int-snw-2617

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.927 3.24e-15 2.92e-03 4.51e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-2617 subnetwork

Genes (16)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
ACACB 32 50.6561.002184Yes-
RSL24D1 51187 361.3001.02059Yes-
PSMA3 5684 120.5331.026218Yes-
[ GARS ] 2617 10.0760.927104Yes-
SNRNP200 23020 10.5380.927146Yes-
UBA1 7317 40.5550.971207Yes-
RBX1 9978 971.1851.151139Yes-
DDX18 8886 90.6601.013173Yes-
PSMC3 5702 90.7191.002255Yes-
DARS 1615 30.6171.000110Yes-
RPL14 9045 421.2501.113143Yes-
HNRNPC 3183 201.8121.026119Yes-
ACTB 60 1671.1531.151587Yes-
RPSA 3921 1561.3271.151152Yes-
PGD 5226 751.2011.106138Yes-

Interactions (31)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PGD 5226 UBA1 7317 pp -- int.I2D: YeastLow
DARS 1615 SNRNP200 23020 pp -- int.I2D: YeastLow
DARS 1615 GARS 2617 pp -- int.I2D: YeastLow
PGD 5226 DDX18 8886 pp -- int.I2D: YeastLow
ACTB 60 GARS 2617 pp -- int.I2D: BioGrid_Yeast
GARS 2617 PSMA3 5684 pp -- int.I2D: BioGrid
DDX18 8886 RSL24D1 51187 pp -- int.I2D: YeastLow, BioGrid_Yeast
PSMC3 5702 UBA1 7317 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
UBA1 7317 SNRNP200 23020 pp -- int.I2D: YeastLow
HNRNPC 3183 PSMA3 5684 pp -- int.I2D: BioGrid
PSMA3 5684 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast, BioGrid, YeastLow
ACTB 60 DARS 1615 pp -- int.I2D: IntAct_Yeast
ACACB 32 UBA1 7317 pp -- int.I2D: Krogan_NonCore
DARS 1615 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
ACACB 32 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
PSMC3 5702 RPL14 9045 pp -- int.I2D: BioGrid_Yeast
GARS 2617 SNRNP200 23020 pp -- int.I2D: YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
DARS 1615 UBA1 7317 pp -- int.I2D: YeastLow
ACACB 32 DARS 1615 pp -- int.I2D: IntAct_Yeast
ACTB 60 PSMA3 5684 pp -- int.I2D: BioGrid, BioGrid_Yeast
ACACB 32 GARS 2617 pp -- int.I2D: IntAct_Yeast
GARS 2617 UBA1 7317 pp -- int.I2D: YeastLow
ACACB 32 RPSA 3921 pp -- int.I2D: IntAct_Yeast, YeastMedium
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPSA 3921 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast
GARS 2617 DDX18 8886 pp -- int.I2D: YeastLow
ACACB 32 SNRNP200 23020 pp -- int.I2D: BioGrid_Yeast
GARS 2617 PSMC3 5702 pp -- int.I2D: BioGrid_Yeast

Related GO terms (217)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0010467gene expression1.90e-072.74e-033.430859669
GO:0005829cytosol6.43e-079.28e-032.116121322496
GO:0005524ATP binding2.80e-054.05e-012.4748601298
GO:0044822poly(A) RNA binding7.02e-051.00e+002.5797491056
GO:0005654nucleoplasm8.21e-051.00e+002.5447761082
GO:0016071mRNA metabolic process8.75e-051.00e+004.015431223
GO:0016070RNA metabolic process1.30e-041.00e+003.868432247
GO:0004004ATP-dependent RNA helicase activity1.75e-041.00e+006.6462218
GO:0016020membrane1.82e-041.00e+002.1018901681
GO:0016032viral process2.12e-041.00e+003.077555534
GO:0043044ATP-dependent chromatin remodeling2.88e-041.00e+006.2932423
GO:0070062extracellular vesicular exosome3.59e-041.00e+001.75791042400
GO:0031492nucleosomal DNA binding3.98e-041.00e+006.0612427
GO:0000082G1/S transition of mitotic cell cycle5.48e-041.00e+004.182332149
GO:0006418tRNA aminoacylation for protein translation9.68e-041.00e+005.4242942
GO:0006426glycyl-tRNA aminoacylation1.11e-031.00e+009.816111
GO:0004820glycine-tRNA ligase activity1.11e-031.00e+009.816111
GO:0006422aspartyl-tRNA aminoacylation1.11e-031.00e+009.816111
GO:0019521D-gluconate metabolic process1.11e-031.00e+009.816111
GO:0006521regulation of cellular amino acid metabolic process1.37e-031.00e+005.17221750
GO:0005515protein binding1.51e-031.00e+000.960131846024
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding1.54e-031.00e+005.0882553
GO:0000502proteasome complex1.84e-031.00e+004.95821758
GO:0006412translation1.92e-031.00e+003.556320230
GO:2001295malonyl-CoA biosynthetic process2.22e-031.00e+008.816112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.22e-031.00e+008.816112
GO:0003989acetyl-CoA carboxylase activity2.22e-031.00e+008.816112
GO:0015966diadenosine tetraphosphate biosynthetic process2.22e-031.00e+008.816112
GO:0019322pentose biosynthetic process2.22e-031.00e+008.816122
GO:0000354cis assembly of pre-catalytic spliceosome2.22e-031.00e+008.816112
GO:0004815aspartate-tRNA ligase activity2.22e-031.00e+008.816122
GO:0005055laminin receptor activity2.22e-031.00e+008.816112
GO:0006407rRNA export from nucleus2.22e-031.00e+008.816112
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2.23e-031.00e+004.81621964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.30e-031.00e+004.79422265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.67e-031.00e+004.68722270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent2.82e-031.00e+004.64622072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle2.97e-031.00e+004.60722274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I3.05e-031.00e+004.58722075
GO:0071013catalytic step 2 spliceosome3.30e-031.00e+004.5312478
GO:0006084acetyl-CoA metabolic process3.32e-031.00e+008.231113
GO:0009051pentose-phosphate shunt, oxidative branch3.32e-031.00e+008.231123
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity3.32e-031.00e+008.231113
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process3.38e-031.00e+004.51222379
GO:0019083viral transcription3.55e-031.00e+004.47621081
GO:0005681spliceosomal complex3.73e-031.00e+004.4412483
GO:0006200ATP catabolic process3.78e-031.00e+003.211315292
GO:0006415translational termination4.09e-031.00e+004.37321087
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)4.43e-031.00e+007.816114
GO:0004046aminoacylase activity4.43e-031.00e+007.816114
GO:003068690S preribosome4.43e-031.00e+007.816114
GO:0031467Cul7-RING ubiquitin ligase complex4.43e-031.00e+007.816114
GO:0004839ubiquitin activating enzyme activity4.43e-031.00e+007.816114
GO:0019788NEDD8 ligase activity4.43e-031.00e+007.816114
GO:0001649osteoblast differentiation4.56e-031.00e+004.2932692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I4.56e-031.00e+004.29322192
GO:0006414translational elongation4.65e-031.00e+004.27721393
GO:0031465Cul4B-RING E3 ubiquitin ligase complex5.54e-031.00e+007.494135
GO:0031461cullin-RING ubiquitin ligase complex5.54e-031.00e+007.494115
GO:0030891VCB complex5.54e-031.00e+007.494125
GO:0000730DNA recombinase assembly5.54e-031.00e+007.494115
GO:0004075biotin carboxylase activity5.54e-031.00e+007.494115
GO:2000001regulation of DNA damage checkpoint5.54e-031.00e+007.494115
GO:0019941modification-dependent protein catabolic process5.54e-031.00e+007.494115
GO:0009374biotin binding5.54e-031.00e+007.494115
GO:0006614SRP-dependent cotranslational protein targeting to membrane5.79e-031.00e+004.116210104
GO:0005730nucleolus6.27e-031.00e+001.7216691641
GO:0005682U5 snRNP6.64e-031.00e+007.231116
GO:0030957Tat protein binding6.64e-031.00e+007.231136
GO:0031466Cul5-RING ubiquitin ligase complex6.64e-031.00e+007.231116
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.91e-031.00e+003.983211114
GO:0019058viral life cycle7.03e-031.00e+003.971213115
GO:0000209protein polyubiquitination7.15e-031.00e+003.958220116
GO:0030867rough endoplasmic reticulum membrane7.74e-031.00e+007.009127
GO:0000028ribosomal small subunit assembly7.74e-031.00e+007.009117
GO:0031462Cul2-RING ubiquitin ligase complex7.74e-031.00e+007.009127
GO:0000278mitotic cell cycle8.51e-031.00e+002.790348391
GO:0000790nuclear chromatin8.78e-031.00e+003.80529129
GO:0019773proteasome core complex, alpha-subunit complex8.84e-031.00e+006.816148
GO:0031464Cul4A-RING E3 ubiquitin ligase complex8.84e-031.00e+006.816128
GO:0006853carnitine shuttle8.84e-031.00e+006.816118
GO:0031325positive regulation of cellular metabolic process8.84e-031.00e+006.816118
GO:0070688MLL5-L complex8.84e-031.00e+006.816118
GO:0045116protein neddylation8.84e-031.00e+006.816128
GO:0006413translational initiation9.04e-031.00e+003.783217131
GO:0003735structural constituent of ribosome9.85e-031.00e+003.718210137
GO:0006768biotin metabolic process9.94e-031.00e+006.646119
GO:0005634nucleus1.06e-021.00e+000.984101364559
GO:0006098pentose-phosphate shunt1.10e-021.00e+006.4941410
GO:0010569regulation of double-strand break repair via homologous recombination1.10e-021.00e+006.4941110
GO:0042981regulation of apoptotic process1.17e-021.00e+003.587224150
GO:0031571mitotic G1 DNA damage checkpoint1.21e-021.00e+006.3571411
GO:0045120pronucleus1.21e-021.00e+006.3571211
GO:00709353'-UTR-mediated mRNA stabilization1.32e-021.00e+006.2311212
GO:0000398mRNA splicing, via spliceosome1.39e-021.00e+003.45928164
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding1.41e-021.00e+003.45027165
GO:0042273ribosomal large subunit biogenesis1.43e-021.00e+006.1161413
GO:0005662DNA replication factor A complex1.43e-021.00e+006.1161113
GO:0008266poly(U) RNA binding1.43e-021.00e+006.1161113
GO:0044267cellular protein metabolic process1.44e-021.00e+002.512329474
GO:0034641cellular nitrogen compound metabolic process1.50e-021.00e+003.398220171
GO:0035267NuA4 histone acetyltransferase complex1.54e-021.00e+006.0091414
GO:0031625ubiquitin protein ligase binding1.62e-021.00e+003.340214178
GO:0050998nitric-oxide synthase binding1.76e-021.00e+005.8161116
GO:0022624proteasome accessory complex1.87e-021.00e+005.7291817
GO:1903506regulation of nucleic acid-templated transcription1.98e-021.00e+005.6461118
GO:0035861site of double-strand break1.98e-021.00e+005.6461118
GO:0005839proteasome core complex1.98e-021.00e+005.6461818
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.09e-021.00e+005.5681119
GO:0004298threonine-type endopeptidase activity2.09e-021.00e+005.5681819
GO:0006298mismatch repair2.20e-021.00e+005.4941320
GO:0032201telomere maintenance via semi-conservative replication2.31e-021.00e+005.4241521
GO:0000718nucleotide-excision repair, DNA damage removal2.31e-021.00e+005.4241421
GO:0006297nucleotide-excision repair, DNA gap filling2.41e-021.00e+005.3571322
GO:0000792heterochromatin2.41e-021.00e+005.3571222
GO:0030863cortical cytoskeleton2.41e-021.00e+005.3571122
GO:0036464cytoplasmic ribonucleoprotein granule2.41e-021.00e+005.3571422
GO:0030057desmosome2.52e-021.00e+005.2931123
GO:0031463Cul3-RING ubiquitin ligase complex2.52e-021.00e+005.2931323
GO:0043236laminin binding2.52e-021.00e+005.2931123
GO:0006513protein monoubiquitination2.52e-021.00e+005.2931123
GO:0008380RNA splicing2.58e-021.00e+002.983211228
GO:0000722telomere maintenance via recombination2.74e-021.00e+005.1721525
GO:0003730mRNA 3'-UTR binding2.85e-021.00e+005.1161226
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia2.85e-021.00e+005.1161326
GO:0043022ribosome binding2.96e-021.00e+005.0611327
GO:0050661NADP binding2.96e-021.00e+005.0611227
GO:0019894kinesin binding3.06e-021.00e+005.0091128
GO:0019005SCF ubiquitin ligase complex3.17e-021.00e+004.9581129
GO:0004842ubiquitin-protein transferase activity3.17e-021.00e+002.82226255
GO:0042254ribosome biogenesis3.28e-021.00e+004.9091130
GO:0006271DNA strand elongation involved in DNA replication3.28e-021.00e+004.9091730
GO:0006281DNA repair3.31e-021.00e+002.788218261
GO:1903507negative regulation of nucleic acid-templated transcription3.49e-021.00e+004.8161232
GO:0006633fatty acid biosynthetic process3.49e-021.00e+004.8161332
GO:0001895retina homeostasis3.71e-021.00e+004.7291134
GO:0034332adherens junction organization3.92e-021.00e+004.6461136
GO:0044281small molecule metabolic process3.98e-021.00e+001.5744581211
GO:0051084'de novo' posttranslational protein folding4.03e-021.00e+004.6071437
GO:0006284base-excision repair4.03e-021.00e+004.6071337
GO:0043234protein complex4.14e-021.00e+002.612218295
GO:0016567protein ubiquitination4.14e-021.00e+002.61225295
GO:0070527platelet aggregation4.14e-021.00e+004.5681238
GO:0022627cytosolic small ribosomal subunit4.24e-021.00e+004.5311439
GO:0000781chromosome, telomeric region4.24e-021.00e+004.5311339
GO:0008026ATP-dependent helicase activity4.24e-021.00e+004.5311339
GO:0014070response to organic cyclic compound4.67e-021.00e+004.3901443
GO:0021762substantia nigra development4.77e-021.00e+004.3571244
GO:0006283transcription-coupled nucleotide-excision repair4.99e-021.00e+004.2931746
GO:0022625cytosolic large ribosomal subunit5.30e-021.00e+004.2011649
GO:0003684damaged DNA binding5.30e-021.00e+004.2011749
GO:0003723RNA binding5.41e-021.00e+002.398220342
GO:0051289protein homotetramerization5.51e-021.00e+004.1441151
GO:0045216cell-cell junction organization5.83e-021.00e+004.0611254
GO:0000932cytoplasmic mRNA processing body5.83e-021.00e+004.0611354
GO:0000724double-strand break repair via homologous recombination5.93e-021.00e+004.0351355
GO:0000723telomere maintenance6.04e-021.00e+004.0091656
GO:0012505endomembrane system6.04e-021.00e+004.0091256
GO:0019903protein phosphatase binding6.66e-021.00e+003.8621462
GO:0006302double-strand break repair6.66e-021.00e+003.8621462
GO:0030141secretory granule6.66e-021.00e+003.8621262
GO:0006289nucleotide-excision repair7.29e-021.00e+003.72911168
GO:0006767water-soluble vitamin metabolic process7.29e-021.00e+003.7291168
GO:0034329cell junction assembly7.29e-021.00e+003.7291168
GO:0003697single-stranded DNA binding7.29e-021.00e+003.7291568
GO:0006766vitamin metabolic process7.60e-021.00e+003.6661171
GO:0043066negative regulation of apoptotic process7.89e-021.00e+002.088231424
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis7.90e-021.00e+003.6071674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process8.01e-021.00e+003.5871275
GO:0047485protein N-terminus binding9.13e-021.00e+003.3901586
GO:0016605PML body9.33e-021.00e+003.3571388
GO:0006928cellular component movement9.64e-021.00e+003.3081791
GO:0005200structural constituent of cytoskeleton9.64e-021.00e+003.3081891
GO:0005737cytoplasm9.70e-021.00e+000.74471103767
GO:0071456cellular response to hypoxia9.74e-021.00e+003.2931692
GO:0042802identical protein binding9.90e-021.00e+001.897220484
GO:0006364rRNA processing9.94e-021.00e+003.2611694
GO:0006112energy reserve metabolic process1.00e-011.00e+003.2461395
GO:0014069postsynaptic density1.10e-011.00e+003.10213105
GO:0005741mitochondrial outer membrane1.10e-011.00e+003.10217105
GO:0006461protein complex assembly1.16e-011.00e+003.02216111
GO:0072562blood microparticle1.16e-011.00e+003.02213111
GO:0030529ribonucleoprotein complex1.17e-011.00e+003.00918112
GO:0046983protein dimerization activity1.23e-011.00e+002.93312118
GO:0006325chromatin organization1.23e-011.00e+002.93315118
GO:0006915apoptotic process1.24e-011.00e+001.700233555
GO:0007219Notch signaling pathway1.25e-011.00e+002.90915120
GO:0006260DNA replication1.26e-011.00e+002.89719121
GO:0044255cellular lipid metabolic process1.38e-011.00e+002.76116133
GO:0016887ATPase activity1.45e-011.00e+002.68717140
GO:0006457protein folding1.47e-011.00e+002.65617143
GO:0061024membrane organization1.49e-011.00e+002.63617145
GO:0010008endosome membrane1.55e-011.00e+002.57817151
GO:0006974cellular response to DNA damage stimulus1.55e-011.00e+002.57818151
GO:0030424axon1.69e-011.00e+002.44114166
GO:0003714transcription corepressor activity1.80e-011.00e+002.34018178
GO:0032403protein complex binding1.85e-011.00e+002.300110183
GO:0005765lysosomal membrane2.03e-011.00e+002.15115203
GO:0005759mitochondrial matrix2.25e-011.00e+001.983114228
GO:0003713transcription coactivator activity2.33e-011.00e+001.927110237
GO:0005975carbohydrate metabolic process2.47e-011.00e+001.83319253
GO:0000166nucleotide binding2.52e-011.00e+001.79915259
GO:0019899enzyme binding2.67e-011.00e+001.702112277
GO:0042493response to drug2.73e-011.00e+001.666113284
GO:0005856cytoskeleton2.78e-011.00e+001.631112291
GO:0019901protein kinase binding2.99e-011.00e+001.508121317
GO:0007411axon guidance3.01e-011.00e+001.499113319
GO:0005739mitochondrion3.05e-011.00e+000.853228998
GO:0005925focal adhesion3.37e-011.00e+001.300119366
GO:0007155cell adhesion3.40e-011.00e+001.28916369
GO:0055114oxidation-reduction process3.77e-011.00e+001.102112420
GO:0007596blood coagulation4.01e-011.00e+000.986118455
GO:0045087innate immune response4.91e-011.00e+000.597124596
GO:0005615extracellular space6.67e-011.00e+00-0.086117957
GO:0008270zinc ion binding6.82e-011.00e+00-0.145112997
GO:0046872metal ion binding7.81e-011.00e+00-0.5361251307
GO:0005886plasma membrane9.57e-011.00e+00-1.5181452582