int-snw-8565

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.961	1.61e-16	1.40e-03	2.65e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-8565 subnetwork

Genes (11)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RSL24D1	51187	36	1.300	1.020	59	Yes	-
EIF6	3692	14	0.700	1.013	267	Yes	-
PSMD2	5708	3	0.463	0.961	386	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMC3	5702	9	0.719	1.002	255	Yes	-
RPL14	9045	42	1.250	1.113	143	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
SAP18	10284	8	1.115	1.069	57	Yes	-
[ YARS ]	8565	1	-0.154	0.961	53	-	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (17)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
YARS	8565	SAP18	10284	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid, IntAct
PSMD2	5708	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	YARS	8565	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMC3	5702	RPL14	9045	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
EIF6	3692	PSMD2	5708	pp	--	int.I2D: YeastLow
PSMD2	5708	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, YeastLow
EIF6	3692	RSL24D1	51187	pp	--	int.I2D: BioGrid_Yeast, YeastLow
EIF6	3692	PGD	5226	pp	--	int.I2D: YeastLow
EIF6	3692	YARS	8565	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, BioGrid
PSMC3	5702	PSMD2	5708	pp	--	int.I2D: IntAct_Yeast, BioGrid_Yeast, Krogan_Core, MINT_Yeast, Tarassov_PCA, YeastLow
ACTB	60	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast
RPSA	3921	PSMC3	5702	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD2	5708	pp	--	int.I2D: BioGrid_Yeast
PSMD2	5708	YARS	8565	pp	--	int.I2D: BioGrid_Yeast
PSMC3	5702	YARS	8565	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (160)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0016071	mRNA metabolic process	1.69e-05	2.43e-01	4.556	4	31	223
GO:0016070	RNA metabolic process	2.52e-05	3.64e-01	4.408	4	32	247
GO:0016032	viral process	2.62e-05	3.78e-01	3.618	5	55	534
GO:0042273	ribosomal large subunit biogenesis	4.11e-05	5.92e-01	7.656	2	4	13
GO:0022624	proteasome accessory complex	7.15e-05	1.00e+00	7.269	2	8	17
GO:0010467	gene expression	7.74e-05	1.00e+00	3.293	5	59	669
GO:0005829	cytosol	7.99e-05	1.00e+00	2.071	8	132	2496
GO:0006413	translational initiation	1.15e-04	1.00e+00	4.908	3	17	131
GO:0043022	ribosome binding	1.84e-04	1.00e+00	6.602	2	3	27
GO:1903507	negative regulation of nucleic acid-templated transcription	2.59e-04	1.00e+00	6.357	2	2	32
GO:0006521	regulation of cellular amino acid metabolic process	6.35e-04	1.00e+00	5.713	2	17	50
GO:0006437	tyrosyl-tRNA aminoacylation	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000054	ribosomal subunit export from nucleus	7.63e-04	1.00e+00	10.357	1	1	1
GO:0019521	D-gluconate metabolic process	7.63e-04	1.00e+00	10.357	1	1	1
GO:0000502	proteasome complex	8.54e-04	1.00e+00	5.499	2	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	1.04e-03	1.00e+00	5.357	2	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.07e-03	1.00e+00	5.334	2	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.24e-03	1.00e+00	5.227	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.31e-03	1.00e+00	5.187	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.39e-03	1.00e+00	5.147	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.42e-03	1.00e+00	5.128	2	20	75
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.52e-03	1.00e+00	9.357	1	1	2
GO:0004831	tyrosine-tRNA ligase activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0019322	pentose biosynthetic process	1.52e-03	1.00e+00	9.357	1	2	2
GO:0005055	laminin receptor activity	1.52e-03	1.00e+00	9.357	1	1	2
GO:0005153	interleukin-8 receptor binding	1.52e-03	1.00e+00	9.357	1	1	2
GO:0006407	rRNA export from nucleus	1.52e-03	1.00e+00	9.357	1	1	2
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.58e-03	1.00e+00	5.053	2	23	79
GO:0019083	viral transcription	1.66e-03	1.00e+00	5.017	2	10	81
GO:0006415	translational termination	1.91e-03	1.00e+00	4.914	2	10	87
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	2.13e-03	1.00e+00	4.833	2	21	92
GO:0006414	translational elongation	2.18e-03	1.00e+00	4.817	2	13	93
GO:0061574	ASAP complex	2.29e-03	1.00e+00	8.772	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	2.29e-03	1.00e+00	8.772	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	2.29e-03	1.00e+00	8.772	1	1	3
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	2.71e-03	1.00e+00	4.656	2	10	104
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.05e-03	1.00e+00	8.357	1	1	4
GO:0030686	90S preribosome	3.05e-03	1.00e+00	8.357	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.05e-03	1.00e+00	8.357	1	1	4
GO:0019788	NEDD8 ligase activity	3.05e-03	1.00e+00	8.357	1	1	4
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	3.25e-03	1.00e+00	4.524	2	11	114
GO:0019058	viral life cycle	3.31e-03	1.00e+00	4.511	2	13	115
GO:0000209	protein polyubiquitination	3.36e-03	1.00e+00	4.499	2	20	116
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.81e-03	1.00e+00	8.035	1	1	5
GO:0042256	mature ribosome assembly	3.81e-03	1.00e+00	8.035	1	1	5
GO:0030891	VCB complex	3.81e-03	1.00e+00	8.035	1	2	5
GO:0005638	lamin filament	3.81e-03	1.00e+00	8.035	1	1	5
GO:0043023	ribosomal large subunit binding	3.81e-03	1.00e+00	8.035	1	1	5
GO:0070062	extracellular vesicular exosome	4.55e-03	1.00e+00	1.713	6	104	2400
GO:0030957	Tat protein binding	4.57e-03	1.00e+00	7.772	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.57e-03	1.00e+00	7.772	1	1	6
GO:0003735	structural constituent of ribosome	4.66e-03	1.00e+00	4.259	2	10	137
GO:0044267	cellular protein metabolic process	4.78e-03	1.00e+00	3.053	3	29	474
GO:0000028	ribosomal small subunit assembly	5.33e-03	1.00e+00	7.549	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.33e-03	1.00e+00	7.549	1	2	7
GO:0016020	membrane	5.39e-03	1.00e+00	1.963	5	90	1681
GO:0000082	G1/S transition of mitotic cell cycle	5.48e-03	1.00e+00	4.137	2	32	149
GO:0042981	regulation of apoptotic process	5.56e-03	1.00e+00	4.128	2	24	150
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.09e-03	1.00e+00	7.357	1	2	8
GO:0070688	MLL5-L complex	6.09e-03	1.00e+00	7.357	1	1	8
GO:0045116	protein neddylation	6.09e-03	1.00e+00	7.357	1	2	8
GO:0044822	poly(A) RNA binding	6.21e-03	1.00e+00	2.312	4	49	1056
GO:0005654	nucleoplasm	6.78e-03	1.00e+00	2.277	4	76	1082
GO:0034641	cellular nitrogen compound metabolic process	7.16e-03	1.00e+00	3.939	2	20	171
GO:0006915	apoptotic process	7.42e-03	1.00e+00	2.825	3	33	555
GO:0006098	pentose-phosphate shunt	7.60e-03	1.00e+00	7.035	1	4	10
GO:0003714	transcription corepressor activity	7.74e-03	1.00e+00	3.881	2	8	178
GO:0005838	proteasome regulatory particle	9.12e-03	1.00e+00	6.772	1	7	12
GO:0030234	enzyme regulator activity	9.87e-03	1.00e+00	6.656	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	1.06e-02	1.00e+00	6.549	1	4	14
GO:0048025	negative regulation of mRNA splicing, via spliceosome	1.14e-02	1.00e+00	6.450	1	1	15
GO:0050998	nitric-oxide synthase binding	1.21e-02	1.00e+00	6.357	1	1	16
GO:0042176	regulation of protein catabolic process	1.21e-02	1.00e+00	6.357	1	3	16
GO:0006412	translation	1.27e-02	1.00e+00	3.511	2	20	230
GO:1903506	regulation of nucleic acid-templated transcription	1.36e-02	1.00e+00	6.187	1	1	18
GO:0035145	exon-exon junction complex	1.44e-02	1.00e+00	6.109	1	1	19
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.44e-02	1.00e+00	6.109	1	1	19
GO:0030863	cortical cytoskeleton	1.67e-02	1.00e+00	5.897	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.67e-02	1.00e+00	5.897	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.74e-02	1.00e+00	5.833	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.74e-02	1.00e+00	5.833	1	3	23
GO:0043236	laminin binding	1.74e-02	1.00e+00	5.833	1	1	23
GO:0006513	protein monoubiquitination	1.74e-02	1.00e+00	5.833	1	1	23
GO:0000381	regulation of alternative mRNA splicing, via spliceosome	1.97e-02	1.00e+00	5.656	1	1	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.97e-02	1.00e+00	5.656	1	3	26
GO:0050661	NADP binding	2.04e-02	1.00e+00	5.602	1	2	27
GO:0031492	nucleosomal DNA binding	2.04e-02	1.00e+00	5.602	1	4	27
GO:0000118	histone deacetylase complex	2.12e-02	1.00e+00	5.549	1	1	28
GO:0019894	kinesin binding	2.12e-02	1.00e+00	5.549	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.19e-02	1.00e+00	5.499	1	1	29
GO:0042254	ribosome biogenesis	2.27e-02	1.00e+00	5.450	1	1	30
GO:0001895	retina homeostasis	2.56e-02	1.00e+00	5.269	1	1	34
GO:0000049	tRNA binding	2.56e-02	1.00e+00	5.269	1	4	34
GO:0034332	adherens junction organization	2.71e-02	1.00e+00	5.187	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.79e-02	1.00e+00	5.147	1	4	37
GO:0070527	platelet aggregation	2.86e-02	1.00e+00	5.109	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.94e-02	1.00e+00	5.071	1	4	39
GO:0006418	tRNA aminoacylation for protein translation	3.16e-02	1.00e+00	4.964	1	9	42
GO:0021762	substantia nigra development	3.31e-02	1.00e+00	4.897	1	2	44
GO:0000278	mitotic cell cycle	3.43e-02	1.00e+00	2.746	2	48	391
GO:0022625	cytosolic large ribosomal subunit	3.68e-02	1.00e+00	4.742	1	6	49
GO:0003743	translation initiation factor activity	3.68e-02	1.00e+00	4.742	1	8	49
GO:0005515	protein binding	3.84e-02	1.00e+00	0.800	8	184	6024
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.97e-02	1.00e+00	4.629	1	5	53
GO:0043066	negative regulation of apoptotic process	3.98e-02	1.00e+00	2.629	2	31	424
GO:0045216	cell-cell junction organization	4.04e-02	1.00e+00	4.602	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.04e-02	1.00e+00	4.602	1	3	54
GO:0005737	cytoplasm	4.20e-02	1.00e+00	1.062	6	110	3767
GO:0034329	cell junction assembly	5.07e-02	1.00e+00	4.269	1	1	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.50e-02	1.00e+00	4.147	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	5.58e-02	1.00e+00	4.128	1	2	75
GO:0044281	small molecule metabolic process	5.85e-02	1.00e+00	1.700	3	58	1211
GO:0006928	cellular component movement	6.73e-02	1.00e+00	3.849	1	7	91
GO:0005200	structural constituent of cytoskeleton	6.73e-02	1.00e+00	3.849	1	8	91
GO:0071456	cellular response to hypoxia	6.80e-02	1.00e+00	3.833	1	6	92
GO:0006364	rRNA processing	6.94e-02	1.00e+00	3.802	1	6	94
GO:0005524	ATP binding	6.94e-02	1.00e+00	1.600	3	60	1298
GO:0014069	postsynaptic density	7.73e-02	1.00e+00	3.642	1	3	105
GO:0072562	blood microparticle	8.15e-02	1.00e+00	3.562	1	3	111
GO:0030529	ribonucleoprotein complex	8.22e-02	1.00e+00	3.549	1	8	112
GO:0006325	chromatin organization	8.64e-02	1.00e+00	3.474	1	5	118
GO:0007219	Notch signaling pathway	8.78e-02	1.00e+00	3.450	1	5	120
GO:0000790	nuclear chromatin	9.41e-02	1.00e+00	3.345	1	9	129
GO:0005634	nucleus	9.78e-02	1.00e+00	0.787	6	136	4559
GO:0016887	ATPase activity	1.02e-01	1.00e+00	3.227	1	7	140
GO:0006457	protein folding	1.04e-01	1.00e+00	3.197	1	7	143
GO:0061024	membrane organization	1.05e-01	1.00e+00	3.177	1	7	145
GO:0006397	mRNA processing	1.16e-01	1.00e+00	3.035	1	2	160
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.19e-01	1.00e+00	2.990	1	7	165
GO:0030424	axon	1.20e-01	1.00e+00	2.982	1	4	166
GO:0005730	nucleolus	1.21e-01	1.00e+00	1.261	3	69	1641
GO:0016607	nuclear speck	1.24e-01	1.00e+00	2.930	1	3	172
GO:0031625	ubiquitin protein ligase binding	1.28e-01	1.00e+00	2.881	1	14	178
GO:0032403	protein complex binding	1.31e-01	1.00e+00	2.841	1	10	183
GO:0004871	signal transducer activity	1.48e-01	1.00e+00	2.656	1	4	208
GO:0008380	RNA splicing	1.61e-01	1.00e+00	2.524	1	11	228
GO:0005615	extracellular space	1.63e-01	1.00e+00	1.454	2	17	957
GO:0003713	transcription coactivator activity	1.67e-01	1.00e+00	2.468	1	10	237
GO:0005975	carbohydrate metabolic process	1.77e-01	1.00e+00	2.374	1	9	253
GO:0004842	ubiquitin-protein transferase activity	1.78e-01	1.00e+00	2.362	1	6	255
GO:0006281	DNA repair	1.82e-01	1.00e+00	2.329	1	18	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.84e-01	1.00e+00	2.312	1	8	264
GO:0043065	positive regulation of apoptotic process	1.86e-01	1.00e+00	2.291	1	10	268
GO:0005856	cytoskeleton	2.01e-01	1.00e+00	2.172	1	12	291
GO:0006200	ATP catabolic process	2.02e-01	1.00e+00	2.167	1	15	292
GO:0043234	protein complex	2.03e-01	1.00e+00	2.152	1	18	295
GO:0016567	protein ubiquitination	2.03e-01	1.00e+00	2.152	1	5	295
GO:0019901	protein kinase binding	2.17e-01	1.00e+00	2.048	1	21	317
GO:0007411	axon guidance	2.18e-01	1.00e+00	2.039	1	13	319
GO:0003723	RNA binding	2.32e-01	1.00e+00	1.939	1	20	342
GO:0005925	focal adhesion	2.46e-01	1.00e+00	1.841	1	19	366
GO:0007155	cell adhesion	2.48e-01	1.00e+00	1.829	1	6	369
GO:0055114	oxidation-reduction process	2.78e-01	1.00e+00	1.642	1	12	420
GO:0007596	blood coagulation	2.97e-01	1.00e+00	1.527	1	18	455
GO:0045087	innate immune response	3.71e-01	1.00e+00	1.137	1	24	596
GO:0007165	signal transduction	5.11e-01	1.00e+00	0.532	1	24	907
GO:0008270	zinc ion binding	5.45e-01	1.00e+00	0.395	1	12	997
GO:0006351	transcription, DNA-templated	6.87e-01	1.00e+00	-0.141	1	31	1446
GO:0005886	plasma membrane	8.86e-01	1.00e+00	-0.978	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-8565

Statistics

Genes (11)

Interactions (17)

Related GO terms (160)