int-snw-7314

Statistics

Dataset Score p-value 1 p-value 2 p-value 3
wolf-screen-ratio-mammosphere-adherent 1.041 6.58e-20 1.93e-04 5.79e-03
wolf-screen-ratio-mammosphere-adherent-int-snw-7314 subnetwork

Genes (7)

Gene Symbol Entrez Gene ID Frequency wolf-screen-ratio-mammosphere-adherent gene score Best subnetwork score Degree wolf adherent-list Hits GI wolf mammosphere no adherent-list Hits GI
RPA2 6118 981.2501.15169Yes-
PSMD11 5717 1211.0951.106183Yes-
ACTB 60 1671.1531.151587Yes-
CASP8 841 80.8041.041141--
[ UBB ] 7314 20.4771.041147--
RBX1 9978 971.1851.151139Yes-
RPSA 3921 1561.3271.151152Yes-

Interactions (7)

Gene Symbol 1 Entrez Gene ID 1 Gene Symbol 2 Entrez Gene ID 2 Type Direction Origin databases / Sources
ACTB 60 UBB 7314 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
RPSA 3921 PSMD11 5717 pp -- int.I2D: IntAct_Yeast
CASP8 841 UBB 7314 pp -- int.Intact: MI:0220(ubiquitination reaction);
int.I2D: IntAct
ACTB 60 RPSA 3921 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct_Yeast, IntAct
ACTB 60 RBX1 9978 pp -- int.I2D: BioGrid_Yeast
ACTB 60 RPA2 6118 pp -- int.Intact: MI:0915(physical association);
int.I2D: IntAct
ACTB 60 PSMD11 5717 pp -- int.I2D: BioGrid_Yeast

Related GO terms (259)

Accession number Name Hypergeometric test Corrected p-value Enrichment ratio Occurrence in subnetwork Occurrences in all snw genes Occurrences in all int/reg genes
GO:0016032viral process1.35e-061.94e-024.270555534
GO:0000082G1/S transition of mitotic cell cycle3.67e-055.29e-015.375332149
GO:0005654nucleoplasm4.35e-056.28e-013.2515761082
GO:0070423nucleotide-binding oligomerization domain containing signaling pathway6.03e-058.69e-017.3652325
GO:0031625ubiquitin protein ligase binding6.24e-059.00e-015.118314178
GO:0061418regulation of transcription from RNA polymerase II promoter in response to hypoxia6.53e-059.41e-017.3082326
GO:0016071mRNA metabolic process1.22e-041.00e+004.793331223
GO:0005829cytosol1.59e-041.00e+002.30861322496
GO:0016070RNA metabolic process1.65e-041.00e+004.645332247
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway1.81e-041.00e+006.5822443
GO:0006281DNA repair1.94e-041.00e+004.566318261
GO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest4.01e-041.00e+006.00921964
GO:0051436negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.14e-041.00e+005.98622265
GO:0051437positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle4.80e-041.00e+005.87922270
GO:0070243regulation of thymocyte apoptotic process4.85e-041.00e+0011.009111
GO:0030690Noc1p-Noc2p complex4.85e-041.00e+0011.009111
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent5.08e-041.00e+005.83922072
GO:0051439regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle5.36e-041.00e+005.79922274
GO:0042590antigen processing and presentation of exogenous peptide antigen via MHC class I5.51e-041.00e+005.78022075
GO:0035666TRIF-dependent toll-like receptor signaling pathway5.66e-041.00e+005.7612376
GO:0002756MyD88-independent toll-like receptor signaling pathway5.96e-041.00e+005.7232378
GO:0034138toll-like receptor 3 signaling pathway6.11e-041.00e+005.7052379
GO:0031145anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process6.11e-041.00e+005.70522379
GO:0000278mitotic cell cycle6.38e-041.00e+003.983348391
GO:0002474antigen processing and presentation of peptide antigen via MHC class I8.28e-041.00e+005.48522192
GO:0071456cellular response to hypoxia8.28e-041.00e+005.4852692
GO:0034142toll-like receptor 4 signaling pathway9.01e-041.00e+005.4242396
GO:0006407rRNA export from nucleus9.70e-041.00e+0010.009112
GO:1902255positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator9.70e-041.00e+0010.009112
GO:0000461endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)9.70e-041.00e+0010.009112
GO:0097199cysteine-type endopeptidase activity involved in apoptotic signaling pathway9.70e-041.00e+0010.009112
GO:0005055laminin receptor activity9.70e-041.00e+0010.009112
GO:0002224toll-like receptor signaling pathway1.16e-031.00e+005.24123109
GO:0097190apoptotic signaling pathway1.25e-031.00e+005.18926113
GO:0019058viral life cycle1.29e-031.00e+005.163213115
GO:0000209protein polyubiquitination1.31e-031.00e+005.151220116
GO:0007219Notch signaling pathway1.40e-031.00e+005.10225120
GO:0036462TRAIL-activated apoptotic signaling pathway1.46e-031.00e+009.424113
GO:0060715syncytiotrophoblast cell differentiation involved in labyrinthine layer development1.46e-031.00e+009.424113
GO:0006915apoptotic process1.77e-031.00e+003.477333555
GO:0000447endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)1.94e-031.00e+009.009114
GO:003068690S preribosome1.94e-031.00e+009.009114
GO:0097153cysteine-type endopeptidase activity involved in apoptotic process1.94e-031.00e+009.009114
GO:0019788NEDD8 ligase activity1.94e-031.00e+009.009114
GO:0035877death effector domain binding1.94e-031.00e+009.009114
GO:0031467Cul7-RING ubiquitin ligase complex1.94e-031.00e+009.009114
GO:0061024membrane organization2.04e-031.00e+004.82927145
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling2.04e-031.00e+004.82924145
GO:0045087innate immune response2.17e-031.00e+003.375324596
GO:0042981regulation of apoptotic process2.18e-031.00e+004.780224150
GO:0005515protein binding2.21e-031.00e+001.26071846024
GO:0043005neuron projection2.39e-031.00e+004.71426157
GO:0031465Cul4B-RING E3 ubiquitin ligase complex2.42e-031.00e+008.687135
GO:2000001regulation of DNA damage checkpoint2.42e-031.00e+008.687115
GO:0031461cullin-RING ubiquitin ligase complex2.42e-031.00e+008.687115
GO:0043248proteasome assembly2.42e-031.00e+008.687115
GO:0030891VCB complex2.42e-031.00e+008.687125
GO:0000730DNA recombinase assembly2.42e-031.00e+008.687115
GO:0032025response to cobalt ion2.42e-031.00e+008.687115
GO:0031466Cul5-RING ubiquitin ligase complex2.91e-031.00e+008.424116
GO:0031265CD95 death-inducing signaling complex2.91e-031.00e+008.424116
GO:0030957Tat protein binding2.91e-031.00e+008.424136
GO:0031264death-inducing signaling complex2.91e-031.00e+008.424116
GO:0010467gene expression3.02e-031.00e+003.208359669
GO:0032403protein complex binding3.22e-031.00e+004.493210183
GO:0060546negative regulation of necroptotic process3.39e-031.00e+008.201117
GO:0000028ribosomal small subunit assembly3.39e-031.00e+008.201117
GO:0031462Cul2-RING ubiquitin ligase complex3.39e-031.00e+008.201127
GO:0097342ripoptosome3.39e-031.00e+008.201117
GO:0031464Cul4A-RING E3 ubiquitin ligase complex3.88e-031.00e+008.009128
GO:0097202activation of cysteine-type endopeptidase activity3.88e-031.00e+008.009118
GO:0070688MLL5-L complex3.88e-031.00e+008.009118
GO:0045116protein neddylation3.88e-031.00e+008.009128
GO:0097284hepatocyte apoptotic process4.36e-031.00e+007.839139
GO:0047497mitochondrion transport along microtubule4.36e-031.00e+007.839139
GO:0010569regulation of double-strand break repair via homologous recombination4.84e-031.00e+007.6871110
GO:0001841neural tube formation4.84e-031.00e+007.6871110
GO:2001239regulation of extrinsic apoptotic signaling pathway in absence of ligand5.33e-031.00e+007.5491111
GO:0031571mitotic G1 DNA damage checkpoint5.33e-031.00e+007.5491411
GO:0045651positive regulation of macrophage differentiation5.33e-031.00e+007.5491111
GO:0061136regulation of proteasomal protein catabolic process5.81e-031.00e+007.4241212
GO:0005838proteasome regulatory particle5.81e-031.00e+007.4241712
GO:1901214regulation of neuron death5.81e-031.00e+007.4241112
GO:0019082viral protein processing5.81e-031.00e+007.4241112
GO:0032479regulation of type I interferon production6.29e-031.00e+007.3081113
GO:0005662DNA replication factor A complex6.29e-031.00e+007.3081113
GO:0035267NuA4 histone acetyltransferase complex6.78e-031.00e+007.2011414
GO:0030225macrophage differentiation7.26e-031.00e+007.1021115
GO:0005123death receptor binding7.26e-031.00e+007.1021115
GO:0030101natural killer cell activation7.74e-031.00e+007.0091116
GO:0051603proteolysis involved in cellular protein catabolic process7.74e-031.00e+007.0091216
GO:0050998nitric-oxide synthase binding7.74e-031.00e+007.0091116
GO:0005856cytoskeleton7.97e-031.00e+003.824212291
GO:0075733intracellular transport of virus8.22e-031.00e+006.9211317
GO:0019068virion assembly8.22e-031.00e+006.9211117
GO:0022624proteasome accessory complex8.22e-031.00e+006.9211817
GO:0035861site of double-strand break8.71e-031.00e+006.8391118
GO:0031146SCF-dependent proteasomal ubiquitin-dependent protein catabolic process9.19e-031.00e+006.7611119
GO:0048863stem cell differentiation9.19e-031.00e+006.7611119
GO:0097194execution phase of apoptosis9.19e-031.00e+006.7611119
GO:0051881regulation of mitochondrial membrane potential9.67e-031.00e+006.6871220
GO:0006298mismatch repair9.67e-031.00e+006.6871320
GO:0045862positive regulation of proteolysis1.01e-021.00e+006.6161121
GO:0000718nucleotide-excision repair, DNA damage removal1.01e-021.00e+006.6161421
GO:0032201telomere maintenance via semi-conservative replication1.01e-021.00e+006.6161521
GO:0007220Notch receptor processing1.06e-021.00e+006.5491122
GO:0006297nucleotide-excision repair, DNA gap filling1.06e-021.00e+006.5491322
GO:0030863cortical cytoskeleton1.06e-021.00e+006.5491122
GO:0036464cytoplasmic ribonucleoprotein granule1.06e-021.00e+006.5491422
GO:0031463Cul3-RING ubiquitin ligase complex1.11e-021.00e+006.4851323
GO:0043236laminin binding1.11e-021.00e+006.4851123
GO:0006513protein monoubiquitination1.11e-021.00e+006.4851123
GO:0043044ATP-dependent chromatin remodeling1.11e-021.00e+006.4851423
GO:0000722telomere maintenance via recombination1.21e-021.00e+006.3651525
GO:0042113B cell activation1.21e-021.00e+006.3651225
GO:0005978glycogen biosynthetic process1.26e-021.00e+006.3081126
GO:1900740positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway1.26e-021.00e+006.3081426
GO:0009409response to cold1.26e-021.00e+006.3081226
GO:0034612response to tumor necrosis factor1.30e-021.00e+006.2541227
GO:0043022ribosome binding1.30e-021.00e+006.2541327
GO:2001238positive regulation of extrinsic apoptotic signaling pathway1.30e-021.00e+006.2541227
GO:0031492nucleosomal DNA binding1.30e-021.00e+006.2541427
GO:0019894kinesin binding1.35e-021.00e+006.2011128
GO:0019005SCF ubiquitin ligase complex1.40e-021.00e+006.1511129
GO:0006271DNA strand elongation involved in DNA replication1.45e-021.00e+006.1021730
GO:0005164tumor necrosis factor receptor binding1.45e-021.00e+006.1021230
GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling1.45e-021.00e+006.1021130
GO:0046677response to antibiotic1.50e-021.00e+006.0551231
GO:0048812neuron projection morphogenesis1.50e-021.00e+006.0551131
GO:0032480negative regulation of type I interferon production1.54e-021.00e+006.0091132
GO:0097110scaffold protein binding1.64e-021.00e+005.9211334
GO:0043066negative regulation of apoptotic process1.64e-021.00e+003.281231424
GO:0001895retina homeostasis1.64e-021.00e+005.9211134
GO:0008625extrinsic apoptotic signaling pathway via death domain receptors1.64e-021.00e+005.9211234
GO:0034332adherens junction organization1.73e-021.00e+005.8391136
GO:0042059negative regulation of epidermal growth factor receptor signaling pathway1.73e-021.00e+005.8391436
GO:0070062extracellular vesicular exosome1.75e-021.00e+001.78041042400
GO:0008234cysteine-type peptidase activity1.78e-021.00e+005.7991337
GO:0051084'de novo' posttranslational protein folding1.78e-021.00e+005.7991437
GO:0006284base-excision repair1.78e-021.00e+005.7991337
GO:0097191extrinsic apoptotic signaling pathway1.83e-021.00e+005.7611338
GO:0071407cellular response to organic cyclic compound1.83e-021.00e+005.7611238
GO:0070527platelet aggregation1.83e-021.00e+005.7611238
GO:0000781chromosome, telomeric region1.88e-021.00e+005.7231339
GO:0022627cytosolic small ribosomal subunit1.88e-021.00e+005.7231439
GO:0007249I-kappaB kinase/NF-kappaB signaling1.97e-021.00e+005.6511241
GO:0042110T cell activation2.02e-021.00e+005.6161342
GO:0044267cellular protein metabolic process2.03e-021.00e+003.120229474
GO:0021762substantia nigra development2.12e-021.00e+005.5491244
GO:0044297cell body2.21e-021.00e+005.4851246
GO:0006283transcription-coupled nucleotide-excision repair2.21e-021.00e+005.4851746
GO:0006921cellular component disassembly involved in execution phase of apoptosis2.26e-021.00e+005.4541547
GO:0007254JNK cascade2.35e-021.00e+005.3941349
GO:0003684damaged DNA binding2.35e-021.00e+005.3941749
GO:0006521regulation of cellular amino acid metabolic process2.40e-021.00e+005.36511750
GO:0004197cysteine-type endopeptidase activity2.40e-021.00e+005.3651350
GO:0030666endocytic vesicle membrane2.54e-021.00e+005.2811453
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding2.54e-021.00e+005.2811553
GO:0008233peptidase activity2.59e-021.00e+005.2541254
GO:0045216cell-cell junction organization2.59e-021.00e+005.2541254
GO:0051403stress-activated MAPK cascade2.59e-021.00e+005.2541254
GO:0097193intrinsic apoptotic signaling pathway2.64e-021.00e+005.2271655
GO:0000724double-strand break repair via homologous recombination2.64e-021.00e+005.2271355
GO:0051291protein heterooligomerization2.69e-021.00e+005.2011256
GO:0000723telomere maintenance2.69e-021.00e+005.2011656
GO:0016197endosomal transport2.73e-021.00e+005.1761157
GO:0000502proteasome complex2.78e-021.00e+005.15111758
GO:0032481positive regulation of type I interferon production2.92e-021.00e+005.0781661
GO:0030512negative regulation of transforming growth factor beta receptor signaling pathway2.92e-021.00e+005.0781261
GO:0006302double-strand break repair2.97e-021.00e+005.0551462
GO:0019903protein phosphatase binding2.97e-021.00e+005.0551462
GO:0071260cellular response to mechanical stimulus3.11e-021.00e+004.9861565
GO:0034166toll-like receptor 10 signaling pathway3.11e-021.00e+004.9861265
GO:0034146toll-like receptor 5 signaling pathway3.11e-021.00e+004.9861265
GO:0006289nucleotide-excision repair3.25e-021.00e+004.92111168
GO:0003697single-stranded DNA binding3.25e-021.00e+004.9211568
GO:0034329cell junction assembly3.25e-021.00e+004.9211168
GO:0038123toll-like receptor TLR1:TLR2 signaling pathway3.40e-021.00e+004.8591271
GO:0032355response to estradiol3.40e-021.00e+004.8591571
GO:0038124toll-like receptor TLR6:TLR2 signaling pathway3.40e-021.00e+004.8591271
GO:0034162toll-like receptor 9 signaling pathway3.44e-021.00e+004.8391272
GO:0034134toll-like receptor 2 signaling pathway3.49e-021.00e+004.8191273
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosis3.54e-021.00e+004.7991674
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process3.58e-021.00e+004.7801275
GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process3.68e-021.00e+004.7421777
GO:0002755MyD88-dependent toll-like receptor signaling pathway3.82e-021.00e+004.6871380
GO:0016020membrane3.85e-021.00e+001.8793901681
GO:0019083viral transcription3.87e-021.00e+004.66911081
GO:0050852T cell receptor signaling pathway4.05e-021.00e+004.5991485
GO:0047485protein N-terminus binding4.10e-021.00e+004.5821586
GO:0045471response to ethanol4.10e-021.00e+004.5821386
GO:0006415translational termination4.15e-021.00e+004.56611087
GO:0016605PML body4.19e-021.00e+004.5491388
GO:0000187activation of MAPK activity4.29e-021.00e+004.5171590
GO:0006928cellular component movement4.33e-021.00e+004.5011791
GO:0005200structural constituent of cytoskeleton4.33e-021.00e+004.5011891
GO:0006414translational elongation4.43e-021.00e+004.47011393
GO:0006614SRP-dependent cotranslational protein targeting to membrane4.94e-021.00e+004.308110104
GO:0014069postsynaptic density4.99e-021.00e+004.29413105
GO:0005741mitochondrial outer membrane4.99e-021.00e+004.29417105
GO:0005815microtubule organizing center5.17e-021.00e+004.24115109
GO:0072562blood microparticle5.27e-021.00e+004.21413111
GO:0030529ribonucleoprotein complex5.31e-021.00e+004.20118112
GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay5.40e-021.00e+004.176111114
GO:0006006glucose metabolic process5.59e-021.00e+004.12617118
GO:0006325chromatin organization5.59e-021.00e+004.12615118
GO:0032496response to lipopolysaccharide5.73e-021.00e+004.09014121
GO:0006260DNA replication5.73e-021.00e+004.09019121
GO:0051092positive regulation of NF-kappaB transcription factor activity5.87e-021.00e+004.05514124
GO:0006511ubiquitin-dependent protein catabolic process5.96e-021.00e+004.03115126
GO:0007179transforming growth factor beta receptor signaling pathway6.05e-021.00e+004.00914128
GO:0000790nuclear chromatin6.10e-021.00e+003.99819129
GO:0006413translational initiation6.19e-021.00e+003.975117131
GO:0000086G2/M transition of mitotic cell cycle6.42e-021.00e+003.92119136
GO:0003735structural constituent of ribosome6.46e-021.00e+003.911110137
GO:0007507heart development6.56e-021.00e+003.89017139
GO:0006457protein folding6.74e-021.00e+003.84917143
GO:0034220ion transmembrane transport7.01e-021.00e+003.79014149
GO:0010008endosome membrane7.10e-021.00e+003.77017151
GO:0045121membrane raft7.33e-021.00e+003.72318156
GO:0008543fibroblast growth factor receptor signaling pathway7.33e-021.00e+003.72319156
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA binding7.74e-021.00e+003.64217165
GO:0030424axon7.79e-021.00e+003.63414166
GO:0038095Fc-epsilon receptor signaling pathway7.88e-021.00e+003.616112168
GO:0005739mitochondrion7.96e-021.00e+002.046228998
GO:0034641cellular nitrogen compound metabolic process8.01e-021.00e+003.591120171
GO:0006367transcription initiation from RNA polymerase II promoter8.60e-021.00e+003.48518184
GO:0007173epidermal growth factor receptor signaling pathway8.82e-021.00e+003.446112189
GO:0001525angiogenesis8.91e-021.00e+003.43114191
GO:0019221cytokine-mediated signaling pathway1.02e-011.00e+003.22119221
GO:0006412translation1.06e-011.00e+003.163120230
GO:0044281small molecule metabolic process1.11e-011.00e+001.7672581211
GO:0043025neuronal cell body1.13e-011.00e+003.07219245
GO:0005975carbohydrate metabolic process1.17e-011.00e+003.02619253
GO:0004842ubiquitin-protein transferase activity1.17e-011.00e+003.01416255
GO:0048011neurotrophin TRK receptor signaling pathway1.23e-011.00e+002.937115269
GO:0043065positive regulation of apoptotic process1.23e-011.00e+002.943110268
GO:0019899enzyme binding1.27e-011.00e+002.895112277
GO:0016567protein ubiquitination1.35e-011.00e+002.80415295
GO:0043234protein complex1.35e-011.00e+002.804118295
GO:0019901protein kinase binding1.44e-011.00e+002.700121317
GO:0007411axon guidance1.45e-011.00e+002.691113319
GO:0005634nucleus1.48e-011.00e+000.85441364559
GO:0005925focal adhesion1.65e-011.00e+002.493119366
GO:0007155cell adhesion1.66e-011.00e+002.48116369
GO:0006508proteolysis1.70e-011.00e+002.44619378
GO:0046982protein heterodimerization activity1.71e-011.00e+002.439113380
GO:0005730nucleolus1.85e-011.00e+001.3282691641
GO:0055085transmembrane transport1.93e-011.00e+002.244110435
GO:0007596blood coagulation2.01e-011.00e+002.179118455
GO:0000122negative regulation of transcription from RNA polymerase II promoter2.46e-011.00e+001.854116570
GO:0005737cytoplasm2.67e-011.00e+000.71431103767
GO:0045944positive regulation of transcription from RNA polymerase II promoter3.26e-011.00e+001.385119789
GO:0005886plasma membrane3.65e-011.00e+000.6742452582
GO:0005615extracellular space3.82e-011.00e+001.106117957
GO:0008270zinc ion binding3.94e-011.00e+001.047112997
GO:0044822poly(A) RNA binding4.13e-011.00e+000.9641491056
GO:0005524ATP binding4.83e-011.00e+000.6671601298
GO:0006351transcription, DNA-templated5.23e-011.00e+000.5111311446