int-snw-2147

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
chia-screen-data-Fav	2.904	2.98e-16	2.08e-04	1.86e-03

chia-screen-data-Fav-int-snw-2147 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	chia-screen-data-Fav gene score	Best subnetwork score	Degree	Chia-Hits Primary	Chia-Hits Secondary
[ F2 ]	2147	1	-1.807	2.904	44	-	-
PROC	5624	1	-1.927	2.904	17	-	-
YAP1	10413	94	-4.256	3.538	53	Yes	-
HNRNPU	3192	76	-2.869	3.538	139	Yes	-
POU5F1	5460	133	-5.148	3.538	179	Yes	Yes
PLAT	5327	2	-1.976	2.904	30	-	-
DDIT3	1649	60	-2.825	3.504	343	Yes	Yes
H1FX	8971	7	-2.421	3.504	35	Yes	Yes

Interactions (7)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
DDIT3	1649	H1FX	8971	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
HNRNPU	3192	YAP1	10413	pp	--	int.I2D: HPRD; int.HPRD: in vitro, in vivo
DDIT3	1649	F2	2147	pp	--	int.Intact: MI:0915(physical association)
DDIT3	1649	HNRNPU	3192	pp	--	int.I2D: BEHRENDS_AUTOPHAGY_LOW
F2	2147	PLAT	5327	pp	--	int.I2D: BioGrid
F2	2147	PROC	5624	pp	--	int.I2D: HPRD
HNRNPU	3192	POU5F1	5460	pp	--	int.I2D: BioGrid_Mouse, IntAct_Mouse

Related GO terms (143)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0017187	peptidyl-glutamic acid carboxylation	1.48e-05	2.13e-01	8.357	2	2	11
GO:0042789	mRNA transcription from RNA polymerase II promoter	2.09e-05	3.02e-01	8.116	2	2	13
GO:0004252	serine-type endopeptidase activity	2.10e-05	3.03e-01	5.673	3	3	106
GO:0042730	fibrinolysis	4.10e-05	5.91e-01	7.646	2	3	18
GO:0045861	negative regulation of proteolysis	4.10e-05	5.91e-01	7.646	2	4	18
GO:0044212	transcription regulatory region DNA binding	8.33e-05	1.00e+00	5.009	3	17	168
GO:0009611	response to wounding	3.52e-04	1.00e+00	6.116	2	5	52
GO:0060795	cell fate commitment involved in formation of primary germ layer	5.55e-04	1.00e+00	10.816	1	1	1
GO:2000016	negative regulation of determination of dorsal identity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090308	regulation of methylation-dependent chromatin silencing	5.55e-04	1.00e+00	10.816	1	1	1
GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0090081	regulation of heart induction by regulation of canonical Wnt signaling pathway	5.55e-04	1.00e+00	10.816	1	1	1
GO:0060965	negative regulation of gene silencing by miRNA	5.55e-04	1.00e+00	10.816	1	1	1
GO:0005796	Golgi lumen	6.75e-04	1.00e+00	5.646	2	3	72
GO:0006508	proteolysis	9.07e-04	1.00e+00	3.839	3	6	378
GO:0060242	contact inhibition	1.11e-03	1.00e+00	9.816	1	1	2
GO:0009786	regulation of asymmetric cell division	1.11e-03	1.00e+00	9.816	1	1	2
GO:0044324	regulation of transcription involved in anterior/posterior axis specification	1.11e-03	1.00e+00	9.816	1	1	2
GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	1.11e-03	1.00e+00	9.816	1	1	2
GO:0007596	blood coagulation	1.55e-03	1.00e+00	3.571	3	11	455
GO:0050900	leukocyte migration	1.57e-03	1.00e+00	5.035	2	2	110
GO:0060279	positive regulation of ovulation	1.66e-03	1.00e+00	9.231	1	1	3
GO:0060913	cardiac cell fate determination	1.66e-03	1.00e+00	9.231	1	1	3
GO:0003130	BMP signaling pathway involved in heart induction	1.66e-03	1.00e+00	9.231	1	1	3
GO:0005654	nucleoplasm	1.73e-03	1.00e+00	2.737	4	64	1082
GO:0044267	cellular protein metabolic process	1.75e-03	1.00e+00	3.512	3	20	474
GO:0070053	thrombospondin receptor activity	2.22e-03	1.00e+00	8.816	1	1	4
GO:0003677	DNA binding	2.68e-03	1.00e+00	2.566	4	49	1218
GO:0005788	endoplasmic reticulum lumen	2.70e-03	1.00e+00	4.636	2	5	145
GO:0001714	endodermal cell fate specification	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043620	regulation of DNA-templated transcription in response to stress	2.77e-03	1.00e+00	8.494	1	1	5
GO:0070934	CRD-mediated mRNA stabilization	2.77e-03	1.00e+00	8.494	1	2	5
GO:0014909	smooth muscle cell migration	2.77e-03	1.00e+00	8.494	1	1	5
GO:0006974	cellular response to DNA damage stimulus	2.93e-03	1.00e+00	4.578	2	7	151
GO:0031639	plasminogen activation	3.32e-03	1.00e+00	8.231	1	1	6
GO:0070937	CRD-mediated mRNA stability complex	3.32e-03	1.00e+00	8.231	1	3	6
GO:0043687	post-translational protein modification	3.36e-03	1.00e+00	4.476	2	5	162
GO:0003714	transcription corepressor activity	4.04e-03	1.00e+00	4.340	2	11	178
GO:0001955	blood vessel maturation	4.43e-03	1.00e+00	7.816	1	1	8
GO:0006983	ER overload response	4.98e-03	1.00e+00	7.646	1	1	9
GO:0010544	negative regulation of platelet activation	4.98e-03	1.00e+00	7.646	1	1	9
GO:0035413	positive regulation of catenin import into nucleus	5.53e-03	1.00e+00	7.494	1	2	10
GO:0030194	positive regulation of blood coagulation	5.53e-03	1.00e+00	7.494	1	1	10
GO:0051918	negative regulation of fibrinolysis	5.53e-03	1.00e+00	7.494	1	1	10
GO:0045662	negative regulation of myoblast differentiation	6.09e-03	1.00e+00	7.357	1	3	11
GO:0060391	positive regulation of SMAD protein import into nucleus	6.09e-03	1.00e+00	7.357	1	4	11
GO:0030195	negative regulation of blood coagulation	6.64e-03	1.00e+00	7.231	1	1	12
GO:0048712	negative regulation of astrocyte differentiation	6.64e-03	1.00e+00	7.231	1	1	12
GO:0035198	miRNA binding	6.64e-03	1.00e+00	7.231	1	1	12
GO:0071480	cellular response to gamma radiation	7.19e-03	1.00e+00	7.116	1	1	13
GO:0008134	transcription factor binding	7.34e-03	1.00e+00	3.897	2	18	242
GO:0030193	regulation of blood coagulation	8.29e-03	1.00e+00	6.909	1	1	15
GO:0001824	blastocyst development	8.29e-03	1.00e+00	6.909	1	2	15
GO:0007597	blood coagulation, intrinsic pathway	9.94e-03	1.00e+00	6.646	1	2	18
GO:0051480	cytosolic calcium ion homeostasis	9.94e-03	1.00e+00	6.646	1	1	18
GO:0071549	cellular response to dexamethasone stimulus	1.10e-02	1.00e+00	6.494	1	3	20
GO:0032757	positive regulation of interleukin-8 production	1.10e-02	1.00e+00	6.494	1	1	20
GO:0005515	protein binding	1.12e-02	1.00e+00	1.067	7	198	6024
GO:0032967	positive regulation of collagen biosynthetic process	1.16e-02	1.00e+00	6.424	1	3	21
GO:0005576	extracellular region	1.21e-02	1.00e+00	2.521	3	13	942
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	2	22
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	1.27e-02	1.00e+00	6.293	1	1	23
GO:2000379	positive regulation of reactive oxygen species metabolic process	1.27e-02	1.00e+00	6.293	1	2	23
GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	1.32e-02	1.00e+00	6.231	1	1	24
GO:0006355	regulation of transcription, DNA-templated	1.42e-02	1.00e+00	2.440	3	43	997
GO:0035329	hippo signaling	1.43e-02	1.00e+00	6.116	1	5	26
GO:0051209	release of sequestered calcium ion into cytosol	1.43e-02	1.00e+00	6.116	1	1	26
GO:0043565	sequence-specific DNA binding	1.46e-02	1.00e+00	3.381	2	11	346
GO:0048008	platelet-derived growth factor receptor signaling pathway	1.49e-02	1.00e+00	6.061	1	2	27
GO:0048167	regulation of synaptic plasticity	1.65e-02	1.00e+00	5.909	1	2	30
GO:0044822	poly(A) RNA binding	1.66e-02	1.00e+00	2.357	3	50	1056
GO:0042594	response to starvation	1.71e-02	1.00e+00	5.862	1	4	31
GO:0035249	synaptic transmission, glutamatergic	1.76e-02	1.00e+00	5.816	1	3	32
GO:1903507	negative regulation of nucleic acid-templated transcription	1.76e-02	1.00e+00	5.816	1	2	32
GO:0006953	acute-phase response	1.93e-02	1.00e+00	5.687	1	1	35
GO:0009986	cell surface	1.94e-02	1.00e+00	3.165	2	9	402
GO:0035019	somatic stem cell maintenance	2.20e-02	1.00e+00	5.494	1	6	40
GO:0051591	response to cAMP	2.47e-02	1.00e+00	5.324	1	4	45
GO:0043434	response to peptide hormone	2.47e-02	1.00e+00	5.324	1	5	45
GO:0043525	positive regulation of neuron apoptotic process	2.52e-02	1.00e+00	5.293	1	4	46
GO:0006986	response to unfolded protein	2.74e-02	1.00e+00	5.172	1	4	50
GO:0034976	response to endoplasmic reticulum stress	2.79e-02	1.00e+00	5.144	1	2	51
GO:0045454	cell redox homeostasis	2.79e-02	1.00e+00	5.144	1	1	51
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	2.79e-02	1.00e+00	5.144	1	2	51
GO:0006396	RNA processing	3.23e-02	1.00e+00	4.933	1	5	59
GO:0000786	nucleosome	3.23e-02	1.00e+00	4.933	1	2	59
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.23e-02	1.00e+00	4.933	1	6	59
GO:0005509	calcium ion binding	3.27e-02	1.00e+00	2.764	2	11	531
GO:0006987	activation of signaling protein activity involved in unfolded protein response	3.33e-02	1.00e+00	4.885	1	2	61
GO:0030141	secretory granule	3.39e-02	1.00e+00	4.862	1	4	62
GO:0010468	regulation of gene expression	3.71e-02	1.00e+00	4.729	1	2	68
GO:0030307	positive regulation of cell growth	3.76e-02	1.00e+00	4.708	1	2	69
GO:0006334	nucleosome assembly	3.93e-02	1.00e+00	4.646	1	3	72
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity	4.03e-02	1.00e+00	4.607	1	4	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.09e-02	1.00e+00	4.587	1	1	75
GO:0071013	catalytic step 2 spliceosome	4.25e-02	1.00e+00	4.531	1	7	78
GO:0030968	endoplasmic reticulum unfolded protein response	4.30e-02	1.00e+00	4.512	1	2	79
GO:0045177	apical part of cell	4.41e-02	1.00e+00	4.476	1	3	81
GO:0009653	anatomical structure morphogenesis	4.51e-02	1.00e+00	4.441	1	2	83
GO:0006464	cellular protein modification process	4.57e-02	1.00e+00	4.424	1	4	84
GO:0090090	negative regulation of canonical Wnt signaling pathway	4.67e-02	1.00e+00	4.390	1	8	86
GO:0001649	osteoblast differentiation	4.99e-02	1.00e+00	4.293	1	5	92
GO:0010467	gene expression	4.99e-02	1.00e+00	2.430	2	45	669
GO:0005770	late endosome	5.04e-02	1.00e+00	4.277	1	2	93
GO:0003700	sequence-specific DNA binding transcription factor activity	5.41e-02	1.00e+00	2.367	2	39	699
GO:0008360	regulation of cell shape	5.57e-02	1.00e+00	4.130	1	4	103
GO:0001934	positive regulation of protein phosphorylation	5.63e-02	1.00e+00	4.116	1	5	104
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0030529	ribonucleoprotein complex	6.05e-02	1.00e+00	4.009	1	5	112
GO:0007050	cell cycle arrest	6.68e-02	1.00e+00	3.862	1	5	124
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	6.72e-02	1.00e+00	2.192	2	41	789
GO:0005634	nucleus	7.14e-02	1.00e+00	0.984	5	159	4559
GO:0045202	synapse	7.30e-02	1.00e+00	3.729	1	5	136
GO:0016055	Wnt signaling pathway	7.40e-02	1.00e+00	3.708	1	4	138
GO:0008083	growth factor activity	7.56e-02	1.00e+00	3.677	1	3	141
GO:0007166	cell surface receptor signaling pathway	7.87e-02	1.00e+00	3.616	1	4	147
GO:0001666	response to hypoxia	7.97e-02	1.00e+00	3.597	1	7	149
GO:0031012	extracellular matrix	8.23e-02	1.00e+00	3.549	1	6	154
GO:0000398	mRNA splicing, via spliceosome	8.74e-02	1.00e+00	3.459	1	15	164
GO:0005667	transcription factor complex	9.31e-02	1.00e+00	3.365	1	17	175
GO:0005615	extracellular space	9.43e-02	1.00e+00	1.914	2	20	957
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	5	178
GO:0006367	transcription initiation from RNA polymerase II promoter	9.76e-02	1.00e+00	3.293	1	22	184
GO:0030168	platelet activation	1.08e-01	1.00e+00	3.137	1	6	205
GO:0008380	RNA splicing	1.20e-01	1.00e+00	2.983	1	22	228
GO:0003713	transcription coactivator activity	1.24e-01	1.00e+00	2.927	1	24	237
GO:0005102	receptor binding	1.35e-01	1.00e+00	2.794	1	2	260
GO:0005829	cytosol	1.47e-01	1.00e+00	1.116	3	86	2496
GO:0007275	multicellular organismal development	1.62e-01	1.00e+00	2.512	1	7	316
GO:0008283	cell proliferation	1.68e-01	1.00e+00	2.459	1	14	328
GO:0003723	RNA binding	1.75e-01	1.00e+00	2.398	1	18	342
GO:0046982	protein heterodimerization activity	1.92e-01	1.00e+00	2.246	1	8	380
GO:0008284	positive regulation of cell proliferation	1.93e-01	1.00e+00	2.239	1	10	382
GO:0045892	negative regulation of transcription, DNA-templated	2.07e-01	1.00e+00	2.126	1	24	413
GO:0006366	transcription from RNA polymerase II promoter	2.10e-01	1.00e+00	2.105	1	30	419
GO:0043066	negative regulation of apoptotic process	2.12e-01	1.00e+00	2.088	1	16	424
GO:0045893	positive regulation of transcription, DNA-templated	2.36e-01	1.00e+00	1.915	1	24	478
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	124	3767
GO:0070062	extracellular vesicular exosome	3.95e-01	1.00e+00	0.587	2	57	2400
GO:0005886	plasma membrane	4.34e-01	1.00e+00	0.482	2	49	2582
GO:0005524	ATP binding	5.30e-01	1.00e+00	0.474	1	31	1298
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	66	1641
GO:0016020	membrane	6.29e-01	1.00e+00	0.101	1	46	1681

chia-Fav

int-snw-2147

Statistics

Genes (8)

Interactions (7)

Related GO terms (143)