int-snw-4145

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.866	7.66e-16	3.32e-04	2.59e-03

chia-screen-data-Fav-int-snw-4145 subnetwork

Genes (7)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
APC	324	13	-2.293	3.004	353	Yes	-
SRSF3	6428	73	-2.992	3.538	54	Yes	-
PXN	5829	19	-2.554	3.193	206	Yes	Yes
[ MATK ]	4145	1	-1.486	2.866	13	-	-
MVP	9961	16	-2.846	3.193	20	Yes	Yes
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
PHB	5245	15	-2.743	3.004	127	Yes	Yes

Interactions (6)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PXN	5829	SRSF3	6428	pp	--	int.I2D: BIND
APC	324	PXN	5829	pp	--	int.I2D: MINT, MINT_Mouse; int.Mint: MI:0914(association)
POU5F1	5460	SRSF3	6428	pp	--	int.I2D: BioGrid
PXN	5829	MVP	9961	pp	--	int.I2D: BIND
APC	324	PHB	5245	pp	--	int.I2D: Jorgensen_EphR
MATK	4145	PXN	5829	pp	--	int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro

Related GO terms (176)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0035019	somatic stem cell maintenance	1.56e-04	1.00e+00	6.687	2	6	40
GO:0019901	protein kinase binding	3.45e-04	1.00e+00	4.285	3	18	317
GO:0008013	beta-catenin binding	3.53e-04	1.00e+00	6.102	2	9	60
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.85e-04	1.00e+00	11.009	1	1	1
GO:0023057	negative regulation of signaling	4.85e-04	1.00e+00	11.009	1	1	1
GO:0051171	regulation of nitrogen compound metabolic process	4.85e-04	1.00e+00	11.009	1	1	1
GO:0072376	protein activation cascade	4.85e-04	1.00e+00	11.009	1	1	1
GO:0051435	BH4 domain binding	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.85e-04	1.00e+00	11.009	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.85e-04	1.00e+00	11.009	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.85e-04	1.00e+00	11.009	1	1	1
GO:0042483	negative regulation of odontogenesis	4.85e-04	1.00e+00	11.009	1	1	1
GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process	9.70e-04	1.00e+00	10.009	1	1	2
GO:0009786	regulation of asymmetric cell division	9.70e-04	1.00e+00	10.009	1	1	2
GO:0009798	axis specification	9.70e-04	1.00e+00	10.009	1	1	2
GO:0060913	cardiac cell fate determination	1.46e-03	1.00e+00	9.424	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.46e-03	1.00e+00	9.424	1	1	3
GO:0030027	lamellipodium	1.52e-03	1.00e+00	5.043	2	7	125
GO:0018108	peptidyl-tyrosine phosphorylation	1.69e-03	1.00e+00	4.964	2	4	132
GO:0005737	cytoplasm	1.72e-03	1.00e+00	1.714	6	124	3767
GO:0038127	ERBB signaling pathway	1.94e-03	1.00e+00	9.009	1	1	4
GO:0019887	protein kinase regulator activity	1.94e-03	1.00e+00	9.009	1	1	4
GO:0005515	protein binding	2.21e-03	1.00e+00	1.260	7	198	6024
GO:0001714	endodermal cell fate specification	2.42e-03	1.00e+00	8.687	1	1	5
GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process	2.42e-03	1.00e+00	8.687	1	2	5
GO:0044212	transcription regulatory region DNA binding	2.73e-03	1.00e+00	4.616	2	17	168
GO:0030858	positive regulation of epithelial cell differentiation	2.91e-03	1.00e+00	8.424	1	1	6
GO:0050847	progesterone receptor signaling pathway	2.91e-03	1.00e+00	8.424	1	2	6
GO:2000323	negative regulation of glucocorticoid receptor signaling pathway	2.91e-03	1.00e+00	8.424	1	1	6
GO:0007091	metaphase/anaphase transition of mitotic cell cycle	3.39e-03	1.00e+00	8.201	1	2	7
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	3.39e-03	1.00e+00	8.201	1	1	7
GO:0071354	cellular response to interleukin-6	3.39e-03	1.00e+00	8.201	1	2	7
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	3.39e-03	1.00e+00	8.201	1	2	7
GO:0061099	negative regulation of protein tyrosine kinase activity	3.39e-03	1.00e+00	8.201	1	1	7
GO:0045670	regulation of osteoclast differentiation	3.88e-03	1.00e+00	8.009	1	2	8
GO:0007172	signal complex assembly	3.88e-03	1.00e+00	8.009	1	1	8
GO:0060396	growth hormone receptor signaling pathway	3.88e-03	1.00e+00	8.009	1	1	8
GO:0045667	regulation of osteoblast differentiation	4.36e-03	1.00e+00	7.839	1	1	9
GO:0031953	negative regulation of protein autophosphorylation	4.36e-03	1.00e+00	7.839	1	1	9
GO:0010944	negative regulation of transcription by competitive promoter binding	4.36e-03	1.00e+00	7.839	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	4.84e-03	1.00e+00	7.687	1	2	10
GO:0031274	positive regulation of pseudopodium assembly	4.84e-03	1.00e+00	7.687	1	2	10
GO:0030877	beta-catenin destruction complex	4.84e-03	1.00e+00	7.687	1	2	10
GO:0031116	positive regulation of microtubule polymerization	5.33e-03	1.00e+00	7.549	1	1	11
GO:0051010	microtubule plus-end binding	5.33e-03	1.00e+00	7.549	1	1	11
GO:0017166	vinculin binding	5.33e-03	1.00e+00	7.549	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	5.33e-03	1.00e+00	7.549	1	4	11
GO:0045295	gamma-catenin binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0032886	regulation of microtubule-based process	5.81e-03	1.00e+00	7.424	1	1	12
GO:0035198	miRNA binding	5.81e-03	1.00e+00	7.424	1	1	12
GO:0060766	negative regulation of androgen receptor signaling pathway	6.29e-03	1.00e+00	7.308	1	3	13
GO:0044295	axonal growth cone	6.29e-03	1.00e+00	7.308	1	1	13
GO:0042789	mRNA transcription from RNA polymerase II promoter	6.29e-03	1.00e+00	7.308	1	2	13
GO:0043409	negative regulation of MAPK cascade	6.29e-03	1.00e+00	7.308	1	2	13
GO:0035371	microtubule plus-end	6.78e-03	1.00e+00	7.201	1	1	14
GO:0034614	cellular response to reactive oxygen species	6.78e-03	1.00e+00	7.201	1	2	14
GO:0001824	blastocyst development	7.26e-03	1.00e+00	7.102	1	2	15
GO:0007026	negative regulation of microtubule depolymerization	7.74e-03	1.00e+00	7.009	1	1	16
GO:0046716	muscle cell cellular homeostasis	7.74e-03	1.00e+00	7.009	1	1	16
GO:0043274	phospholipase binding	7.74e-03	1.00e+00	7.009	1	1	16
GO:0051276	chromosome organization	7.74e-03	1.00e+00	7.009	1	2	16
GO:0031122	cytoplasmic microtubule organization	8.71e-03	1.00e+00	6.839	1	1	18
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity	9.19e-03	1.00e+00	6.761	1	2	19
GO:0008283	cell proliferation	1.00e-02	1.00e+00	3.651	2	14	328
GO:0048041	focal adhesion assembly	1.01e-02	1.00e+00	6.616	1	1	21
GO:0009954	proximal/distal pattern formation	1.01e-02	1.00e+00	6.616	1	1	21
GO:0016575	histone deacetylation	1.01e-02	1.00e+00	6.616	1	3	21
GO:0000281	mitotic cytokinesis	1.01e-02	1.00e+00	6.616	1	2	21
GO:0008285	negative regulation of cell proliferation	1.16e-02	1.00e+00	3.545	2	10	353
GO:0045296	cadherin binding	1.16e-02	1.00e+00	6.424	1	3	24
GO:0005654	nucleoplasm	1.17e-02	1.00e+00	2.514	3	64	1082
GO:0007155	cell adhesion	1.26e-02	1.00e+00	3.481	2	5	369
GO:0007498	mesoderm development	1.26e-02	1.00e+00	6.308	1	1	26
GO:0048754	branching morphogenesis of an epithelial tube	1.30e-02	1.00e+00	6.254	1	1	27
GO:0005875	microtubule associated complex	1.35e-02	1.00e+00	6.201	1	1	28
GO:0071897	DNA biosynthetic process	1.35e-02	1.00e+00	6.201	1	1	28
GO:0070830	tight junction assembly	1.35e-02	1.00e+00	6.201	1	1	28
GO:0030032	lamellipodium assembly	1.40e-02	1.00e+00	6.151	1	1	29
GO:0005913	cell-cell adherens junction	1.40e-02	1.00e+00	6.151	1	3	29
GO:0009953	dorsal/ventral pattern formation	1.50e-02	1.00e+00	6.055	1	2	31
GO:0007094	mitotic spindle assembly checkpoint	1.50e-02	1.00e+00	6.055	1	3	31
GO:0033077	T cell differentiation in thymus	1.59e-02	1.00e+00	5.964	1	1	33
GO:0006366	transcription from RNA polymerase II promoter	1.60e-02	1.00e+00	3.298	2	30	419
GO:0001942	hair follicle development	1.69e-02	1.00e+00	5.879	1	2	35
GO:0034446	substrate adhesion-dependent cell spreading	1.73e-02	1.00e+00	5.839	1	2	36
GO:0048538	thymus development	1.73e-02	1.00e+00	5.839	1	2	36
GO:0051781	positive regulation of cell division	1.88e-02	1.00e+00	5.723	1	1	39
GO:0005881	cytoplasmic microtubule	1.93e-02	1.00e+00	5.687	1	1	40
GO:0045785	positive regulation of cell adhesion	1.93e-02	1.00e+00	5.687	1	2	40
GO:0004715	non-membrane spanning protein tyrosine kinase activity	2.02e-02	1.00e+00	5.616	1	3	42
GO:0031124	mRNA 3'-end processing	2.02e-02	1.00e+00	5.616	1	2	42
GO:0006369	termination of RNA polymerase II transcription	2.16e-02	1.00e+00	5.517	1	2	45
GO:0016328	lateral plasma membrane	2.21e-02	1.00e+00	5.485	1	3	46
GO:0006921	cellular component disassembly involved in execution phase of apoptosis	2.26e-02	1.00e+00	5.454	1	2	47
GO:0045732	positive regulation of protein catabolic process	2.40e-02	1.00e+00	5.365	1	1	50
GO:0060041	retina development in camera-type eye	2.45e-02	1.00e+00	5.336	1	2	51
GO:0051028	mRNA transport	2.50e-02	1.00e+00	5.308	1	4	52
GO:0009611	response to wounding	2.50e-02	1.00e+00	5.308	1	5	52
GO:0001725	stress fiber	2.64e-02	1.00e+00	5.227	1	4	55
GO:0005643	nuclear pore	2.73e-02	1.00e+00	5.176	1	11	57
GO:0006406	mRNA export from nucleus	2.92e-02	1.00e+00	5.078	1	4	61
GO:0019903	protein phosphatase binding	2.97e-02	1.00e+00	5.055	1	2	62
GO:0000776	kinetochore	3.02e-02	1.00e+00	5.031	1	5	63
GO:0007409	axonogenesis	3.11e-02	1.00e+00	4.986	1	2	65
GO:0010468	regulation of gene expression	3.25e-02	1.00e+00	4.921	1	2	68
GO:0034329	cell junction assembly	3.25e-02	1.00e+00	4.921	1	3	68
GO:0032587	ruffle membrane	3.35e-02	1.00e+00	4.879	1	3	70
GO:0042826	histone deacetylase binding	3.44e-02	1.00e+00	4.839	1	4	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.54e-02	1.00e+00	4.799	1	4	74
GO:0060070	canonical Wnt signaling pathway	3.58e-02	1.00e+00	4.780	1	4	75
GO:0005634	nucleus	3.60e-02	1.00e+00	1.176	5	159	4559
GO:0001822	kidney development	3.73e-02	1.00e+00	4.723	1	3	78
GO:0007229	integrin-mediated signaling pathway	3.73e-02	1.00e+00	4.723	1	3	78
GO:0016020	membrane	3.85e-02	1.00e+00	1.879	3	46	1681
GO:0004713	protein tyrosine kinase activity	3.91e-02	1.00e+00	4.651	1	3	82
GO:0009653	anatomical structure morphogenesis	3.96e-02	1.00e+00	4.634	1	2	83
GO:0009952	anterior/posterior pattern specification	3.96e-02	1.00e+00	4.634	1	4	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.10e-02	1.00e+00	4.582	1	8	86
GO:0005923	tight junction	4.10e-02	1.00e+00	4.582	1	2	86
GO:0006936	muscle contraction	4.15e-02	1.00e+00	4.566	1	3	87
GO:0000187	activation of MAPK activity	4.29e-02	1.00e+00	4.517	1	3	90
GO:0007010	cytoskeleton organization	4.33e-02	1.00e+00	4.501	1	4	91
GO:0006928	cellular component movement	4.33e-02	1.00e+00	4.501	1	3	91
GO:0001649	osteoblast differentiation	4.38e-02	1.00e+00	4.485	1	5	92
GO:0005178	integrin binding	4.57e-02	1.00e+00	4.424	1	4	96
GO:0008360	regulation of cell shape	4.89e-02	1.00e+00	4.322	1	4	103
GO:0005938	cell cortex	4.94e-02	1.00e+00	4.308	1	5	104
GO:0030308	negative regulation of cell growth	5.22e-02	1.00e+00	4.227	1	6	110
GO:0006461	protein complex assembly	5.27e-02	1.00e+00	4.214	1	4	111
GO:0030529	ribonucleoprotein complex	5.31e-02	1.00e+00	4.201	1	5	112
GO:0007050	cell cycle arrest	5.87e-02	1.00e+00	4.055	1	5	124
GO:0030335	positive regulation of cell migration	6.00e-02	1.00e+00	4.020	1	5	127
GO:0007179	transforming growth factor beta receptor signaling pathway	6.05e-02	1.00e+00	4.009	1	11	128
GO:0016477	cell migration	6.05e-02	1.00e+00	4.009	1	4	128
GO:0007165	signal transduction	6.72e-02	1.00e+00	2.184	2	13	907
GO:0008017	microtubule binding	6.92e-02	1.00e+00	3.809	1	2	147
GO:0042981	regulation of apoptotic process	7.06e-02	1.00e+00	3.780	1	4	150
GO:0006974	cellular response to DNA damage stimulus	7.10e-02	1.00e+00	3.770	1	7	151
GO:0000398	mRNA splicing, via spliceosome	7.69e-02	1.00e+00	3.651	1	15	164
GO:0006355	regulation of transcription, DNA-templated	7.95e-02	1.00e+00	2.047	2	43	997
GO:0016607	nuclear speck	8.06e-02	1.00e+00	3.582	1	12	172
GO:0005667	transcription factor complex	8.19e-02	1.00e+00	3.558	1	17	175
GO:0031625	ubiquitin protein ligase binding	8.33e-02	1.00e+00	3.533	1	5	178
GO:0044822	poly(A) RNA binding	8.79e-02	1.00e+00	1.964	2	50	1056
GO:0007173	epidermal growth factor receptor signaling pathway	8.82e-02	1.00e+00	3.446	1	5	189
GO:0005829	cytosol	1.05e-01	1.00e+00	1.308	3	86	2496
GO:0008380	RNA splicing	1.06e-01	1.00e+00	3.176	1	22	228
GO:0008134	transcription factor binding	1.12e-01	1.00e+00	3.090	1	18	242
GO:0000166	nucleotide binding	1.19e-01	1.00e+00	2.992	1	13	259
GO:0043065	positive regulation of apoptotic process	1.23e-01	1.00e+00	2.943	1	7	268
GO:0005743	mitochondrial inner membrane	1.27e-01	1.00e+00	2.895	1	6	277
GO:0019899	enzyme binding	1.27e-01	1.00e+00	2.895	1	9	277
GO:0005856	cytoskeleton	1.33e-01	1.00e+00	2.824	1	9	291
GO:0005813	centrosome	1.48e-01	1.00e+00	2.660	1	7	326
GO:0015031	protein transport	1.54e-01	1.00e+00	2.595	1	11	341
GO:0003723	RNA binding	1.55e-01	1.00e+00	2.591	1	18	342
GO:0043565	sequence-specific DNA binding	1.56e-01	1.00e+00	2.574	1	11	346
GO:0005925	focal adhesion	1.65e-01	1.00e+00	2.493	1	9	366
GO:0008284	positive regulation of cell proliferation	1.71e-01	1.00e+00	2.431	1	10	382
GO:0045892	negative regulation of transcription, DNA-templated	1.84e-01	1.00e+00	2.319	1	24	413
GO:0006468	protein phosphorylation	2.03e-01	1.00e+00	2.163	1	10	460
GO:0045893	positive regulation of transcription, DNA-templated	2.10e-01	1.00e+00	2.108	1	24	478
GO:0048471	perinuclear region of cytoplasm	2.20e-01	1.00e+00	2.037	1	8	502
GO:0006915	apoptotic process	2.40e-01	1.00e+00	1.892	1	12	555
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	2.46e-01	1.00e+00	1.854	1	37	570
GO:0010467	gene expression	2.83e-01	1.00e+00	1.623	1	45	669
GO:0003700	sequence-specific DNA binding transcription factor activity	2.94e-01	1.00e+00	1.560	1	39	699
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.26e-01	1.00e+00	1.385	1	41	789
GO:0070062	extracellular vesicular exosome	3.29e-01	1.00e+00	0.780	2	57	2400
GO:0005887	integral component of plasma membrane	3.59e-01	1.00e+00	1.214	1	10	888
GO:0005886	plasma membrane	3.65e-01	1.00e+00	0.674	2	49	2582
GO:0008270	zinc ion binding	3.94e-01	1.00e+00	1.047	1	27	997
GO:0005739	mitochondrion	3.95e-01	1.00e+00	1.046	1	23	998
GO:0003677	DNA binding	4.61e-01	1.00e+00	0.758	1	49	1218
GO:0005524	ATP binding	4.83e-01	1.00e+00	0.667	1	31	1298
GO:0005730	nucleolus	5.71e-01	1.00e+00	0.328	1	66	1641

chia-Fav

int-snw-4145

Statistics

Genes (7)

Interactions (6)

Related GO terms (176)