Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 1.041 | 6.58e-20 | 1.93e-04 | 5.79e-03 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
CASP8 | 841 | 8 | 0.804 | 1.041 | 141 | - | - |
[ UBB ] | 7314 | 2 | 0.477 | 1.041 | 147 | - | - |
RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
ACTB | 60 | UBB | 7314 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
CASP8 | 841 | UBB | 7314 | pp | -- | int.Intact: MI:0220(ubiquitination reaction); int.I2D: IntAct |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0016032 | viral process | 1.35e-06 | 1.94e-02 | 4.270 | 5 | 55 | 534 |
GO:0000082 | G1/S transition of mitotic cell cycle | 3.67e-05 | 5.29e-01 | 5.375 | 3 | 32 | 149 |
GO:0005654 | nucleoplasm | 4.35e-05 | 6.28e-01 | 3.251 | 5 | 76 | 1082 |
GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 6.03e-05 | 8.69e-01 | 7.365 | 2 | 3 | 25 |
GO:0031625 | ubiquitin protein ligase binding | 6.24e-05 | 9.00e-01 | 5.118 | 3 | 14 | 178 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 6.53e-05 | 9.41e-01 | 7.308 | 2 | 3 | 26 |
GO:0016071 | mRNA metabolic process | 1.22e-04 | 1.00e+00 | 4.793 | 3 | 31 | 223 |
GO:0005829 | cytosol | 1.59e-04 | 1.00e+00 | 2.308 | 6 | 132 | 2496 |
GO:0016070 | RNA metabolic process | 1.65e-04 | 1.00e+00 | 4.645 | 3 | 32 | 247 |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 1.81e-04 | 1.00e+00 | 6.582 | 2 | 4 | 43 |
GO:0006281 | DNA repair | 1.94e-04 | 1.00e+00 | 4.566 | 3 | 18 | 261 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 4.01e-04 | 1.00e+00 | 6.009 | 2 | 19 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 4.14e-04 | 1.00e+00 | 5.986 | 2 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 4.80e-04 | 1.00e+00 | 5.879 | 2 | 22 | 70 |
GO:0070243 | regulation of thymocyte apoptotic process | 4.85e-04 | 1.00e+00 | 11.009 | 1 | 1 | 1 |
GO:0030690 | Noc1p-Noc2p complex | 4.85e-04 | 1.00e+00 | 11.009 | 1 | 1 | 1 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 5.08e-04 | 1.00e+00 | 5.839 | 2 | 20 | 72 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 5.36e-04 | 1.00e+00 | 5.799 | 2 | 22 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 5.51e-04 | 1.00e+00 | 5.780 | 2 | 20 | 75 |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 5.66e-04 | 1.00e+00 | 5.761 | 2 | 3 | 76 |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 5.96e-04 | 1.00e+00 | 5.723 | 2 | 3 | 78 |
GO:0034138 | toll-like receptor 3 signaling pathway | 6.11e-04 | 1.00e+00 | 5.705 | 2 | 3 | 79 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 6.11e-04 | 1.00e+00 | 5.705 | 2 | 23 | 79 |
GO:0000278 | mitotic cell cycle | 6.38e-04 | 1.00e+00 | 3.983 | 3 | 48 | 391 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 8.28e-04 | 1.00e+00 | 5.485 | 2 | 21 | 92 |
GO:0071456 | cellular response to hypoxia | 8.28e-04 | 1.00e+00 | 5.485 | 2 | 6 | 92 |
GO:0034142 | toll-like receptor 4 signaling pathway | 9.01e-04 | 1.00e+00 | 5.424 | 2 | 3 | 96 |
GO:0006407 | rRNA export from nucleus | 9.70e-04 | 1.00e+00 | 10.009 | 1 | 1 | 2 |
GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator | 9.70e-04 | 1.00e+00 | 10.009 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 9.70e-04 | 1.00e+00 | 10.009 | 1 | 1 | 2 |
GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 9.70e-04 | 1.00e+00 | 10.009 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 9.70e-04 | 1.00e+00 | 10.009 | 1 | 1 | 2 |
GO:0002224 | toll-like receptor signaling pathway | 1.16e-03 | 1.00e+00 | 5.241 | 2 | 3 | 109 |
GO:0097190 | apoptotic signaling pathway | 1.25e-03 | 1.00e+00 | 5.189 | 2 | 6 | 113 |
GO:0019058 | viral life cycle | 1.29e-03 | 1.00e+00 | 5.163 | 2 | 13 | 115 |
GO:0000209 | protein polyubiquitination | 1.31e-03 | 1.00e+00 | 5.151 | 2 | 20 | 116 |
GO:0007219 | Notch signaling pathway | 1.40e-03 | 1.00e+00 | 5.102 | 2 | 5 | 120 |
GO:0036462 | TRAIL-activated apoptotic signaling pathway | 1.46e-03 | 1.00e+00 | 9.424 | 1 | 1 | 3 |
GO:0060715 | syncytiotrophoblast cell differentiation involved in labyrinthine layer development | 1.46e-03 | 1.00e+00 | 9.424 | 1 | 1 | 3 |
GO:0006915 | apoptotic process | 1.77e-03 | 1.00e+00 | 3.477 | 3 | 33 | 555 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0035877 | death effector domain binding | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 1.94e-03 | 1.00e+00 | 9.009 | 1 | 1 | 4 |
GO:0061024 | membrane organization | 2.04e-03 | 1.00e+00 | 4.829 | 2 | 7 | 145 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 2.04e-03 | 1.00e+00 | 4.829 | 2 | 4 | 145 |
GO:0045087 | innate immune response | 2.17e-03 | 1.00e+00 | 3.375 | 3 | 24 | 596 |
GO:0042981 | regulation of apoptotic process | 2.18e-03 | 1.00e+00 | 4.780 | 2 | 24 | 150 |
GO:0005515 | protein binding | 2.21e-03 | 1.00e+00 | 1.260 | 7 | 184 | 6024 |
GO:0043005 | neuron projection | 2.39e-03 | 1.00e+00 | 4.714 | 2 | 6 | 157 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 3 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 1 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 2 | 5 |
GO:0000730 | DNA recombinase assembly | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 1 | 5 |
GO:0032025 | response to cobalt ion | 2.42e-03 | 1.00e+00 | 8.687 | 1 | 1 | 5 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 6 |
GO:0031265 | CD95 death-inducing signaling complex | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 3 | 6 |
GO:0031264 | death-inducing signaling complex | 2.91e-03 | 1.00e+00 | 8.424 | 1 | 1 | 6 |
GO:0010467 | gene expression | 3.02e-03 | 1.00e+00 | 3.208 | 3 | 59 | 669 |
GO:0032403 | protein complex binding | 3.22e-03 | 1.00e+00 | 4.493 | 2 | 10 | 183 |
GO:0060546 | negative regulation of necroptotic process | 3.39e-03 | 1.00e+00 | 8.201 | 1 | 1 | 7 |
GO:0000028 | ribosomal small subunit assembly | 3.39e-03 | 1.00e+00 | 8.201 | 1 | 1 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 3.39e-03 | 1.00e+00 | 8.201 | 1 | 2 | 7 |
GO:0097342 | ripoptosome | 3.39e-03 | 1.00e+00 | 8.201 | 1 | 1 | 7 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 2 | 8 |
GO:0097202 | activation of cysteine-type endopeptidase activity | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 3.88e-03 | 1.00e+00 | 8.009 | 1 | 2 | 8 |
GO:0097284 | hepatocyte apoptotic process | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 3 | 9 |
GO:0047497 | mitochondrion transport along microtubule | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 3 | 9 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 10 |
GO:0001841 | neural tube formation | 4.84e-03 | 1.00e+00 | 7.687 | 1 | 1 | 10 |
GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | 5.33e-03 | 1.00e+00 | 7.549 | 1 | 1 | 11 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 5.33e-03 | 1.00e+00 | 7.549 | 1 | 4 | 11 |
GO:0045651 | positive regulation of macrophage differentiation | 5.33e-03 | 1.00e+00 | 7.549 | 1 | 1 | 11 |
GO:0061136 | regulation of proteasomal protein catabolic process | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 2 | 12 |
GO:0005838 | proteasome regulatory particle | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 7 | 12 |
GO:1901214 | regulation of neuron death | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 12 |
GO:0019082 | viral protein processing | 5.81e-03 | 1.00e+00 | 7.424 | 1 | 1 | 12 |
GO:0032479 | regulation of type I interferon production | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 13 |
GO:0005662 | DNA replication factor A complex | 6.29e-03 | 1.00e+00 | 7.308 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 6.78e-03 | 1.00e+00 | 7.201 | 1 | 4 | 14 |
GO:0030225 | macrophage differentiation | 7.26e-03 | 1.00e+00 | 7.102 | 1 | 1 | 15 |
GO:0005123 | death receptor binding | 7.26e-03 | 1.00e+00 | 7.102 | 1 | 1 | 15 |
GO:0030101 | natural killer cell activation | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 16 |
GO:0051603 | proteolysis involved in cellular protein catabolic process | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 2 | 16 |
GO:0050998 | nitric-oxide synthase binding | 7.74e-03 | 1.00e+00 | 7.009 | 1 | 1 | 16 |
GO:0005856 | cytoskeleton | 7.97e-03 | 1.00e+00 | 3.824 | 2 | 12 | 291 |
GO:0075733 | intracellular transport of virus | 8.22e-03 | 1.00e+00 | 6.921 | 1 | 3 | 17 |
GO:0019068 | virion assembly | 8.22e-03 | 1.00e+00 | 6.921 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 8.22e-03 | 1.00e+00 | 6.921 | 1 | 8 | 17 |
GO:0035861 | site of double-strand break | 8.71e-03 | 1.00e+00 | 6.839 | 1 | 1 | 18 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 19 |
GO:0097194 | execution phase of apoptosis | 9.19e-03 | 1.00e+00 | 6.761 | 1 | 1 | 19 |
GO:0051881 | regulation of mitochondrial membrane potential | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 2 | 20 |
GO:0006298 | mismatch repair | 9.67e-03 | 1.00e+00 | 6.687 | 1 | 3 | 20 |
GO:0045862 | positive regulation of proteolysis | 1.01e-02 | 1.00e+00 | 6.616 | 1 | 1 | 21 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 1.01e-02 | 1.00e+00 | 6.616 | 1 | 4 | 21 |
GO:0032201 | telomere maintenance via semi-conservative replication | 1.01e-02 | 1.00e+00 | 6.616 | 1 | 5 | 21 |
GO:0007220 | Notch receptor processing | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 1 | 22 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 3 | 22 |
GO:0030863 | cortical cytoskeleton | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.06e-02 | 1.00e+00 | 6.549 | 1 | 4 | 22 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 1.11e-02 | 1.00e+00 | 6.485 | 1 | 3 | 23 |
GO:0043236 | laminin binding | 1.11e-02 | 1.00e+00 | 6.485 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 1.11e-02 | 1.00e+00 | 6.485 | 1 | 1 | 23 |
GO:0043044 | ATP-dependent chromatin remodeling | 1.11e-02 | 1.00e+00 | 6.485 | 1 | 4 | 23 |
GO:0000722 | telomere maintenance via recombination | 1.21e-02 | 1.00e+00 | 6.365 | 1 | 5 | 25 |
GO:0042113 | B cell activation | 1.21e-02 | 1.00e+00 | 6.365 | 1 | 2 | 25 |
GO:0005978 | glycogen biosynthetic process | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 1 | 26 |
GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 4 | 26 |
GO:0009409 | response to cold | 1.26e-02 | 1.00e+00 | 6.308 | 1 | 2 | 26 |
GO:0034612 | response to tumor necrosis factor | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 2 | 27 |
GO:0043022 | ribosome binding | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 3 | 27 |
GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 2 | 27 |
GO:0031492 | nucleosomal DNA binding | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 4 | 27 |
GO:0019894 | kinesin binding | 1.35e-02 | 1.00e+00 | 6.201 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 1.40e-02 | 1.00e+00 | 6.151 | 1 | 1 | 29 |
GO:0006271 | DNA strand elongation involved in DNA replication | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 7 | 30 |
GO:0005164 | tumor necrosis factor receptor binding | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 2 | 30 |
GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 1.45e-02 | 1.00e+00 | 6.102 | 1 | 1 | 30 |
GO:0046677 | response to antibiotic | 1.50e-02 | 1.00e+00 | 6.055 | 1 | 2 | 31 |
GO:0048812 | neuron projection morphogenesis | 1.50e-02 | 1.00e+00 | 6.055 | 1 | 1 | 31 |
GO:0032480 | negative regulation of type I interferon production | 1.54e-02 | 1.00e+00 | 6.009 | 1 | 1 | 32 |
GO:0097110 | scaffold protein binding | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 3 | 34 |
GO:0043066 | negative regulation of apoptotic process | 1.64e-02 | 1.00e+00 | 3.281 | 2 | 31 | 424 |
GO:0001895 | retina homeostasis | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 1 | 34 |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 1.64e-02 | 1.00e+00 | 5.921 | 1 | 2 | 34 |
GO:0034332 | adherens junction organization | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 1 | 36 |
GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 4 | 36 |
GO:0070062 | extracellular vesicular exosome | 1.75e-02 | 1.00e+00 | 1.780 | 4 | 104 | 2400 |
GO:0008234 | cysteine-type peptidase activity | 1.78e-02 | 1.00e+00 | 5.799 | 1 | 3 | 37 |
GO:0051084 | 'de novo' posttranslational protein folding | 1.78e-02 | 1.00e+00 | 5.799 | 1 | 4 | 37 |
GO:0006284 | base-excision repair | 1.78e-02 | 1.00e+00 | 5.799 | 1 | 3 | 37 |
GO:0097191 | extrinsic apoptotic signaling pathway | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 3 | 38 |
GO:0071407 | cellular response to organic cyclic compound | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 2 | 38 |
GO:0070527 | platelet aggregation | 1.83e-02 | 1.00e+00 | 5.761 | 1 | 2 | 38 |
GO:0000781 | chromosome, telomeric region | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 3 | 39 |
GO:0022627 | cytosolic small ribosomal subunit | 1.88e-02 | 1.00e+00 | 5.723 | 1 | 4 | 39 |
GO:0007249 | I-kappaB kinase/NF-kappaB signaling | 1.97e-02 | 1.00e+00 | 5.651 | 1 | 2 | 41 |
GO:0042110 | T cell activation | 2.02e-02 | 1.00e+00 | 5.616 | 1 | 3 | 42 |
GO:0044267 | cellular protein metabolic process | 2.03e-02 | 1.00e+00 | 3.120 | 2 | 29 | 474 |
GO:0021762 | substantia nigra development | 2.12e-02 | 1.00e+00 | 5.549 | 1 | 2 | 44 |
GO:0044297 | cell body | 2.21e-02 | 1.00e+00 | 5.485 | 1 | 2 | 46 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 2.21e-02 | 1.00e+00 | 5.485 | 1 | 7 | 46 |
GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 2.26e-02 | 1.00e+00 | 5.454 | 1 | 5 | 47 |
GO:0007254 | JNK cascade | 2.35e-02 | 1.00e+00 | 5.394 | 1 | 3 | 49 |
GO:0003684 | damaged DNA binding | 2.35e-02 | 1.00e+00 | 5.394 | 1 | 7 | 49 |
GO:0006521 | regulation of cellular amino acid metabolic process | 2.40e-02 | 1.00e+00 | 5.365 | 1 | 17 | 50 |
GO:0004197 | cysteine-type endopeptidase activity | 2.40e-02 | 1.00e+00 | 5.365 | 1 | 3 | 50 |
GO:0030666 | endocytic vesicle membrane | 2.54e-02 | 1.00e+00 | 5.281 | 1 | 4 | 53 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 2.54e-02 | 1.00e+00 | 5.281 | 1 | 5 | 53 |
GO:0008233 | peptidase activity | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 2 | 54 |
GO:0045216 | cell-cell junction organization | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 2 | 54 |
GO:0051403 | stress-activated MAPK cascade | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 2 | 54 |
GO:0097193 | intrinsic apoptotic signaling pathway | 2.64e-02 | 1.00e+00 | 5.227 | 1 | 6 | 55 |
GO:0000724 | double-strand break repair via homologous recombination | 2.64e-02 | 1.00e+00 | 5.227 | 1 | 3 | 55 |
GO:0051291 | protein heterooligomerization | 2.69e-02 | 1.00e+00 | 5.201 | 1 | 2 | 56 |
GO:0000723 | telomere maintenance | 2.69e-02 | 1.00e+00 | 5.201 | 1 | 6 | 56 |
GO:0016197 | endosomal transport | 2.73e-02 | 1.00e+00 | 5.176 | 1 | 1 | 57 |
GO:0000502 | proteasome complex | 2.78e-02 | 1.00e+00 | 5.151 | 1 | 17 | 58 |
GO:0032481 | positive regulation of type I interferon production | 2.92e-02 | 1.00e+00 | 5.078 | 1 | 6 | 61 |
GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway | 2.92e-02 | 1.00e+00 | 5.078 | 1 | 2 | 61 |
GO:0006302 | double-strand break repair | 2.97e-02 | 1.00e+00 | 5.055 | 1 | 4 | 62 |
GO:0019903 | protein phosphatase binding | 2.97e-02 | 1.00e+00 | 5.055 | 1 | 4 | 62 |
GO:0071260 | cellular response to mechanical stimulus | 3.11e-02 | 1.00e+00 | 4.986 | 1 | 5 | 65 |
GO:0034166 | toll-like receptor 10 signaling pathway | 3.11e-02 | 1.00e+00 | 4.986 | 1 | 2 | 65 |
GO:0034146 | toll-like receptor 5 signaling pathway | 3.11e-02 | 1.00e+00 | 4.986 | 1 | 2 | 65 |
GO:0006289 | nucleotide-excision repair | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 11 | 68 |
GO:0003697 | single-stranded DNA binding | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 5 | 68 |
GO:0034329 | cell junction assembly | 3.25e-02 | 1.00e+00 | 4.921 | 1 | 1 | 68 |
GO:0038123 | toll-like receptor TLR1:TLR2 signaling pathway | 3.40e-02 | 1.00e+00 | 4.859 | 1 | 2 | 71 |
GO:0032355 | response to estradiol | 3.40e-02 | 1.00e+00 | 4.859 | 1 | 5 | 71 |
GO:0038124 | toll-like receptor TLR6:TLR2 signaling pathway | 3.40e-02 | 1.00e+00 | 4.859 | 1 | 2 | 71 |
GO:0034162 | toll-like receptor 9 signaling pathway | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 2 | 72 |
GO:0034134 | toll-like receptor 2 signaling pathway | 3.49e-02 | 1.00e+00 | 4.819 | 1 | 2 | 73 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 3.54e-02 | 1.00e+00 | 4.799 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 3.58e-02 | 1.00e+00 | 4.780 | 1 | 2 | 75 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 3.68e-02 | 1.00e+00 | 4.742 | 1 | 7 | 77 |
GO:0002755 | MyD88-dependent toll-like receptor signaling pathway | 3.82e-02 | 1.00e+00 | 4.687 | 1 | 3 | 80 |
GO:0016020 | membrane | 3.85e-02 | 1.00e+00 | 1.879 | 3 | 90 | 1681 |
GO:0019083 | viral transcription | 3.87e-02 | 1.00e+00 | 4.669 | 1 | 10 | 81 |
GO:0050852 | T cell receptor signaling pathway | 4.05e-02 | 1.00e+00 | 4.599 | 1 | 4 | 85 |
GO:0047485 | protein N-terminus binding | 4.10e-02 | 1.00e+00 | 4.582 | 1 | 5 | 86 |
GO:0045471 | response to ethanol | 4.10e-02 | 1.00e+00 | 4.582 | 1 | 3 | 86 |
GO:0006415 | translational termination | 4.15e-02 | 1.00e+00 | 4.566 | 1 | 10 | 87 |
GO:0016605 | PML body | 4.19e-02 | 1.00e+00 | 4.549 | 1 | 3 | 88 |
GO:0000187 | activation of MAPK activity | 4.29e-02 | 1.00e+00 | 4.517 | 1 | 5 | 90 |
GO:0006928 | cellular component movement | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 4.33e-02 | 1.00e+00 | 4.501 | 1 | 8 | 91 |
GO:0006414 | translational elongation | 4.43e-02 | 1.00e+00 | 4.470 | 1 | 13 | 93 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 4.94e-02 | 1.00e+00 | 4.308 | 1 | 10 | 104 |
GO:0014069 | postsynaptic density | 4.99e-02 | 1.00e+00 | 4.294 | 1 | 3 | 105 |
GO:0005741 | mitochondrial outer membrane | 4.99e-02 | 1.00e+00 | 4.294 | 1 | 7 | 105 |
GO:0005815 | microtubule organizing center | 5.17e-02 | 1.00e+00 | 4.241 | 1 | 5 | 109 |
GO:0072562 | blood microparticle | 5.27e-02 | 1.00e+00 | 4.214 | 1 | 3 | 111 |
GO:0030529 | ribonucleoprotein complex | 5.31e-02 | 1.00e+00 | 4.201 | 1 | 8 | 112 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 5.40e-02 | 1.00e+00 | 4.176 | 1 | 11 | 114 |
GO:0006006 | glucose metabolic process | 5.59e-02 | 1.00e+00 | 4.126 | 1 | 7 | 118 |
GO:0006325 | chromatin organization | 5.59e-02 | 1.00e+00 | 4.126 | 1 | 5 | 118 |
GO:0032496 | response to lipopolysaccharide | 5.73e-02 | 1.00e+00 | 4.090 | 1 | 4 | 121 |
GO:0006260 | DNA replication | 5.73e-02 | 1.00e+00 | 4.090 | 1 | 9 | 121 |
GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 5.87e-02 | 1.00e+00 | 4.055 | 1 | 4 | 124 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 5.96e-02 | 1.00e+00 | 4.031 | 1 | 5 | 126 |
GO:0007179 | transforming growth factor beta receptor signaling pathway | 6.05e-02 | 1.00e+00 | 4.009 | 1 | 4 | 128 |
GO:0000790 | nuclear chromatin | 6.10e-02 | 1.00e+00 | 3.998 | 1 | 9 | 129 |
GO:0006413 | translational initiation | 6.19e-02 | 1.00e+00 | 3.975 | 1 | 17 | 131 |
GO:0000086 | G2/M transition of mitotic cell cycle | 6.42e-02 | 1.00e+00 | 3.921 | 1 | 9 | 136 |
GO:0003735 | structural constituent of ribosome | 6.46e-02 | 1.00e+00 | 3.911 | 1 | 10 | 137 |
GO:0007507 | heart development | 6.56e-02 | 1.00e+00 | 3.890 | 1 | 7 | 139 |
GO:0006457 | protein folding | 6.74e-02 | 1.00e+00 | 3.849 | 1 | 7 | 143 |
GO:0034220 | ion transmembrane transport | 7.01e-02 | 1.00e+00 | 3.790 | 1 | 4 | 149 |
GO:0010008 | endosome membrane | 7.10e-02 | 1.00e+00 | 3.770 | 1 | 7 | 151 |
GO:0045121 | membrane raft | 7.33e-02 | 1.00e+00 | 3.723 | 1 | 8 | 156 |
GO:0008543 | fibroblast growth factor receptor signaling pathway | 7.33e-02 | 1.00e+00 | 3.723 | 1 | 9 | 156 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 7.74e-02 | 1.00e+00 | 3.642 | 1 | 7 | 165 |
GO:0030424 | axon | 7.79e-02 | 1.00e+00 | 3.634 | 1 | 4 | 166 |
GO:0038095 | Fc-epsilon receptor signaling pathway | 7.88e-02 | 1.00e+00 | 3.616 | 1 | 12 | 168 |
GO:0005739 | mitochondrion | 7.96e-02 | 1.00e+00 | 2.046 | 2 | 28 | 998 |
GO:0034641 | cellular nitrogen compound metabolic process | 8.01e-02 | 1.00e+00 | 3.591 | 1 | 20 | 171 |
GO:0006367 | transcription initiation from RNA polymerase II promoter | 8.60e-02 | 1.00e+00 | 3.485 | 1 | 8 | 184 |
GO:0007173 | epidermal growth factor receptor signaling pathway | 8.82e-02 | 1.00e+00 | 3.446 | 1 | 12 | 189 |
GO:0001525 | angiogenesis | 8.91e-02 | 1.00e+00 | 3.431 | 1 | 4 | 191 |
GO:0019221 | cytokine-mediated signaling pathway | 1.02e-01 | 1.00e+00 | 3.221 | 1 | 9 | 221 |
GO:0006412 | translation | 1.06e-01 | 1.00e+00 | 3.163 | 1 | 20 | 230 |
GO:0044281 | small molecule metabolic process | 1.11e-01 | 1.00e+00 | 1.767 | 2 | 58 | 1211 |
GO:0043025 | neuronal cell body | 1.13e-01 | 1.00e+00 | 3.072 | 1 | 9 | 245 |
GO:0005975 | carbohydrate metabolic process | 1.17e-01 | 1.00e+00 | 3.026 | 1 | 9 | 253 |
GO:0004842 | ubiquitin-protein transferase activity | 1.17e-01 | 1.00e+00 | 3.014 | 1 | 6 | 255 |
GO:0048011 | neurotrophin TRK receptor signaling pathway | 1.23e-01 | 1.00e+00 | 2.937 | 1 | 15 | 269 |
GO:0043065 | positive regulation of apoptotic process | 1.23e-01 | 1.00e+00 | 2.943 | 1 | 10 | 268 |
GO:0019899 | enzyme binding | 1.27e-01 | 1.00e+00 | 2.895 | 1 | 12 | 277 |
GO:0016567 | protein ubiquitination | 1.35e-01 | 1.00e+00 | 2.804 | 1 | 5 | 295 |
GO:0043234 | protein complex | 1.35e-01 | 1.00e+00 | 2.804 | 1 | 18 | 295 |
GO:0019901 | protein kinase binding | 1.44e-01 | 1.00e+00 | 2.700 | 1 | 21 | 317 |
GO:0007411 | axon guidance | 1.45e-01 | 1.00e+00 | 2.691 | 1 | 13 | 319 |
GO:0005634 | nucleus | 1.48e-01 | 1.00e+00 | 0.854 | 4 | 136 | 4559 |
GO:0005925 | focal adhesion | 1.65e-01 | 1.00e+00 | 2.493 | 1 | 19 | 366 |
GO:0007155 | cell adhesion | 1.66e-01 | 1.00e+00 | 2.481 | 1 | 6 | 369 |
GO:0006508 | proteolysis | 1.70e-01 | 1.00e+00 | 2.446 | 1 | 9 | 378 |
GO:0046982 | protein heterodimerization activity | 1.71e-01 | 1.00e+00 | 2.439 | 1 | 13 | 380 |
GO:0005730 | nucleolus | 1.85e-01 | 1.00e+00 | 1.328 | 2 | 69 | 1641 |
GO:0055085 | transmembrane transport | 1.93e-01 | 1.00e+00 | 2.244 | 1 | 10 | 435 |
GO:0007596 | blood coagulation | 2.01e-01 | 1.00e+00 | 2.179 | 1 | 18 | 455 |
GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 2.46e-01 | 1.00e+00 | 1.854 | 1 | 16 | 570 |
GO:0005737 | cytoplasm | 2.67e-01 | 1.00e+00 | 0.714 | 3 | 110 | 3767 |
GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 3.26e-01 | 1.00e+00 | 1.385 | 1 | 19 | 789 |
GO:0005886 | plasma membrane | 3.65e-01 | 1.00e+00 | 0.674 | 2 | 45 | 2582 |
GO:0005615 | extracellular space | 3.82e-01 | 1.00e+00 | 1.106 | 1 | 17 | 957 |
GO:0008270 | zinc ion binding | 3.94e-01 | 1.00e+00 | 1.047 | 1 | 12 | 997 |
GO:0044822 | poly(A) RNA binding | 4.13e-01 | 1.00e+00 | 0.964 | 1 | 49 | 1056 |
GO:0005524 | ATP binding | 4.83e-01 | 1.00e+00 | 0.667 | 1 | 60 | 1298 |
GO:0006351 | transcription, DNA-templated | 5.23e-01 | 1.00e+00 | 0.511 | 1 | 31 | 1446 |