int-snw-5706

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
tai-screen-luciferase 6.189 4.80e-127 1.20e-06 4.35e-03
tai-screen-luciferase-int-snw-5706 subnetwork

Genes (25)

Gene Symbol Entrez Gene ID Frequency tai-screen-luciferase gene score Best subnetwork score Degree List-Gonzales GI Tai-Hits
PLK1 5347 2-3.6906.189217Yes-
RPS20 6224 4-4.7576.314153Yes-
RPS8 6202 10-5.5457.555234--
CHMP2A 27243 10-9.0377.55541YesYes
RPS15 6209 7-5.0407.011116Yes-
COPA 1314 32-9.3959.063170YesYes
RPS24 6229 21-7.0348.389217Yes-
RPS9 6203 18-7.1277.555140Yes-
COPB2 9276 32-13.1689.06341YesYes
RPS4X 6191 18-6.7477.555263Yes-
COPZ1 22818 32-8.3019.06313YesYes
PSMD1 5707 3-3.6046.408113-Yes
ATP6V1D 51382 8-4.1317.286149--
RPS15A 6210 8-5.4137.555177Yes-
CDC42 998 11-6.9608.389265YesYes
RPS27A 6233 15-5.6318.389342Yes-
[ PSMC6 ] 5706 2-3.1696.408158--
RPS11 6205 17-6.5887.555175Yes-
PSMD3 5709 3-3.9356.408146-Yes
RPS6 6194 17-5.6038.046208Yes-
SKP1 6500 4-3.7506.413203--
RAN 5901 4-3.8096.905175YesYes
RPS26 6231 17-7.4788.04660Yes-
ARCN1 372 32-8.2329.063118YesYes
RPS13 6207 17-6.5897.555174Yes-

Interactions (75)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPS9 6203 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS9 6203 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RAN 5901 RPS11 6205 pp -- int.I2D: IntAct_Worm, BioGrid_Worm, BIND_Worm, MINT_Worm, NON_CORE
CDC42 998 RPS27A 6233 pp -- int.I2D: SOURAV_MAPK_HIGH
RPS4X 6191 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 RPS27A 6233 pp -- int.I2D: YeastLow
RPS9 6203 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 RAN 5901 pp -- int.I2D: YeastLow
PSMC6 5706 SKP1 6500 pp -- int.I2D: YeastLow
RPS6 6194 RPS20 6224 pp -- int.I2D: YeastLow
RPS4X 6191 RPS8 6202 pp -- int.I2D: BioGrid_Yeast
RAN 5901 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPA 1314 pp -- int.I2D: BCI, BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, YeastHigh, HPRD, Krogan_Core;
int.HPRD: in vivo
PSMC6 5706 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastHigh
RPS15 6209 RPS15A 6210 pp -- int.I2D: YeastMedium, INTEROLOG
RPS4X 6191 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, MINT_Yeast, Tarassov_PCA, YeastMedium, INTEROLOG
COPA 1314 COPB2 9276 pp -- int.I2D: BioGrid, HPRD, BCI;
int.HPRD: in vivo
RPS11 6205 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS27A 6233 pp -- int.I2D: YeastLow
RPS8 6202 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
PLK1 5347 RPS8 6202 pp -- int.I2D: BioGrid_Fly, FlyEmbryo, IntAct_Fly
RPS9 6203 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS8 6202 pp -- int.I2D: BioGrid_Yeast, YeastLow
COPA 1314 COPZ1 22818 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastMedium
RPS11 6205 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS11 6205 RPS20 6224 pp -- int.I2D: YeastMedium, INTEROLOG
COPA 1314 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS13 6207 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS11 6205 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS15A 6210 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastHigh, YeastMedium
SKP1 6500 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS4X 6191 RPS9 6203 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 RAN 5901 pp -- int.I2D: YeastLow
RPS15A 6210 RPS27A 6233 pp -- int.I2D: YeastLow
RPS6 6194 RPS15 6209 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS20 6224 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS20 6224 RPS26 6231 pp -- int.I2D: YeastLow
PLK1 5347 PSMD1 5707 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RAN 5901 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS11 6205 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS8 6202 SKP1 6500 pp -- int.I2D: BioGrid_Yeast
RPS15A 6210 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS26 6231 pp -- int.I2D: YeastLow
COPA 1314 RPS27A 6233 pp -- int.I2D: YeastLow
RPS6 6194 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS11 6205 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
PSMC6 5706 PSMD1 5707 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, BioGrid_Yeast, Krogan_Core, MINT_Yeast
PSMD1 5707 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, MINT_Yeast, Krogan_Core
PLK1 5347 RPS27A 6233 pp -- int.I2D: YeastLow
RAN 5901 RPS15 6209 pp -- int.I2D: YeastLow
RPS6 6194 RPS11 6205 pp -- int.I2D: BioGrid_Yeast
RPS6 6194 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS4X 6191 RPS6 6194 pp -- int.I2D: BioGrid_Yeast
RPS15 6209 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 ATP6V1D 51382 pp -- int.I2D: BioGrid_Yeast
RPS13 6207 RPS24 6229 pp -- int.I2D: BioGrid_Yeast
ARCN1 372 COPB2 9276 pp -- int.I2D: HPRD, BCI;
int.HPRD: in vivo
RPS8 6202 CHMP2A 27243 pp -- int.I2D: BioGrid_Yeast
PLK1 5347 PSMC6 5706 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast
RPS8 6202 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast
RPS20 6224 RPS27A 6233 pp -- int.I2D: YeastLow
RPS15 6209 RPS20 6224 pp -- int.I2D: BioGrid_Yeast, INTEROLOG, YeastMedium
RPS4X 6191 RPS15 6209 pp -- int.I2D: INTEROLOG, YeastMedium
RPS27A 6233 SKP1 6500 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMC6 5706 ATP6V1D 51382 pp -- int.I2D: YeastLow
RPS4X 6191 RPS15A 6210 pp -- int.I2D: BioGrid_Yeast, YeastMedium, INTEROLOG
RPS8 6202 RPS13 6207 pp -- int.I2D: BioGrid_Yeast
RPS24 6229 RPS27A 6233 pp -- int.I2D: YeastMedium

Related GO terms (326)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0022627cytosolic small ribosomal subunit1.18e-251.70e-217.472122039
GO:0019058viral life cycle7.68e-241.11e-196.1341423115
GO:0016071mRNA metabolic process1.22e-211.77e-175.2781525223
GO:0019083viral transcription2.06e-212.97e-176.417122081
GO:0016032viral process4.88e-217.04e-174.2811833534
GO:0006415translational termination5.14e-217.42e-176.314122087
GO:0016070RNA metabolic process5.86e-218.45e-175.1311525247
GO:0006414translational elongation1.20e-201.73e-166.218122093
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.94e-207.13e-166.0571220104
GO:0005829cytosol8.15e-201.18e-152.53125612496
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.57e-192.26e-155.9241220114
GO:0006413translational initiation8.87e-191.28e-145.7241221131
GO:0003735structural constituent of ribosome1.55e-182.23e-145.6591222137
GO:0016020membrane1.77e-162.55e-122.84921411681
GO:0010467gene expression5.33e-167.69e-123.7861629669
GO:0006412translation8.79e-161.27e-114.9121223230
GO:0044267cellular protein metabolic process4.88e-127.04e-083.8681223474
GO:0015935small ribosomal subunit6.24e-119.00e-077.4075917
GO:0044822poly(A) RNA binding2.43e-103.50e-062.93514321056
GO:0070062extracellular vesicular exosome1.33e-091.91e-052.11318402400
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.73e-092.49e-055.6286870
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.43e-093.51e-055.5486874
GO:0030126COPI vesicle coat3.44e-094.96e-057.5874712
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.63e-095.23e-055.4536879
GO:0048205COPI coating of Golgi vesicle4.97e-097.16e-057.4724813
GO:0006890retrograde vesicle-mediated transport, Golgi to ER8.66e-081.25e-036.5284825
GO:0061024membrane organization1.41e-072.03e-034.577612145
GO:0000082G1/S transition of mitotic cell cycle1.66e-072.39e-034.53869149
GO:0042274ribosomal small subunit biogenesis1.00e-061.44e-027.1723612
GO:0005925focal adhesion2.07e-062.99e-023.464719366
GO:0042176regulation of protein catabolic process2.54e-063.66e-026.7573316
GO:0005840ribosome2.80e-064.03e-025.3144858
GO:0022624proteasome accessory complex3.08e-064.44e-026.6703417
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.16e-066.00e-025.1724664
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.43e-066.38e-025.1504665
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent6.67e-069.62e-025.0024672
GO:0036464cytoplasmic ribonucleoprotein granule6.93e-061.00e-016.2983322
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I7.85e-061.13e-014.9434675
GO:0000056ribosomal small subunit export from nucleus8.64e-061.25e-018.587223
GO:0019843rRNA binding1.31e-051.89e-016.0023427
GO:0002474antigen processing and presentation of peptide antigen via MHC class I1.77e-052.55e-014.6494692
GO:0000462maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.88e-054.15e-017.850235
GO:0033119negative regulation of RNA splicing2.88e-054.15e-017.850225
GO:0030529ribonucleoprotein complex3.84e-055.54e-014.36547112
GO:0000278mitotic cell cycle4.37e-056.30e-013.146611391
GO:0000209protein polyubiquitination4.41e-056.36e-014.31447116
GO:0043066negative regulation of apoptotic process6.86e-059.90e-013.029613424
GO:0006521regulation of cellular amino acid metabolic process8.54e-051.00e+005.1133450
GO:0042981regulation of apoptotic process1.20e-041.00e+003.94347150
GO:0000502proteasome complex1.33e-041.00e+004.8993458
GO:0005838proteasome regulatory particle1.88e-041.00e+006.5872312
GO:0006886intracellular protein transport1.99e-041.00e+003.75447171
GO:0030234enzyme regulator activity2.22e-041.00e+006.4722213
GO:0051233spindle midzone2.99e-041.00e+006.2652215
GO:0005654nucleoplasm3.33e-041.00e+002.0938151082
GO:0075733intracellular transport of virus3.86e-041.00e+006.0852317
GO:0006891intra-Golgi vesicle-mediated transport3.86e-041.00e+006.0852417
GO:0006364rRNA processing5.56e-041.00e+004.2033794
GO:0005844polysome7.14e-041.00e+005.6492223
GO:0045184establishment of protein localization9.86e-041.00e+005.4172227
GO:0000086G2/M transition of mitotic cell cycle1.62e-031.00e+003.67035136
GO:0022605oogenesis stage1.73e-031.00e+009.172111
GO:0033176proton-transporting V-type ATPase complex1.73e-031.00e+009.172111
GO:0021691cerebellar Purkinje cell layer maturation1.73e-031.00e+009.172111
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway1.75e-031.00e+005.0022336
GO:0034641cellular nitrogen compound metabolic process3.11e-031.00e+003.33934171
GO:0071338positive regulation of hair follicle cell proliferation3.46e-031.00e+008.172112
GO:0007092activation of mitotic anaphase-promoting complex activity3.46e-031.00e+008.172112
GO:0040038polar body extrusion after meiotic divisions3.46e-031.00e+008.172112
GO:0060661submandibular salivary gland formation3.46e-031.00e+008.172112
GO:0090135actin filament branching3.46e-031.00e+008.172112
GO:0016197endosomal transport4.34e-031.00e+004.3392357
GO:0005737cytoplasm5.04e-031.00e+000.99313433767
GO:0051683establishment of Golgi localization5.19e-031.00e+007.587123
GO:0034191apolipoprotein A-I receptor binding5.19e-031.00e+007.587113
GO:0003161cardiac conduction system development5.19e-031.00e+007.587113
GO:0010997anaphase-promoting complex binding5.19e-031.00e+007.587113
GO:0000942condensed nuclear chromosome outer kinetochore5.19e-031.00e+007.587113
GO:0007067mitotic nuclear division6.85e-031.00e+002.93135227
GO:0003729mRNA binding6.85e-031.00e+004.0022272
GO:0048664neuron fate determination6.92e-031.00e+007.172114
GO:0060684epithelial-mesenchymal cell signaling6.92e-031.00e+007.172114
GO:0051835positive regulation of synapse structural plasticity6.92e-031.00e+007.172114
GO:0031467Cul7-RING ubiquitin ligase complex6.92e-031.00e+007.172114
GO:0000055ribosomal large subunit export from nucleus6.92e-031.00e+007.172114
GO:0072384organelle transport along microtubule6.92e-031.00e+007.172124
GO:0036336dendritic cell migration8.64e-031.00e+006.850115
GO:0030071regulation of mitotic metaphase/anaphase transition8.64e-031.00e+006.850115
GO:0035088establishment or maintenance of apical/basal cell polarity8.64e-031.00e+006.850115
GO:1902188positive regulation of viral release from host cell8.64e-031.00e+006.850115
GO:0071168protein localization to chromatin8.64e-031.00e+006.850115
GO:0031256leading edge membrane8.64e-031.00e+006.850115
GO:0007097nuclear migration1.04e-021.00e+006.587116
GO:0061512protein localization to cilium1.04e-021.00e+006.587116
GO:0003334keratinocyte development1.04e-021.00e+006.587116
GO:0002309T cell proliferation involved in immune response1.04e-021.00e+006.587116
GO:0045182translation regulator activity1.04e-021.00e+006.587126
GO:0060789hair follicle placode formation1.04e-021.00e+006.587116
GO:0048554positive regulation of metalloenzyme activity1.04e-021.00e+006.587116
GO:0006924activation-induced cell death of T cells1.04e-021.00e+006.587116
GO:0043497regulation of protein heterodimerization activity1.04e-021.00e+006.587116
GO:0050792regulation of viral process1.04e-021.00e+006.587116
GO:0001649osteoblast differentiation1.10e-021.00e+003.6492392
GO:0007091metaphase/anaphase transition of mitotic cell cycle1.21e-021.00e+006.365117
GO:0051988regulation of attachment of spindle microtubules to kinetochore1.21e-021.00e+006.365117
GO:0000028ribosomal small subunit assembly1.21e-021.00e+006.365137
GO:0034101erythrocyte homeostasis1.21e-021.00e+006.365117
GO:0051489regulation of filopodium assembly1.21e-021.00e+006.365117
GO:0030157pancreatic juice secretion1.21e-021.00e+006.365117
GO:0039702viral budding via host ESCRT complex1.38e-021.00e+006.172118
GO:0006915apoptotic process1.44e-021.00e+002.05649555
GO:0030496midbody1.49e-021.00e+003.41722108
GO:0090136epithelial cell-cell adhesion1.55e-021.00e+006.002119
GO:0019901protein kinase binding1.69e-021.00e+002.44936317
GO:0031274positive regulation of pseudopodium assembly1.72e-021.00e+005.8501210
GO:0060047heart contraction1.72e-021.00e+005.8501110
GO:0007219Notch signaling pathway1.82e-021.00e+003.26523120
GO:0005730nucleolus1.85e-021.00e+001.2997241641
GO:0035518histone H2A monoubiquitination1.89e-021.00e+005.7131111
GO:0051443positive regulation of ubiquitin-protein transferase activity2.06e-021.00e+005.5871112
GO:1903543positive regulation of exosomal secretion2.06e-021.00e+005.5871112
GO:0019082viral protein processing2.06e-021.00e+005.5871212
GO:0031929TOR signaling2.23e-021.00e+005.4721113
GO:0032479regulation of type I interferon production2.23e-021.00e+005.4721213
GO:0031333negative regulation of protein complex assembly2.40e-021.00e+005.3651114
GO:0031996thioesterase binding2.40e-021.00e+005.3651114
GO:0030131clathrin adaptor complex2.40e-021.00e+005.3651214
GO:0008286insulin receptor signaling pathway2.49e-021.00e+003.02223142
GO:0048821erythrocyte development2.57e-021.00e+005.2651115
GO:0030225macrophage differentiation2.57e-021.00e+005.2651115
GO:0031369translation initiation factor binding2.57e-021.00e+005.2651115
GO:0008284positive regulation of cell proliferation2.75e-021.00e+002.18037382
GO:0005198structural molecule activity2.76e-021.00e+002.94326150
GO:0010800positive regulation of peptidyl-threonine phosphorylation2.91e-021.00e+005.0851117
GO:0030742GTP-dependent protein binding2.91e-021.00e+005.0851117
GO:0090316positive regulation of intracellular protein transport2.91e-021.00e+005.0851117
GO:0019068virion assembly2.91e-021.00e+005.0851217
GO:0007088regulation of mitosis3.08e-021.00e+005.0021118
GO:0046847filopodium assembly3.24e-021.00e+004.9241119
GO:0006259DNA metabolic process3.24e-021.00e+004.9241119
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process3.24e-021.00e+004.9241119
GO:0031572G2 DNA damage checkpoint3.24e-021.00e+004.9241119
GO:0007369gastrulation3.24e-021.00e+004.9241119
GO:0000070mitotic sister chromatid segregation3.24e-021.00e+004.9241119
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activity3.24e-021.00e+004.9241119
GO:0001578microtubule bundle formation3.41e-021.00e+004.8501120
GO:0043473pigmentation3.41e-021.00e+004.8501120
GO:0043393regulation of protein binding3.41e-021.00e+004.8501220
GO:0031435mitogen-activated protein kinase kinase kinase binding3.58e-021.00e+004.7801121
GO:0045862positive regulation of proteolysis3.58e-021.00e+004.7801121
GO:0031648protein destabilization3.58e-021.00e+004.7801121
GO:0000281mitotic cytokinesis3.58e-021.00e+004.7801121
GO:0031424keratinization3.75e-021.00e+004.7131122
GO:0051297centrosome organization3.75e-021.00e+004.7131222
GO:0007220Notch receptor processing3.75e-021.00e+004.7131222
GO:0045787positive regulation of cell cycle3.75e-021.00e+004.7131222
GO:0007052mitotic spindle organization3.75e-021.00e+004.7131122
GO:0019904protein domain specific binding3.81e-021.00e+002.68823179
GO:1900026positive regulation of substrate adhesion-dependent cell spreading3.91e-021.00e+004.6491123
GO:0002040sprouting angiogenesis3.91e-021.00e+004.6491123
GO:0051017actin filament bundle assembly3.91e-021.00e+004.6491123
GO:0007163establishment or maintenance of cell polarity4.08e-021.00e+004.5871124
GO:0007173epidermal growth factor receptor signaling pathway4.21e-021.00e+002.61024189
GO:0006611protein export from nucleus4.25e-021.00e+004.5281125
GO:0031519PcG protein complex4.25e-021.00e+004.5281125
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway4.25e-021.00e+004.5281225
GO:0005978glycogen biosynthetic process4.41e-021.00e+004.4721226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia4.41e-021.00e+004.4721226
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity4.41e-021.00e+004.4721226
GO:0045859regulation of protein kinase activity4.41e-021.00e+004.4721126
GO:0042626ATPase activity, coupled to transmembrane movement of substances4.41e-021.00e+004.4721126
GO:0003924GTPase activity4.53e-021.00e+002.55027197
GO:0051149positive regulation of muscle cell differentiation4.58e-021.00e+004.4171127
GO:0032467positive regulation of cytokinesis4.58e-021.00e+004.4171127
GO:0031069hair follicle morphogenesis4.58e-021.00e+004.4171127
GO:0019005SCF ubiquitin ligase complex4.91e-021.00e+004.3141129
GO:0015992proton transport4.91e-021.00e+004.3141129
GO:0007346regulation of mitotic cell cycle4.91e-021.00e+004.3141229
GO:0072686mitotic spindle4.91e-021.00e+004.3141129
GO:0031647regulation of protein stability5.08e-021.00e+004.2651130
GO:0033572transferrin transport5.08e-021.00e+004.2651130
GO:0046677response to antibiotic5.24e-021.00e+004.2181131
GO:0001890placenta development5.24e-021.00e+004.2181131
GO:0007093mitotic cell cycle checkpoint5.24e-021.00e+004.2181131
GO:0007094mitotic spindle assembly checkpoint5.24e-021.00e+004.2181131
GO:0006184GTP catabolic process5.26e-021.00e+002.43127214
GO:0044281small molecule metabolic process5.36e-021.00e+001.2525151211
GO:0032480negative regulation of type I interferon production5.41e-021.00e+004.1721232
GO:0051701interaction with host5.41e-021.00e+004.1721132
GO:0016301kinase activity5.57e-021.00e+004.1281233
GO:0033077T cell differentiation in thymus5.57e-021.00e+004.1281133
GO:0042692muscle cell differentiation5.73e-021.00e+004.0851134
GO:0005876spindle microtubule5.73e-021.00e+004.0851134
GO:0034332adherens junction organization6.06e-021.00e+004.0021236
GO:0007077mitotic nuclear envelope disassembly6.06e-021.00e+004.0021136
GO:0045740positive regulation of DNA replication6.06e-021.00e+004.0021136
GO:0090382phagosome maturation6.06e-021.00e+004.0021136
GO:0032092positive regulation of protein binding6.39e-021.00e+003.9241138
GO:0050681androgen receptor binding6.39e-021.00e+003.9241138
GO:0007286spermatid development6.88e-021.00e+003.8151141
GO:0007249I-kappaB kinase/NF-kappaB signaling6.88e-021.00e+003.8151341
GO:0030521androgen receptor signaling pathway6.88e-021.00e+003.8151141
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway7.20e-021.00e+003.7461243
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process7.36e-021.00e+003.7131144
GO:0021762substantia nigra development7.36e-021.00e+003.7131144
GO:0034613cellular protein localization7.36e-021.00e+003.7131244
GO:0045727positive regulation of translation7.36e-021.00e+003.7131144
GO:0008344adult locomotory behavior7.36e-021.00e+003.7131144
GO:0044297cell body7.68e-021.00e+003.6491146
GO:0043525positive regulation of neuron apoptotic process7.68e-021.00e+003.6491246
GO:0043065positive regulation of apoptotic process7.80e-021.00e+002.10626268
GO:0019003GDP binding7.84e-021.00e+003.6181247
GO:0007030Golgi organization8.16e-021.00e+003.5581249
GO:0007254JNK cascade8.16e-021.00e+003.5581349
GO:0030175filopodium8.32e-021.00e+003.5281250
GO:0007264small GTPase mediated signal transduction8.36e-021.00e+002.04827279
GO:0000910cytokinesis8.48e-021.00e+003.5001251
GO:0006879cellular iron ion homeostasis8.48e-021.00e+003.5001151
GO:0030674protein binding, bridging8.48e-021.00e+003.5001151
GO:0030666endocytic vesicle membrane8.80e-021.00e+003.4441253
GO:0051403stress-activated MAPK cascade8.96e-021.00e+003.4171354
GO:0046330positive regulation of JNK cascade9.12e-021.00e+003.3911155
GO:0016567protein ubiquitination9.19e-021.00e+001.96823295
GO:0005643nuclear pore9.43e-021.00e+003.3391157
GO:0033138positive regulation of peptidyl-serine phosphorylation9.75e-021.00e+003.2901159
GO:0005525GTP binding1.00e-011.00e+001.89627310
GO:0032481positive regulation of type I interferon production1.01e-011.00e+003.2411361
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway1.01e-011.00e+003.2411261
GO:0030141secretory granule1.02e-011.00e+003.2181162
GO:0006417regulation of translation1.02e-011.00e+003.2181262
GO:0000776kinetochore1.04e-011.00e+003.1951263
GO:0031295T cell costimulation1.07e-011.00e+003.1501365
GO:0034166toll-like receptor 10 signaling pathway1.07e-011.00e+003.1501465
GO:0034146toll-like receptor 5 signaling pathway1.07e-011.00e+003.1501465
GO:0005515protein binding1.08e-011.00e+000.42314626024
GO:0005813centrosome1.09e-011.00e+001.82325326
GO:0035264multicellular organism growth1.10e-011.00e+003.1061167
GO:0018105peptidyl-serine phosphorylation1.13e-011.00e+003.0641469
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway1.16e-011.00e+003.0221471
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway1.16e-011.00e+003.0221471
GO:0034162toll-like receptor 9 signaling pathway1.18e-011.00e+003.0021472
GO:0034134toll-like receptor 2 signaling pathway1.19e-011.00e+002.9821473
GO:0000785chromatin1.19e-011.00e+002.9821173
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.21e-011.00e+002.9631274
GO:0060070canonical Wnt signaling pathway1.22e-011.00e+002.9431175
GO:0035666TRIF-dependent toll-like receptor signaling pathway1.24e-011.00e+002.9241476
GO:0010629negative regulation of gene expression1.25e-011.00e+002.9051277
GO:0031902late endosome membrane1.25e-011.00e+002.9051277
GO:0005929cilium1.25e-011.00e+002.9051177
GO:0002756MyD88-independent toll-like receptor signaling pathway1.27e-011.00e+002.8871478
GO:0034138toll-like receptor 3 signaling pathway1.28e-011.00e+002.8681479
GO:0005179hormone activity1.28e-011.00e+002.8681179
GO:0002755MyD88-dependent toll-like receptor signaling pathway1.30e-011.00e+002.8501480
GO:0045177apical part of cell1.31e-011.00e+002.8321181
GO:0050852T cell receptor signaling pathway1.37e-011.00e+002.7631285
GO:0042384cilium assembly1.39e-011.00e+002.7461186
GO:0042593glucose homeostasis1.40e-011.00e+002.7291187
GO:0000922spindle pole1.40e-011.00e+002.7291387
GO:0000187activation of MAPK activity1.45e-011.00e+002.6801290
GO:0042470melanosome1.46e-011.00e+002.6641291
GO:0071456cellular response to hypoxia1.48e-011.00e+002.6491392
GO:0034142toll-like receptor 4 signaling pathway1.54e-011.00e+002.5871496
GO:0051726regulation of cell cycle1.55e-011.00e+002.5721197
GO:0055085transmembrane transport1.73e-011.00e+001.40723435
GO:0002224toll-like receptor signaling pathway1.73e-011.00e+002.40414109
GO:0005815microtubule organizing center1.73e-011.00e+002.40413109
GO:0015630microtubule cytoskeleton1.74e-011.00e+002.39113110
GO:0005819spindle1.77e-011.00e+002.36512112
GO:0097190apoptotic signaling pathway1.79e-011.00e+002.35213113
GO:0051056regulation of small GTPase mediated signal transduction1.82e-011.00e+002.32714115
GO:0006006glucose metabolic process1.86e-011.00e+002.29013118
GO:0030036actin cytoskeleton organization1.93e-011.00e+002.23012123
GO:0051092positive regulation of NF-kappaB transcription factor activity1.94e-011.00e+002.21813124
GO:0009615response to virus1.97e-011.00e+002.19512126
GO:0006511ubiquitin-dependent protein catabolic process1.97e-011.00e+002.19512126
GO:0007179transforming growth factor beta receptor signaling pathway2.00e-011.00e+002.17213128
GO:0005911cell-cell junction2.11e-011.00e+002.08512136
GO:0016887ATPase activity2.17e-011.00e+002.04311140
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.23e-011.00e+001.99213145
GO:0010628positive regulation of gene expression2.25e-011.00e+001.98214146
GO:0008017microtubule binding2.26e-011.00e+001.97311147
GO:0034220ion transmembrane transport2.29e-011.00e+001.95312149
GO:0010008endosome membrane2.32e-011.00e+001.93415151
GO:0008543fibroblast growth factor receptor signaling pathway2.38e-011.00e+001.88713156
GO:0043005neuron projection2.40e-011.00e+001.87816157
GO:0005634nucleus2.42e-011.00e+000.34010434559
GO:0038095Fc-epsilon receptor signaling pathway2.54e-011.00e+001.78013168
GO:0000122negative regulation of transcription from RNA polymerase II promoter2.60e-011.00e+001.01727570
GO:0004672protein kinase activity2.66e-011.00e+001.70514177
GO:0006367transcription initiation from RNA polymerase II promoter2.75e-011.00e+001.64913184
GO:0045087innate immune response2.77e-011.00e+000.95328596
GO:0005765lysosomal membrane2.99e-011.00e+001.50712203
GO:0019221cytokine-mediated signaling pathway3.20e-011.00e+001.38412221
GO:0030425dendrite3.31e-011.00e+001.32712230
GO:0003713transcription coactivator activity3.39e-011.00e+001.28314237
GO:0043025neuronal cell body3.49e-011.00e+001.23614245
GO:0005975carbohydrate metabolic process3.58e-011.00e+001.18913253
GO:0004842ubiquitin-protein transferase activity3.60e-011.00e+001.17812255
GO:0000166nucleotide binding3.65e-011.00e+001.15512259
GO:0006281DNA repair3.67e-011.00e+001.14414261
GO:0048011neurotrophin TRK receptor signaling pathway3.76e-011.00e+001.10114269
GO:0006200ATP catabolic process4.01e-011.00e+000.98213292
GO:0004674protein serine/threonine kinase activity4.17e-011.00e+000.90515308
GO:0007275multicellular organismal development4.26e-011.00e+000.86811316
GO:0043231intracellular membrane-bounded organelle4.28e-011.00e+000.85915318
GO:0007411axon guidance4.29e-011.00e+000.85513319
GO:0003682chromatin binding4.37e-011.00e+000.81913327
GO:0008283cell proliferation4.38e-011.00e+000.81514328
GO:0015031protein transport4.50e-011.00e+000.75918341
GO:0003723RNA binding4.51e-011.00e+000.75418342
GO:0000139Golgi membrane4.70e-011.00e+000.67616361
GO:0007596blood coagulation5.52e-011.00e+000.34313455
GO:0006468protein phosphorylation5.56e-011.00e+000.32716460
GO:0045893positive regulation of transcription, DNA-templated5.70e-011.00e+000.27115478
GO:0042802identical protein binding5.74e-011.00e+000.25313484
GO:0048471perinuclear region of cytoplasm5.88e-011.00e+000.20117502
GO:0005783endoplasmic reticulum6.26e-011.00e+000.05313556
GO:0005794Golgi apparatus6.61e-011.00e+00-0.08019610
GO:0005524ATP binding6.72e-011.00e+00-0.1702151298
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.55e-011.00e+00-0.45216789
GO:0007165signal transduction8.03e-011.00e+00-0.65313907
GO:0005615extracellular space8.21e-011.00e+00-0.73012957
GO:0003677DNA binding8.90e-011.00e+00-1.078131218
GO:0046872metal ion binding9.07e-011.00e+00-1.1801101307
GO:0006351transcription, DNA-templated9.29e-011.00e+00-1.326161446
GO:0005886plasma membrane9.54e-011.00e+00-1.1622202582