int-snw-8453

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.955	2.74e-16	1.60e-03	2.91e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-8453 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
KEAP1	9817	3	0.580	0.981	63	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
[ CUL2 ]	8453	1	0.020	0.955	64	-	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (13)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
KEAP1	9817	RBX1	9978	pp	--	int.I2D: BioGrid, BioGrid_Mouse
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
CUL2	8453	RBX1	9978	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid, IntAct, IntAct_Worm, MINT; int.Mint: MI:0915(physical association), MI:0914(association)
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
CUL2	8453	KEAP1	9817	pp	--	int.I2D: BioGrid
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (166)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0000082	G1/S transition of mitotic cell cycle	1.34e-08	1.93e-04	5.749	5	32	149
GO:0016032	viral process	1.91e-07	2.76e-03	4.170	6	55	534
GO:0005654	nucleoplasm	4.13e-07	5.96e-03	3.374	7	76	1082
GO:0006521	regulation of cellular amino acid metabolic process	3.25e-06	4.68e-02	6.587	3	17	50
GO:0030891	VCB complex	3.46e-06	4.99e-02	9.324	2	2	5
GO:0000502	proteasome complex	5.10e-06	7.35e-02	6.373	3	17	58
GO:0005829	cytosol	6.07e-06	8.76e-02	2.361	8	132	2496
GO:0016071	mRNA metabolic process	6.60e-06	9.51e-02	4.845	4	31	223
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	6.87e-06	9.91e-02	6.231	3	19	64
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.20e-06	1.04e-01	6.209	3	22	65
GO:0031462	Cul2-RING ubiquitin ligase complex	7.26e-06	1.05e-01	8.839	2	2	7
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.01e-06	1.30e-01	6.102	3	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	9.81e-06	1.41e-01	6.061	3	20	72
GO:0016070	RNA metabolic process	9.89e-06	1.43e-01	4.698	4	32	247
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	1.07e-05	1.54e-01	6.022	3	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.11e-05	1.60e-01	6.002	3	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.30e-05	1.87e-01	5.927	3	23	79
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	2.05e-05	2.96e-01	5.708	3	21	92
GO:0005838	proteasome regulatory particle	2.28e-05	3.28e-01	8.061	2	7	12
GO:0000209	protein polyubiquitination	4.11e-05	5.93e-01	5.373	3	20	116
GO:0022624	proteasome accessory complex	4.68e-05	6.76e-01	7.559	2	8	17
GO:0000278	mitotic cell cycle	6.02e-05	8.68e-01	4.035	4	48	391
GO:0031463	Cul3-RING ubiquitin ligase complex	8.70e-05	1.00e+00	7.123	2	3	23
GO:0042981	regulation of apoptotic process	8.85e-05	1.00e+00	5.002	3	24	150
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	1.12e-04	1.00e+00	6.946	2	3	26
GO:0034641	cellular nitrogen compound metabolic process	1.31e-04	1.00e+00	4.813	3	20	171
GO:0031625	ubiquitin protein ligase binding	1.47e-04	1.00e+00	4.755	3	14	178
GO:0010467	gene expression	4.79e-04	1.00e+00	3.260	4	59	669
GO:0016567	protein ubiquitination	6.49e-04	1.00e+00	4.027	3	5	295
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0071456	cellular response to hypoxia	1.41e-03	1.00e+00	5.123	2	6	92
GO:0005730	nucleolus	1.61e-03	1.00e+00	2.288	5	69	1641
GO:0043066	negative regulation of apoptotic process	1.86e-03	1.00e+00	3.503	3	31	424
GO:0045604	regulation of epidermal cell differentiation	1.87e-03	1.00e+00	9.061	1	1	3
GO:0010499	proteasomal ubiquitin-independent protein catabolic process	2.49e-03	1.00e+00	8.646	1	2	4
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	2.49e-03	1.00e+00	8.646	1	1	4
GO:0019788	NEDD8 ligase activity	2.49e-03	1.00e+00	8.646	1	1	4
GO:0006511	ubiquitin-dependent protein catabolic process	2.62e-03	1.00e+00	4.669	2	5	126
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0043248	proteasome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0000730	DNA recombinase assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:2000001	regulation of DNA damage checkpoint	3.12e-03	1.00e+00	8.324	1	1	5
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0006915	apoptotic process	4.00e-03	1.00e+00	3.115	3	33	555
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0019773	proteasome core complex, alpha-subunit complex	4.98e-03	1.00e+00	7.646	1	4	8
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	2	8
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0045116	protein neddylation	4.98e-03	1.00e+00	7.646	1	2	8
GO:0005515	protein binding	5.23e-03	1.00e+00	1.090	8	184	6024
GO:0032403	protein complex binding	5.44e-03	1.00e+00	4.130	2	10	183
GO:0005634	nucleus	5.94e-03	1.00e+00	1.299	7	136	4559
GO:0010569	regulation of double-strand break repair via homologous recombination	6.22e-03	1.00e+00	7.324	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	6.85e-03	1.00e+00	7.187	1	4	11
GO:0005662	DNA replication factor A complex	8.09e-03	1.00e+00	6.946	1	1	13
GO:0030234	enzyme regulator activity	8.09e-03	1.00e+00	6.946	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0070062	extracellular vesicular exosome	8.87e-03	1.00e+00	1.739	5	104	2400
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0042176	regulation of protein catabolic process	9.94e-03	1.00e+00	6.646	1	3	16
GO:0006281	DNA repair	1.08e-02	1.00e+00	3.618	2	18	261
GO:0035861	site of double-strand break	1.12e-02	1.00e+00	6.476	1	1	18
GO:0005839	proteasome core complex	1.12e-02	1.00e+00	6.476	1	8	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.18e-02	1.00e+00	6.398	1	1	19
GO:0048863	stem cell differentiation	1.18e-02	1.00e+00	6.398	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.18e-02	1.00e+00	6.398	1	8	19
GO:0071353	cellular response to interleukin-4	1.24e-02	1.00e+00	6.324	1	1	20
GO:0006298	mismatch repair	1.24e-02	1.00e+00	6.324	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.30e-02	1.00e+00	6.254	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.30e-02	1.00e+00	6.254	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.36e-02	1.00e+00	6.187	1	3	22
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0005844	polysome	1.43e-02	1.00e+00	6.123	1	4	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0016020	membrane	1.43e-02	1.00e+00	1.931	4	90	1681
GO:0006513	protein monoubiquitination	1.43e-02	1.00e+00	6.123	1	1	23
GO:0000722	telomere maintenance via recombination	1.55e-02	1.00e+00	6.002	1	5	25
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0019005	SCF ubiquitin ligase complex	1.80e-02	1.00e+00	5.788	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	1.86e-02	1.00e+00	5.739	1	7	30
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0006284	base-excision repair	2.29e-02	1.00e+00	5.437	1	3	37
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0000781	chromosome, telomeric region	2.41e-02	1.00e+00	5.361	1	3	39
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	2.71e-02	1.00e+00	5.187	1	3	44
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	2.83e-02	1.00e+00	5.123	1	7	46
GO:0003684	damaged DNA binding	3.02e-02	1.00e+00	5.031	1	7	49
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0044281	small molecule metabolic process	3.38e-02	1.00e+00	1.989	3	58	1211
GO:0097193	intrinsic apoptotic signaling pathway	3.38e-02	1.00e+00	4.865	1	6	55
GO:0000724	double-strand break repair via homologous recombination	3.38e-02	1.00e+00	4.865	1	3	55
GO:0000723	telomere maintenance	3.44e-02	1.00e+00	4.839	1	6	56
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity	3.62e-02	1.00e+00	4.764	1	2	59
GO:0019903	protein phosphatase binding	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006302	double-strand break repair	3.80e-02	1.00e+00	4.692	1	4	62
GO:0006289	nucleotide-excision repair	4.17e-02	1.00e+00	4.559	1	11	68
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0003697	single-stranded DNA binding	4.17e-02	1.00e+00	4.559	1	5	68
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	4.59e-02	1.00e+00	4.417	1	2	75
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0047485	protein N-terminus binding	5.24e-02	1.00e+00	4.220	1	5	86
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0016605	PML body	5.36e-02	1.00e+00	4.187	1	3	88
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0030496	midbody	6.54e-02	1.00e+00	3.891	1	5	108
GO:0005815	microtubule organizing center	6.60e-02	1.00e+00	3.878	1	5	109
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0007219	Notch signaling pathway	7.25e-02	1.00e+00	3.739	1	5	120
GO:0006260	DNA replication	7.30e-02	1.00e+00	3.727	1	9	121
GO:0007050	cell cycle arrest	7.48e-02	1.00e+00	3.692	1	9	124
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0061024	membrane organization	8.69e-02	1.00e+00	3.466	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0001701	in utero embryonic development	1.19e-01	1.00e+00	2.995	1	8	201
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0008134	transcription factor binding	1.41e-01	1.00e+00	2.727	1	8	242
GO:0004842	ubiquitin-protein transferase activity	1.48e-01	1.00e+00	2.652	1	6	255
GO:0019899	enzyme binding	1.60e-01	1.00e+00	2.532	1	12	277
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0043234	protein complex	1.70e-01	1.00e+00	2.442	1	18	295
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	21	317
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005813	centrosome	1.86e-01	1.00e+00	2.297	1	14	326
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	110	3767
GO:0003723	RNA binding	1.94e-01	1.00e+00	2.228	1	20	342
GO:0008285	negative regulation of cell proliferation	2.00e-01	1.00e+00	2.183	1	11	353
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0005783	endoplasmic reticulum	2.98e-01	1.00e+00	1.527	1	10	556
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0005615	extracellular space	4.61e-01	1.00e+00	0.744	1	17	957
GO:0008270	zinc ion binding	4.75e-01	1.00e+00	0.685	1	12	997
GO:0044822	poly(A) RNA binding	4.96e-01	1.00e+00	0.602	1	49	1056
GO:0005524	ATP binding	5.72e-01	1.00e+00	0.304	1	60	1298
GO:0006351	transcription, DNA-templated	6.14e-01	1.00e+00	0.148	1	31	1446
GO:0005886	plasma membrane	8.31e-01	1.00e+00	-0.688	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-8453

Statistics

Genes (9)

Interactions (13)

Related GO terms (166)