int-snw-8407

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	1.009	1.73e-18	4.48e-04	1.12e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-8407 subnetwork

Genes (12)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
RPA2	6118	98	1.250	1.151	69	Yes	-
CDC16	8881	25	0.950	1.020	80	Yes	-
RBX1	9978	97	1.185	1.151	139	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
PSMD3	5709	57	0.986	1.106	146	Yes	-
PSMB7	5695	48	0.982	1.052	57	Yes	-
PSMA1	5682	61	0.996	1.052	123	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
[ TAGLN2 ]	8407	1	-0.238	1.009	32	-	-
PSMD6	9861	11	0.848	1.009	131	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-

Interactions (27)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ACTB	60	TAGLN2	8407	pp	--	int.Intact: MI:0915(physical association)
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPA2	6118	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
PSMA2	5683	PSMD6	9861	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, YeastLow, BioGrid
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
PSMA1	5682	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
PSMA1	5682	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastMedium
PSMD3	5709	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, INTEROLOG
ACTB	60	PSMB7	5695	pp	--	int.I2D: BioGrid_Yeast
PSMA1	5682	PSMA2	5683	pp	--	int.Intact: MI:0915(physical association), MI:0914(association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, HPRD, IntAct, IntAct_Mouse, IntAct_Yeast, INTEROLOG, MINT_Worm, BioGrid, IntAct_Fly, IntAct_Worm, Krogan_Core, MINT_Yeast, YeastHigh; int.HPRD: yeast 2-hybrid
PSMB7	5695	PSMD6	9861	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct
PSMD11	5717	PSMD6	9861	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Yeast, Krogan_Core, MINT_Yeast, YeastHigh, BioGrid, INTEROLOG
PSMA1	5682	PSMD6	9861	pp	--	int.Proteinpedia: Mass spectrometry; int.Intact: MI:0915(physical association); int.I2D: BioGrid_Yeast, IntAct, YeastMedium
PSMA1	5682	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BioGrid_Yeast, IntAct, IntAct_Mouse, IntAct_Yeast, YeastLow, Krogan_Core, MINT_Yeast
PSMA2	5683	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RBX1	9978	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	CDC16	8881	pp	--	int.I2D: YeastLow
ACTB	60	PSMD6	9861	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMD3	5709	PSMD6	9861	pp	--	int.Intact: MI:0915(physical association); int.I2D: BioGrid_Worm, BioGrid_Yeast, BIND_Worm, CE_DATA, IntAct, IntAct_Yeast, MINT_Worm, MINT_Yeast, YeastHigh, BioGrid, BIND_Yeast, IntAct_Worm, INTEROLOG, Krogan_Core, MIPS
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
PSMB7	5695	PSMD3	5709	pp	--	int.I2D: BioGrid_Yeast
PSMA2	5683	PSMB7	5695	pp	--	int.Intact: MI:0914(association); int.I2D: BCI, BioGrid, BioGrid_Yeast, BIND_Yeast, IntAct, Krogan_Core, MINT_Yeast, YeastLow, IntAct_Yeast
ACTB	60	PSMA1	5682	pp	--	int.I2D: BioGrid_Yeast
TAGLN2	8407	PSMD6	9861	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct

Related GO terms (168)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	2.11e-14	3.04e-10	7.016	7	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	3.62e-14	5.22e-10	6.909	7	22	70
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.43e-14	7.83e-10	6.829	7	22	74
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.73e-14	1.26e-09	6.735	7	23	79
GO:0006521	regulation of cellular amino acid metabolic process	1.16e-12	1.67e-08	7.172	6	17	50
GO:0000502	proteasome complex	2.94e-12	4.24e-08	6.958	6	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.43e-12	7.84e-08	6.816	6	19	64
GO:0000082	G1/S transition of mitotic cell cycle	8.27e-12	1.19e-07	5.819	7	32	149
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	1.13e-11	1.63e-07	6.646	6	20	72
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	1.45e-11	2.10e-07	6.587	6	20	75
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.12e-11	7.38e-07	6.293	6	21	92
GO:0000278	mitotic cell cycle	1.22e-10	1.76e-06	4.620	8	48	391
GO:0016071	mRNA metabolic process	1.43e-10	2.06e-06	5.238	7	31	223
GO:0000209	protein polyubiquitination	2.11e-10	3.04e-06	5.958	6	20	116
GO:0016070	RNA metabolic process	2.92e-10	4.21e-06	5.090	7	32	247
GO:0005654	nucleoplasm	3.12e-10	4.50e-06	3.474	10	76	1082
GO:0042981	regulation of apoptotic process	1.00e-09	1.45e-05	5.587	6	24	150
GO:0016032	viral process	1.46e-09	2.10e-05	4.170	8	55	534
GO:0034641	cellular nitrogen compound metabolic process	2.22e-09	3.20e-05	5.398	6	20	171
GO:0010467	gene expression	2.89e-07	4.17e-03	3.653	7	59	669
GO:0022624	proteasome accessory complex	2.97e-07	4.29e-03	7.729	3	8	17
GO:0005839	proteasome core complex	3.57e-07	5.14e-03	7.646	3	8	18
GO:0004298	threonine-type endopeptidase activity	4.23e-07	6.10e-03	7.568	3	8	19
GO:0043066	negative regulation of apoptotic process	4.96e-07	7.15e-03	4.088	6	31	424
GO:0005829	cytosol	1.11e-06	1.61e-02	2.268	10	132	2496
GO:0006915	apoptotic process	2.40e-06	3.46e-02	3.700	6	33	555
GO:0070062	extracellular vesicular exosome	1.31e-05	1.89e-01	2.172	9	104	2400
GO:0019773	proteasome core complex, alpha-subunit complex	1.77e-05	2.56e-01	8.231	2	4	8
GO:0005838	proteasome regulatory particle	4.17e-05	6.01e-01	7.646	2	7	12
GO:0044281	small molecule metabolic process	2.05e-04	1.00e+00	2.574	6	58	1211
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.66e-03	1.00e+00	9.231	1	1	2
GO:0005055	laminin receptor activity	1.66e-03	1.00e+00	9.231	1	1	2
GO:0006407	rRNA export from nucleus	1.66e-03	1.00e+00	9.231	1	1	2
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	3.32e-03	1.00e+00	8.231	1	1	4
GO:0030686	90S preribosome	3.32e-03	1.00e+00	8.231	1	1	4
GO:0031467	Cul7-RING ubiquitin ligase complex	3.32e-03	1.00e+00	8.231	1	1	4
GO:0019788	NEDD8 ligase activity	3.32e-03	1.00e+00	8.231	1	1	4
GO:0005515	protein binding	4.10e-03	1.00e+00	0.997	10	184	6024
GO:0031465	Cul4B-RING E3 ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	3	5
GO:0031461	cullin-RING ubiquitin ligase complex	4.15e-03	1.00e+00	7.909	1	1	5
GO:0043248	proteasome assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:0030891	VCB complex	4.15e-03	1.00e+00	7.909	1	2	5
GO:0000730	DNA recombinase assembly	4.15e-03	1.00e+00	7.909	1	1	5
GO:2000001	regulation of DNA damage checkpoint	4.15e-03	1.00e+00	7.909	1	1	5
GO:0030957	Tat protein binding	4.98e-03	1.00e+00	7.646	1	3	6
GO:0031466	Cul5-RING ubiquitin ligase complex	4.98e-03	1.00e+00	7.646	1	1	6
GO:0000028	ribosomal small subunit assembly	5.81e-03	1.00e+00	7.424	1	1	7
GO:0031462	Cul2-RING ubiquitin ligase complex	5.81e-03	1.00e+00	7.424	1	2	7
GO:0031464	Cul4A-RING E3 ubiquitin ligase complex	6.64e-03	1.00e+00	7.231	1	2	8
GO:0070688	MLL5-L complex	6.64e-03	1.00e+00	7.231	1	1	8
GO:0045116	protein neddylation	6.64e-03	1.00e+00	7.231	1	2	8
GO:0010569	regulation of double-strand break repair via homologous recombination	8.29e-03	1.00e+00	6.909	1	1	10
GO:0031571	mitotic G1 DNA damage checkpoint	9.12e-03	1.00e+00	6.772	1	4	11
GO:0031625	ubiquitin protein ligase binding	9.22e-03	1.00e+00	3.755	2	14	178
GO:0005662	DNA replication factor A complex	1.08e-02	1.00e+00	6.531	1	1	13
GO:0030234	enzyme regulator activity	1.08e-02	1.00e+00	6.531	1	3	13
GO:0035267	NuA4 histone acetyltransferase complex	1.16e-02	1.00e+00	6.424	1	4	14
GO:0050998	nitric-oxide synthase binding	1.32e-02	1.00e+00	6.231	1	1	16
GO:0042176	regulation of protein catabolic process	1.32e-02	1.00e+00	6.231	1	3	16
GO:0007088	regulation of mitosis	1.49e-02	1.00e+00	6.061	1	1	18
GO:0035861	site of double-strand break	1.49e-02	1.00e+00	6.061	1	1	18
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	1.57e-02	1.00e+00	5.983	1	1	19
GO:0048863	stem cell differentiation	1.57e-02	1.00e+00	5.983	1	1	19
GO:0005680	anaphase-promoting complex	1.65e-02	1.00e+00	5.909	1	4	20
GO:0006298	mismatch repair	1.65e-02	1.00e+00	5.909	1	3	20
GO:0032201	telomere maintenance via semi-conservative replication	1.73e-02	1.00e+00	5.839	1	5	21
GO:0000718	nucleotide-excision repair, DNA damage removal	1.73e-02	1.00e+00	5.839	1	4	21
GO:0006297	nucleotide-excision repair, DNA gap filling	1.82e-02	1.00e+00	5.772	1	3	22
GO:0030863	cortical cytoskeleton	1.82e-02	1.00e+00	5.772	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.82e-02	1.00e+00	5.772	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.90e-02	1.00e+00	5.708	1	4	23
GO:0005844	polysome	1.90e-02	1.00e+00	5.708	1	4	23
GO:0031463	Cul3-RING ubiquitin ligase complex	1.90e-02	1.00e+00	5.708	1	3	23
GO:0043236	laminin binding	1.90e-02	1.00e+00	5.708	1	1	23
GO:0006513	protein monoubiquitination	1.90e-02	1.00e+00	5.708	1	1	23
GO:0006281	DNA repair	1.91e-02	1.00e+00	3.203	2	18	261
GO:0000722	telomere maintenance via recombination	2.06e-02	1.00e+00	5.587	1	5	25
GO:0070979	protein K11-linked ubiquitination	2.14e-02	1.00e+00	5.531	1	6	26
GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia	2.14e-02	1.00e+00	5.531	1	3	26
GO:0043022	ribosome binding	2.22e-02	1.00e+00	5.476	1	3	27
GO:0031492	nucleosomal DNA binding	2.22e-02	1.00e+00	5.476	1	4	27
GO:0019894	kinesin binding	2.31e-02	1.00e+00	5.424	1	1	28
GO:0019005	SCF ubiquitin ligase complex	2.39e-02	1.00e+00	5.373	1	1	29
GO:0006271	DNA strand elongation involved in DNA replication	2.47e-02	1.00e+00	5.324	1	7	30
GO:0007094	mitotic spindle assembly checkpoint	2.55e-02	1.00e+00	5.277	1	4	31
GO:0001895	retina homeostasis	2.79e-02	1.00e+00	5.144	1	1	34
GO:0005876	spindle microtubule	2.79e-02	1.00e+00	5.144	1	2	34
GO:0005813	centrosome	2.89e-02	1.00e+00	2.882	2	14	326
GO:0034332	adherens junction organization	2.96e-02	1.00e+00	5.061	1	1	36
GO:0051084	'de novo' posttranslational protein folding	3.04e-02	1.00e+00	5.022	1	4	37
GO:0006284	base-excision repair	3.04e-02	1.00e+00	5.022	1	3	37
GO:0070527	platelet aggregation	3.12e-02	1.00e+00	4.983	1	2	38
GO:0022627	cytosolic small ribosomal subunit	3.20e-02	1.00e+00	4.946	1	4	39
GO:0000781	chromosome, telomeric region	3.20e-02	1.00e+00	4.946	1	3	39
GO:0021762	substantia nigra development	3.60e-02	1.00e+00	4.772	1	2	44
GO:0006283	transcription-coupled nucleotide-excision repair	3.76e-02	1.00e+00	4.708	1	7	46
GO:0005730	nucleolus	3.91e-02	1.00e+00	1.551	4	69	1641
GO:0003684	damaged DNA binding	4.00e-02	1.00e+00	4.616	1	7	49
GO:0016020	membrane	4.22e-02	1.00e+00	1.516	4	90	1681
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	4.32e-02	1.00e+00	4.503	1	5	53
GO:0045216	cell-cell junction organization	4.40e-02	1.00e+00	4.476	1	2	54
GO:0000932	cytoplasmic mRNA processing body	4.40e-02	1.00e+00	4.476	1	3	54
GO:0000724	double-strand break repair via homologous recombination	4.48e-02	1.00e+00	4.450	1	3	55
GO:0000723	telomere maintenance	4.56e-02	1.00e+00	4.424	1	6	56
GO:0030855	epithelial cell differentiation	4.96e-02	1.00e+00	4.300	1	4	61
GO:0019903	protein phosphatase binding	5.04e-02	1.00e+00	4.277	1	4	62
GO:0006302	double-strand break repair	5.04e-02	1.00e+00	4.277	1	4	62
GO:0005634	nucleus	5.06e-02	1.00e+00	0.884	7	136	4559
GO:0006289	nucleotide-excision repair	5.52e-02	1.00e+00	4.144	1	11	68
GO:0034329	cell junction assembly	5.52e-02	1.00e+00	4.144	1	1	68
GO:0003697	single-stranded DNA binding	5.52e-02	1.00e+00	4.144	1	5	68
GO:0044267	cellular protein metabolic process	5.72e-02	1.00e+00	2.342	2	29	474
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	5.99e-02	1.00e+00	4.022	1	6	74
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6.07e-02	1.00e+00	4.002	1	2	75
GO:0019083	viral transcription	6.54e-02	1.00e+00	3.891	1	10	81
GO:0047485	protein N-terminus binding	6.93e-02	1.00e+00	3.805	1	5	86
GO:0006415	translational termination	7.01e-02	1.00e+00	3.788	1	10	87
GO:0016605	PML body	7.08e-02	1.00e+00	3.772	1	3	88
GO:0006928	cellular component movement	7.32e-02	1.00e+00	3.723	1	7	91
GO:0005200	structural constituent of cytoskeleton	7.32e-02	1.00e+00	3.723	1	8	91
GO:0071456	cellular response to hypoxia	7.39e-02	1.00e+00	3.708	1	6	92
GO:0006414	translational elongation	7.47e-02	1.00e+00	3.692	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	8.32e-02	1.00e+00	3.531	1	10	104
GO:0014069	postsynaptic density	8.40e-02	1.00e+00	3.517	1	3	105
GO:0015630	microtubule cytoskeleton	8.78e-02	1.00e+00	3.450	1	4	110
GO:0072562	blood microparticle	8.86e-02	1.00e+00	3.437	1	3	111
GO:0030529	ribonucleoprotein complex	8.93e-02	1.00e+00	3.424	1	8	112
GO:0005819	spindle	8.93e-02	1.00e+00	3.424	1	7	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	9.09e-02	1.00e+00	3.398	1	11	114
GO:0019058	viral life cycle	9.16e-02	1.00e+00	3.386	1	13	115
GO:0006325	chromatin organization	9.39e-02	1.00e+00	3.348	1	5	118
GO:0007219	Notch signaling pathway	9.54e-02	1.00e+00	3.324	1	5	120
GO:0006260	DNA replication	9.62e-02	1.00e+00	3.312	1	9	121
GO:0006511	ubiquitin-dependent protein catabolic process	1.00e-01	1.00e+00	3.254	1	5	126
GO:0009615	response to virus	1.00e-01	1.00e+00	3.254	1	5	126
GO:0000790	nuclear chromatin	1.02e-01	1.00e+00	3.220	1	9	129
GO:0006413	translational initiation	1.04e-01	1.00e+00	3.198	1	17	131
GO:0031982	vesicle	1.04e-01	1.00e+00	3.198	1	9	131
GO:0003735	structural constituent of ribosome	1.08e-01	1.00e+00	3.133	1	10	137
GO:0016887	ATPase activity	1.10e-01	1.00e+00	3.102	1	7	140
GO:0006457	protein folding	1.13e-01	1.00e+00	3.071	1	7	143
GO:0061024	membrane organization	1.14e-01	1.00e+00	3.051	1	7	145
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	1.29e-01	1.00e+00	2.865	1	7	165
GO:0030424	axon	1.30e-01	1.00e+00	2.856	1	4	166
GO:0032403	protein complex binding	1.42e-01	1.00e+00	2.715	1	10	183
GO:0007067	mitotic nuclear division	1.73e-01	1.00e+00	2.405	1	14	227
GO:0006412	translation	1.75e-01	1.00e+00	2.386	1	20	230
GO:0004842	ubiquitin-protein transferase activity	1.93e-01	1.00e+00	2.237	1	6	255
GO:0019899	enzyme binding	2.08e-01	1.00e+00	2.117	1	12	277
GO:0005856	cytoskeleton	2.17e-01	1.00e+00	2.046	1	12	291
GO:0006200	ATP catabolic process	2.18e-01	1.00e+00	2.041	1	15	292
GO:0043234	protein complex	2.20e-01	1.00e+00	2.027	1	18	295
GO:0016567	protein ubiquitination	2.20e-01	1.00e+00	2.027	1	5	295
GO:0019901	protein kinase binding	2.34e-01	1.00e+00	1.923	1	21	317
GO:0007411	axon guidance	2.35e-01	1.00e+00	1.914	1	13	319
GO:0008283	cell proliferation	2.41e-01	1.00e+00	1.874	1	14	328
GO:0003723	RNA binding	2.50e-01	1.00e+00	1.813	1	20	342
GO:0005925	focal adhesion	2.65e-01	1.00e+00	1.715	1	19	366
GO:0007155	cell adhesion	2.67e-01	1.00e+00	1.704	1	6	369
GO:0006508	proteolysis	2.73e-01	1.00e+00	1.669	1	9	378
GO:0007596	blood coagulation	3.19e-01	1.00e+00	1.401	1	18	455
GO:0005737	cytoplasm	3.86e-01	1.00e+00	0.352	4	110	3767
GO:0045087	innate immune response	3.97e-01	1.00e+00	1.012	1	24	596
GO:0005615	extracellular space	5.61e-01	1.00e+00	0.329	1	17	957
GO:0008270	zinc ion binding	5.77e-01	1.00e+00	0.270	1	12	997
GO:0044822	poly(A) RNA binding	5.99e-01	1.00e+00	0.187	1	49	1056
GO:0005524	ATP binding	6.78e-01	1.00e+00	-0.111	1	60	1298
GO:0005886	plasma membrane	9.06e-01	1.00e+00	-1.103	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-8407

Statistics

Genes (12)

Interactions (27)

Related GO terms (168)