int-snw-55742

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.845	1.29e-15	4.28e-04	3.11e-03

chia-screen-data-Fav-int-snw-55742 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
PXN	5829	19	-2.554	3.193	206	Yes	Yes
ANXA4	307	7	-2.478	3.062	15	Yes	Yes
ACTA1	58	3	-2.128	3.062	180	Yes	-
[ PARVA ]	55742	1	-1.790	2.845	17	-	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
MVP	9961	16	-2.846	3.193	20	Yes	Yes
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes

Interactions (8)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	PARVA	55742	pp	--	int.Intact: MI:0915(physical association); int.HPRD: in vitro, in vivo; int.DIP: MI:0407(direct interaction)
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
ACTA1	58	PARVA	55742	pp	--	int.HPRD: in vitro
ACTA1	58	POU5F1	5460	pp	--	int.I2D: BioGrid
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
ACTA1	58	ANXA4	307	pp	--	int.I2D: IntAct_Mouse
ACTA1	58	DDIT3	1649	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW

Related GO terms (164)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0034446	substrate adhesion-dependent cell spreading	1.68e-04	1.00e+00	6.646	2	2	36
GO:0001725	stress fiber	3.94e-04	1.00e+00	6.035	2	4	55
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:0023057	negative regulation of signaling	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0072376	protein activation cascade	5.55e-04	1.00e+00	10.816	1	1	1
GO:0051435	BH4 domain binding	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0034329	cell junction assembly	6.02e-04	1.00e+00	5.729	2	3	68
GO:0006936	muscle contraction	9.84e-04	1.00e+00	5.373	2	3	87
GO:0071670	smooth muscle cell chemotaxis	1.11e-03	1.00e+00	9.816	1	1	2
GO:0070252	actin-mediated cell contraction	1.11e-03	1.00e+00	9.816	1	1	2
GO:2000483	negative regulation of interleukin-8 secretion	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:0043503	skeletal muscle fiber adaptation	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0008360	regulation of cell shape	1.38e-03	1.00e+00	5.130	2	4	103
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0030027	lamellipodium	2.02e-03	1.00e+00	4.850	2	7	125
GO:0038127	ERBB signaling pathway	2.22e-03	1.00e+00	8.816	1	1	4
GO:0009991	response to extracellular stimulus	2.22e-03	1.00e+00	8.816	1	1	4
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0030240	skeletal muscle thin filament assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0004859	phospholipase inhibitor activity	3.32e-03	1.00e+00	8.231	1	1	6
GO:0005865	striated muscle thin filament	3.32e-03	1.00e+00	8.231	1	1	6
GO:0044212	transcription regulatory region DNA binding	3.61e-03	1.00e+00	4.424	2	17	168
GO:0061099	negative regulation of protein tyrosine kinase activity	3.88e-03	1.00e+00	8.009	1	1	7
GO:0015629	actin cytoskeleton	3.99e-03	1.00e+00	4.348	2	5	177
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0007172	signal complex assembly	4.43e-03	1.00e+00	7.816	1	1	8
GO:0060396	growth hormone receptor signaling pathway	4.43e-03	1.00e+00	7.816	1	1	8
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	4.98e-03	1.00e+00	7.646	1	1	9
GO:0005737	cytoplasm	5.35e-03	1.00e+00	1.522	6	124	3767
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0010226	response to lithium ion	5.53e-03	1.00e+00	7.494	1	2	10
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0017166	vinculin binding	6.09e-03	1.00e+00	7.357	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0048545	response to steroid hormone	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0003148	outflow tract septum morphogenesis	7.74e-03	1.00e+00	7.009	1	1	14
GO:0034614	cellular response to reactive oxygen species	7.74e-03	1.00e+00	7.009	1	2	14
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0043274	phospholipase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0048741	skeletal muscle fiber development	8.84e-03	1.00e+00	6.816	1	1	16
GO:0017022	myosin binding	9.39e-03	1.00e+00	6.729	1	2	17
GO:0012506	vesicle membrane	9.39e-03	1.00e+00	6.729	1	1	17
GO:0034113	heterotypic cell-cell adhesion	1.05e-02	1.00e+00	6.568	1	1	19
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	198	6024
GO:0048041	focal adhesion assembly	1.16e-02	1.00e+00	6.424	1	1	21
GO:0019901	protein kinase binding	1.24e-02	1.00e+00	3.508	2	18	317
GO:0002040	sprouting angiogenesis	1.27e-02	1.00e+00	6.293	1	2	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:0007163	establishment or maintenance of cell polarity	1.32e-02	1.00e+00	6.231	1	2	24
GO:0051059	NF-kappaB binding	1.38e-02	1.00e+00	6.172	1	3	25
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0048754	branching morphogenesis of an epithelial tube	1.49e-02	1.00e+00	6.061	1	1	27
GO:0005634	nucleus	1.49e-02	1.00e+00	1.247	6	159	4559
GO:0043531	ADP binding	1.54e-02	1.00e+00	6.009	1	3	28
GO:0005875	microtubule associated complex	1.54e-02	1.00e+00	6.009	1	1	28
GO:0030032	lamellipodium assembly	1.60e-02	1.00e+00	5.958	1	1	29
GO:0005925	focal adhesion	1.63e-02	1.00e+00	3.300	2	9	366
GO:0005544	calcium-dependent phospholipid binding	1.65e-02	1.00e+00	5.909	1	1	30
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:0005654	nucleoplasm	1.77e-02	1.00e+00	2.322	3	64	1082
GO:0030017	sarcomere	1.87e-02	1.00e+00	5.729	1	2	34
GO:0060271	cilium morphogenesis	2.03e-02	1.00e+00	5.607	1	3	37
GO:0030049	muscle filament sliding	2.09e-02	1.00e+00	5.568	1	3	38
GO:0006366	transcription from RNA polymerase II promoter	2.10e-02	1.00e+00	3.105	2	30	419
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0031532	actin cytoskeleton reorganization	2.25e-02	1.00e+00	5.459	1	2	41
GO:0031124	mRNA 3'-end processing	2.31e-02	1.00e+00	5.424	1	2	42
GO:0005884	actin filament	2.42e-02	1.00e+00	5.357	1	3	44
GO:0006369	termination of RNA polymerase II transcription	2.47e-02	1.00e+00	5.324	1	2	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0016049	cell growth	2.69e-02	1.00e+00	5.201	1	3	49
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0009612	response to mechanical stimulus	2.74e-02	1.00e+00	5.172	1	1	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0051028	mRNA transport	2.85e-02	1.00e+00	5.116	1	4	52
GO:0009611	response to wounding	2.85e-02	1.00e+00	5.116	1	5	52
GO:0048471	perinuclear region of cytoplasm	2.95e-02	1.00e+00	2.845	2	8	502
GO:0048306	calcium-dependent protein binding	3.06e-02	1.00e+00	5.009	1	2	56
GO:0005643	nuclear pore	3.12e-02	1.00e+00	4.983	1	11	57
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0008013	beta-catenin binding	3.28e-02	1.00e+00	4.909	1	9	60
GO:0030855	epithelial cell differentiation	3.33e-02	1.00e+00	4.885	1	1	61
GO:0006406	mRNA export from nucleus	3.33e-02	1.00e+00	4.885	1	4	61
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0019903	protein phosphatase binding	3.39e-02	1.00e+00	4.862	1	2	62
GO:0032088	negative regulation of NF-kappaB transcription factor activity	3.44e-02	1.00e+00	4.839	1	3	63
GO:0005829	cytosol	3.48e-02	1.00e+00	1.531	4	86	2496
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0043086	negative regulation of catalytic activity	3.93e-02	1.00e+00	4.646	1	2	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0007229	integrin-mediated signaling pathway	4.25e-02	1.00e+00	4.531	1	3	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0000187	activation of MAPK activity	4.89e-02	1.00e+00	4.324	1	3	90
GO:0007010	cytoskeleton organization	4.94e-02	1.00e+00	4.308	1	4	91
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	3	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	6	91
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0005178	integrin binding	5.20e-02	1.00e+00	4.231	1	4	96
GO:0030018	Z disc	5.26e-02	1.00e+00	4.216	1	4	97
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0005938	cell cortex	5.63e-02	1.00e+00	4.116	1	5	104
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	5	112
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0007179	transforming growth factor beta receptor signaling pathway	6.88e-02	1.00e+00	3.816	1	11	128
GO:0018108	peptidyl-tyrosine phosphorylation	7.09e-02	1.00e+00	3.772	1	4	132
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0006974	cellular response to DNA damage stimulus	8.08e-02	1.00e+00	3.578	1	7	151
GO:0007165	signal transduction	8.59e-02	1.00e+00	1.991	2	13	907
GO:0000398	mRNA splicing, via spliceosome	8.74e-02	1.00e+00	3.459	1	15	164
GO:0031965	nuclear membrane	8.95e-02	1.00e+00	3.424	1	10	168
GO:0016607	nuclear speck	9.15e-02	1.00e+00	3.390	1	12	172
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0003714	transcription corepressor activity	9.46e-02	1.00e+00	3.340	1	11	178
GO:0007173	epidermal growth factor receptor signaling pathway	1.00e-01	1.00e+00	3.254	1	5	189
GO:0006355	regulation of transcription, DNA-templated	1.01e-01	1.00e+00	1.855	2	43	997
GO:0044822	poly(A) RNA binding	1.12e-01	1.00e+00	1.772	2	50	1056
GO:0008380	RNA splicing	1.20e-01	1.00e+00	2.983	1	22	228
GO:0070062	extracellular vesicular exosome	1.34e-01	1.00e+00	1.172	3	57	2400
GO:0000166	nucleotide binding	1.35e-01	1.00e+00	2.799	1	13	259
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.37e-01	1.00e+00	2.772	1	23	264
GO:0003779	actin binding	1.38e-01	1.00e+00	2.761	1	10	266
GO:0003677	DNA binding	1.42e-01	1.00e+00	1.566	2	49	1218
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	9	291
GO:0005886	plasma membrane	1.59e-01	1.00e+00	1.067	3	49	2582
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0015031	protein transport	1.74e-01	1.00e+00	2.402	1	11	341
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	18	342
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	5	369
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0009986	cell surface	2.02e-01	1.00e+00	2.165	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0043066	negative regulation of apoptotic process	2.12e-01	1.00e+00	2.088	1	16	424
GO:0044267	cellular protein metabolic process	2.35e-01	1.00e+00	1.927	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0042802	identical protein binding	2.39e-01	1.00e+00	1.897	1	19	484
GO:0005509	calcium ion binding	2.59e-01	1.00e+00	1.764	1	11	531
GO:0010467	gene expression	3.16e-01	1.00e+00	1.430	1	45	669
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	20	957
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	27	997
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681

chia-Fav

int-snw-55742

Statistics

Genes (8)

Interactions (8)

Related GO terms (164)