meta-int-snw-1460

Interacting subnets

Subnetwork Dataset Score p-value 1 p-value 2 p-value 3 Size Highlighted genes
reg-snw-56655 wolf-screen-ratio-mammosphere-adherent 0.828 9.29e-07 2.91e-03 5.53e-03 8 7
int-snw-1460 wolf-screen-ratio-mammosphere-adherent 0.978 3.10e-17 9.28e-04 1.95e-02 13 12
reg-snw-317781 wolf-screen-ratio-mammosphere-adherent 0.823 1.13e-06 3.23e-03 6.07e-03 9 9
reg-snw-5925 wolf-screen-ratio-mammosphere-adherent 0.802 2.42e-06 4.82e-03 8.69e-03 8 5
wolf-screen-ratio-mammosphere-adherent-meta-int-snw-1460 subnetwork

Genes (26)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
PPCS 79717 31-0.5690.8022-Yes
PSMA2 5683 1121.0931.106108Yes-
RBX1 9978 1151.1850.934148Yes-
PPIE 10450 310.5670.80241--
PSMB7 5695 1180.9820.93490Yes-
VARS 7407 860.5491.002204Yes-
CSNK2B 1460 4-0.0640.978217--
OGDH 4967 720.8470.802126Yes-
DDX51 317781 530.0590.823210Yes-
POLE4 56655 630.1770.82856--
TFRC 7037 310.7300.80217--
RPSA 3921 1201.3271.151152Yes-
PSMB3 5691 640.6680.90119Yes-
PGD 5226 891.2011.106152Yes-
ADH5 128 160.6330.99443Yes-
RPA2 6118 961.2501.15176Yes-
EIF6 3692 670.7000.876316Yes-
RB1 5925 31-0.1020.802351--
RSL24D1 51187 381.3001.02059Yes-
EIF2S2 8894 391.0750.940103Yes-
PPP2R1A 5518 190.6440.985249Yes-
PSMD3 5709 1000.9861.106201Yes-
PSMB2 5690 1160.8770.956169Yes-
TUBG1 7283 980.9740.97391Yes-
PSMD11 5717 1241.0951.106218Yes-
ACTB 60 1341.1531.151610Yes-

Interactions (70)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
PPP2R1A 5518 PSMB3 5691 pp -- int.I2D: IntAct_Mouse
RB1 5925 PPCS 79717 pd > reg.pazar.txt: no annot
RB1 5925 RPA2 6118 pd > reg.pazar.txt: no annot
PSMB7 5695 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
PSMA2 5683 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
ACTB 60 CSNK2B 1460 pp -- int.Intact: MI:0915(physical association)
PSMB2 5690 POLE4 56655 pd < reg.ITFP.txt: no annot
PSMB3 5691 PSMD3 5709 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
PGD 5226 RB1 5925 pd < reg.pazar.txt: no annot
ACTB 60 PSMB2 5690 pp -- int.I2D: BioGrid_Yeast
RBX1 9978 PPIE 10450 pd <> reg.ITFP.txt: no annot
ACTB 60 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 OGDH 4967 pp -- int.I2D: YeastLow
RPSA 3921 VARS 7407 pp -- int.I2D: IntAct_Yeast
PSMD3 5709 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
EIF6 3692 PGD 5226 pp -- int.I2D: YeastLow
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
CSNK2B 1460 EIF6 3692 pp -- int.I2D: BioGrid, MINT;
int.Mint: MI:0915(physical association)
TUBG1 7283 VARS 7407 pd < reg.ITFP.txt: no annot
ADH5 128 CSNK2B 1460 pp -- int.Intact: MI:0915(physical association)
OGDH 4967 RB1 5925 pd < reg.ITFP.txt: no annot
PPP2R1A 5518 PSMB2 5690 pp -- int.I2D: IntAct_Mouse
CSNK2B 1460 PPP2R1A 5518 pp -- int.I2D: IntAct_Mouse
ACTB 60 PPP2R1A 5518 pp -- int.I2D: BioGrid_Yeast
OGDH 4967 PGD 5226 pp -- int.I2D: YeastLow
PSMB7 5695 RBX1 9978 pd < reg.ITFP.txt: no annot
PGD 5226 PSMD11 5717 pp -- int.I2D: YeastLow
VARS 7407 POLE4 56655 pd <> reg.ITFP.txt: no annot
PSMA2 5683 PSMB3 5691 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Fly, IntAct_Yeast, INTEROLOG, Krogan_Core, MINT_Yeast, YeastHigh, Yu_GoldStd
PSMD3 5709 TUBG1 7283 pd > reg.ITFP.txt: no annot
PPP2R1A 5518 PSMB7 5695 pp -- int.I2D: IntAct_Mouse
PSMB7 5695 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RB1 5925 pd < reg.ITFP.txt: no annot
PSMA2 5683 POLE4 56655 pd < reg.ITFP.txt: no annot
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
PGD 5226 PSMD3 5709 pp -- int.I2D: YeastLow
PSMB7 5695 DDX51 317781 pd < reg.ITFP.txt: no annot
PSMB7 5695 POLE4 56655 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMB7 5695 pp -- int.Intact: MI:0914(association);
int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, YeastLow, IntAct
PSMB3 5691 PSMB7 5695 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, IntAct, IntAct_Yeast, YeastHigh, HPRD, Krogan_Core, MINT_Yeast, MIPS;
int.HPRD: yeast 2-hybrid
PSMB2 5690 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastMedium
VARS 7407 DDX51 317781 pd <> reg.ITFP.txt: no annot
PSMD3 5709 VARS 7407 pd <> reg.ITFP.txt: no annot
PGD 5226 PPP2R1A 5518 pp -- int.I2D: YeastLow
PSMA2 5683 PSMD3 5709 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMD11 5717 TUBG1 7283 pd > reg.ITFP.txt: no annot
ACTB 60 PSMB7 5695 pp -- int.I2D: BioGrid_Yeast
EIF6 3692 RSL24D1 51187 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct, INTEROLOG, MINT, Yu_GoldStd, BCI, BioGrid_Yeast, BIND_Yeast, HPRD, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh;
int.Mint: MI:0915(physical association);
int.HPRD: yeast 2-hybrid
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
OGDH 4967 PSMD3 5709 pp -- int.I2D: YeastLow
PSMB2 5690 DDX51 317781 pd < reg.ITFP.txt: no annot
OGDH 4967 PSMD11 5717 pp -- int.I2D: YeastLow
PSMB3 5691 POLE4 56655 pd < reg.ITFP.txt: no annot
CSNK2B 1460 EIF2S2 8894 pp -- int.I2D: BIND, BCI, HPRD;
int.HPRD: in vitro
PSMB7 5695 PPIE 10450 pd < reg.ITFP.txt: no annot
PPP2R1A 5518 PSMA2 5683 pp -- int.I2D: IntAct_Mouse
RB1 5925 TFRC 7037 pd > reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pd < reg.ITFP.txt: no annot
PSMB2 5690 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast, YeastLow
PSMB2 5690 VARS 7407 pd < reg.ITFP.txt: no annot
PSMB3 5691 PSMD11 5717 pp -- int.I2D: YeastLow
RB1 5925 PPIE 10450 pd > reg.pazar.txt: no annot
EIF6 3692 DDX51 317781 pd < reg.ITFP.txt: no annot
EIF6 3692 PSMB3 5691 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
EIF6 3692 PPP2R1A 5518 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
PSMD11 5717 EIF2S2 8894 pd > reg.ITFP.txt: no annot
PSMA2 5683 PSMB2 5690 pp -- int.Intact: MI:0914(association);
int.I2D: BCI, BioGrid, BioGrid_Yeast, IntAct, INTEROLOG, MINT_Yeast, YeastHigh, IntAct_Yeast, Krogan_Core

Related GO terms (377)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0000278mitotic cell cycle8.79e-121.44e-074.1171152398
GO:0000082G1/S transition of mitotic cell cycle5.73e-119.35e-075.065833150
GO:0006521regulation of cellular amino acid metabolic process1.33e-102.17e-066.23562150
GO:0000502proteasome complex3.36e-105.49e-066.02162258
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle6.81e-101.11e-055.85762465
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest6.81e-101.11e-055.85762265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.08e-091.76e-055.75062470
GO:0016071mRNA metabolic process1.35e-092.21e-054.493834223
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent1.39e-092.27e-055.68962373
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle1.51e-092.47e-055.67062474
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I1.93e-093.15e-055.61262377
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process2.26e-093.69e-055.57562579
GO:0016070RNA metabolic process3.03e-094.95e-054.346834247
GO:0016032viral process4.77e-097.78e-053.5391055540
GO:0002474antigen processing and presentation of peptide antigen via MHC class I6.52e-091.06e-045.32462394
GO:0034641cellular nitrogen compound metabolic process8.66e-091.41e-044.634725177
GO:0005839proteasome core complex1.52e-082.49e-047.12441118
GO:0000209protein polyubiquitination2.32e-083.79e-045.021621116
GO:0004298threonine-type endopeptidase activity2.41e-083.93e-046.97241120
GO:0010467gene expression3.67e-085.99e-043.2301058669
GO:0042981regulation of apoptotic process1.12e-071.83e-034.641626151
GO:0005829cytosol1.42e-072.32e-031.971161252562
GO:0070062extracellular vesicular exosome8.97e-071.46e-021.90415982516
GO:0005654nucleoplasm3.50e-065.70e-022.51910831095
GO:0006915apoptotic process2.28e-053.72e-012.944734571
GO:0043066negative regulation of apoptotic process4.94e-058.06e-013.121630433
GO:0044281small molecule metabolic process1.10e-041.00e+002.1259571295
GO:0005838proteasome regulatory particle1.59e-041.00e+006.7092712
GO:0022624proteasome accessory complex3.27e-041.00e+006.2072917
GO:0005634nucleus7.10e-041.00e+001.057161314828
GO:0043022ribosome binding8.99e-041.00e+005.4872328
GO:0005515protein binding1.04e-031.00e+000.883181726127
GO:0006413translational initiation1.15e-031.00e+003.846312131
GO:0018467formaldehyde dehydrogenase activity1.59e-031.00e+009.294111
GO:0034602oxoglutarate dehydrogenase (NAD+) activity1.59e-031.00e+009.294111
GO:0051903S-(hydroxymethyl)glutathione dehydrogenase activity1.59e-031.00e+009.294111
GO:0005956protein kinase CK2 complex1.59e-031.00e+009.294111
GO:0090230regulation of centromere complex assembly1.59e-031.00e+009.294111
GO:0070262peptidyl-serine dephosphorylation1.59e-031.00e+009.294111
GO:0004632phosphopantothenate--cysteine ligase activity1.59e-031.00e+009.294111
GO:0000054ribosomal subunit export from nucleus1.59e-031.00e+009.294111
GO:0019521D-gluconate metabolic process1.59e-031.00e+009.294111
GO:0003743translation initiation factor activity2.74e-031.00e+004.6792449
GO:0031625ubiquitin protein ligase binding2.85e-031.00e+003.387313180
GO:0004832valine-tRNA ligase activity3.18e-031.00e+008.294112
GO:0045252oxoglutarate dehydrogenase complex3.18e-031.00e+008.294122
GO:0002176male germ cell proliferation3.18e-031.00e+008.294112
GO:0097286iron ion import3.18e-031.00e+008.294112
GO:0006407rRNA export from nucleus3.18e-031.00e+008.294112
GO:0006438valyl-tRNA aminoacylation3.18e-031.00e+008.294112
GO:0046294formaldehyde catabolic process3.18e-031.00e+008.294112
GO:0061034olfactory bulb mitral cell layer development3.18e-031.00e+008.294112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)3.18e-031.00e+008.294112
GO:0004998transferrin receptor activity3.18e-031.00e+008.294112
GO:0019322pentose biosynthetic process3.18e-031.00e+008.294112
GO:0031134sister chromatid biorientation3.18e-031.00e+008.294112
GO:0005055laminin receptor activity3.18e-031.00e+008.294112
GO:0007070negative regulation of transcription from RNA polymerase II promoter during mitosis3.18e-031.00e+008.294122
GO:0016020membrane4.51e-031.00e+001.5248801746
GO:0018119peptidyl-cysteine S-nitrosylation4.77e-031.00e+007.709113
GO:0004591oxoglutarate dehydrogenase (succinyl-transferring) activity4.77e-031.00e+007.709113
GO:0022028tangential migration from the subventricular zone to the olfactory bulb4.77e-031.00e+007.709113
GO:0004616phosphogluconate dehydrogenase (decarboxylating) activity4.77e-031.00e+007.709113
GO:0071459protein localization to chromosome, centromeric region4.77e-031.00e+007.709113
GO:0005850eukaryotic translation initiation factor 2 complex4.77e-031.00e+007.709113
GO:0009051pentose-phosphate shunt, oxidative branch4.77e-031.00e+007.709113
GO:0071930negative regulation of transcription involved in G1/S transition of mitotic cell cycle4.77e-031.00e+007.709113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)6.36e-031.00e+007.294114
GO:0000212meiotic spindle organization6.36e-031.00e+007.294114
GO:003068690S preribosome6.36e-031.00e+007.294114
GO:0071922regulation of cohesin localization to chromatin6.36e-031.00e+007.294114
GO:0019788NEDD8 ligase activity6.36e-031.00e+007.294114
GO:0051409response to nitrosative stress6.36e-031.00e+007.294114
GO:0006068ethanol catabolic process6.36e-031.00e+007.294114
GO:0006104succinyl-CoA metabolic process6.36e-031.00e+007.294114
GO:0031467Cul7-RING ubiquitin ligase complex6.36e-031.00e+007.294114
GO:0043550regulation of lipid kinase activity6.36e-031.00e+007.294114
GO:0035189Rb-E2F complex6.36e-031.00e+007.294114
GO:0034349glial cell apoptotic process6.36e-031.00e+007.294114
GO:0034088maintenance of mitotic sister chromatid cohesion6.36e-031.00e+007.294114
GO:0019887protein kinase regulator activity6.36e-031.00e+007.294124
GO:0031465Cul4B-RING E3 ubiquitin ligase complex7.94e-031.00e+006.972125
GO:0019932second-messenger-mediated signaling7.94e-031.00e+006.972115
GO:0042256mature ribosome assembly7.94e-031.00e+006.972115
GO:0042518negative regulation of tyrosine phosphorylation of Stat3 protein7.94e-031.00e+006.972115
GO:2000001regulation of DNA damage checkpoint7.94e-031.00e+006.972115
GO:0051101regulation of DNA binding7.94e-031.00e+006.972115
GO:0008622epsilon DNA polymerase complex7.94e-031.00e+006.972115
GO:0061154endothelial tube morphogenesis7.94e-031.00e+006.972115
GO:0031461cullin-RING ubiquitin ligase complex7.94e-031.00e+006.972115
GO:0043248proteasome assembly7.94e-031.00e+006.972115
GO:0048667cell morphogenesis involved in neuron differentiation7.94e-031.00e+006.972115
GO:0004022alcohol dehydrogenase (NAD) activity7.94e-031.00e+006.972115
GO:0030891VCB complex7.94e-031.00e+006.972125
GO:0005827polar microtubule7.94e-031.00e+006.972115
GO:0000730DNA recombinase assembly7.94e-031.00e+006.972135
GO:0005638lamin filament7.94e-031.00e+006.972115
GO:0006734NADH metabolic process7.94e-031.00e+006.972115
GO:0030976thiamine pyrophosphate binding7.94e-031.00e+006.972115
GO:0016605PML body9.35e-031.00e+003.7702592
GO:0043353enucleate erythrocyte differentiation9.52e-031.00e+006.709116
GO:0009108coenzyme biosynthetic process9.52e-031.00e+006.709116
GO:0045842positive regulation of mitotic metaphase/anaphase transition9.52e-031.00e+006.709116
GO:0032927positive regulation of activin receptor signaling pathway9.52e-031.00e+006.709116
GO:0021860pyramidal neuron development9.52e-031.00e+006.709116
GO:0043023ribosomal large subunit binding9.52e-031.00e+006.709126
GO:0031466Cul5-RING ubiquitin ligase complex9.52e-031.00e+006.709116
GO:0021695cerebellar cortex development9.52e-031.00e+006.709116
GO:0030957Tat protein binding9.52e-031.00e+006.709146
GO:0033211adiponectin-activated signaling pathway9.52e-031.00e+006.709116
GO:0005200structural constituent of cytoskeleton9.55e-031.00e+003.7552793
GO:0000028ribosomal small subunit assembly1.11e-021.00e+006.487117
GO:0002161aminoacyl-tRNA editing activity1.11e-021.00e+006.487127
GO:0031462Cul2-RING ubiquitin ligase complex1.11e-021.00e+006.487127
GO:0000930gamma-tubulin complex1.11e-021.00e+006.487117
GO:0016018cyclosporin A binding1.11e-021.00e+006.487117
GO:0031464Cul4A-RING E3 ubiquitin ligase complex1.27e-021.00e+006.294128
GO:0070688MLL5-L complex1.27e-021.00e+006.294118
GO:0006554lysine catabolic process1.27e-021.00e+006.294128
GO:0045116protein neddylation1.27e-021.00e+006.294128
GO:0019773proteasome core complex, alpha-subunit complex1.27e-021.00e+006.294158
GO:0015630microtubule cytoskeleton1.36e-021.00e+003.48725112
GO:0005730nucleolus1.39e-021.00e+001.3847701684
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay1.41e-021.00e+003.461210114
GO:0003016respiratory system process1.42e-021.00e+006.124119
GO:0015937coenzyme A biosynthetic process1.42e-021.00e+006.124119
GO:0097284hepatocyte apoptotic process1.42e-021.00e+006.124129
GO:0000075cell cycle checkpoint1.42e-021.00e+006.124129
GO:0072562blood microparticle1.46e-021.00e+003.43624116
GO:0006450regulation of translational fidelity1.58e-021.00e+005.9721210
GO:0007084mitotic nuclear envelope reassembly1.58e-021.00e+005.9721110
GO:0015939pantothenate metabolic process1.58e-021.00e+005.9721110
GO:0006069ethanol oxidation1.58e-021.00e+005.9721110
GO:0051775response to redox state1.58e-021.00e+005.9721110
GO:0021756striatum development1.58e-021.00e+005.9721110
GO:0006098pentose-phosphate shunt1.74e-021.00e+005.8351311
GO:0010569regulation of double-strand break repair via homologous recombination1.74e-021.00e+005.8351111
GO:0031571mitotic G1 DNA damage checkpoint1.74e-021.00e+005.8351311
GO:0042551neuron maturation1.74e-021.00e+005.8351211
GO:0045651positive regulation of macrophage differentiation1.74e-021.00e+005.8351211
GO:0051146striated muscle cell differentiation1.90e-021.00e+005.7091112
GO:0006275regulation of DNA replication1.90e-021.00e+005.7091212
GO:0021794thalamus development1.90e-021.00e+005.7091112
GO:0030111regulation of Wnt signaling pathway1.90e-021.00e+005.7091112
GO:0000086G2/M transition of mitotic cell cycle1.99e-021.00e+003.19627137
GO:0042273ribosomal large subunit biogenesis2.05e-021.00e+005.5941413
GO:0005662DNA replication factor A complex2.05e-021.00e+005.5941313
GO:0045780positive regulation of bone resorption2.05e-021.00e+005.5941113
GO:0043537negative regulation of blood vessel endothelial cell migration2.05e-021.00e+005.5941113
GO:0030234enzyme regulator activity2.05e-021.00e+005.5941313
GO:0035267NuA4 histone acetyltransferase complex2.21e-021.00e+005.4871414
GO:0005504fatty acid binding2.21e-021.00e+005.4871114
GO:0007020microtubule nucleation2.21e-021.00e+005.4871114
GO:0005739mitochondrion2.28e-021.00e+001.5855241046
GO:0006457protein folding2.33e-021.00e+003.07528149
GO:0006672ceramide metabolic process2.36e-021.00e+005.3871115
GO:0045445myoblast differentiation2.36e-021.00e+005.3871215
GO:2001241positive regulation of extrinsic apoptotic signaling pathway in absence of ligand2.36e-021.00e+005.3871215
GO:0005671Ada2/Gcn5/Ada3 transcription activator complex2.36e-021.00e+005.3871115
GO:0016514SWI/SNF complex2.36e-021.00e+005.3871315
GO:0042176regulation of protein catabolic process2.52e-021.00e+005.2941316
GO:0043623cellular protein complex assembly2.52e-021.00e+005.2941116
GO:0050998nitric-oxide synthase binding2.52e-021.00e+005.2941116
GO:00061032-oxoglutarate metabolic process2.52e-021.00e+005.2941116
GO:0044822poly(A) RNA binding2.56e-021.00e+001.5425501078
GO:0010243response to organonitrogen compound2.68e-021.00e+005.2071217
GO:0045070positive regulation of viral genome replication2.68e-021.00e+005.2071117
GO:0045777positive regulation of blood pressure2.68e-021.00e+005.2071117
GO:0031122cytoplasmic microtubule organization2.83e-021.00e+005.1241218
GO:0035861site of double-strand break2.83e-021.00e+005.1241118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process2.99e-021.00e+005.0461119
GO:0048863stem cell differentiation2.99e-021.00e+005.0461119
GO:2000134negative regulation of G1/S transition of mitotic cell cycle3.14e-021.00e+004.9721220
GO:0008601protein phosphatase type 2A regulator activity3.14e-021.00e+004.9721320
GO:0006298mismatch repair3.14e-021.00e+004.9721620
GO:0000159protein phosphatase type 2A complex3.14e-021.00e+004.9721220
GO:0045595regulation of cell differentiation3.29e-021.00e+004.9021121
GO:0000718nucleotide-excision repair, DNA damage removal3.29e-021.00e+004.9021521
GO:0030316osteoclast differentiation3.45e-021.00e+004.8351222
GO:0006297nucleotide-excision repair, DNA gap filling3.45e-021.00e+004.8351522
GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle3.45e-021.00e+004.8351322
GO:0032201telomere maintenance via semi-conservative replication3.45e-021.00e+004.8351722
GO:0030863cortical cytoskeleton3.45e-021.00e+004.8351122
GO:0036464cytoplasmic ribonucleoprotein granule3.45e-021.00e+004.8351422
GO:0031463Cul3-RING ubiquitin ligase complex3.60e-021.00e+004.7701223
GO:0043236laminin binding3.60e-021.00e+004.7701123
GO:0006513protein monoubiquitination3.60e-021.00e+004.7701123
GO:0043044ATP-dependent chromatin remodeling3.60e-021.00e+004.7701423
GO:0045879negative regulation of smoothened signaling pathway3.60e-021.00e+004.7701123
GO:0008135translation factor activity, nucleic acid binding3.76e-021.00e+004.7091424
GO:0000794condensed nuclear chromosome3.76e-021.00e+004.7091224
GO:0031519PcG protein complex3.91e-021.00e+004.6501425
GO:0000722telomere maintenance via recombination4.06e-021.00e+004.5941726
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia4.06e-021.00e+004.5941226
GO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation4.06e-021.00e+004.5941126
GO:0045859regulation of protein kinase activity4.06e-021.00e+004.5941126
GO:0042802identical protein binding4.21e-021.00e+001.939318491
GO:0000188inactivation of MAPK activity4.22e-021.00e+004.5391127
GO:0048565digestive tract development4.22e-021.00e+004.5391127
GO:0044267cellular protein metabolic process4.30e-021.00e+001.928324495
GO:0003823antigen binding4.37e-021.00e+004.4871128
GO:0010033response to organic substance4.37e-021.00e+004.4871228
GO:0031492nucleosomal DNA binding4.37e-021.00e+004.4871428
GO:0019894kinesin binding4.37e-021.00e+004.4871128
GO:0006099tricarboxylic acid cycle4.52e-021.00e+004.4361329
GO:0019005SCF ubiquitin ligase complex4.52e-021.00e+004.4361129
GO:0003887DNA-directed DNA polymerase activity4.52e-021.00e+004.4361329
GO:0071897DNA biosynthetic process4.52e-021.00e+004.4361229
GO:0042254ribosome biogenesis4.67e-021.00e+004.3871130
GO:0007346regulation of mitotic cell cycle4.67e-021.00e+004.3871330
GO:0006271DNA strand elongation involved in DNA replication4.83e-021.00e+004.3401931
GO:0007093mitotic cell cycle checkpoint4.83e-021.00e+004.3401231
GO:0050661NADP binding4.98e-021.00e+004.2941132
GO:0051219phosphoprotein binding4.98e-021.00e+004.2941332
GO:0033572transferrin transport4.98e-021.00e+004.2941632
GO:0031072heat shock protein binding5.13e-021.00e+004.2501233
GO:0000413protein peptidyl-prolyl isomerization5.28e-021.00e+004.2071134
GO:0003755peptidyl-prolyl cis-trans isomerase activity5.28e-021.00e+004.2071134
GO:0006412translation5.35e-021.00e+002.417215235
GO:0034332adherens junction organization5.58e-021.00e+004.1241136
GO:0051402neuron apoptotic process5.58e-021.00e+004.1241236
GO:0001895retina homeostasis5.58e-021.00e+004.1241136
GO:0001102RNA polymerase II activating transcription factor binding5.73e-021.00e+004.0851437
GO:0051084'de novo' posttranslational protein folding5.73e-021.00e+004.0851437
GO:0008134transcription factor binding5.80e-021.00e+002.35128246
GO:0070527platelet aggregation5.88e-021.00e+004.0461238
GO:0050681androgen receptor binding5.88e-021.00e+004.0461438
GO:0021766hippocampus development6.04e-021.00e+004.0091439
GO:0008026ATP-dependent helicase activity6.04e-021.00e+004.0091339
GO:0006284base-excision repair6.04e-021.00e+004.0091739
GO:0006096glycolytic process6.04e-021.00e+004.0091439
GO:0022627cytosolic small ribosomal subunit6.04e-021.00e+004.0091339
GO:0000781chromosome, telomeric region6.19e-021.00e+003.9721240
GO:0030521androgen receptor signaling pathway6.34e-021.00e+003.9361241
GO:0006418tRNA aminoacylation for protein translation6.48e-021.00e+003.9021542
GO:0004722protein serine/threonine phosphatase activity6.48e-021.00e+003.9021142
GO:0035914skeletal muscle cell differentiation6.48e-021.00e+003.9021142
GO:0030155regulation of cell adhesion6.48e-021.00e+003.9021342
GO:0006281DNA repair6.57e-021.00e+002.250222264
GO:0014070response to organic cyclic compound6.63e-021.00e+003.8681343
GO:0043966histone H3 acetylation6.93e-021.00e+003.8021245
GO:0021762substantia nigra development7.08e-021.00e+003.7701146
GO:0001047core promoter binding7.08e-021.00e+003.7701246
GO:0006283transcription-coupled nucleotide-excision repair7.08e-021.00e+003.7701846
GO:0001523retinoid metabolic process7.67e-021.00e+003.6501250
GO:0006091generation of precursor metabolites and energy7.82e-021.00e+003.6221351
GO:0005905coated pit7.82e-021.00e+003.6221251
GO:0040008regulation of growth7.82e-021.00e+003.6221351
GO:0003684damaged DNA binding7.82e-021.00e+003.62211151
GO:0000775chromosome, centromeric region7.97e-021.00e+003.5941252
GO:0003725double-stranded RNA binding8.26e-021.00e+003.5391654
GO:0019900kinase binding8.26e-021.00e+003.5391154
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding8.26e-021.00e+003.5391554
GO:0050680negative regulation of epithelial cell proliferation8.26e-021.00e+003.5391154
GO:0000226microtubule cytoskeleton organization8.41e-021.00e+003.5131355
GO:0000932cytoplasmic mRNA processing body8.55e-021.00e+003.4871356
GO:0006879cellular iron ion homeostasis8.70e-021.00e+003.4611557
GO:0000724double-strand break repair via homologous recombination8.70e-021.00e+003.4611657
GO:0051087chaperone binding8.99e-021.00e+003.4111659
GO:0043433negative regulation of sequence-specific DNA binding transcription factor activity8.99e-021.00e+003.4111459
GO:0045216cell-cell junction organization8.99e-021.00e+003.4111259
GO:0000723telomere maintenance8.99e-021.00e+003.4111859
GO:0031966mitochondrial membrane8.99e-021.00e+003.4111159
GO:0006302double-strand break repair9.43e-021.00e+003.3401862
GO:0007411axon guidance9.50e-021.00e+001.94129327
GO:0019903protein phosphatase binding9.57e-021.00e+003.3171463
GO:0007059chromosome segregation9.72e-021.00e+003.2941364
GO:0006469negative regulation of protein kinase activity9.86e-021.00e+003.2721265
GO:0001558regulation of cell growth1.00e-011.00e+003.2501466
GO:0006338chromatin remodeling1.03e-011.00e+003.2071468
GO:0009055electron carrier activity1.03e-011.00e+003.2071168
GO:0006289nucleotide-excision repair1.04e-011.00e+003.18511269
GO:0003697single-stranded DNA binding1.04e-011.00e+003.1851969
GO:0034329cell junction assembly1.07e-011.00e+003.1441171
GO:0003723RNA binding1.09e-011.00e+001.822219355
GO:0055037recycling endosome1.10e-011.00e+003.1041273
GO:0000785chromatin1.10e-011.00e+003.1041573
GO:0006767water-soluble vitamin metabolic process1.13e-011.00e+003.0651375
GO:0007265Ras protein signal transduction1.13e-011.00e+003.0651375
GO:0031175neuron projection development1.13e-011.00e+003.0651175
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process1.14e-011.00e+003.0461376
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis1.16e-011.00e+003.0271577
GO:0008584male gonad development1.16e-011.00e+003.0271277
GO:0006766vitamin metabolic process1.17e-011.00e+003.0091378
GO:0071013catalytic step 2 spliceosome1.19e-011.00e+002.9901779
GO:0019083viral transcription1.21e-011.00e+002.9541881
GO:0047485protein N-terminus binding1.28e-011.00e+002.8681486
GO:0006898receptor-mediated endocytosis1.28e-011.00e+002.8681286
GO:0006415translational termination1.30e-011.00e+002.8511887
GO:0046982protein heterodimerization activity1.32e-011.00e+001.654211399
GO:0042470melanosome1.37e-011.00e+002.77011092
GO:0006928cellular component movement1.37e-011.00e+002.7701792
GO:0006414translational elongation1.38e-011.00e+002.75511193
GO:0006364rRNA processing1.42e-011.00e+002.7091596
GO:0071456cellular response to hypoxia1.45e-011.00e+002.6791498
GO:0006470protein dephosphorylation1.46e-011.00e+002.6651199
GO:0006614SRP-dependent cotranslational protein targeting to membrane1.53e-011.00e+002.59418104
GO:0014069postsynaptic density1.56e-011.00e+002.56611106
GO:0016023cytoplasmic membrane-bounded vesicle1.57e-011.00e+002.55313107
GO:0042127regulation of cell proliferation1.63e-011.00e+002.50014111
GO:0006461protein complex assembly1.63e-011.00e+002.50016111
GO:0030308negative regulation of cell growth1.65e-011.00e+002.47416113
GO:0030529ribonucleoprotein complex1.67e-011.00e+002.46118114
GO:0005819spindle1.67e-011.00e+002.46117114
GO:0019058viral life cycle1.68e-011.00e+002.449110115
GO:0044237cellular metabolic process1.72e-011.00e+002.41113118
GO:0032496response to lipopolysaccharide1.77e-011.00e+002.36314122
GO:0006325chromatin organization1.79e-011.00e+002.35114123
GO:0007568aging1.79e-011.00e+002.35113123
GO:0007219Notch signaling pathway1.81e-011.00e+002.32814125
GO:0006260DNA replication1.81e-011.00e+002.328112125
GO:0007050cell cycle arrest1.83e-011.00e+002.31717126
GO:0006511ubiquitin-dependent protein catabolic process1.84e-011.00e+002.30515127
GO:0009615response to virus1.90e-011.00e+002.25016132
GO:0000790nuclear chromatin1.92e-011.00e+002.23917133
GO:0031982vesicle1.93e-011.00e+002.228110134
GO:0003735structural constituent of ribosome2.02e-011.00e+002.15418141
GO:0016055Wnt signaling pathway2.02e-011.00e+002.15416141
GO:0061024membrane organization2.08e-011.00e+002.10415146
GO:0008543fibroblast growth factor receptor signaling pathway2.25e-011.00e+001.98114159
GO:0000398mRNA splicing, via spliceosome2.32e-011.00e+001.928112165
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding2.36e-011.00e+001.90215168
GO:0030424axon2.41e-011.00e+001.86813172
GO:0005768endosome2.43e-011.00e+001.85115174
GO:0019904protein domain specific binding2.52e-011.00e+001.79416181
GO:0009897external side of plasma membrane2.54e-011.00e+001.77814183
GO:0015629actin cytoskeleton2.54e-011.00e+001.77815183
GO:0032403protein complex binding2.57e-011.00e+001.76317185
GO:0003924GTPase activity2.78e-011.00e+001.62919203
GO:0001701in utero embryonic development2.86e-011.00e+001.58016210
GO:0006184GTP catabolic process2.98e-011.00e+001.51319220
GO:0008380RNA splicing3.11e-011.00e+001.436113232
GO:0005759mitochondrial matrix3.12e-011.00e+001.430112233
GO:0003713transcription coactivator activity3.19e-011.00e+001.393110239
GO:0004842ubiquitin-protein transferase activity3.37e-011.00e+001.29414256
GO:0005102receptor binding3.50e-011.00e+001.22815268
GO:0000166nucleotide binding3.54e-011.00e+001.20716272
GO:0005975carbohydrate metabolic process3.56e-011.00e+001.19615274
GO:0005524ATP binding3.67e-011.00e+000.4763461354
GO:0019899enzyme binding3.71e-011.00e+001.124111288
GO:0016567protein ubiquitination3.82e-011.00e+001.07015299
GO:0043234protein complex3.83e-011.00e+001.065117300
GO:0006200ATP catabolic process3.86e-011.00e+001.051114303
GO:0005856cytoskeleton3.94e-011.00e+001.01318311
GO:0004674protein serine/threonine kinase activity3.95e-011.00e+001.00916312
GO:0019901protein kinase binding4.03e-011.00e+000.972121320
GO:0005525GTP binding4.10e-011.00e+000.936111328
GO:0043231intracellular membrane-bounded organelle4.14e-011.00e+000.91918332
GO:0046872metal ion binding4.17e-011.00e+000.3623241465
GO:0005813centrosome4.21e-011.00e+000.889112339
GO:0043565sequence-specific DNA binding4.45e-011.00e+000.78214365
GO:0008285negative regulation of cell proliferation4.47e-011.00e+000.774111367
GO:0005925focal adhesion4.49e-011.00e+000.763118370
GO:0005737cytoplasm4.54e-011.00e+000.1447983976
GO:0007155cell adhesion4.62e-011.00e+000.70918384
GO:0005615extracellular space4.84e-011.00e+000.3142171010
GO:0009986cell surface4.94e-011.00e+000.57319422
GO:0045892negative regulation of transcription, DNA-templated4.96e-011.00e+000.566114424
GO:0008270zinc ion binding5.14e-011.00e+000.2352121067
GO:0007596blood coagulation5.28e-011.00e+000.436114464
GO:0006468protein phosphorylation5.30e-011.00e+000.427110467
GO:0006355regulation of transcription, DNA-templated5.33e-011.00e+000.1852171104
GO:0055114oxidation-reduction process5.41e-011.00e+000.384111481
GO:0045893positive regulation of transcription, DNA-templated5.45e-011.00e+000.366117487
GO:0055085transmembrane transport5.65e-011.00e+000.28818514
GO:0048471perinuclear region of cytoplasm5.71e-011.00e+000.263112523
GO:0042803protein homodimerization activity6.33e-011.00e+000.025111617
GO:0045087innate immune response6.33e-011.00e+000.027120616
GO:0005794Golgi apparatus6.53e-011.00e+00-0.050114650
GO:0003700sequence-specific DNA binding transcription factor activity7.05e-011.00e+00-0.253111748
GO:0045944positive regulation of transcription from RNA polymerase II promoter7.35e-011.00e+00-0.370119811
GO:0007165signal transduction7.90e-011.00e+00-0.598117950
GO:0005887integral component of plasma membrane7.94e-011.00e+00-0.61417961
GO:0005576extracellular region8.22e-011.00e+00-0.741191049
GO:0005886plasma membrane8.54e-011.00e+00-0.5903382834
GO:0003677DNA binding8.94e-011.00e+00-1.1061261351
GO:0006351transcription, DNA-templated9.30e-011.00e+00-1.3361251585