int-snw-8936

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.016	8.46e-19	3.73e-04	9.70e-03

wolf-screen-ratio-mammosphere-adherent-int-snw-8936 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
PSMB1	5689	1	0.688	1.016	85	Yes	-
[ WASF1 ]	8936	1	-0.420	1.016	42	-	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
PSMB7	5695	48	0.982	1.052	57	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (25)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
PSMA2	5683	PSMB1	5689	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, Krogan_Core, MINT_Yeast, BCI, BioGrid, IntAct, YeastHigh
PSMA1	5682	PSMB1	5689	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, BIND_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, IntAct, IntAct_Mouse, IntAct_Yeast, Yu_GoldStd
ACTB	60	WASF1	8936	pp	--	int.I2D: BCI, HPRD, MINT_Rat; int.HPRD: in vitro
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
PSMB1	5689	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMB1	5689	PSMB7	5695	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BCI, BioGrid_Yeast, BIND_Yeast, HPRD, MINT, YeastLow, IntAct, Krogan_Core, MINT_Yeast, Yu_GoldStd; int.Mint: MI:0915(physical association); int.HPRD: yeast 2-hybrid
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMA1	5682	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMA2	5683	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB1	5689	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMB1	5689	WASF1	8936	pp	--	int.I2D: BioGrid_Worm, CORE_1, MINT_Worm, IntAct_Worm
PSMB7	5695	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (165)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0006521	regulation of cellular amino acid metabolic process	5.80e-13	8.37e-09	7.298	6	17	50
GO:0000502	proteasome complex	1.47e-12	2.13e-08	7.084	6	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	2.73e-12	3.93e-08	6.942	6	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.00e-12	4.33e-08	6.919	6	22	65
GO:0000082	G1/S transition of mitotic cell cycle	3.47e-12	5.01e-08	5.945	7	32	149
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	4.76e-12	6.86e-08	6.812	6	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	5.67e-12	8.17e-08	6.772	6	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.72e-12	9.69e-08	6.732	6	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.30e-12	1.05e-07	6.713	6	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.01e-11	1.45e-07	6.638	6	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	2.57e-11	3.71e-07	6.418	6	21	92
GO:0016071	mRNA metabolic process	6.02e-11	8.68e-07	5.363	7	31	223
GO:0000209	protein polyubiquitination	1.06e-10	1.53e-06	6.084	6	20	116
GO:0016070	RNA metabolic process	1.24e-10	1.78e-06	5.216	7	32	247
GO:0016032	viral process	5.02e-10	7.24e-06	4.296	8	55	534
GO:0042981	regulation of apoptotic process	5.07e-10	7.31e-06	5.713	6	24	150
GO:0005839	proteasome core complex	5.57e-10	8.04e-06	8.187	4	8	18
GO:0004298	threonine-type endopeptidase activity	7.06e-10	1.02e-05	8.109	4	8	19
GO:0034641	cellular nitrogen compound metabolic process	1.12e-09	1.61e-05	5.524	6	20	171
GO:0000278	mitotic cell cycle	3.07e-09	4.42e-05	4.553	7	48	391
GO:0005654	nucleoplasm	3.49e-09	5.04e-05	3.447	9	76	1082
GO:0010467	gene expression	1.26e-07	1.81e-03	3.778	7	59	669
GO:0043066	negative regulation of apoptotic process	2.54e-07	3.66e-03	4.214	6	31	424
GO:0006915	apoptotic process	1.24e-06	1.79e-02	3.825	6	33	555
GO:0005829	cytosol	5.40e-06	7.79e-02	2.241	9	132	2496
GO:0019773	proteasome core complex, alpha-subunit complex	1.48e-05	2.13e-01	8.357	2	4	8
GO:0005838	proteasome regulatory particle	3.48e-05	5.01e-01	7.772	2	7	12
GO:0070062	extracellular vesicular exosome	5.96e-05	8.59e-01	2.128	8	104	2400
GO:0022624	proteasome accessory complex	7.15e-05	1.00e+00	7.269	2	8	17
GO:0044281	small molecule metabolic process	1.10e-04	1.00e+00	2.700	6	58	1211
GO:0005515	protein binding	1.10e-03	1.00e+00	1.122	10	184	6024
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006928	cellular component movement	2.09e-03	1.00e+00	4.849	2	7	91
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.05e-03	1.00e+00	8.357	1	1	4
GO:0019788	NEDD8 ligase activity	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043248	proteasome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0030891	VCB complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0000730	DNA recombinase assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.81e-03	1.00e+00	8.035	1	1	5
GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation	4.57e-03	1.00e+00	7.772	1	1	6
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.33e-03	1.00e+00	7.549	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.09e-03	1.00e+00	7.357	1	2	8
GO:0031209	SCAR complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0045116	protein neddylation	6.09e-03	1.00e+00	7.357	1	2	8
GO:0005634	nucleus	6.13e-03	1.00e+00	1.202	8	136	4559
GO:0010569	regulation of double-strand break repair via homologous recombination	7.60e-03	1.00e+00	7.035	1	1	10
GO:0031625	ubiquitin protein ligase binding	7.74e-03	1.00e+00	3.881	2	14	178
GO:0032403	protein complex binding	8.17e-03	1.00e+00	3.841	2	10	183
GO:0031571	mitotic G1 DNA damage checkpoint	8.36e-03	1.00e+00	6.897	1	4	11
GO:0005662	DNA replication factor A complex	9.87e-03	1.00e+00	6.656	1	1	13
GO:0030234	enzyme regulator activity	9.87e-03	1.00e+00	6.656	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	1.06e-02	1.00e+00	6.549	1	4	14
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0042176	regulation of protein catabolic process	1.21e-02	1.00e+00	6.357	1	3	16
GO:0016601	Rac protein signal transduction	1.29e-02	1.00e+00	6.269	1	1	17
GO:0035861	site of double-strand break	1.36e-02	1.00e+00	6.187	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.44e-02	1.00e+00	6.109	1	1	19
GO:0048863	stem cell differentiation	1.44e-02	1.00e+00	6.109	1	1	19
GO:0006298	mismatch repair	1.52e-02	1.00e+00	6.035	1	3	20
GO:0030041	actin filament polymerization	1.59e-02	1.00e+00	5.964	1	3	21
GO:0032201	telomere maintenance via semi-conservative replication	1.59e-02	1.00e+00	5.964	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.59e-02	1.00e+00	5.964	1	4	21
GO:0006281	DNA repair	1.61e-02	1.00e+00	3.329	2	18	261
GO:0006297	nucleotide-excision repair, DNA gap filling	1.67e-02	1.00e+00	5.897	1	3	22
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0005844	polysome	1.74e-02	1.00e+00	5.833	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.74e-02	1.00e+00	5.833	1	3	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0006513	protein monoubiquitination	1.74e-02	1.00e+00	5.833	1	1	23
GO:0000722	telomere maintenance via recombination	1.89e-02	1.00e+00	5.713	1	5	25
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.97e-02	1.00e+00	5.656	1	3	26
GO:0005856	cytoskeleton	1.98e-02	1.00e+00	3.172	2	12	291
GO:0043022	ribosome binding	2.04e-02	1.00e+00	5.602	1	3	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0048365	Rac GTPase binding	2.19e-02	1.00e+00	5.499	1	2	29
GO:0019005	SCF ubiquitin ligase complex	2.19e-02	1.00e+00	5.499	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	2.27e-02	1.00e+00	5.450	1	7	30
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0006284	base-excision repair	2.79e-02	1.00e+00	5.147	1	3	37
GO:0005730	nucleolus	2.86e-02	1.00e+00	1.676	4	69	1641
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0000781	chromosome, telomeric region	2.94e-02	1.00e+00	5.071	1	3	39
GO:0016020	membrane	3.09e-02	1.00e+00	1.642	4	90	1681
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	3.45e-02	1.00e+00	4.833	1	7	46
GO:0003684	damaged DNA binding	3.68e-02	1.00e+00	4.742	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.04e-02	1.00e+00	4.602	1	3	54
GO:0000724	double-strand break repair via homologous recombination	4.12e-02	1.00e+00	4.575	1	3	55
GO:0000723	telomere maintenance	4.19e-02	1.00e+00	4.549	1	6	56
GO:0019903	protein phosphatase binding	4.63e-02	1.00e+00	4.402	1	4	62
GO:0006302	double-strand break repair	4.63e-02	1.00e+00	4.402	1	4	62
GO:0044267	cellular protein metabolic process	4.87e-02	1.00e+00	2.468	2	29	474
GO:0006289	nucleotide-excision repair	5.07e-02	1.00e+00	4.269	1	11	68
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0003697	single-stranded DNA binding	5.07e-02	1.00e+00	4.269	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.50e-02	1.00e+00	4.147	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	2	75
GO:0019083	viral transcription	6.01e-02	1.00e+00	4.017	1	10	81
GO:0047485	protein N-terminus binding	6.37e-02	1.00e+00	3.930	1	5	86
GO:0006415	translational termination	6.44e-02	1.00e+00	3.914	1	10	87
GO:0016605	PML body	6.51e-02	1.00e+00	3.897	1	3	88
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0071456	cellular response to hypoxia	6.80e-02	1.00e+00	3.833	1	6	92
GO:0006414	translational elongation	6.87e-02	1.00e+00	3.817	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7.65e-02	1.00e+00	3.656	1	10	104
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0015630	microtubule cytoskeleton	8.08e-02	1.00e+00	3.575	1	4	110
GO:0006461	protein complex assembly	8.15e-02	1.00e+00	3.562	1	6	111
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	8.36e-02	1.00e+00	3.524	1	11	114
GO:0019058	viral life cycle	8.43e-02	1.00e+00	3.511	1	13	115
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	5	118
GO:0007219	Notch signaling pathway	8.78e-02	1.00e+00	3.450	1	5	120
GO:0006260	DNA replication	8.85e-02	1.00e+00	3.438	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	9.20e-02	1.00e+00	3.379	1	5	126
GO:0009615	response to virus	9.20e-02	1.00e+00	3.379	1	5	126
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0006413	translational initiation	9.55e-02	1.00e+00	3.323	1	17	131
GO:0045202	synapse	9.90e-02	1.00e+00	3.269	1	3	136
GO:0003735	structural constituent of ribosome	9.97e-02	1.00e+00	3.259	1	10	137
GO:0006457	protein folding	1.04e-01	1.00e+00	3.197	1	7	143
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0015629	actin cytoskeleton	1.27e-01	1.00e+00	2.889	1	3	177
GO:0006412	translation	1.62e-01	1.00e+00	2.511	1	20	230
GO:0004842	ubiquitin-protein transferase activity	1.78e-01	1.00e+00	2.362	1	6	255
GO:0003779	actin binding	1.85e-01	1.00e+00	2.301	1	12	266
GO:0019899	enzyme binding	1.92e-01	1.00e+00	2.243	1	12	277
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0016567	protein ubiquitination	2.03e-01	1.00e+00	2.152	1	5	295
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	21	317
GO:0007411	axon guidance	2.18e-01	1.00e+00	2.039	1	13	319
GO:0005813	centrosome	2.22e-01	1.00e+00	2.008	1	14	326
GO:0030054	cell junction	2.28e-01	1.00e+00	1.964	1	5	336
GO:0003723	RNA binding	2.32e-01	1.00e+00	1.939	1	20	342
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	19	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0007596	blood coagulation	2.97e-01	1.00e+00	1.527	1	18	455
GO:0045087	innate immune response	3.71e-01	1.00e+00	1.137	1	24	596
GO:0005615	extracellular space	5.30e-01	1.00e+00	0.454	1	17	957
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	12	997
GO:0044822	poly(A) RNA binding	5.67e-01	1.00e+00	0.312	1	49	1056
GO:0005737	cytoplasm	5.79e-01	1.00e+00	0.062	3	110	3767
GO:0005524	ATP binding	6.46e-01	1.00e+00	0.015	1	60	1298
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-8936

Statistics

Genes (11)

Interactions (25)

Related GO terms (165)