int-snw-9097

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.974	4.93e-17	8.32e-05	9.74e-04

chia-screen-data-Fav-int-snw-9097 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
EDF1	8721	2	-2.377	2.974	66	Yes	Yes
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
[ USP14 ]	9097	2	-1.714	2.974	167	-	-
LUC7L3	51747	33	-3.523	3.449	18	Yes	-
PLS3	5358	1	-2.045	2.974	115	Yes	-
SRPK2	6733	2	-1.817	3.104	98	-	-

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
SRPK2	6733	LUC7L3	51747	pp	--	int.I2D: BioGrid
SRSF3	6428	SRPK2	6733	pp	--	int.I2D: BioGrid
EDF1	8721	USP14	9097	pp	--	int.I2D: BioGrid_Yeast
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
SRPK2	6733	USP14	9097	pp	--	int.I2D: BioGrid_Yeast, Yeast_Kinome
PLS3	5358	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PLS3	5358	USP14	9097	pp	--	int.I2D: Krogan_NonCore
PSMD2	5708	USP14	9097	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid, BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast

Related GO terms (125)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0044822	poly(A) RNA binding	9.68e-05	1.00e+00	3.094	5	50	1056
GO:0008380	RNA splicing	2.06e-04	1.00e+00	4.568	3	22	228
GO:0000502	proteasome complex	4.38e-04	1.00e+00	5.958	2	3	58
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0035063	nuclear speck organization	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0008193	tRNA guanylyltransferase activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0050920	regulation of chemotaxis	2.77e-03	1.00e+00	8.494	1	1	5
GO:0048024	regulation of mRNA splicing, via spliceosome	3.32e-03	1.00e+00	8.231	1	1	6
GO:0016607	nuclear speck	3.78e-03	1.00e+00	4.390	2	12	172
GO:0045446	endothelial cell differentiation	3.88e-03	1.00e+00	8.009	1	1	7
GO:0005737	cytoplasm	5.35e-03	1.00e+00	1.522	6	124	3767
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0070628	proteasome binding	5.53e-03	1.00e+00	7.494	1	1	10
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0061136	regulation of proteasomal protein catabolic process	6.64e-03	1.00e+00	7.231	1	1	12
GO:0005838	proteasome regulatory particle	6.64e-03	1.00e+00	7.231	1	1	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0030234	enzyme regulator activity	7.19e-03	1.00e+00	7.116	1	2	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	7.19e-03	1.00e+00	7.116	1	2	13
GO:0005685	U1 snRNP	7.74e-03	1.00e+00	7.009	1	1	14
GO:0006376	mRNA splice site selection	8.29e-03	1.00e+00	6.909	1	1	15
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0019216	regulation of lipid metabolic process	8.84e-03	1.00e+00	6.816	1	1	16
GO:0043274	phospholipase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0042176	regulation of protein catabolic process	8.84e-03	1.00e+00	6.816	1	2	16
GO:0022624	proteasome accessory complex	9.39e-03	1.00e+00	6.729	1	1	17
GO:0045070	positive regulation of viral genome replication	9.39e-03	1.00e+00	6.729	1	1	17
GO:0071889	14-3-3 protein binding	9.94e-03	1.00e+00	6.646	1	2	18
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	198	6024
GO:0000245	spliceosomal complex assembly	1.16e-02	1.00e+00	6.424	1	2	21
GO:0005669	transcription factor TFIID complex	1.21e-02	1.00e+00	6.357	1	4	22
GO:0045787	positive regulation of cell cycle	1.21e-02	1.00e+00	6.357	1	2	22
GO:0043388	positive regulation of DNA binding	1.32e-02	1.00e+00	6.231	1	2	24
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0004866	endopeptidase inhibitor activity	1.60e-02	1.00e+00	5.958	1	3	29
GO:0005654	nucleoplasm	1.77e-02	1.00e+00	2.322	3	64	1082
GO:0060348	bone development	1.82e-02	1.00e+00	5.772	1	2	33
GO:0045071	negative regulation of viral genome replication	1.87e-02	1.00e+00	5.729	1	1	34
GO:0004221	ubiquitin thiolesterase activity	1.98e-02	1.00e+00	5.646	1	1	36
GO:0006366	transcription from RNA polymerase II promoter	2.10e-02	1.00e+00	3.105	2	30	419
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0008168	methyltransferase activity	2.25e-02	1.00e+00	5.459	1	2	41
GO:0031124	mRNA 3'-end processing	2.31e-02	1.00e+00	5.424	1	2	42
GO:0016579	protein deubiquitination	2.31e-02	1.00e+00	5.424	1	1	42
GO:0004402	histone acetyltransferase activity	2.36e-02	1.00e+00	5.390	1	6	43
GO:0006369	termination of RNA polymerase II transcription	2.47e-02	1.00e+00	5.324	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0004197	cysteine-type endopeptidase activity	2.74e-02	1.00e+00	5.172	1	1	50
GO:0006521	regulation of cellular amino acid metabolic process	2.74e-02	1.00e+00	5.172	1	1	50
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0006406	mRNA export from nucleus	3.33e-02	1.00e+00	4.885	1	4	61
GO:0004843	ubiquitin-specific protease activity	3.50e-02	1.00e+00	4.816	1	1	64
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.50e-02	1.00e+00	4.816	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.55e-02	1.00e+00	4.794	1	2	65
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.82e-02	1.00e+00	4.687	1	2	70
GO:0003729	mRNA binding	3.93e-02	1.00e+00	4.646	1	4	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	3.93e-02	1.00e+00	4.646	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.03e-02	1.00e+00	4.607	1	2	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.09e-02	1.00e+00	4.587	1	1	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	4.99e-02	1.00e+00	4.293	1	1	92
GO:0010467	gene expression	4.99e-02	1.00e+00	2.430	2	45	669
GO:0005730	nucleolus	5.31e-02	1.00e+00	1.721	3	66	1641
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0010951	negative regulation of endopeptidase activity	5.63e-02	1.00e+00	4.116	1	6	104
GO:0016023	cytoplasmic membrane-bounded vesicle	5.68e-02	1.00e+00	4.102	1	8	105
GO:0000209	protein polyubiquitination	6.26e-02	1.00e+00	3.958	1	3	116
GO:0006511	ubiquitin-dependent protein catabolic process	6.78e-02	1.00e+00	3.839	1	5	126
GO:0045202	synapse	7.30e-02	1.00e+00	3.729	1	5	136
GO:0010628	positive regulation of gene expression	7.82e-02	1.00e+00	3.626	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	7.97e-02	1.00e+00	3.597	1	3	149
GO:0042981	regulation of apoptotic process	8.03e-02	1.00e+00	3.587	1	4	150
GO:0005516	calmodulin binding	8.54e-02	1.00e+00	3.494	1	2	160
GO:0000287	magnesium ion binding	8.74e-02	1.00e+00	3.459	1	4	164
GO:0000398	mRNA splicing, via spliceosome	8.74e-02	1.00e+00	3.459	1	15	164
GO:0044212	transcription regulatory region DNA binding	8.95e-02	1.00e+00	3.424	1	17	168
GO:0034641	cellular nitrogen compound metabolic process	9.10e-02	1.00e+00	3.398	1	2	171
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0001525	angiogenesis	1.01e-01	1.00e+00	3.239	1	7	191
GO:0006355	regulation of transcription, DNA-templated	1.01e-01	1.00e+00	1.855	2	43	997
GO:0005622	intracellular	1.09e-01	1.00e+00	3.123	1	6	207
GO:0016071	mRNA metabolic process	1.17e-01	1.00e+00	3.015	1	8	223
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0008134	transcription factor binding	1.27e-01	1.00e+00	2.897	1	18	242
GO:0016070	RNA metabolic process	1.29e-01	1.00e+00	2.868	1	8	247
GO:0070062	extracellular vesicular exosome	1.34e-01	1.00e+00	1.172	3	57	2400
GO:0000166	nucleotide binding	1.35e-01	1.00e+00	2.799	1	13	259
GO:0003779	actin binding	1.38e-01	1.00e+00	2.761	1	10	266
GO:0003677	DNA binding	1.42e-01	1.00e+00	1.566	2	49	1218
GO:0030154	cell differentiation	1.55e-01	1.00e+00	2.582	1	5	301
GO:0035556	intracellular signal transduction	1.56e-01	1.00e+00	2.573	1	9	303
GO:0004674	protein serine/threonine kinase activity	1.59e-01	1.00e+00	2.549	1	6	308
GO:0007275	multicellular organismal development	1.62e-01	1.00e+00	2.512	1	7	316
GO:0007268	synaptic transmission	1.70e-01	1.00e+00	2.441	1	5	332
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	18	342
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	9	366
GO:0008284	positive regulation of cell proliferation	1.93e-01	1.00e+00	2.239	1	10	382
GO:0000278	mitotic cell cycle	1.97e-01	1.00e+00	2.205	1	15	391
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0043066	negative regulation of apoptotic process	2.12e-01	1.00e+00	2.088	1	16	424
GO:0005634	nucleus	2.24e-01	1.00e+00	0.662	4	159	4559
GO:0006468	protein phosphorylation	2.28e-01	1.00e+00	1.971	1	10	460
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0005509	calcium ion binding	2.59e-01	1.00e+00	1.764	1	11	531
GO:0016032	viral process	2.61e-01	1.00e+00	1.755	1	26	534
GO:0006915	apoptotic process	2.69e-01	1.00e+00	1.700	1	12	555
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	15	596
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.62e-01	1.00e+00	1.192	1	41	789
GO:0005829	cytosol	4.15e-01	1.00e+00	0.531	2	86	2496
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	49	2582
GO:0044281	small molecule metabolic process	5.04e-01	1.00e+00	0.574	1	20	1211
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0006351	transcription, DNA-templated	5.71e-01	1.00e+00	0.318	1	57	1446
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681

chia-Fav

int-snw-9097

Statistics

Genes (8)

Interactions (8)

Related GO terms (125)