int-snw-6613

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.983	2.05e-17	8.36e-04	1.80e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-6613 subnetwork

Genes (8)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
CAD	790	17	0.807	1.007	333	-	-
RUVBL1	8607	17	0.720	1.013	343	Yes	-
PSMA2	5683	60	1.093	1.106	89	Yes	-
[ SUMO2 ]	6613	3	-0.466	0.983	199	-	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-

Interactions (13)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
PSMD11	5717	SUMO2	6613	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct
CAD	790	SUMO2	6613	pp	--	int.I2D: BioGrid
CAD	790	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
CAD	790	RUVBL1	8607	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
PSMA2	5683	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast, YeastLow
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
ACTB	60	CAD	790	pp	--	int.I2D: IntAct_Yeast
SUMO2	6613	RUVBL1	8607	pp	--	int.I2D: BioGrid
ACTB	60	RUVBL1	8607	pp	--	int.I2D: IntAct_Yeast, BioGrid, BioGrid_Yeast
PSMD11	5717	RUVBL1	8607	pp	--	int.I2D: YeastLow
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast

Related GO terms (170)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0070062	extracellular vesicular exosome	2.40e-05	3.46e-01	2.395	7	104	2400
GO:0035267	NuA4 histone acetyltransferase complex	2.44e-05	3.52e-01	8.009	2	4	14
GO:0005654	nucleoplasm	1.09e-04	1.00e+00	3.059	5	76	1082
GO:0016071	mRNA metabolic process	1.93e-04	1.00e+00	4.600	3	31	223
GO:0016070	RNA metabolic process	2.61e-04	1.00e+00	4.453	3	32	247
GO:0006521	regulation of cellular amino acid metabolic process	3.25e-04	1.00e+00	6.172	2	17	50
GO:0000502	proteasome complex	4.38e-04	1.00e+00	5.958	2	17	58
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	5.33e-04	1.00e+00	5.816	2	19	64
GO:0005829	cytosol	5.44e-04	1.00e+00	2.116	6	132	2496
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	5.50e-04	1.00e+00	5.794	2	22	65
GO:0004151	dihydroorotase activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0019521	D-gluconate metabolic process	5.55e-04	1.00e+00	10.816	1	1	1
GO:0004070	aspartate carbamoyltransferase activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0004088	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	5.55e-04	1.00e+00	10.816	1	1	1
GO:0070335	aspartate binding	5.55e-04	1.00e+00	10.816	1	1	1
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	6.38e-04	1.00e+00	5.687	2	22	70
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	6.75e-04	1.00e+00	5.646	2	20	72
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.13e-04	1.00e+00	5.607	2	22	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	7.32e-04	1.00e+00	5.587	2	20	75
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	8.12e-04	1.00e+00	5.512	2	23	79
GO:0016020	membrane	8.83e-04	1.00e+00	2.423	5	90	1681
GO:0016363	nuclear matrix	1.08e-03	1.00e+00	5.308	2	12	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	1.10e-03	1.00e+00	5.293	2	21	92
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.11e-03	1.00e+00	9.816	1	1	2
GO:0019322	pentose biosynthetic process	1.11e-03	1.00e+00	9.816	1	2	2
GO:0005055	laminin receptor activity	1.11e-03	1.00e+00	9.816	1	1	2
GO:0006407	rRNA export from nucleus	1.11e-03	1.00e+00	9.816	1	1	2
GO:0070409	carbamoyl phosphate biosynthetic process	1.11e-03	1.00e+00	9.816	1	1	2
GO:0030529	ribonucleoprotein complex	1.62e-03	1.00e+00	5.009	2	8	112
GO:0009051	pentose-phosphate shunt, oxidative branch	1.66e-03	1.00e+00	9.231	1	2	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.66e-03	1.00e+00	9.231	1	1	3
GO:0044205	'de novo' UMP biosynthetic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process	1.66e-03	1.00e+00	9.231	1	1	3
GO:0000209	protein polyubiquitination	1.74e-03	1.00e+00	4.958	2	20	116
GO:0044267	cellular protein metabolic process	1.75e-03	1.00e+00	3.512	3	29	474
GO:0006325	chromatin organization	1.80e-03	1.00e+00	4.933	2	5	118
GO:0005634	nucleus	1.82e-03	1.00e+00	1.469	7	136	4559
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.22e-03	1.00e+00	8.816	1	1	4
GO:0030686	90S preribosome	2.22e-03	1.00e+00	8.816	1	1	4
GO:0006543	glutamine catabolic process	2.22e-03	1.00e+00	8.816	1	1	4
GO:0016032	viral process	2.46e-03	1.00e+00	3.340	3	55	534
GO:0044281	small molecule metabolic process	2.63e-03	1.00e+00	2.574	4	58	1211
GO:0051414	response to cortisol	2.77e-03	1.00e+00	8.494	1	1	5
GO:0043248	proteasome assembly	2.77e-03	1.00e+00	8.494	1	1	5
GO:0000082	G1/S transition of mitotic cell cycle	2.85e-03	1.00e+00	4.597	2	32	149
GO:0042981	regulation of apoptotic process	2.89e-03	1.00e+00	4.587	2	24	150
GO:0030957	Tat protein binding	3.32e-03	1.00e+00	8.231	1	3	6
GO:0046134	pyrimidine nucleoside biosynthetic process	3.32e-03	1.00e+00	8.231	1	1	6
GO:0034641	cellular nitrogen compound metabolic process	3.73e-03	1.00e+00	4.398	2	20	171
GO:0000028	ribosomal small subunit assembly	3.88e-03	1.00e+00	8.009	1	1	7
GO:0019773	proteasome core complex, alpha-subunit complex	4.43e-03	1.00e+00	7.816	1	4	8
GO:0070688	MLL5-L complex	4.43e-03	1.00e+00	7.816	1	1	8
GO:0000812	Swr1 complex	4.43e-03	1.00e+00	7.816	1	3	8
GO:0010467	gene expression	4.67e-03	1.00e+00	3.015	3	59	669
GO:0006228	UTP biosynthetic process	4.98e-03	1.00e+00	7.646	1	1	9
GO:0014075	response to amine	4.98e-03	1.00e+00	7.646	1	1	9
GO:0031000	response to caffeine	4.98e-03	1.00e+00	7.646	1	2	9
GO:0006098	pentose-phosphate shunt	5.53e-03	1.00e+00	7.494	1	4	10
GO:0019789	SUMO ligase activity	6.09e-03	1.00e+00	7.357	1	1	11
GO:0043968	histone H2A acetylation	6.64e-03	1.00e+00	7.231	1	3	12
GO:0005838	proteasome regulatory particle	6.64e-03	1.00e+00	7.231	1	7	12
GO:0031011	Ino80 complex	7.74e-03	1.00e+00	7.009	1	3	14
GO:0050998	nitric-oxide synthase binding	8.84e-03	1.00e+00	6.816	1	1	16
GO:0006541	glutamine metabolic process	9.39e-03	1.00e+00	6.729	1	1	17
GO:0003678	DNA helicase activity	9.39e-03	1.00e+00	6.729	1	3	17
GO:0022624	proteasome accessory complex	9.39e-03	1.00e+00	6.729	1	8	17
GO:0017144	drug metabolic process	9.94e-03	1.00e+00	6.646	1	1	18
GO:0005839	proteasome core complex	9.94e-03	1.00e+00	6.646	1	8	18
GO:0048863	stem cell differentiation	1.05e-02	1.00e+00	6.568	1	1	19
GO:0004298	threonine-type endopeptidase activity	1.05e-02	1.00e+00	6.568	1	8	19
GO:0043234	protein complex	1.08e-02	1.00e+00	3.612	2	18	295
GO:0071364	cellular response to epidermal growth factor stimulus	1.16e-02	1.00e+00	6.424	1	1	21
GO:0006206	pyrimidine nucleobase metabolic process	1.21e-02	1.00e+00	6.357	1	2	22
GO:0033574	response to testosterone	1.21e-02	1.00e+00	6.357	1	2	22
GO:0030863	cortical cytoskeleton	1.21e-02	1.00e+00	6.357	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.21e-02	1.00e+00	6.357	1	4	22
GO:0043044	ATP-dependent chromatin remodeling	1.27e-02	1.00e+00	6.293	1	4	23
GO:0043236	laminin binding	1.27e-02	1.00e+00	6.293	1	1	23
GO:0034080	CENP-A containing nucleosome assembly	1.38e-02	1.00e+00	6.172	1	1	25
GO:0016925	protein sumoylation	1.38e-02	1.00e+00	6.172	1	1	25
GO:0043022	ribosome binding	1.49e-02	1.00e+00	6.061	1	3	27
GO:0050661	NADP binding	1.49e-02	1.00e+00	6.061	1	2	27
GO:0071339	MLL1 complex	1.49e-02	1.00e+00	6.061	1	3	27
GO:0043967	histone H4 acetylation	1.49e-02	1.00e+00	6.061	1	3	27
GO:0031492	nucleosomal DNA binding	1.49e-02	1.00e+00	6.061	1	4	27
GO:0019894	kinesin binding	1.54e-02	1.00e+00	6.009	1	1	28
GO:0000278	mitotic cell cycle	1.84e-02	1.00e+00	3.205	2	48	391
GO:0001895	retina homeostasis	1.87e-02	1.00e+00	5.729	1	1	34
GO:0034332	adherens junction organization	1.98e-02	1.00e+00	5.646	1	1	36
GO:0018107	peptidyl-threonine phosphorylation	2.03e-02	1.00e+00	5.607	1	4	37
GO:0051084	'de novo' posttranslational protein folding	2.03e-02	1.00e+00	5.607	1	4	37
GO:0070527	platelet aggregation	2.09e-02	1.00e+00	5.568	1	2	38
GO:0022627	cytosolic small ribosomal subunit	2.14e-02	1.00e+00	5.531	1	4	39
GO:0007595	lactation	2.14e-02	1.00e+00	5.531	1	2	39
GO:0043066	negative regulation of apoptotic process	2.15e-02	1.00e+00	3.088	2	31	424
GO:0043195	terminal bouton	2.25e-02	1.00e+00	5.459	1	1	41
GO:0032508	DNA duplex unwinding	2.25e-02	1.00e+00	5.459	1	3	41
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	2.42e-02	1.00e+00	5.357	1	3	44
GO:0021762	substantia nigra development	2.42e-02	1.00e+00	5.357	1	2	44
GO:0035690	cellular response to drug	2.69e-02	1.00e+00	5.201	1	2	49
GO:0031100	organ regeneration	2.74e-02	1.00e+00	5.172	1	4	50
GO:0040008	regulation of growth	2.74e-02	1.00e+00	5.172	1	5	50
GO:0005524	ATP binding	2.88e-02	1.00e+00	2.059	3	60	1298
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	2.90e-02	1.00e+00	5.088	1	5	53
GO:0045216	cell-cell junction organization	2.96e-02	1.00e+00	5.061	1	2	54
GO:0000932	cytoplasmic mRNA processing body	2.96e-02	1.00e+00	5.061	1	3	54
GO:0042995	cell projection	3.28e-02	1.00e+00	4.909	1	6	60
GO:0006915	apoptotic process	3.55e-02	1.00e+00	2.700	2	33	555
GO:0006310	DNA recombination	3.55e-02	1.00e+00	4.794	1	2	65
GO:0034329	cell junction assembly	3.71e-02	1.00e+00	4.729	1	1	68
GO:0055086	nucleobase-containing small molecule metabolic process	3.82e-02	1.00e+00	4.687	1	2	70
GO:0006334	nucleosome assembly	3.93e-02	1.00e+00	4.646	1	2	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.03e-02	1.00e+00	4.607	1	6	74
GO:0001889	liver development	4.19e-02	1.00e+00	4.549	1	4	77
GO:0007565	female pregnancy	4.25e-02	1.00e+00	4.531	1	1	78
GO:0019083	viral transcription	4.41e-02	1.00e+00	4.476	1	10	81
GO:0006415	translational termination	4.73e-02	1.00e+00	4.373	1	10	87
GO:0016605	PML body	4.78e-02	1.00e+00	4.357	1	3	88
GO:0006928	cellular component movement	4.94e-02	1.00e+00	4.308	1	7	91
GO:0005200	structural constituent of cytoskeleton	4.94e-02	1.00e+00	4.308	1	8	91
GO:0006414	translational elongation	5.04e-02	1.00e+00	4.277	1	13	93
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	5.63e-02	1.00e+00	4.116	1	10	104
GO:0014069	postsynaptic density	5.68e-02	1.00e+00	4.102	1	3	105
GO:0005815	microtubule organizing center	5.89e-02	1.00e+00	4.048	1	5	109
GO:0072562	blood microparticle	5.99e-02	1.00e+00	4.022	1	3	111
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.15e-02	1.00e+00	3.983	1	11	114
GO:0005515	protein binding	6.16e-02	1.00e+00	0.845	6	184	6024
GO:0019058	viral life cycle	6.20e-02	1.00e+00	3.971	1	13	115
GO:0006511	ubiquitin-dependent protein catabolic process	6.78e-02	1.00e+00	3.839	1	5	126
GO:0009615	response to virus	6.78e-02	1.00e+00	3.839	1	5	126
GO:0000790	nuclear chromatin	6.94e-02	1.00e+00	3.805	1	9	129
GO:0006413	translational initiation	7.04e-02	1.00e+00	3.783	1	17	131
GO:0003735	structural constituent of ribosome	7.35e-02	1.00e+00	3.718	1	10	137
GO:0007507	heart development	7.46e-02	1.00e+00	3.697	1	7	139
GO:0016887	ATPase activity	7.51e-02	1.00e+00	3.687	1	7	140
GO:0006457	protein folding	7.66e-02	1.00e+00	3.656	1	7	143
GO:0061024	membrane organization	7.77e-02	1.00e+00	3.636	1	7	145
GO:0046777	protein autophosphorylation	8.44e-02	1.00e+00	3.512	1	7	158
GO:0043687	post-translational protein modification	8.64e-02	1.00e+00	3.476	1	5	162
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	8.80e-02	1.00e+00	3.450	1	7	165
GO:0030424	axon	8.85e-02	1.00e+00	3.441	1	4	166
GO:0004672	protein kinase activity	9.41e-02	1.00e+00	3.348	1	6	177
GO:0031625	ubiquitin protein ligase binding	9.46e-02	1.00e+00	3.340	1	14	178
GO:0044822	poly(A) RNA binding	1.12e-01	1.00e+00	1.772	2	49	1056
GO:0007067	mitotic nuclear division	1.19e-01	1.00e+00	2.990	1	14	227
GO:0006412	translation	1.21e-01	1.00e+00	2.971	1	20	230
GO:0043025	neuronal cell body	1.28e-01	1.00e+00	2.879	1	9	245
GO:0005975	carbohydrate metabolic process	1.32e-01	1.00e+00	2.833	1	9	253
GO:0007283	spermatogenesis	1.36e-01	1.00e+00	2.783	1	8	262
GO:0006281	DNA repair	1.36e-01	1.00e+00	2.788	1	18	261
GO:0006357	regulation of transcription from RNA polymerase II promoter	1.37e-01	1.00e+00	2.772	1	8	264
GO:0019899	enzyme binding	1.44e-01	1.00e+00	2.702	1	12	277
GO:0005856	cytoskeleton	1.50e-01	1.00e+00	2.631	1	12	291
GO:0019901	protein kinase binding	1.63e-01	1.00e+00	2.508	1	21	317
GO:0043231	intracellular membrane-bounded organelle	1.63e-01	1.00e+00	2.503	1	9	318
GO:0007411	axon guidance	1.64e-01	1.00e+00	2.499	1	13	319
GO:0005925	focal adhesion	1.86e-01	1.00e+00	2.300	1	19	366
GO:0007155	cell adhesion	1.87e-01	1.00e+00	2.289	1	6	369
GO:0055114	oxidation-reduction process	2.11e-01	1.00e+00	2.102	1	12	420
GO:0007596	blood coagulation	2.26e-01	1.00e+00	1.986	1	18	455
GO:0042802	identical protein binding	2.39e-01	1.00e+00	1.897	1	20	484
GO:0045087	innate immune response	2.87e-01	1.00e+00	1.597	1	24	596
GO:0005794	Golgi apparatus	2.92e-01	1.00e+00	1.563	1	15	610
GO:0005737	cytoplasm	3.49e-01	1.00e+00	0.522	3	110	3767
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	3.62e-01	1.00e+00	1.192	1	19	789
GO:0005615	extracellular space	4.23e-01	1.00e+00	0.914	1	17	957
GO:0008270	zinc ion binding	4.36e-01	1.00e+00	0.855	1	12	997
GO:0006351	transcription, DNA-templated	5.71e-01	1.00e+00	0.318	1	31	1446
GO:0005730	nucleolus	6.20e-01	1.00e+00	0.136	1	69	1641
GO:0005886	plasma membrane	7.94e-01	1.00e+00	-0.518	1	45	2582

Wolf-ratios-Mammosphere-Adherent

int-snw-6613

Statistics

Genes (8)

Interactions (13)

Related GO terms (170)