meta-int-snw-2617

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-4800 wolf-screen-ratio-mammosphere-adherent 0.833 7.78e-07 2.65e-03 5.08e-03 7 5
int-snw-2617 wolf-screen-ratio-mammosphere-adherent 0.927 3.24e-15 2.92e-03 4.51e-02 16 16
reg-snw-5925 wolf-screen-ratio-mammosphere-adherent 0.802 2.42e-06 4.82e-03 8.69e-03 8 5
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-2617 subnetwork

Genes (25)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
ACACB 32 120.6561.002184Yes-
GARS 2617 30.0760.927104Yes-
SNRNP200 23020 30.5380.927146Yes-
PSMA3 5684 900.5330.815238Yes-
PPCS 79717 31-0.5690.8022-Yes
UBA1 7317 60.5550.971207Yes-
COPA 1314 70.4340.833170Yes-
DDX18 8886 250.6601.013215Yes-
RBX1 9978 1151.1850.934148Yes-
PPIE 10450 310.5670.80241--
PSMC3 5702 510.7191.002276Yes-
HNRNPC 3183 1081.8120.973181Yes-
TP53 7157 230.4320.833665--
OGDH 4967 720.8470.802126Yes-
TFRC 7037 310.7300.80217--
RPSA 3921 1201.3271.151152Yes-
PGD 5226 891.2011.106152Yes-
RPA2 6118 961.2501.15176Yes-
RB1 5925 31-0.1020.802351--
RSL24D1 51187 381.3001.02059Yes-
CCNA2 890 540.5500.973246Yes-
NFYA 4800 70.1980.83380--
DARS 1615 140.6171.000110Yes-
RPL14 9045 491.2501.113166Yes-
ACTB 60 1341.1531.151610Yes-

Interactions (57)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
UBA1 7317 SNRNP200 23020 pp -- int.I2D: YeastLow
RB1 5925 PPCS 79717 pd > reg.pazar.txt: no annot
COPA 1314 RB1 5925 pd <> reg.ITFP.txt: no annot
RB1 5925 RPA2 6118 pd > reg.pazar.txt: no annot
GARS 2617 UBA1 7317 pp -- int.I2D: YeastLow
ACACB 32 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 NFYA 4800 pd < reg.pazar.txt: no annot;
reg.oreganno.txt: no annot
PGD 5226 RB1 5925 pd < reg.pazar.txt: no annot
RPA2 6118 TP53 7157 pp -- int.Transfac: -
ACACB 32 COPA 1314 pp -- int.I2D: YeastLow
RBX1 9978 PPIE 10450 pd <> reg.ITFP.txt: no annot
DARS 1615 SNRNP200 23020 pp -- int.I2D: YeastLow
PSMC3 5702 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMC3 5702 UBA1 7317 pp -- int.I2D: BioGrid_Yeast
ACACB 32 SNRNP200 23020 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast
RB1 5925 TP53 7157 pd < reg.TRANSFAC.txt: no annot
RB1 5925 TP53 7157 pp -- int.Intact: MI:0914(association)
RPSA 3921 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
OGDH 4967 RB1 5925 pd < reg.ITFP.txt: no annot
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
PGD 5226 UBA1 7317 pp -- int.I2D: YeastLow
PSMC3 5702 TP53 7157 pp -- int.I2D: BioGrid
DARS 1615 UBA1 7317 pp -- int.I2D: YeastLow
COPA 1314 OGDH 4967 pd > reg.ITFP.txt: no annot
ACTB 60 RB1 5925 pd < reg.ITFP.txt: no annot
HNRNPC 3183 TP53 7157 pd < reg.ITFP.txt: no annot
ACTB 60 COPA 1314 pd < reg.ITFP.txt: no annot
ACTB 60 COPA 1314 pp -- int.I2D: BioGrid_Yeast
OGDH 4967 DDX18 8886 pp -- int.I2D: YeastLow
CCNA2 890 RB1 5925 pp -- int.I2D: IntAct
ACACB 32 GARS 2617 pp -- int.I2D: IntAct_Yeast
ACTB 60 GARS 2617 pp -- int.I2D: BioGrid_Yeast
GARS 2617 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
COPA 1314 RPL14 9045 pd > reg.ITFP.txt: no annot
ACACB 32 UBA1 7317 pp -- int.I2D: Krogan_NonCore
GARS 2617 PSMA3 5684 pp -- int.I2D: BioGrid
NFYA 4800 TP53 7157 pd > reg.pazar.txt: no annot
NFYA 4800 TP53 7157 pp -- int.Intact: MI:0914(association), MI:0915(physical association), MI:0403(colocalization);
int.I2D: BioGrid, HPRD, IntAct, BCI;
int.Ravasi: -;
int.HPRD: in vivo
ACACB 32 RPSA 3921 pp -- int.I2D: IntAct_Yeast, YeastMedium
CCNA2 890 TP53 7157 pp -- int.I2D: HPRD, BCI, BioGrid;
int.HPRD: in vitro
ACTB 60 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMA3 5684 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, BioGrid, YeastLow
DARS 1615 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
ACTB 60 DARS 1615 pp -- int.I2D: IntAct_Yeast
DARS 1615 GARS 2617 pp -- int.I2D: YeastLow
CCNA2 890 NFYA 4800 pd < reg.TRANSFAC.txt: no annot
COPA 1314 PSMA3 5684 pp -- int.I2D: YeastLow
RB1 5925 TFRC 7037 pd > reg.ITFP.txt: no annot
ACACB 32 DARS 1615 pp -- int.I2D: IntAct_Yeast
GARS 2617 DDX18 8886 pp -- int.I2D: YeastLow
RB1 5925 PPIE 10450 pd > reg.pazar.txt: no annot
GARS 2617 SNRNP200 23020 pp -- int.I2D: YeastLow
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
COPA 1314 NFYA 4800 pd > reg.ITFP.txt: no annot

Related GO terms (437)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0005654nucleoplasm2.19e-073.58e-032.71311831095
GO:0005829cytosol5.64e-079.21e-031.934151252562
GO:0016032viral process8.97e-071.46e-023.274855540
GO:0010467gene expression4.45e-067.26e-022.965858669
GO:0044822poly(A) RNA binding1.80e-052.94e-012.4469501078
GO:0000082G1/S transition of mitotic cell cycle7.46e-051.00e+004.122433150
GO:0005515protein binding1.03e-041.00e+001.018191726127
GO:0005524ATP binding1.09e-041.00e+002.1179461354
GO:0031571mitotic G1 DNA damage checkpoint1.23e-041.00e+006.8912311
GO:0070062extracellular vesicular exosome1.27e-041.00e+001.63912982516
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest1.30e-041.00e+004.91332265
GO:0016020membrane1.38e-041.00e+001.90310801746
GO:0031625ubiquitin protein ligase binding1.51e-041.00e+003.859413180
GO:0007265Ras protein signal transduction1.99e-041.00e+004.7073375
GO:0071013catalytic step 2 spliceosome2.32e-041.00e+004.6323779
GO:0000278mitotic cell cycle2.99e-041.00e+003.036552398
GO:0004004ATP-dependent RNA helicase activity3.40e-041.00e+006.1812218
GO:0016071mRNA metabolic process3.43e-041.00e+003.550434223
GO:0016605PML body3.64e-041.00e+004.4123592
GO:0016070RNA metabolic process5.04e-041.00e+003.402434247
GO:0043044ATP-dependent chromatin remodeling5.59e-041.00e+005.8272423
GO:0042802identical protein binding7.79e-041.00e+002.733518491
GO:0031492nucleosomal DNA binding8.31e-041.00e+005.5432428
GO:0000790nuclear chromatin1.07e-031.00e+003.88037133
GO:0051402neuron apoptotic process1.37e-031.00e+005.1812236
GO:0005634nucleus1.51e-031.00e+001.020151314828
GO:0006426glycyl-tRNA aminoacylation1.53e-031.00e+009.351111
GO:0004820glycine-tRNA ligase activity1.53e-031.00e+009.351111
GO:0034602oxoglutarate dehydrogenase (NAD+) activity1.53e-031.00e+009.351111
GO:0090230regulation of centromere complex assembly1.53e-031.00e+009.351111
GO:0006422aspartyl-tRNA aminoacylation1.53e-031.00e+009.351111
GO:0004632phosphopantothenate--cysteine ligase activity1.53e-031.00e+009.351111
GO:0019521D-gluconate metabolic process1.53e-031.00e+009.351111
GO:0042981regulation of apoptotic process1.54e-031.00e+003.697326151
GO:0006284base-excision repair1.61e-031.00e+005.0652739
GO:0006418tRNA aminoacylation for protein translation1.87e-031.00e+004.9582542
GO:0000398mRNA splicing, via spliceosome1.98e-031.00e+003.569312165
GO:0034641cellular nitrogen compound metabolic process2.42e-031.00e+003.468325177
GO:0044281small molecule metabolic process2.62e-031.00e+001.8197571295
GO:0006521regulation of cellular amino acid metabolic process2.64e-031.00e+004.70722150
GO:0003684damaged DNA binding2.74e-031.00e+004.67821151
GO:0097252oligodendrocyte apoptotic process3.06e-031.00e+008.351112
GO:0045252oxoglutarate dehydrogenase complex3.06e-031.00e+008.351122
GO:1901525negative regulation of macromitophagy3.06e-031.00e+008.351112
GO:0097286iron ion import3.06e-031.00e+008.351112
GO:0006407rRNA export from nucleus3.06e-031.00e+008.351112
GO:0061034olfactory bulb mitral cell layer development3.06e-031.00e+008.351112
GO:2001295malonyl-CoA biosynthetic process3.06e-031.00e+008.351112
GO:0090343positive regulation of cell aging3.06e-031.00e+008.351112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.06e-031.00e+008.351112
GO:0004998transferrin receptor activity3.06e-031.00e+008.351112
GO:0003989acetyl-CoA carboxylase activity3.06e-031.00e+008.351112
GO:0015966diadenosine tetraphosphate biosynthetic process3.06e-031.00e+008.351112
GO:0019322pentose biosynthetic process3.06e-031.00e+008.351112
GO:0000354cis assembly of pre-catalytic spliceosome3.06e-031.00e+008.351112
GO:0004815aspartate-tRNA ligase activity3.06e-031.00e+008.351112
GO:0031134sister chromatid biorientation3.06e-031.00e+008.351112
GO:0005055laminin receptor activity3.06e-031.00e+008.351112
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis3.06e-031.00e+008.351122
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.07e-031.00e+004.5962554
GO:0000502proteasome complex3.53e-031.00e+004.49322258
GO:0051087chaperone binding3.65e-031.00e+004.4682659
GO:0006302double-strand break repair4.03e-031.00e+004.3962862
GO:0019903protein phosphatase binding4.15e-031.00e+004.3732463
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.42e-031.00e+004.32822465
GO:0006084acetyl-CoA metabolic process4.59e-031.00e+007.766113
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity4.59e-031.00e+007.766113
GO:0022028tangential migration from the subventricular zone to the olfactory bulb4.59e-031.00e+007.766113
GO:0035794positive regulation of mitochondrial membrane permeability4.59e-031.00e+007.766113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity4.59e-031.00e+007.766113
GO:0071459protein localization to chromosome, centromeric region4.59e-031.00e+007.766113
GO:0051097negative regulation of helicase activity4.59e-031.00e+007.766113
GO:0035033histone deacetylase regulator activity4.59e-031.00e+007.766113
GO:0002360T cell lineage commitment4.59e-031.00e+007.766113
GO:0009051pentose-phosphate shunt, oxidative branch4.59e-031.00e+007.766113
GO:0034103regulation of tissue remodeling4.59e-031.00e+007.766113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle4.59e-031.00e+007.766113
GO:0006289nucleotide-excision repair4.96e-031.00e+004.24221269
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.10e-031.00e+004.22122470
GO:0005759mitochondrial matrix5.24e-031.00e+003.071312233
GO:0006412translation5.36e-031.00e+003.059315235
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.54e-031.00e+004.16122373
GO:0000785chromatin5.54e-031.00e+004.1612573
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.69e-031.00e+004.14122474
GO:0006767water-soluble vitamin metabolic process5.84e-031.00e+004.1222375
GO:0045893positive regulation of transcription, DNA-templated6.02e-031.00e+002.423417487
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)6.11e-031.00e+007.351114
GO:003068690S preribosome6.11e-031.00e+007.351114
GO:0071922regulation of cohesin localization to chromatin6.11e-031.00e+007.351114
GO:0019788NEDD8 ligase activity6.11e-031.00e+007.351114
GO:0090403oxidative stress-induced premature senescence6.11e-031.00e+007.351114
GO:0004046aminoacylase activity6.11e-031.00e+007.351114
GO:0002326B cell lineage commitment6.11e-031.00e+007.351114
GO:0006104succinyl-CoA metabolic process6.11e-031.00e+007.351114
GO:0031467Cul7-RING ubiquitin ligase complex6.11e-031.00e+007.351114
GO:0043550regulation of lipid kinase activity6.11e-031.00e+007.351114
GO:0004839ubiquitin activating enzyme activity6.11e-031.00e+007.351114
GO:0035189Rb-E2F complex6.11e-031.00e+007.351114
GO:0034349glial cell apoptotic process6.11e-031.00e+007.351114
GO:0034088maintenance of mitotic sister chromatid cohesion6.11e-031.00e+007.351114
GO:0016602CCAAT-binding factor complex6.11e-031.00e+007.351114
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I6.14e-031.00e+004.08422377
GO:0006766vitamin metabolic process6.30e-031.00e+004.0652378
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.46e-031.00e+004.04722579
GO:0019083viral transcription6.78e-031.00e+004.0112881
GO:0005681spliceosomal complex7.11e-031.00e+003.9762383
GO:0047485protein N-terminus binding7.61e-031.00e+003.9242486
GO:0031465Cul4B-RING E3 ubiquitin ligase complex7.64e-031.00e+007.029125
GO:0001940male pronucleus7.64e-031.00e+007.029115
GO:2000001regulation of DNA damage checkpoint7.64e-031.00e+007.029115
GO:0019941modification-dependent protein catabolic process7.64e-031.00e+007.029115
GO:0009374biotin binding7.64e-031.00e+007.029115
GO:0097371MDM2/MDM4 family protein binding7.64e-031.00e+007.029115
GO:0031461cullin-RING ubiquitin ligase complex7.64e-031.00e+007.029115
GO:0048667cell morphogenesis involved in neuron differentiation7.64e-031.00e+007.029115
GO:0030891VCB complex7.64e-031.00e+007.029125
GO:0000730DNA recombinase assembly7.64e-031.00e+007.029135
GO:0006734NADH metabolic process7.64e-031.00e+007.029115
GO:0030976thiamine pyrophosphate binding7.64e-031.00e+007.029115
GO:0006415translational termination7.78e-031.00e+003.9082887
GO:0006414translational elongation8.85e-031.00e+003.81121193
GO:0002474antigen processing and presentation of peptide antigen via MHC class I9.03e-031.00e+003.79622394
GO:0043353enucleate erythrocyte differentiation9.16e-031.00e+006.766116
GO:0009108coenzyme biosynthetic process9.16e-031.00e+006.766116
GO:0010666positive regulation of cardiac muscle cell apoptotic process9.16e-031.00e+006.766116
GO:0001221transcription cofactor binding9.16e-031.00e+006.766116
GO:0005682U5 snRNP9.16e-031.00e+006.766116
GO:1902108regulation of mitochondrial membrane permeability involved in apoptotic process9.16e-031.00e+006.766116
GO:0002309T cell proliferation involved in immune response9.16e-031.00e+006.766116
GO:0045842positive regulation of mitotic metaphase/anaphase transition9.16e-031.00e+006.766116
GO:0021860pyramidal neuron development9.16e-031.00e+006.766116
GO:0031466Cul5-RING ubiquitin ligase complex9.16e-031.00e+006.766116
GO:0021695cerebellar cortex development9.16e-031.00e+006.766116
GO:0030957Tat protein binding9.16e-031.00e+006.766146
GO:0070245positive regulation of thymocyte apoptotic process9.16e-031.00e+006.766116
GO:0007406negative regulation of neuroblast proliferation9.16e-031.00e+006.766116
GO:0004075biotin carboxylase activity9.16e-031.00e+006.766116
GO:0001649osteoblast differentiation9.22e-031.00e+003.7812695
GO:0071456cellular response to hypoxia9.79e-031.00e+003.7362498
GO:0043234protein complex1.05e-021.00e+002.707317300
GO:0000028ribosomal small subunit assembly1.07e-021.00e+006.543117
GO:0001939female pronucleus1.07e-021.00e+006.543117
GO:0031462Cul2-RING ubiquitin ligase complex1.07e-021.00e+006.543127
GO:0030157pancreatic juice secretion1.07e-021.00e+006.543117
GO:0030867rough endoplasmic reticulum membrane1.07e-021.00e+006.543117
GO:0031497chromatin assembly1.07e-021.00e+006.543117
GO:0016018cyclosporin A binding1.07e-021.00e+006.543117
GO:0006200ATP catabolic process1.08e-021.00e+002.692314303
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.10e-021.00e+003.65028104
GO:0005730nucleolus1.11e-021.00e+001.4407701684
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.22e-021.00e+006.351128
GO:0000733DNA strand renaturation1.22e-021.00e+006.351118
GO:0031325positive regulation of cellular metabolic process1.22e-021.00e+006.351118
GO:0070688MLL5-L complex1.22e-021.00e+006.351118
GO:0006554lysine catabolic process1.22e-021.00e+006.351128
GO:0045116protein neddylation1.22e-021.00e+006.351128
GO:0019773proteasome core complex, alpha-subunit complex1.22e-021.00e+006.351158
GO:0006461protein complex assembly1.24e-021.00e+003.55626111
GO:0019901protein kinase binding1.25e-021.00e+002.614321320
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.31e-021.00e+003.518210114
GO:0019058viral life cycle1.33e-021.00e+003.505210115
GO:0000209protein polyubiquitination1.35e-021.00e+003.493221116
GO:0072562blood microparticle1.35e-021.00e+003.49324116
GO:0006853carnitine shuttle1.37e-021.00e+006.181119
GO:0015937coenzyme A biosynthetic process1.37e-021.00e+006.181119
GO:0097284hepatocyte apoptotic process1.37e-021.00e+006.181129
GO:0010389regulation of G2/M transition of mitotic cell cycle1.37e-021.00e+006.181119
GO:0006983ER overload response1.37e-021.00e+006.181129
GO:0031065positive regulation of histone deacetylation1.37e-021.00e+006.181119
GO:0000075cell cycle checkpoint1.37e-021.00e+006.181129
GO:0006768biotin metabolic process1.52e-021.00e+006.0291110
GO:0090399replicative senescence1.52e-021.00e+006.0291110
GO:2000648positive regulation of stem cell proliferation1.52e-021.00e+006.0291110
GO:0015939pantothenate metabolic process1.52e-021.00e+006.0291110
GO:0046902regulation of mitochondrial membrane permeability1.52e-021.00e+006.0291110
GO:0021756striatum development1.52e-021.00e+006.0291110
GO:0007219Notch signaling pathway1.56e-021.00e+003.38524125
GO:0007050cell cycle arrest1.58e-021.00e+003.37327126
GO:0003723RNA binding1.65e-021.00e+002.464319355
GO:0006098pentose-phosphate shunt1.67e-021.00e+005.8911311
GO:0008340determination of adult lifespan1.67e-021.00e+005.8911111
GO:0010569regulation of double-strand break repair via homologous recombination1.67e-021.00e+005.8911111
GO:0071850mitotic cell cycle arrest1.67e-021.00e+005.8911111
GO:0042551neuron maturation1.67e-021.00e+005.8911211
GO:0045651positive regulation of macrophage differentiation1.67e-021.00e+005.8911211
GO:0045120pronucleus1.67e-021.00e+005.8911111
GO:0033762response to glucagon1.67e-021.00e+005.8911111
GO:2000036regulation of stem cell maintenance1.67e-021.00e+005.8911211
GO:0006413translational initiation1.70e-021.00e+003.317212131
GO:00709353'-UTR-mediated mRNA stabilization1.82e-021.00e+005.7661212
GO:0051146striated muscle cell differentiation1.82e-021.00e+005.7661112
GO:0021794thalamus development1.82e-021.00e+005.7661112
GO:0070266necroptotic process1.82e-021.00e+005.7661112
GO:0032461positive regulation of protein oligomerization1.82e-021.00e+005.7661112
GO:0009303rRNA transcription1.82e-021.00e+005.7661112
GO:0044255cellular lipid metabolic process1.93e-021.00e+003.22124140
GO:0003735structural constituent of ribosome1.95e-021.00e+003.21128141
GO:0042273ribosomal large subunit biogenesis1.97e-021.00e+005.6501413
GO:0005662DNA replication factor A complex1.97e-021.00e+005.6501313
GO:0045780positive regulation of bone resorption1.97e-021.00e+005.6501113
GO:0048205COPI coating of Golgi vesicle1.97e-021.00e+005.6501113
GO:0030126COPI vesicle coat1.97e-021.00e+005.6501113
GO:0008266poly(U) RNA binding1.97e-021.00e+005.6501113
GO:0061024membrane organization2.08e-021.00e+003.16125146
GO:0035267NuA4 histone acetyltransferase complex2.12e-021.00e+005.5431414
GO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator2.12e-021.00e+005.5431214
GO:2000378negative regulation of reactive oxygen species metabolic process2.12e-021.00e+005.5431114
GO:0030330DNA damage response, signal transduction by p53 class mediator2.12e-021.00e+005.5431114
GO:0007095mitotic G2 DNA damage checkpoint2.12e-021.00e+005.5431114
GO:0009651response to salt stress2.12e-021.00e+005.5431214
GO:0048568embryonic organ development2.12e-021.00e+005.5431114
GO:0006457protein folding2.16e-021.00e+003.13128149
GO:0045445myoblast differentiation2.27e-021.00e+005.4441215
GO:0016514SWI/SNF complex2.27e-021.00e+005.4441315
GO:0006974cellular response to DNA damage stimulus2.41e-021.00e+003.04728158
GO:0050998nitric-oxide synthase binding2.42e-021.00e+005.3511116
GO:00061032-oxoglutarate metabolic process2.42e-021.00e+005.3511116
GO:0042149cellular response to glucose starvation2.57e-021.00e+005.2631117
GO:0045070positive regulation of viral genome replication2.57e-021.00e+005.2631117
GO:0022624proteasome accessory complex2.57e-021.00e+005.2631917
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.71e-021.00e+002.95825168
GO:0035861site of double-strand break2.72e-021.00e+005.1811118
GO:0051721protein phosphatase 2A binding2.72e-021.00e+005.1811118
GO:0005839proteasome core complex2.72e-021.00e+005.18111118
GO:0005657replication fork2.72e-021.00e+005.1811318
GO:0043066negative regulation of apoptotic process2.77e-021.00e+002.177330433
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.87e-021.00e+005.1031119
GO:0035035histone acetyltransferase binding2.87e-021.00e+005.1031119
GO:0071158positive regulation of cell cycle arrest2.87e-021.00e+005.1031119
GO:1903506regulation of nucleic acid-templated transcription2.87e-021.00e+005.1031119
GO:0010165response to X-ray2.87e-021.00e+005.1031219
GO:2000134negative regulation of G1/S transition of mitotic cell cycle3.02e-021.00e+005.0291220
GO:0004298threonine-type endopeptidase activity3.02e-021.00e+005.02911120
GO:0002931response to ischemia3.02e-021.00e+005.0291120
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator3.02e-021.00e+005.0291120
GO:0006298mismatch repair3.02e-021.00e+005.0291620
GO:0008156negative regulation of DNA replication3.17e-021.00e+004.9581121
GO:0007369gastrulation3.17e-021.00e+004.9581121
GO:0000718nucleotide-excision repair, DNA damage removal3.17e-021.00e+004.9581521
GO:0030316osteoclast differentiation3.32e-021.00e+004.8911222
GO:0000792heterochromatin3.32e-021.00e+004.8911222
GO:0005669transcription factor TFIID complex3.32e-021.00e+004.8911122
GO:0090200positive regulation of release of cytochrome c from mitochondria3.32e-021.00e+004.8911122
GO:0006297nucleotide-excision repair, DNA gap filling3.32e-021.00e+004.8911522
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle3.32e-021.00e+004.8911322
GO:0032201telomere maintenance via semi-conservative replication3.32e-021.00e+004.8911722
GO:0030863cortical cytoskeleton3.32e-021.00e+004.8911122
GO:0036464cytoplasmic ribonucleoprotein granule3.32e-021.00e+004.8911422
GO:0030057desmosome3.47e-021.00e+004.8271123
GO:0031463Cul3-RING ubiquitin ligase complex3.47e-021.00e+004.8271223
GO:0043236laminin binding3.47e-021.00e+004.8271123
GO:0006513protein monoubiquitination3.47e-021.00e+004.8271123
GO:0045879negative regulation of smoothened signaling pathway3.47e-021.00e+004.8271123
GO:0001836release of cytochrome c from mitochondria3.61e-021.00e+004.7661224
GO:0048147negative regulation of fibroblast proliferation3.61e-021.00e+004.7661124
GO:0000060protein import into nucleus, translocation3.61e-021.00e+004.7661424
GO:2000379positive regulation of reactive oxygen species metabolic process3.61e-021.00e+004.7661124
GO:0006890retrograde vesicle-mediated transport, Golgi to ER3.76e-021.00e+004.7071125
GO:0007569cell aging3.76e-021.00e+004.7071225
GO:0071479cellular response to ionizing radiation3.76e-021.00e+004.7071125
GO:0044267cellular protein metabolic process3.89e-021.00e+001.984324495
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway3.91e-021.00e+004.6501326
GO:0000722telomere maintenance via recombination3.91e-021.00e+004.6501726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia3.91e-021.00e+004.6501226
GO:0048565digestive tract development4.06e-021.00e+004.5961127
GO:0001046core promoter sequence-specific DNA binding4.20e-021.00e+004.5431128
GO:0043022ribosome binding4.20e-021.00e+004.5431328
GO:0019894kinesin binding4.20e-021.00e+004.5431128
GO:0006099tricarboxylic acid cycle4.35e-021.00e+004.4931329
GO:0019005SCF ubiquitin ligase complex4.35e-021.00e+004.4931129
GO:0010332response to gamma radiation4.35e-021.00e+004.4931229
GO:0003730mRNA 3'-UTR binding4.35e-021.00e+004.4931229
GO:0051262protein tetramerization4.50e-021.00e+004.4441330
GO:0042254ribosome biogenesis4.50e-021.00e+004.4441130
GO:0021549cerebellum development4.50e-021.00e+004.4441130
GO:0007346regulation of mitotic cell cycle4.50e-021.00e+004.4441330
GO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator4.50e-021.00e+004.4441230
GO:0046677response to antibiotic4.65e-021.00e+004.3961231
GO:0016604nuclear body4.65e-021.00e+004.3961231
GO:0006271DNA strand elongation involved in DNA replication4.65e-021.00e+004.3961931
GO:0007093mitotic cell cycle checkpoint4.65e-021.00e+004.3961231
GO:0050661NADP binding4.79e-021.00e+004.3511132
GO:0051219phosphoprotein binding4.79e-021.00e+004.3511332
GO:0034644cellular response to UV4.79e-021.00e+004.3511532
GO:0033572transferrin transport4.79e-021.00e+004.3511632
GO:1903507negative regulation of nucleic acid-templated transcription4.79e-021.00e+004.3511232
GO:0008380RNA splicing4.87e-021.00e+002.493213232
GO:0030971receptor tyrosine kinase binding4.94e-021.00e+004.3061233
GO:0033077T cell differentiation in thymus4.94e-021.00e+004.3061233
GO:2001244positive regulation of intrinsic apoptotic signaling pathway4.94e-021.00e+004.3061133
GO:0031072heat shock protein binding4.94e-021.00e+004.3061233
GO:0000413protein peptidyl-prolyl isomerization5.08e-021.00e+004.2631134
GO:0001085RNA polymerase II transcription factor binding5.08e-021.00e+004.2631234
GO:0003755peptidyl-prolyl cis-trans isomerase activity5.08e-021.00e+004.2631134
GO:0003713transcription coactivator activity5.14e-021.00e+002.450210239
GO:0034332adherens junction organization5.37e-021.00e+004.1811136
GO:0001895retina homeostasis5.37e-021.00e+004.1811136
GO:0008134transcription factor binding5.41e-021.00e+002.40828246
GO:0001102RNA polymerase II activating transcription factor binding5.52e-021.00e+004.1411437
GO:0051084'de novo' posttranslational protein folding5.52e-021.00e+004.1411437
GO:0006633fatty acid biosynthetic process5.52e-021.00e+004.1411237
GO:0006915apoptotic process5.54e-021.00e+001.778334571
GO:0001756somitogenesis5.67e-021.00e+004.1031138
GO:0070527platelet aggregation5.67e-021.00e+004.1031238
GO:0050681androgen receptor binding5.67e-021.00e+004.1031438
GO:0004842ubiquitin-protein transferase activity5.80e-021.00e+002.35124256
GO:0021766hippocampus development5.81e-021.00e+004.0651439
GO:0008026ATP-dependent helicase activity5.81e-021.00e+004.0651339
GO:0006096glycolytic process5.81e-021.00e+004.0651439
GO:0022627cytosolic small ribosomal subunit5.81e-021.00e+004.0651339
GO:0000781chromosome, telomeric region5.95e-021.00e+004.0291240
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription5.95e-021.00e+004.0291240
GO:0030521androgen receptor signaling pathway6.10e-021.00e+003.9931241
GO:0005737cytoplasm6.11e-021.00e+000.71510983976
GO:0006281DNA repair6.13e-021.00e+002.306222264
GO:0035914skeletal muscle cell differentiation6.24e-021.00e+003.9581142
GO:0014070response to organic cyclic compound6.39e-021.00e+003.9241343
GO:0000166nucleotide binding6.46e-021.00e+002.26326272
GO:0048146positive regulation of fibroblast proliferation6.53e-021.00e+003.8911244
GO:0034613cellular protein localization6.53e-021.00e+003.8911144
GO:0000979RNA polymerase II core promoter sequence-specific DNA binding6.53e-021.00e+003.8911244
GO:0021762substantia nigra development6.82e-021.00e+003.8271146
GO:0001047core promoter binding6.82e-021.00e+003.8271246
GO:0043525positive regulation of neuron apoptotic process6.82e-021.00e+003.8271246
GO:0006283transcription-coupled nucleotide-excision repair6.82e-021.00e+003.8271846
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity6.96e-021.00e+003.7961347
GO:0048511rhythmic process6.96e-021.00e+003.7961247
GO:0005507copper ion binding7.10e-021.00e+003.7661248
GO:0019899enzyme binding7.14e-021.00e+002.181211288
GO:0005739mitochondrion7.25e-021.00e+001.3204241046
GO:0022625cytosolic large ribosomal subunit7.25e-021.00e+003.7361549
GO:0031100organ regeneration7.39e-021.00e+003.7071450
GO:0035690cellular response to drug7.39e-021.00e+003.7071250
GO:0006091generation of precursor metabolites and energy7.53e-021.00e+003.6781351
GO:0005905coated pit7.53e-021.00e+003.6781251
GO:0016567protein ubiquitination7.61e-021.00e+002.12725299
GO:0003725double-stranded RNA binding7.96e-021.00e+003.5961654
GO:0019900kinase binding7.96e-021.00e+003.5961154
GO:0050680negative regulation of epithelial cell proliferation7.96e-021.00e+003.5961154
GO:0051289protein homotetramerization7.96e-021.00e+003.5961154
GO:0097193intrinsic apoptotic signaling pathway8.10e-021.00e+003.5691455
GO:0002039p53 binding8.10e-021.00e+003.5691755
GO:0000932cytoplasmic mRNA processing body8.24e-021.00e+003.5431356
GO:0008104protein localization8.24e-021.00e+003.5431356
GO:0006879cellular iron ion homeostasis8.38e-021.00e+003.5181557
GO:0000724double-strand break repair via homologous recombination8.38e-021.00e+003.5181657
GO:0012505endomembrane system8.38e-021.00e+003.5181257
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity8.66e-021.00e+003.4681459
GO:0045216cell-cell junction organization8.66e-021.00e+003.4681259
GO:0000723telomere maintenance8.66e-021.00e+003.4681859
GO:0031966mitochondrial membrane8.66e-021.00e+003.4681159
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway9.36e-021.00e+003.3511164
GO:0006469negative regulation of protein kinase activity9.50e-021.00e+003.3281265
GO:0001558regulation of cell growth9.64e-021.00e+003.3061466
GO:0030141secretory granule9.78e-021.00e+003.2841267
GO:0006338chromatin remodeling9.92e-021.00e+003.2631468
GO:0003697single-stranded DNA binding1.01e-011.00e+003.2421969
GO:0035264multicellular organism growth1.02e-011.00e+003.2211170
GO:0034329cell junction assembly1.03e-011.00e+003.2011171
GO:0003700sequence-specific DNA binding transcription factor activity1.05e-011.00e+001.389311748
GO:0055037recycling endosome1.06e-011.00e+003.1611273
GO:0032355response to estradiol1.06e-011.00e+003.1611573
GO:0002020protease binding1.07e-011.00e+003.1411474
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation1.09e-011.00e+003.1221175
GO:0031175neuron projection development1.09e-011.00e+003.1221175
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.10e-011.00e+003.1031376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.12e-011.00e+003.0841577
GO:0005179hormone activity1.21e-011.00e+002.9581184
GO:0006898receptor-mediated endocytosis1.24e-011.00e+002.9241286
GO:0045944positive regulation of transcription from RNA polymerase II promoter1.25e-011.00e+001.272319811
GO:0016363nuclear matrix1.32e-011.00e+002.82711192
GO:0042470melanosome1.32e-011.00e+002.82711092
GO:0006928cellular component movement1.32e-011.00e+002.8271792
GO:0005200structural constituent of cytoskeleton1.33e-011.00e+002.8111793
GO:0045892negative regulation of transcription, DNA-templated1.37e-011.00e+001.623214424
GO:0006364rRNA processing1.37e-011.00e+002.7661596
GO:0006112energy reserve metabolic process1.41e-011.00e+002.7211199
GO:0014069postsynaptic density1.50e-011.00e+002.62311106
GO:0016023cytoplasmic membrane-bounded vesicle1.52e-011.00e+002.60913107
GO:0005741mitochondrial outer membrane1.53e-011.00e+002.59614108
GO:0042127regulation of cell proliferation1.57e-011.00e+002.55614111
GO:0007596blood coagulation1.58e-011.00e+001.493214464
GO:0030308negative regulation of cell growth1.60e-011.00e+002.53016113
GO:0030529ribonucleoprotein complex1.61e-011.00e+002.51818114
GO:0005819spindle1.61e-011.00e+002.51817114
GO:0044237cellular metabolic process1.66e-011.00e+002.46813118
GO:0006325chromatin organization1.72e-011.00e+002.40814123
GO:0006260DNA replication1.75e-011.00e+002.385112125
GO:0007179transforming growth factor beta receptor signaling pathway1.81e-011.00e+002.32813130
GO:0046983protein dimerization activity1.83e-011.00e+002.31713131
GO:0031982vesicle1.86e-011.00e+002.284110134
GO:0000086G2/M transition of mitotic cell cycle1.90e-011.00e+002.25317137
GO:0005615extracellular space1.99e-011.00e+000.9553171010
GO:0016887ATPase activity1.99e-011.00e+002.18117144
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription2.07e-011.00e+002.11212151
GO:0010008endosome membrane2.15e-011.00e+002.05616157
GO:0005198structural molecule activity2.17e-011.00e+002.03814159
GO:0044212transcription regulatory region DNA binding2.32e-011.00e+001.93316171
GO:0030424axon2.33e-011.00e+001.92413172
GO:0006886intracellular protein transport2.34e-011.00e+001.91614173
GO:0005768endosome2.35e-011.00e+001.90815174
GO:0006355regulation of transcription, DNA-templated2.37e-011.00e+000.8273171104
GO:0003714transcription corepressor activity2.41e-011.00e+001.86717179
GO:0009897external side of plasma membrane2.46e-011.00e+001.83514183
GO:0032403protein complex binding2.48e-011.00e+001.81917185
GO:0001701in utero embryonic development2.77e-011.00e+001.63616210
GO:0005765lysosomal membrane2.86e-011.00e+001.58215218
GO:0007067mitotic nuclear division3.00e-011.00e+001.499113231
GO:0003677DNA binding3.43e-011.00e+000.5363261351
GO:0005975carbohydrate metabolic process3.45e-011.00e+001.25315274
GO:0043065positive regulation of apoptotic process3.45e-011.00e+001.25318274
GO:0042493response to drug3.59e-011.00e+001.181111288
GO:0005856cytoskeleton3.82e-011.00e+001.07018311
GO:0030154cell differentiation3.95e-011.00e+001.00615325
GO:0007411axon guidance3.97e-011.00e+000.99719327
GO:0008283cell proliferation4.01e-011.00e+000.980112331
GO:0043231intracellular membrane-bounded organelle4.02e-011.00e+000.97618332
GO:0003682chromatin binding4.04e-011.00e+000.967112334
GO:0007275multicellular organismal development4.13e-011.00e+000.92415344
GO:0008285negative regulation of cell proliferation4.34e-011.00e+000.831111367
GO:0005925focal adhesion4.37e-011.00e+000.819118370
GO:0007155cell adhesion4.49e-011.00e+000.76618384
GO:0046982protein heterodimerization activity4.62e-011.00e+000.710111399
GO:0009986cell surface4.81e-011.00e+000.62919422
GO:0006366transcription from RNA polymerase II promoter4.83e-011.00e+000.619112425
GO:0008270zinc ion binding4.93e-011.00e+000.2912121067
GO:0055114oxidation-reduction process5.27e-011.00e+000.441111481
GO:0055085transmembrane transport5.51e-011.00e+000.34518514
GO:0048471perinuclear region of cytoplasm5.57e-011.00e+000.320112523
GO:0000122negative regulation of transcription from RNA polymerase II promoter6.01e-011.00e+000.148112589
GO:0005783endoplasmic reticulum6.14e-011.00e+000.09819610
GO:0045087innate immune response6.18e-011.00e+000.084120616
GO:0046872metal ion binding6.70e-011.00e+00-0.1662241465
GO:0005887integral component of plasma membrane7.81e-011.00e+00-0.55817961
GO:0005576extracellular region8.10e-011.00e+00-0.684191049
GO:0006351transcription, DNA-templated9.22e-011.00e+00-1.2801251585
GO:0005886plasma membrane9.47e-011.00e+00-1.1182382834