int-snw-22898

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.935	1.35e-16	1.39e-04	1.40e-03

chia-screen-data-Fav-int-snw-22898 subnetwork

Genes (6)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
YAP1	10413	94	-4.256	3.538	53	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
[ DENND3 ]	22898	1	-0.105	2.935	3	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
MED28	80306	16	-2.404	3.216	80	Yes	-

Interactions (5)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
YAP1	10413	MED28	80306	pp	--	int.I2D: MINT; int.Mint: MI:0915(physical association)
YAP1	10413	DENND3	22898	pp	--	int.I2D: BioGrid
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo

Related GO terms (94)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0042789	mRNA transcription from RNA polymerase II promoter	1.12e-05	1.62e-01	8.531	2	2	13
GO:0044212	transcription regulatory region DNA binding	3.03e-05	4.36e-01	5.424	3	17	168
GO:0006355	regulation of transcription, DNA-templated	3.04e-04	1.00e+00	3.270	4	43	997
GO:0060795	cell fate commitment involved in formation of primary germ layer	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	4.16e-04	1.00e+00	11.231	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	4.16e-04	1.00e+00	11.231	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	4.16e-04	1.00e+00	11.231	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	4.16e-04	1.00e+00	11.231	1	1	1
GO:0005654	nucleoplasm	4.18e-04	1.00e+00	3.152	4	64	1082
GO:0009786	regulation of asymmetric cell division	8.32e-04	1.00e+00	10.231	1	1	2
GO:0060242	contact inhibition	8.32e-04	1.00e+00	10.231	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	8.32e-04	1.00e+00	10.231	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	8.32e-04	1.00e+00	10.231	1	1	2
GO:0060913	cardiac cell fate determination	1.25e-03	1.00e+00	9.646	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.25e-03	1.00e+00	9.646	1	1	3
GO:0006974	cellular response to DNA damage stimulus	1.59e-03	1.00e+00	4.993	2	7	151
GO:0051151	negative regulation of smooth muscle cell differentiation	1.66e-03	1.00e+00	9.231	1	1	4
GO:0001714	endodermal cell fate specification	2.08e-03	1.00e+00	8.909	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.08e-03	1.00e+00	8.909	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.08e-03	1.00e+00	8.909	1	2	5
GO:0003714	transcription corepressor activity	2.20e-03	1.00e+00	4.755	2	11	178
GO:0070937	CRD-mediated mRNA stability complex	2.49e-03	1.00e+00	8.646	1	3	6
GO:0001955	blood vessel maturation	3.32e-03	1.00e+00	8.231	1	1	8
GO:0006983	ER overload response	3.74e-03	1.00e+00	8.061	1	1	9
GO:0008134	transcription factor binding	4.02e-03	1.00e+00	4.312	2	18	242
GO:0035413	positive regulation of catenin import into nucleus	4.15e-03	1.00e+00	7.909	1	2	10
GO:0045662	negative regulation of myoblast differentiation	4.57e-03	1.00e+00	7.772	1	3	11
GO:0044257	cellular protein catabolic process	4.57e-03	1.00e+00	7.772	1	1	11
GO:0060391	positive regulation of SMAD protein import into nucleus	4.57e-03	1.00e+00	7.772	1	4	11
GO:0035198	miRNA binding	4.98e-03	1.00e+00	7.646	1	1	12
GO:0071480	cellular response to gamma radiation	5.40e-03	1.00e+00	7.531	1	1	13
GO:0001824	blastocyst development	6.22e-03	1.00e+00	7.324	1	2	15
GO:0043565	sequence-specific DNA binding	8.07e-03	1.00e+00	3.796	2	11	346
GO:0017112	Rab guanyl-nucleotide exchange factor activity	8.29e-03	1.00e+00	6.909	1	1	20
GO:0032757	positive regulation of interleukin-8 production	8.29e-03	1.00e+00	6.909	1	1	20
GO:0036464	cytoplasmic ribonucleoprotein granule	9.12e-03	1.00e+00	6.772	1	2	22
GO:0030864	cortical actin cytoskeleton	9.53e-03	1.00e+00	6.708	1	1	23
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	9.53e-03	1.00e+00	6.708	1	1	23
GO:0003677	DNA binding	9.89e-03	1.00e+00	2.566	3	49	1218
GO:0035329	hippo signaling	1.08e-02	1.00e+00	6.531	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.08e-02	1.00e+00	6.531	1	1	26
GO:0008333	endosome to lysosome transport	1.20e-02	1.00e+00	6.373	1	2	29
GO:0042594	response to starvation	1.28e-02	1.00e+00	6.277	1	4	31
GO:1903507	negative regulation of nucleic acid-templated transcription	1.32e-02	1.00e+00	6.231	1	2	32
GO:0016592	mediator complex	1.45e-02	1.00e+00	6.102	1	10	35
GO:0035019	somatic stem cell maintenance	1.65e-02	1.00e+00	5.909	1	6	40
GO:0043525	positive regulation of neuron apoptotic process	1.90e-02	1.00e+00	5.708	1	4	46
GO:0019827	stem cell maintenance	1.94e-02	1.00e+00	5.677	1	7	47
GO:0006986	response to unfolded protein	2.06e-02	1.00e+00	5.587	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.10e-02	1.00e+00	5.559	1	2	51
GO:0045454	cell redox homeostasis	2.10e-02	1.00e+00	5.559	1	1	51
GO:0009611	response to wounding	2.14e-02	1.00e+00	5.531	1	5	52
GO:0032851	positive regulation of Rab GTPase activity	2.19e-02	1.00e+00	5.503	1	2	53
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	2.43e-02	1.00e+00	5.348	1	6	59
GO:0006396	RNA processing	2.43e-02	1.00e+00	5.348	1	5	59
GO:0006987	activation of signaling protein activity involved in unfolded protein response	2.51e-02	1.00e+00	5.300	1	2	61
GO:0010468	regulation of gene expression	2.80e-02	1.00e+00	5.144	1	2	68
GO:0010467	gene expression	2.85e-02	1.00e+00	2.845	2	45	669
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	3.04e-02	1.00e+00	5.022	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	3.08e-02	1.00e+00	5.002	1	1	75
GO:0003700	sequence-specific DNA binding transcription factor activity	3.09e-02	1.00e+00	2.782	2	39	699
GO:0071013	catalytic step 2 spliceosome	3.20e-02	1.00e+00	4.946	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	3.24e-02	1.00e+00	4.927	1	2	79
GO:0009653	anatomical structure morphogenesis	3.40e-02	1.00e+00	4.856	1	2	83
GO:0090090	negative regulation of canonical Wnt signaling pathway	3.53e-02	1.00e+00	4.805	1	8	86
GO:0001649	osteoblast differentiation	3.77e-02	1.00e+00	4.708	1	5	92
GO:0005770	late endosome	3.81e-02	1.00e+00	4.692	1	2	93
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.87e-02	1.00e+00	2.607	2	41	789
GO:0030529	ribonucleoprotein complex	4.57e-02	1.00e+00	4.424	1	5	112
GO:0005515	protein binding	4.97e-02	1.00e+00	0.997	5	198	6024
GO:0007050	cell cycle arrest	5.05e-02	1.00e+00	4.277	1	5	124
GO:0016055	Wnt signaling pathway	5.61e-02	1.00e+00	4.123	1	4	138
GO:0044822	poly(A) RNA binding	6.59e-02	1.00e+00	2.187	2	50	1056
GO:0000398	mRNA splicing, via spliceosome	6.63e-02	1.00e+00	3.874	1	15	164
GO:0005829	cytosol	6.86e-02	1.00e+00	1.531	3	86	2496
GO:0005667	transcription factor complex	7.06e-02	1.00e+00	3.780	1	17	175
GO:0031625	ubiquitin protein ligase binding	7.18e-02	1.00e+00	3.755	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	7.42e-02	1.00e+00	3.708	1	22	184
GO:0005634	nucleus	8.39e-02	1.00e+00	1.077	4	159	4559
GO:0008380	RNA splicing	9.12e-02	1.00e+00	3.398	1	22	228
GO:0003713	transcription coactivator activity	9.46e-02	1.00e+00	3.342	1	24	237
GO:0003779	actin binding	1.06e-01	1.00e+00	3.176	1	10	266
GO:0008283	cell proliferation	1.29e-01	1.00e+00	2.874	1	14	328
GO:0003723	RNA binding	1.34e-01	1.00e+00	2.813	1	18	342
GO:0016020	membrane	1.48e-01	1.00e+00	1.516	2	46	1681
GO:0046982	protein heterodimerization activity	1.48e-01	1.00e+00	2.661	1	8	380
GO:0009986	cell surface	1.56e-01	1.00e+00	2.580	1	9	402
GO:0045892	negative regulation of transcription, DNA-templated	1.60e-01	1.00e+00	2.541	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	1.62e-01	1.00e+00	2.520	1	30	419
GO:0044267	cellular protein metabolic process	1.82e-01	1.00e+00	2.342	1	20	474
GO:0045893	positive regulation of transcription, DNA-templated	1.83e-01	1.00e+00	2.330	1	24	478
GO:0005524	ATP binding	4.32e-01	1.00e+00	0.889	1	31	1298
GO:0006351	transcription, DNA-templated	4.70e-01	1.00e+00	0.733	1	57	1446
GO:0005737	cytoplasm	4.92e-01	1.00e+00	0.352	2	124	3767

chia-Fav

int-snw-22898

Statistics

Genes (6)

Interactions (5)

Related GO terms (94)