int-snw-5514

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.901	3.18e-16	2.15e-04	1.90e-03

chia-screen-data-Fav-int-snw-5514 subnetwork

Genes (10)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
HCFC1	3054	40	-2.925	3.449	71	Yes	Yes
PSMD2	5708	47	-4.172	3.157	386	Yes	Yes
TCP1	6950	10	-2.383	3.119	241	Yes	-
[ PPP1R10 ]	5514	1	-1.652	2.901	12	-	-
WDR82	80335	7	-2.455	3.129	64	Yes	-
CCT7	10574	2	-2.335	2.924	135	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
RBM10	8241	2	-2.329	3.129	40	Yes	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
SF3A1	10291	4	-2.787	3.129	43	Yes	Yes

Interactions (11)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
CCT7	10574	WDR82	80335	pp	--	int.I2D: BioGrid
HCFC1	3054	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HCFC1	3054	WDR82	80335	pp	--	int.I2D: BioGrid
RBM10	8241	WDR82	80335	pp	--	int.I2D: BioGrid
TCP1	6950	CCT7	10574	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, IntAct, BioGrid_Mouse, HPRD; int.HPRD: in vitro
RBM10	8241	SF3A1	10291	pp	--	int.Mint: MI:0915(physical association)
DDIT3	1649	TCP1	6950	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
PSMD2	5708	TCP1	6950	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
PSMD2	5708	CCT7	10574	pp	--	int.I2D: BioGrid_Yeast
PPP1R10	5514	WDR82	80335	pp	--	int.I2D: BioGrid
TCP1	6950	WDR82	80335	pp	--	int.I2D: BioGrid

Related GO terms (158)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0072357	PTW/PP1 phosphatase complex	9.07e-06	1.31e-01	8.687	2	2	7
GO:0048188	Set1C/COMPASS complex	1.55e-05	2.24e-01	8.324	2	4	9
GO:0005832	chaperonin-containing T-complex	1.55e-05	2.24e-01	8.324	2	2	9
GO:0002199	zona pellucida receptor complex	1.94e-05	2.80e-01	8.172	2	2	10
GO:0042789	mRNA transcription from RNA polymerase II promoter	3.36e-05	4.85e-01	7.794	2	2	13
GO:0007339	binding of sperm to zona pellucida	1.29e-04	1.00e+00	6.850	2	2	25
GO:0051084	'de novo' posttranslational protein folding	2.84e-04	1.00e+00	6.285	2	5	37
GO:0044822	poly(A) RNA binding	3.85e-04	1.00e+00	2.772	5	50	1056
GO:0005654	nucleoplasm	4.31e-04	1.00e+00	2.737	5	64	1082
GO:0044297	cell body	4.41e-04	1.00e+00	5.971	2	2	46
GO:0060795	cell fate commitment involved in formation of primary germ layer	6.93e-04	1.00e+00	10.494	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	6.93e-04	1.00e+00	10.494	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	6.93e-04	1.00e+00	10.494	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	6.93e-04	1.00e+00	10.494	1	1	1
GO:0000785	chromatin	1.11e-03	1.00e+00	5.304	2	6	73
GO:0005684	U2-type spliceosomal complex	1.39e-03	1.00e+00	9.494	1	1	2
GO:0019046	release from viral latency	1.39e-03	1.00e+00	9.494	1	2	2
GO:0009786	regulation of asymmetric cell division	1.39e-03	1.00e+00	9.494	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.39e-03	1.00e+00	9.494	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.39e-03	1.00e+00	9.494	1	1	2
GO:0051082	unfolded protein binding	1.79e-03	1.00e+00	4.955	2	7	93
GO:0060913	cardiac cell fate determination	2.08e-03	1.00e+00	8.909	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	2.08e-03	1.00e+00	8.909	1	1	3
GO:0005515	protein binding	2.41e-03	1.00e+00	1.108	9	198	6024
GO:0007021	tubulin complex assembly	2.77e-03	1.00e+00	8.494	1	1	4
GO:0070461	SAGA-type complex	3.46e-03	1.00e+00	8.172	1	2	5
GO:0001714	endodermal cell fate specification	3.46e-03	1.00e+00	8.172	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	3.46e-03	1.00e+00	8.172	1	1	5
GO:0000389	mRNA 3'-splice site recognition	3.46e-03	1.00e+00	8.172	1	2	5
GO:0034393	positive regulation of smooth muscle cell apoptotic process	3.46e-03	1.00e+00	8.172	1	2	5
GO:0044267	cellular protein metabolic process	3.56e-03	1.00e+00	3.190	3	20	474
GO:0042802	identical protein binding	3.78e-03	1.00e+00	3.160	3	19	484
GO:0006457	protein folding	4.17e-03	1.00e+00	4.334	2	7	143
GO:0006397	mRNA processing	5.19e-03	1.00e+00	4.172	2	10	160
GO:0001955	blood vessel maturation	5.53e-03	1.00e+00	7.494	1	1	8
GO:0070688	MLL5-L complex	5.53e-03	1.00e+00	7.494	1	1	8
GO:0043254	regulation of protein complex assembly	5.53e-03	1.00e+00	7.494	1	1	8
GO:0044212	transcription regulatory region DNA binding	5.71e-03	1.00e+00	4.102	2	17	168
GO:0043995	histone acetyltransferase activity (H4-K5 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0046972	histone acetyltransferase activity (H4-K16 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0006983	ER overload response	6.22e-03	1.00e+00	7.324	1	1	9
GO:0043996	histone acetyltransferase activity (H4-K8 specific)	6.22e-03	1.00e+00	7.324	1	5	9
GO:0035413	positive regulation of catenin import into nucleus	6.91e-03	1.00e+00	7.172	1	2	10
GO:0045662	negative regulation of myoblast differentiation	7.60e-03	1.00e+00	7.035	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	7.60e-03	1.00e+00	7.035	1	4	11
GO:0070935	3'-UTR-mediated mRNA stabilization	8.29e-03	1.00e+00	6.909	1	3	12
GO:0005838	proteasome regulatory particle	8.29e-03	1.00e+00	6.909	1	1	12
GO:0035198	miRNA binding	8.29e-03	1.00e+00	6.909	1	1	12
GO:0042800	histone methyltransferase activity (H3-K4 specific)	8.98e-03	1.00e+00	6.794	1	3	13
GO:0030234	enzyme regulator activity	8.98e-03	1.00e+00	6.794	1	2	13
GO:0000242	pericentriolar material	9.67e-03	1.00e+00	6.687	1	1	14
GO:0008380	RNA splicing	1.03e-02	1.00e+00	3.661	2	22	228
GO:0043981	histone H4-K5 acetylation	1.04e-02	1.00e+00	6.587	1	5	15
GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex	1.04e-02	1.00e+00	6.587	1	3	15
GO:0001824	blastocyst development	1.04e-02	1.00e+00	6.587	1	2	15
GO:0043982	histone H4-K8 acetylation	1.04e-02	1.00e+00	6.587	1	5	15
GO:0003700	sequence-specific DNA binding transcription factor activity	1.05e-02	1.00e+00	2.630	3	39	699
GO:0042176	regulation of protein catabolic process	1.10e-02	1.00e+00	6.494	1	2	16
GO:0008134	transcription factor binding	1.15e-02	1.00e+00	3.575	2	18	242
GO:0051568	histone H3-K4 methylation	1.17e-02	1.00e+00	6.407	1	3	17
GO:0022624	proteasome accessory complex	1.17e-02	1.00e+00	6.407	1	1	17
GO:0005874	microtubule	1.22e-02	1.00e+00	3.534	2	7	249
GO:0043984	histone H4-K16 acetylation	1.31e-02	1.00e+00	6.246	1	5	19
GO:0032757	positive regulation of interleukin-8 production	1.38e-02	1.00e+00	6.172	1	1	20
GO:0000123	histone acetyltransferase complex	1.45e-02	1.00e+00	6.102	1	6	21
GO:0035097	histone methyltransferase complex	1.45e-02	1.00e+00	6.102	1	3	21
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	1.47e-02	1.00e+00	2.455	3	41	789
GO:0045787	positive regulation of cell cycle	1.52e-02	1.00e+00	6.035	1	2	22
GO:0005720	nuclear heterochromatin	1.52e-02	1.00e+00	6.035	1	2	22
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	1.52e-02	1.00e+00	6.035	1	4	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.58e-02	1.00e+00	5.971	1	1	23
GO:0004864	protein phosphatase inhibitor activity	1.65e-02	1.00e+00	5.909	1	1	24
GO:0051209	release of sequestered calcium ion into cytosol	1.79e-02	1.00e+00	5.794	1	1	26
GO:0005829	cytosol	1.81e-02	1.00e+00	1.531	5	86	2496
GO:0071339	MLL1 complex	1.86e-02	1.00e+00	5.739	1	6	27
GO:0005730	nucleolus	1.99e-02	1.00e+00	1.814	4	66	1641
GO:0003682	chromatin binding	2.04e-02	1.00e+00	3.141	2	19	327
GO:0006606	protein import into nucleus	2.06e-02	1.00e+00	5.587	1	2	30
GO:0042594	response to starvation	2.13e-02	1.00e+00	5.540	1	4	31
GO:0043565	sequence-specific DNA binding	2.27e-02	1.00e+00	3.060	2	11	346
GO:0035019	somatic stem cell maintenance	2.74e-02	1.00e+00	5.172	1	6	40
GO:0006355	regulation of transcription, DNA-templated	2.74e-02	1.00e+00	2.118	3	43	997
GO:0043525	positive regulation of neuron apoptotic process	3.14e-02	1.00e+00	4.971	1	4	46
GO:0006366	transcription from RNA polymerase II promoter	3.25e-02	1.00e+00	2.783	2	30	419
GO:0001669	acrosomal vesicle	3.35e-02	1.00e+00	4.879	1	2	49
GO:0006521	regulation of cellular amino acid metabolic process	3.41e-02	1.00e+00	4.850	1	1	50
GO:0006986	response to unfolded protein	3.41e-02	1.00e+00	4.850	1	4	50
GO:0034976	response to endoplasmic reticulum stress	3.48e-02	1.00e+00	4.822	1	2	51
GO:0045454	cell redox homeostasis	3.48e-02	1.00e+00	4.822	1	1	51
GO:0009611	response to wounding	3.55e-02	1.00e+00	4.794	1	5	52
GO:0000502	proteasome complex	3.95e-02	1.00e+00	4.636	1	3	58
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	4.02e-02	1.00e+00	4.612	1	6	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	4.15e-02	1.00e+00	4.563	1	2	61
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	4.35e-02	1.00e+00	4.494	1	1	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.42e-02	1.00e+00	4.472	1	2	65
GO:0003677	DNA binding	4.60e-02	1.00e+00	1.829	3	49	1218
GO:0010468	regulation of gene expression	4.62e-02	1.00e+00	4.407	1	2	68
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.75e-02	1.00e+00	4.365	1	2	70
GO:0043086	negative regulation of catalytic activity	4.88e-02	1.00e+00	4.324	1	2	72
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.88e-02	1.00e+00	4.324	1	1	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	5.02e-02	1.00e+00	4.285	1	4	74
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.02e-02	1.00e+00	4.285	1	2	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.08e-02	1.00e+00	4.265	1	1	75
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	5.08e-02	1.00e+00	4.265	1	1	75
GO:0071013	catalytic step 2 spliceosome	5.28e-02	1.00e+00	4.209	1	7	78
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	5.35e-02	1.00e+00	4.190	1	2	79
GO:0030968	endoplasmic reticulum unfolded protein response	5.35e-02	1.00e+00	4.190	1	2	79
GO:0009653	anatomical structure morphogenesis	5.61e-02	1.00e+00	4.119	1	2	83
GO:0005681	spliceosomal complex	5.61e-02	1.00e+00	4.119	1	3	83
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	5.69e-02	1.00e+00	2.339	2	37	570
GO:0090090	negative regulation of canonical Wnt signaling pathway	5.81e-02	1.00e+00	4.068	1	8	86
GO:0050821	protein stabilization	5.94e-02	1.00e+00	4.035	1	3	88
GO:0005634	nucleus	6.02e-02	1.00e+00	0.925	6	159	4559
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	6.20e-02	1.00e+00	3.971	1	1	92
GO:0005770	late endosome	6.27e-02	1.00e+00	3.955	1	2	93
GO:0010467	gene expression	7.55e-02	1.00e+00	2.108	2	45	669
GO:0000209	protein polyubiquitination	7.76e-02	1.00e+00	3.636	1	3	116
GO:0006325	chromatin organization	7.89e-02	1.00e+00	3.612	1	12	118
GO:0007050	cell cycle arrest	8.27e-02	1.00e+00	3.540	1	5	124
GO:0016055	Wnt signaling pathway	9.17e-02	1.00e+00	3.386	1	4	138
GO:0010628	positive regulation of gene expression	9.68e-02	1.00e+00	3.304	1	7	146
GO:0000082	G1/S transition of mitotic cell cycle	9.87e-02	1.00e+00	3.275	1	3	149
GO:0042981	regulation of apoptotic process	9.93e-02	1.00e+00	3.265	1	4	150
GO:0006974	cellular response to DNA damage stimulus	9.99e-02	1.00e+00	3.256	1	7	151
GO:0000398	mRNA splicing, via spliceosome	1.08e-01	1.00e+00	3.137	1	15	164
GO:0034641	cellular nitrogen compound metabolic process	1.12e-01	1.00e+00	3.076	1	2	171
GO:0007049	cell cycle	1.14e-01	1.00e+00	3.051	1	6	174
GO:0005667	transcription factor complex	1.15e-01	1.00e+00	3.043	1	17	175
GO:0031625	ubiquitin protein ligase binding	1.17e-01	1.00e+00	3.018	1	5	178
GO:0003714	transcription corepressor activity	1.17e-01	1.00e+00	3.018	1	11	178
GO:0032403	protein complex binding	1.20e-01	1.00e+00	2.978	1	6	183
GO:0016071	mRNA metabolic process	1.44e-01	1.00e+00	2.693	1	8	223
GO:0005739	mitochondrion	1.49e-01	1.00e+00	1.531	2	23	998
GO:0003713	transcription coactivator activity	1.53e-01	1.00e+00	2.605	1	24	237
GO:0043025	neuronal cell body	1.57e-01	1.00e+00	2.558	1	9	245
GO:0016070	RNA metabolic process	1.59e-01	1.00e+00	2.546	1	8	247
GO:0000166	nucleotide binding	1.66e-01	1.00e+00	2.477	1	13	259
GO:0005813	centrosome	2.04e-01	1.00e+00	2.145	1	7	326
GO:0003723	RNA binding	2.13e-01	1.00e+00	2.076	1	18	342
GO:0008285	negative regulation of cell proliferation	2.20e-01	1.00e+00	2.031	1	10	353
GO:0070062	extracellular vesicular exosome	2.24e-01	1.00e+00	0.850	3	57	2400
GO:0005524	ATP binding	2.25e-01	1.00e+00	1.152	2	31	1298
GO:0046982	protein heterodimerization activity	2.34e-01	1.00e+00	1.924	1	8	380
GO:0008150	biological_process	2.39e-01	1.00e+00	1.891	1	4	389
GO:0000278	mitotic cell cycle	2.40e-01	1.00e+00	1.883	1	15	391
GO:0045892	negative regulation of transcription, DNA-templated	2.52e-01	1.00e+00	1.804	1	24	413
GO:0043066	negative regulation of apoptotic process	2.58e-01	1.00e+00	1.766	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	2.86e-01	1.00e+00	1.593	1	24	478
GO:0016032	viral process	3.14e-01	1.00e+00	1.433	1	26	534
GO:0006915	apoptotic process	3.25e-01	1.00e+00	1.378	1	12	555
GO:0016020	membrane	3.28e-01	1.00e+00	0.779	2	46	1681
GO:0005794	Golgi apparatus	3.51e-01	1.00e+00	1.241	1	9	610
GO:0005737	cytoplasm	5.08e-01	1.00e+00	0.200	3	124	3767
GO:0008270	zinc ion binding	5.12e-01	1.00e+00	0.533	1	27	997
GO:0044281	small molecule metabolic process	5.84e-01	1.00e+00	0.252	1	20	1211
GO:0046872	metal ion binding	6.13e-01	1.00e+00	0.142	1	29	1307
GO:0006351	transcription, DNA-templated	6.52e-01	1.00e+00	-0.004	1	57	1446

chia-Fav

int-snw-5514

Statistics

Genes (10)

Interactions (11)

Related GO terms (158)