int-snw-81565

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 0.956 2.38e-16 1.54e-03 2.84e-02
wolf-screen-ratio-mammosphere-adherent-int-snw-81565 subnetwork

Genes (9)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
[ NDEL1 ] 81565 1-0.2710.95641-Yes
RBX1 9978 971.1851.151139Yes-
PAFAH1B1 5048 60.6911.07671Yes-
PHB2 11331 90.8291.076140Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
TACC3 10460 20.8060.95610Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (11)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
RPSA 3921 PHB2 11331 pp -- int.I2D: IntAct_Yeast
PAFAH1B1 5048 NDEL1 81565 pp -- int.Intact: MI:0915(physical association);
int.I2D: BCI, BioGrid, IntAct, IntAct_Mouse, HPRD;
int.HPRD: in vivo, yeast 2-hybrid
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PAFAH1B1 5048 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 PHB2 11331 pp -- int.I2D: IntAct_Yeast
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast
TACC3 10460 NDEL1 81565 pp -- int.I2D: BioGrid
PAFAH1B1 5048 PHB2 11331 pp -- int.I2D: BioGrid_Yeast

Related GO terms (242)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0051081nuclear envelope disassembly3.46e-074.99e-0310.646222
GO:0008090retrograde axon cargo transport5.19e-067.48e-029.061226
GO:0047496vesicle transport along microtubule2.28e-053.28e-018.0612212
GO:0045773positive regulation of axon extension5.27e-057.60e-017.4762418
GO:0000278mitotic cell cycle6.02e-058.68e-014.035448391
GO:0031252cell leading edge1.30e-041.00e+006.8392428
GO:0021987cerebral cortex development2.94e-041.00e+006.2542342
GO:0005871kinesin complex3.23e-041.00e+006.1872344
GO:0005515protein binding3.85e-041.00e+001.26091846024
GO:0000235astral microtubule6.24e-041.00e+0010.646111
GO:0051660establishment of centrosome localization6.24e-041.00e+0010.646111
GO:0046469platelet activating factor metabolic process6.24e-041.00e+0010.646111
GO:0070012oligopeptidase activity6.24e-041.00e+0010.646111
GO:0000776kinetochore6.63e-041.00e+005.6692463
GO:0005813centrosome8.69e-041.00e+003.882314326
GO:0060053neurofilament cytoskeleton1.25e-031.00e+009.646112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.25e-031.00e+009.646112
GO:0005055laminin receptor activity1.25e-031.00e+009.646112
GO:0006407rRNA export from nucleus1.25e-031.00e+009.646112
GO:0021540corpus callosum morphogenesis1.25e-031.00e+009.646112
GO:0036035osteoclast development1.25e-031.00e+009.646122
GO:0005829cytosol1.39e-031.00e+001.94661322496
GO:0001764neuron migration1.44e-031.00e+005.1072393
GO:0030953astral microtubule organization1.87e-031.00e+009.061113
GO:0045505dynein intermediate chain binding1.87e-031.00e+009.061113
GO:0048680positive regulation of axon regeneration1.87e-031.00e+009.061113
GO:0005635nuclear envelope2.11e-031.00e+004.82626113
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)2.49e-031.00e+008.646114
GO:003068690S preribosome2.49e-031.00e+008.646114
GO:0031467Cul7-RING ubiquitin ligase complex2.49e-031.00e+008.646114
GO:0019788NEDD8 ligase activity2.49e-031.00e+008.646114
GO:0032864activation of Cdc42 GTPase activity2.49e-031.00e+008.646114
GO:0007100mitotic centrosome separation2.49e-031.00e+008.646124
GO:0005654nucleoplasm2.92e-031.00e+002.5674761082
GO:0031465Cul4B-RING E3 ubiquitin ligase complex3.12e-031.00e+008.324135
GO:0031461cullin-RING ubiquitin ligase complex3.12e-031.00e+008.324115
GO:0043248proteasome assembly3.12e-031.00e+008.324115
GO:1990138neuron projection extension3.12e-031.00e+008.324115
GO:0030891VCB complex3.12e-031.00e+008.324125
GO:0033600negative regulation of mammary gland epithelial cell proliferation3.12e-031.00e+008.324115
GO:0060052neurofilament cytoskeleton organization3.12e-031.00e+008.324115
GO:0000730DNA recombinase assembly3.12e-031.00e+008.324115
GO:2000001regulation of DNA damage checkpoint3.12e-031.00e+008.324115
GO:0021955central nervous system neuron axonogenesis3.12e-031.00e+008.324115
GO:0031023microtubule organizing center organization3.12e-031.00e+008.324115
GO:0008017microtubule binding3.54e-031.00e+004.44626147
GO:0016032viral process3.59e-031.00e+003.170355534
GO:0000082G1/S transition of mitotic cell cycle3.64e-031.00e+004.427232149
GO:0007097nuclear migration3.74e-031.00e+008.061116
GO:0030957Tat protein binding3.74e-031.00e+008.061136
GO:0034452dynactin binding3.74e-031.00e+008.061116
GO:0060744mammary gland branching involved in thelarche3.74e-031.00e+008.061116
GO:0001667ameboidal-type cell migration3.74e-031.00e+008.061116
GO:0060762regulation of branching involved in mammary gland duct morphogenesis3.74e-031.00e+008.061116
GO:0031466Cul5-RING ubiquitin ligase complex3.74e-031.00e+008.061116
GO:0001961positive regulation of cytokine-mediated signaling pathway4.36e-031.00e+007.839117
GO:0000028ribosomal small subunit assembly4.36e-031.00e+007.839117
GO:0017145stem cell division4.36e-031.00e+007.839117
GO:0021799cerebral cortex radially oriented cell migration4.36e-031.00e+007.839127
GO:0043203axon hillock4.36e-031.00e+007.839117
GO:0031462Cul2-RING ubiquitin ligase complex4.36e-031.00e+007.839127
GO:0030424axon4.50e-031.00e+004.27124166
GO:0031512motile primary cilium4.98e-031.00e+007.646118
GO:0031464Cul4A-RING E3 ubiquitin ligase complex4.98e-031.00e+007.646128
GO:0070688MLL5-L complex4.98e-031.00e+007.646118
GO:0045116protein neddylation4.98e-031.00e+007.646128
GO:0031625ubiquitin protein ligase binding5.15e-031.00e+004.170214178
GO:0032319regulation of Rho GTPase activity5.60e-031.00e+007.476129
GO:0021895cerebral cortex neuron differentiation5.60e-031.00e+007.476119
GO:0022027interkinetic nuclear migration5.60e-031.00e+007.476119
GO:0033147negative regulation of intracellular estrogen receptor signaling pathway6.22e-031.00e+007.3241110
GO:0010569regulation of double-strand break repair via homologous recombination6.22e-031.00e+007.3241110
GO:0001675acrosome assembly6.22e-031.00e+007.3241110
GO:0045502dynein binding6.85e-031.00e+007.1871211
GO:0031571mitotic G1 DNA damage checkpoint6.85e-031.00e+007.1871411
GO:0021819layer formation in cerebral cortex6.85e-031.00e+007.1871111
GO:0032886regulation of microtubule-based process7.47e-031.00e+007.0611312
GO:0051642centrosome localization7.47e-031.00e+007.0611112
GO:0005838proteasome regulatory particle7.47e-031.00e+007.0611712
GO:0016071mRNA metabolic process7.98e-031.00e+003.845231223
GO:0005662DNA replication factor A complex8.09e-031.00e+006.9461113
GO:0001833inner cell mass cell proliferation8.09e-031.00e+006.9461113
GO:0042994cytoplasmic sequestering of transcription factor8.09e-031.00e+006.9461113
GO:0035267NuA4 histone acetyltransferase complex8.70e-031.00e+006.8391414
GO:0019226transmission of nerve impulse8.70e-031.00e+006.8391114
GO:0070062extracellular vesicular exosome8.87e-031.00e+001.73951042400
GO:0048854brain morphogenesis9.32e-031.00e+006.7391115
GO:0060749mammary gland alveolus development9.32e-031.00e+006.7391215
GO:0016070RNA metabolic process9.71e-031.00e+003.698232247
GO:0050998nitric-oxide synthase binding9.94e-031.00e+006.6461116
GO:0007405neuroblast proliferation9.94e-031.00e+006.6461116
GO:0043274phospholipase binding9.94e-031.00e+006.6461116
GO:0000132establishment of mitotic spindle orientation9.94e-031.00e+006.6461116
GO:0022624proteasome accessory complex1.06e-021.00e+006.5591817
GO:0006281DNA repair1.08e-021.00e+003.618218261
GO:0035861site of double-strand break1.12e-021.00e+006.4761118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process1.18e-021.00e+006.3981119
GO:0048863stem cell differentiation1.18e-021.00e+006.3981119
GO:0009306protein secretion1.24e-021.00e+006.3241120
GO:0006298mismatch repair1.24e-021.00e+006.3241320
GO:0032201telomere maintenance via semi-conservative replication1.30e-021.00e+006.2541521
GO:0000718nucleotide-excision repair, DNA damage removal1.30e-021.00e+006.2541421
GO:0006297nucleotide-excision repair, DNA gap filling1.36e-021.00e+006.1871322
GO:0030863cortical cytoskeleton1.36e-021.00e+006.1871122
GO:0036464cytoplasmic ribonucleoprotein granule1.36e-021.00e+006.1871422
GO:0043234protein complex1.37e-021.00e+003.442218295
GO:0046329negative regulation of JNK cascade1.43e-021.00e+006.1231123
GO:0043044ATP-dependent chromatin remodeling1.43e-021.00e+006.1231423
GO:0043014alpha-tubulin binding1.43e-021.00e+006.1231123
GO:0031463Cul3-RING ubiquitin ligase complex1.43e-021.00e+006.1231323
GO:0043236laminin binding1.43e-021.00e+006.1231123
GO:0006513protein monoubiquitination1.43e-021.00e+006.1231123
GO:0022008neurogenesis1.49e-021.00e+006.0611124
GO:0000722telomere maintenance via recombination1.55e-021.00e+006.0021525
GO:0045931positive regulation of mitotic cell cycle1.61e-021.00e+005.9461126
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia1.61e-021.00e+005.9461326
GO:0030331estrogen receptor binding1.67e-021.00e+005.8911227
GO:0007017microtubule-based process1.67e-021.00e+005.8911327
GO:0043022ribosome binding1.67e-021.00e+005.8911327
GO:0031492nucleosomal DNA binding1.67e-021.00e+005.8911427
GO:0010977negative regulation of neuron projection development1.73e-021.00e+005.8391228
GO:0005875microtubule associated complex1.73e-021.00e+005.8391228
GO:0019894kinesin binding1.73e-021.00e+005.8391128
GO:0019005SCF ubiquitin ligase complex1.80e-021.00e+005.7881129
GO:0048487beta-tubulin binding1.86e-021.00e+005.7391230
GO:0006271DNA strand elongation involved in DNA replication1.86e-021.00e+005.7391730
GO:0051219phosphoprotein binding1.98e-021.00e+005.6461232
GO:0001895retina homeostasis2.10e-021.00e+005.5591134
GO:0007611learning or memory2.10e-021.00e+005.5591234
GO:0034332adherens junction organization2.22e-021.00e+005.4761136
GO:0051084'de novo' posttranslational protein folding2.29e-021.00e+005.4371437
GO:0006284base-excision repair2.29e-021.00e+005.4371337
GO:0021766hippocampus development2.35e-021.00e+005.3981438
GO:0070527platelet aggregation2.35e-021.00e+005.3981238
GO:0022627cytosolic small ribosomal subunit2.41e-021.00e+005.3611439
GO:0000781chromosome, telomeric region2.41e-021.00e+005.3611339
GO:0050885neuromuscular process controlling balance2.47e-021.00e+005.3241140
GO:0021762substantia nigra development2.71e-021.00e+005.1871244
GO:0008344adult locomotory behavior2.71e-021.00e+005.1871144
GO:0006283transcription-coupled nucleotide-excision repair2.83e-021.00e+005.1231746
GO:0016042lipid catabolic process2.96e-021.00e+005.0611248
GO:0003684damaged DNA binding3.02e-021.00e+005.0311749
GO:0006521regulation of cellular amino acid metabolic process3.08e-021.00e+005.00211750
GO:0000226microtubule cytoskeleton organization3.20e-021.00e+004.9461352
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding3.26e-021.00e+004.9181553
GO:0045216cell-cell junction organization3.32e-021.00e+004.8911254
GO:0044267cellular protein metabolic process3.33e-021.00e+002.757229474
GO:0000724double-strand break repair via homologous recombination3.38e-021.00e+004.8651355
GO:0000723telomere maintenance3.44e-021.00e+004.8391656
GO:0030097hemopoiesis3.44e-021.00e+004.8391156
GO:0000502proteasome complex3.56e-021.00e+004.78811758
GO:0019903protein phosphatase binding3.80e-021.00e+004.6921462
GO:0007059chromosome segregation3.80e-021.00e+004.6921462
GO:0006302double-strand break repair3.80e-021.00e+004.6921462
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest3.92e-021.00e+004.64611964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle3.98e-021.00e+004.62412265
GO:0006289nucleotide-excision repair4.17e-021.00e+004.55911168
GO:0034329cell junction assembly4.17e-021.00e+004.5591168
GO:0003697single-stranded DNA binding4.17e-021.00e+004.5591568
GO:0000777condensed chromosome kinetochore4.17e-021.00e+004.5591468
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.29e-021.00e+004.51712270
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent4.41e-021.00e+004.47612072
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis4.53e-021.00e+004.4371674
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.53e-021.00e+004.43712274
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process4.59e-021.00e+004.4171275
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I4.59e-021.00e+004.41712075
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process4.82e-021.00e+004.34212379
GO:0019083viral transcription4.94e-021.00e+004.30611081
GO:0047485protein N-terminus binding5.24e-021.00e+004.2201586
GO:0006415translational termination5.30e-021.00e+004.20311087
GO:0016605PML body5.36e-021.00e+004.1871388
GO:0016363nuclear matrix5.54e-021.00e+004.13811291
GO:0006928cellular component movement5.54e-021.00e+004.1381791
GO:0005200structural constituent of cytoskeleton5.54e-021.00e+004.1381891
GO:0071456cellular response to hypoxia5.60e-021.00e+004.1231692
GO:0002474antigen processing and presentation of peptide antigen via MHC class I5.60e-021.00e+004.12312192
GO:0006414translational elongation5.66e-021.00e+004.10711393
GO:0030426growth cone5.83e-021.00e+004.0611596
GO:0051726regulation of cell cycle5.89e-021.00e+004.0461597
GO:0010467gene expression6.23e-021.00e+002.260259669
GO:0006614SRP-dependent cotranslational protein targeting to membrane6.31e-021.00e+003.946110104
GO:0005938cell cortex6.31e-021.00e+003.94613104
GO:0014069postsynaptic density6.37e-021.00e+003.93213105
GO:0072562blood microparticle6.72e-021.00e+003.85213111
GO:0030529ribonucleoprotein complex6.78e-021.00e+003.83918112
GO:0005819spindle6.78e-021.00e+003.83917112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay6.89e-021.00e+003.813111114
GO:0019058viral life cycle6.95e-021.00e+003.801113115
GO:0000209protein polyubiquitination7.01e-021.00e+003.788120116
GO:0006325chromatin organization7.13e-021.00e+003.76415118
GO:0007219Notch signaling pathway7.25e-021.00e+003.73915120
GO:0006260DNA replication7.30e-021.00e+003.72719121
GO:0008201heparin binding7.36e-021.00e+003.71514122
GO:0030036actin cytoskeleton organization7.42e-021.00e+003.70415123
GO:0006511ubiquitin-dependent protein catabolic process7.60e-021.00e+003.66915126
GO:0016020membrane7.75e-021.00e+001.5163901681
GO:0000790nuclear chromatin7.77e-021.00e+003.63519129
GO:0006413translational initiation7.89e-021.00e+003.613117131
GO:0000086G2/M transition of mitotic cell cycle8.18e-021.00e+003.55919136
GO:0003735structural constituent of ribosome8.23e-021.00e+003.548110137
GO:0006457protein folding8.58e-021.00e+003.48617143
GO:0061024membrane organization8.69e-021.00e+003.46617145
GO:0001666response to hypoxia8.92e-021.00e+003.42715149
GO:0042981regulation of apoptotic process8.98e-021.00e+003.417124150
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding9.84e-021.00e+003.28017165
GO:0031965nuclear membrane1.00e-011.00e+003.25413168
GO:0034641cellular nitrogen compound metabolic process1.02e-011.00e+003.228120171
GO:0019904protein domain specific binding1.06e-011.00e+003.16216179
GO:0032403protein complex binding1.09e-011.00e+003.130110183
GO:0007067mitotic nuclear division1.33e-011.00e+002.820114227
GO:0006412translation1.35e-011.00e+002.801120230
GO:0043025neuronal cell body1.43e-011.00e+002.71019245
GO:0005874microtubule1.45e-011.00e+002.68617249
GO:0004842ubiquitin-protein transferase activity1.48e-011.00e+002.65216255
GO:0005743mitochondrial inner membrane1.60e-011.00e+002.53218277
GO:0019899enzyme binding1.60e-011.00e+002.532112277
GO:0005856cytoskeleton1.68e-011.00e+002.461112291
GO:0016567protein ubiquitination1.70e-011.00e+002.44215295
GO:0019901protein kinase binding1.81e-011.00e+002.338121317
GO:0007411axon guidance1.82e-011.00e+002.329113319
GO:0005737cytoplasm1.87e-011.00e+000.76741103767
GO:0007268synaptic transmission1.89e-011.00e+002.27116332
GO:0005925focal adhesion2.07e-011.00e+002.130119366
GO:0007155cell adhesion2.08e-011.00e+002.11916369
GO:0006508proteolysis2.13e-011.00e+002.08419378
GO:0045892negative regulation of transcription, DNA-templated2.30e-011.00e+001.956115413
GO:0043066negative regulation of apoptotic process2.36e-011.00e+001.918131424
GO:0007596blood coagulation2.51e-011.00e+001.816118455
GO:0005730nucleolus2.73e-011.00e+000.9662691641
GO:0048471perinuclear region of cytoplasm2.73e-011.00e+001.675113502
GO:0006915apoptotic process2.98e-011.00e+001.530133555
GO:0005634nucleus3.08e-011.00e+000.49241364559
GO:0042803protein homodimerization activity3.16e-011.00e+001.429112595
GO:0045087innate immune response3.16e-011.00e+001.427124596
GO:0005615extracellular space4.61e-011.00e+000.744117957
GO:0008270zinc ion binding4.75e-011.00e+000.685112997
GO:0005739mitochondrion4.76e-011.00e+000.683128998
GO:0044822poly(A) RNA binding4.96e-011.00e+000.6021491056
GO:0044281small molecule metabolic process5.46e-011.00e+000.4041581211
GO:0005524ATP binding5.72e-011.00e+000.3041601298
GO:0006351transcription, DNA-templated6.14e-011.00e+000.1481311446
GO:0005886plasma membrane8.31e-011.00e+00-0.6881452582