e+003.4271441
GO:0030521androgen receptor signaling pathway8.90e-021.00e+003.4271341
GO:0031532actin cytoskeleton reorganization9.10e-021.00e+003.3931242
GO:0042147retrograde transport, endosome to Golgi9.10e-021.00e+003.3931142
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway9.31e-021.00e+003.3591243
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process9.52e-021.00e+003.3261144
GO:0007286spermatid development9.52e-021.00e+003.3261144
GO:0034613cellular protein localization9.52e-021.00e+003.3261244
GO:0008380RNA splicing9.69e-021.00e+001.92725232
GO:0021762substantia nigra development9.93e-021.00e+003.2611246
GO:0044297cell body9.93e-021.00e+003.2611146
GO:0045727positive regulation of translation9.93e-021.00e+003.2611146
GO:0030216keratinocyte differentiation1.01e-011.00e+003.2301147
GO:0008344adult locomotory behavior1.01e-011.00e+003.2301247
GO:0005634nucleus1.02e-011.00e+000.45515664828
GO:0019003GDP binding1.03e-011.00e+003.2001148
GO:0060326cell chemotaxis1.09e-011.00e+003.1131151
GO:0000910cytokinesis1.09e-011.00e+003.1131251
GO:0007254JNK cascade1.09e-011.00e+003.1131351
GO:0030674protein binding, bridging1.11e-011.00e+003.0851152
GO:0030175filopodium1.14e-011.00e+003.0571253
GO:0030666endocytic vesicle membrane1.16e-011.00e+003.0301254
GO:0019900kinase binding1.16e-011.00e+003.0301354
GO:0006661phosphatidylinositol biosynthetic process1.16e-011.00e+003.0301154
GO:0051403stress-activated MAPK cascade1.16e-011.00e+003.0301454
GO:0046330positive regulation of JNK cascade1.18e-011.00e+003.0041155
GO:0005793endoplasmic reticulum-Golgi intermediate compartment1.22e-011.00e+002.9521157
GO:0006879cellular iron ion homeostasis1.22e-011.00e+002.9521257
GO:0005643nuclear pore1.26e-011.00e+002.9021159
GO:0043065positive regulation of apoptotic process1.28e-011.00e+001.68726274
GO:0033138positive regulation of peptidyl-serine phosphorylation1.30e-011.00e+002.8541161
GO:0032481positive regulation of type I interferon production1.30e-011.00e+002.8541361
GO:0000776kinetochore1.33e-011.00e+002.8081363
GO:0006417regulation of translation1.33e-011.00e+002.8081463
GO:0007059chromosome segregation1.35e-011.00e+002.7851364
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway1.35e-011.00e+002.7851264
GO:0034166toll-like receptor 10 signaling pathway1.37e-011.00e+002.7631565
GO:0034146toll-like receptor 5 signaling pathway1.37e-011.00e+002.7631565
GO:0031295T cell costimulation1.41e-011.00e+002.7191367
GO:0030141secretory granule1.41e-011.00e+002.7191267
GO:0006665sphingolipid metabolic process1.43e-011.00e+002.6981168
GO:0018105peptidyl-serine phosphorylation1.45e-011.00e+002.6761569
GO:0016567protein ubiquitination1.47e-011.00e+001.56123299
GO:0035264multicellular organism growth1.47e-011.00e+002.6561170
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.49e-011.00e+002.6351571
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.49e-011.00e+002.6351571
GO:0034162toll-like receptor 9 signaling pathway1.51e-011.00e+002.6151572
GO:0032587ruffle membrane1.51e-011.00e+002.6151172
GO:0034134toll-like receptor 2 signaling pathway1.53e-011.00e+002.5951573
GO:0000785chromatin1.53e-011.00e+002.5951273
GO:0060070canonical Wnt signaling pathway1.57e-011.00e+002.5561275
GO:0046474glycerophospholipid biosynthetic process1.59e-011.00e+002.5371276
GO:0035666TRIF-dependent toll-like receptor signaling pathway1.59e-011.00e+002.5371576
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.61e-011.00e+002.5181477
GO:0035556intracellular signal transduction1.61e-011.00e+001.47725317
GO:0002756MyD88-independent toll-like receptor signaling pathway1.63e-011.00e+002.5001578
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.66e-011.00e+002.4631580
GO:0034138toll-like receptor 3 signaling pathway1.66e-011.00e+002.4631580
GO:0010629negative regulation of gene expression1.66e-011.00e+002.4631280
GO:0031902late endosome membrane1.66e-011.00e+002.4631180
GO:0045177apical part of cell1.70e-011.00e+002.4271182
GO:0008283cell proliferation1.72e-011.00e+001.41424331
GO:0043231intracellular membrane-bounded organelle1.73e-011.00e+001.41023332
GO:0005179hormone activity1.74e-011.00e+002.3931184
GO:0005929cilium1.74e-011.00e+002.3931284
GO:0005813centrosome1.79e-011.00e+001.38029339
GO:0050852T cell receptor signaling pathway1.81e-011.00e+002.3261288
GO:0005794Golgi apparatus1.82e-011.00e+001.02638650
GO:0042593glucose homeostasis1.83e-011.00e+002.3091189
GO:0000187activation of MAPK activity1.85e-011.00e+002.2931390
GO:0042384cilium assembly1.85e-011.00e+002.2931290
GO:0000922spindle pole1.87e-011.00e+002.2771591
GO:0016363nuclear matrix1.89e-011.00e+002.2611492
GO:0042470melanosome1.89e-011.00e+002.2611292
GO:0003723RNA binding1.92e-011.00e+001.313210355
GO:0016310phosphorylation1.94e-011.00e+002.2151195
GO:0034142toll-like receptor 4 signaling pathway1.96e-011.00e+002.2001596
GO:0071456cellular response to hypoxia2.00e-011.00e+002.1701398
GO:0051726regulation of cell cycle2.07e-011.00e+002.11312102
GO:0002224toll-like receptor signaling pathway2.20e-011.00e+002.01715109
GO:0005815microtubule organizing center2.22e-011.00e+002.00414110
GO:0015630microtubule cytoskeleton2.25e-011.00e+001.97814112
GO:0005819spindle2.29e-011.00e+001.95214114
GO:0097190apoptotic signaling pathway2.32e-011.00e+001.92713116
GO:0005802trans-Golgi network2.32e-011.00e+001.92712116
GO:0006006glucose metabolic process2.37e-011.00e+001.89014119
GO:0051056regulation of small GTPase mediated signal transduction2.44e-011.00e+001.84213123
GO:0051092positive regulation of NF-kappaB transcription factor activity2.48e-011.00e+001.81913125
GO:0006511ubiquitin-dependent protein catabolic process2.51e-011.00e+001.79613127
GO:0030036actin cytoskeleton organization2.55e-011.00e+001.77413129
GO:0030027lamellipodium2.56e-011.00e+001.76313130
GO:0007179transforming growth factor beta receptor signaling pathway2.56e-011.00e+001.76314130
GO:0016477cell migration2.58e-011.00e+001.75211131
GO:0009615response to virus2.60e-011.00e+001.74114132
GO:0005911cell-cell junction2.77e-011.00e+001.63512142
GO:0016887ATPase activity2.80e-011.00e+001.61511144
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.86e-011.00e+001.57613148
GO:0008017microtubule binding2.90e-011.00e+001.55612150
GO:0010008endosome membrane3.01e-011.00e+001.49012157
GO:0008543fibroblast growth factor receptor signaling pathway3.04e-011.00e+001.47213159
GO:0043005neuron projection3.07e-011.00e+001.45416161
GO:0034220ion transmembrane transport3.17e-011.00e+001.40112167
GO:0006397mRNA processing3.20e-011.00e+001.38413169
GO:0038095Fc-epsilon receptor signaling pathway3.23e-011.00e+001.36713171
GO:0007420brain development3.25e-011.00e+001.35913172
GO:0055085transmembrane transport3.26e-011.00e+000.77923514
GO:0016607nuclear speck3.29e-011.00e+001.33412175
GO:0006367transcription initiation from RNA polymerase II promoter3.43e-011.00e+001.26115184
GO:0001525angiogenesis3.67e-011.00e+001.14113200
GO:0000122negative regulation of transcription from RNA polymerase II promoter3.88e-011.00e+000.58329589
GO:0005783endoplasmic reticulum4.05e-011.00e+000.53226610
GO:0019221cytokine-mediated signaling pathway4.09e-011.00e+000.93915230
GO:0003713transcription coactivator activity4.21e-011.00e+000.88416239
GO:0030425dendrite4.22e-011.00e+000.87813240
GO:0043025neuronal cell body4.41e-011.00e+000.79615254
GO:0004842ubiquitin-protein transferase activity4.43e-011.00e+000.78513256
GO:0006281DNA repair4.53e-011.00e+000.74115264
GO:0000166nucleotide binding4.63e-011.00e+000.69812272
GO:0048011neurotrophin TRK receptor signaling pathway4.65e-011.00e+000.69215273
GO:0005975carbohydrate metabolic process4.66e-011.00e+000.68713274
GO:0006200ATP catabolic process5.00e-011.00e+000.54214303
GO:0005575cellular_component5.22e-011.00e+000.45412322
GO:0030154cell differentiation5.25e-011.00e+000.44113325
GO:0007411axon guidance5.27e-011.00e+000.43213327
GO:0003682chromatin binding5.35e-011.00e+000.40114334
GO:0007275multicellular organismal development5.46e-011.00e+000.35912344
GO:0015031protein transport5.59e-011.00e+000.30514357
GO:0007165signal transduction6.43e-011.00e+00-0.10727950
GO:0008150biological_process6.52e-011.00e+00-0.05713459
GO:0007596blood coagulation6.56e-011.00e+00-0.07315464
GO:0045893positive regulation of transcription, DNA-templated6.74e-011.00e+00-0.14318487
GO:0042802identical protein binding6.77e-011.00e+00-0.15514491
GO:0048471perinuclear region of cytoplasm7.01e-011.00e+00-0.24619523
GO:0005886plasma membrane7.94e-011.00e+00-0.3625242834
GO:0003677DNA binding8.23e-011.00e+00-0.6152141351
GO:0045944positive regulation of transcription from RNA polymerase II promoter8.49e-011.00e+00-0.879111811
GO:0046872metal ion binding8.57e-011.00e+00-0.7322141465
GO:0005615extracellular space9.06e-011.00e+00-1.195131010
GO:0008270zinc ion binding9.18e-011.00e+00-1.274171067
GO:0006351transcription, DNA-templated9.77e-011.00e+00-1.8451171585