int-snw-6576

Statistics

Dataset	Score	p-value 1	p-value 2	p-value 3
wolf-screen-ratio-mammosphere-adherent	0.947	5.67e-16	1.91e-03	3.32e-02

wolf-screen-ratio-mammosphere-adherent-int-snw-6576 subnetwork

Genes (9)

Gene Symbol	Entrez Gene ID	Frequency	wolf-screen-ratio-mammosphere-adherent gene score	Best subnetwork score	Degree	wolf adherent-list Hits GI	wolf mammosphere no adherent-list Hits GI
ACO2	50	50	1.000	1.076	191	Yes	-
CDC16	8881	25	0.950	1.020	80	Yes	-
ACTB	60	167	1.153	1.151	587	Yes	-
PSMD11	5717	121	1.095	1.106	183	Yes	-
ATP6V1B2	526	44	0.881	1.076	278	-	-
HSPD1	3329	35	0.913	1.035	286	Yes	-
RPSA	3921	156	1.327	1.151	152	Yes	-
PGD	5226	75	1.201	1.106	138	Yes	-
[ SLC25A1 ]	6576	1	0.001	0.947	47	-	-

Interactions (16)

Gene Symbol 1	Entrez Gene ID 1	Gene Symbol 2	Entrez Gene ID 2	Type	Direction	Origin databases / Sources
ATP6V1B2	526	RPSA	3921	pp	--	int.I2D: IntAct_Yeast
ACTB	60	ATP6V1B2	526	pp	--	int.I2D: BioGrid_Yeast
PGD	5226	PSMD11	5717	pp	--	int.I2D: YeastLow
RPSA	3921	PSMD11	5717	pp	--	int.I2D: IntAct_Yeast
ACTB	60	RPSA	3921	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct
HSPD1	3329	SLC25A1	6576	pp	--	int.I2D: IntAct_Yeast
ATP6V1B2	526	CDC16	8881	pp	--	int.I2D: IntAct_Yeast
ACO2	50	SLC25A1	6576	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	CDC16	8881	pp	--	int.I2D: YeastLow
ACO2	50	PSMD11	5717	pp	--	int.I2D: YeastLow
HSPD1	3329	RPSA	3921	pp	--	int.I2D: BioGrid_Yeast, IntAct_Yeast
ACO2	50	PGD	5226	pp	--	int.I2D: YeastLow
ACO2	50	HSPD1	3329	pp	--	int.I2D: IntAct_Yeast
ACTB	60	PSMD11	5717	pp	--	int.I2D: BioGrid_Yeast
ACTB	60	HSPD1	3329	pp	--	int.Intact: MI:0915(physical association); int.I2D: IntAct, YeastLow
ATP6V1B2	526	SLC25A1	6576	pp	--	int.I2D: IntAct_Yeast

Related GO terms (187)

Accession number	Name	Hypergeometric test	Corrected p-value	Enrichment ratio	Occurrence in subnetwork	Occurrences in all snw genes	Occurrences in all int/reg genes
GO:0070062	extracellular vesicular exosome	9.23e-05	1.00e+00	2.225	7	104	2400
GO:0005829	cytosol	1.20e-04	1.00e+00	2.168	7	132	2496
GO:0002842	positive regulation of T cell mediated immune response to tumor cell	6.24e-04	1.00e+00	10.646	1	1	1
GO:0048291	isotype switching to IgG isotypes	6.24e-04	1.00e+00	10.646	1	1	1
GO:0019521	D-gluconate metabolic process	6.24e-04	1.00e+00	10.646	1	1	1
GO:0002368	B cell cytokine production	6.24e-04	1.00e+00	10.646	1	1	1
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	7.05e-04	1.00e+00	5.624	2	22	65
GO:0051437	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	8.18e-04	1.00e+00	5.517	2	22	70
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	9.13e-04	1.00e+00	5.437	2	22	74
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	1.04e-03	1.00e+00	5.342	2	23	79
GO:0015746	citrate transport	1.25e-03	1.00e+00	9.646	1	1	2
GO:0051538	3 iron, 4 sulfur cluster binding	1.25e-03	1.00e+00	9.646	1	1	2
GO:0000461	endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	1.25e-03	1.00e+00	9.646	1	1	2
GO:0015137	citrate transmembrane transporter activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0019322	pentose biosynthetic process	1.25e-03	1.00e+00	9.646	1	2	2
GO:0003994	aconitate hydratase activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0005055	laminin receptor activity	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006407	rRNA export from nucleus	1.25e-03	1.00e+00	9.646	1	1	2
GO:0006458	'de novo' protein folding	1.87e-03	1.00e+00	9.061	1	1	3
GO:0009051	pentose-phosphate shunt, oxidative branch	1.87e-03	1.00e+00	9.061	1	2	3
GO:0030135	coated vesicle	1.87e-03	1.00e+00	9.061	1	1	3
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity	1.87e-03	1.00e+00	9.061	1	1	3
GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	2.49e-03	1.00e+00	8.646	1	1	4
GO:0030686	90S preribosome	2.49e-03	1.00e+00	8.646	1	1	4
GO:0043248	proteasome assembly	3.12e-03	1.00e+00	8.324	1	1	5
GO:0046696	lipopolysaccharide receptor complex	3.12e-03	1.00e+00	8.324	1	1	5
GO:0006102	isocitrate metabolic process	3.12e-03	1.00e+00	8.324	1	1	5
GO:0016032	viral process	3.59e-03	1.00e+00	3.170	3	55	534
GO:0003688	DNA replication origin binding	3.74e-03	1.00e+00	8.061	1	2	6
GO:0030957	Tat protein binding	3.74e-03	1.00e+00	8.061	1	3	6
GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex	3.74e-03	1.00e+00	8.061	1	1	6
GO:0006101	citrate metabolic process	3.74e-03	1.00e+00	8.061	1	1	6
GO:0033180	proton-transporting V-type ATPase, V1 domain	4.36e-03	1.00e+00	7.839	1	2	7
GO:0000028	ribosomal small subunit assembly	4.36e-03	1.00e+00	7.839	1	1	7
GO:0044281	small molecule metabolic process	4.42e-03	1.00e+00	2.404	4	58	1211
GO:0070688	MLL5-L complex	4.98e-03	1.00e+00	7.646	1	1	8
GO:0051604	protein maturation	4.98e-03	1.00e+00	7.646	1	1	8
GO:0006098	pentose-phosphate shunt	6.22e-03	1.00e+00	7.324	1	4	10
GO:0043032	positive regulation of macrophage activation	6.22e-03	1.00e+00	7.324	1	1	10
GO:0032727	positive regulation of interferon-alpha production	6.85e-03	1.00e+00	7.187	1	1	11
GO:0005838	proteasome regulatory particle	7.47e-03	1.00e+00	7.061	1	7	12
GO:0016071	mRNA metabolic process	7.98e-03	1.00e+00	3.845	2	31	223
GO:0035338	long-chain fatty-acyl-CoA biosynthetic process	8.09e-03	1.00e+00	6.946	1	3	13
GO:0001530	lipopolysaccharide binding	8.09e-03	1.00e+00	6.946	1	3	13
GO:0051131	chaperone-mediated protein complex assembly	8.09e-03	1.00e+00	6.946	1	1	13
GO:0005759	mitochondrial matrix	8.32e-03	1.00e+00	3.813	2	14	228
GO:0035267	NuA4 histone acetyltransferase complex	8.70e-03	1.00e+00	6.839	1	4	14
GO:0046961	proton-transporting ATPase activity, rotational mechanism	9.32e-03	1.00e+00	6.739	1	3	15
GO:0042026	protein refolding	9.32e-03	1.00e+00	6.739	1	2	15
GO:0046034	ATP metabolic process	9.32e-03	1.00e+00	6.739	1	1	15
GO:0016070	RNA metabolic process	9.71e-03	1.00e+00	3.698	2	32	247
GO:0050998	nitric-oxide synthase binding	9.94e-03	1.00e+00	6.646	1	1	16
GO:0005975	carbohydrate metabolic process	1.02e-02	1.00e+00	3.663	2	9	253
GO:0050870	positive regulation of T cell activation	1.06e-02	1.00e+00	6.559	1	1	17
GO:0022624	proteasome accessory complex	1.06e-02	1.00e+00	6.559	1	8	17
GO:0007088	regulation of mitosis	1.12e-02	1.00e+00	6.476	1	1	18
GO:0015078	hydrogen ion transmembrane transporter activity	1.18e-02	1.00e+00	6.398	1	3	19
GO:0032733	positive regulation of interleukin-10 production	1.18e-02	1.00e+00	6.398	1	1	19
GO:0048863	stem cell differentiation	1.18e-02	1.00e+00	6.398	1	1	19
GO:0005743	mitochondrial inner membrane	1.21e-02	1.00e+00	3.532	2	8	277
GO:0005680	anaphase-promoting complex	1.24e-02	1.00e+00	6.324	1	4	20
GO:0042100	B cell proliferation	1.30e-02	1.00e+00	6.254	1	1	21
GO:0030863	cortical cytoskeleton	1.36e-02	1.00e+00	6.187	1	1	22
GO:0036464	cytoplasmic ribonucleoprotein granule	1.36e-02	1.00e+00	6.187	1	4	22
GO:0043234	protein complex	1.37e-02	1.00e+00	3.442	2	18	295
GO:0043044	ATP-dependent chromatin remodeling	1.43e-02	1.00e+00	6.123	1	4	23
GO:0043236	laminin binding	1.43e-02	1.00e+00	6.123	1	1	23
GO:0016020	membrane	1.43e-02	1.00e+00	1.931	4	90	1681
GO:0042113	B cell activation	1.55e-02	1.00e+00	6.002	1	2	25
GO:0032735	positive regulation of interleukin-12 production	1.55e-02	1.00e+00	6.002	1	1	25
GO:0070979	protein K11-linked ubiquitination	1.61e-02	1.00e+00	5.946	1	6	26
GO:0015991	ATP hydrolysis coupled proton transport	1.61e-02	1.00e+00	5.946	1	4	26
GO:0043022	ribosome binding	1.67e-02	1.00e+00	5.891	1	3	27
GO:0050661	NADP binding	1.67e-02	1.00e+00	5.891	1	2	27
GO:0031492	nucleosomal DNA binding	1.67e-02	1.00e+00	5.891	1	4	27
GO:0006099	tricarboxylic acid cycle	1.73e-02	1.00e+00	5.839	1	4	28
GO:0019894	kinesin binding	1.73e-02	1.00e+00	5.839	1	1	28
GO:0015992	proton transport	1.80e-02	1.00e+00	5.788	1	3	29
GO:0019432	triglyceride biosynthetic process	1.86e-02	1.00e+00	5.739	1	3	30
GO:0033572	transferrin transport	1.86e-02	1.00e+00	5.739	1	5	30
GO:0007094	mitotic spindle assembly checkpoint	1.92e-02	1.00e+00	5.692	1	4	31
GO:0051701	interaction with host	1.98e-02	1.00e+00	5.646	1	4	32
GO:0001895	retina homeostasis	2.10e-02	1.00e+00	5.559	1	1	34
GO:0005876	spindle microtubule	2.10e-02	1.00e+00	5.559	1	2	34
GO:0051539	4 iron, 4 sulfur cluster binding	2.16e-02	1.00e+00	5.517	1	3	35
GO:0034332	adherens junction organization	2.22e-02	1.00e+00	5.476	1	1	36
GO:0090382	phagosome maturation	2.22e-02	1.00e+00	5.476	1	5	36
GO:0032755	positive regulation of interleukin-6 production	2.22e-02	1.00e+00	5.476	1	2	36
GO:0051084	'de novo' posttranslational protein folding	2.29e-02	1.00e+00	5.437	1	4	37
GO:0000278	mitotic cell cycle	2.33e-02	1.00e+00	3.035	2	48	391
GO:0005902	microvillus	2.35e-02	1.00e+00	5.398	1	2	38
GO:0070527	platelet aggregation	2.35e-02	1.00e+00	5.398	1	2	38
GO:0032729	positive regulation of interferon-gamma production	2.41e-02	1.00e+00	5.361	1	2	39
GO:0022627	cytosolic small ribosomal subunit	2.41e-02	1.00e+00	5.361	1	4	39
GO:0005654	nucleoplasm	2.51e-02	1.00e+00	2.152	3	76	1082
GO:0042110	T cell activation	2.59e-02	1.00e+00	5.254	1	3	42
GO:0006094	gluconeogenesis	2.65e-02	1.00e+00	5.220	1	5	43
GO:0021762	substantia nigra development	2.71e-02	1.00e+00	5.187	1	2	44
GO:0043066	negative regulation of apoptotic process	2.71e-02	1.00e+00	2.918	2	31	424
GO:0055085	transmembrane transport	2.84e-02	1.00e+00	2.881	2	10	435
GO:0006091	generation of precursor metabolites and energy	3.08e-02	1.00e+00	5.002	1	3	50
GO:0006521	regulation of cellular amino acid metabolic process	3.08e-02	1.00e+00	5.002	1	17	50
GO:0006986	response to unfolded protein	3.08e-02	1.00e+00	5.002	1	2	50
GO:0005905	coated pit	3.08e-02	1.00e+00	5.002	1	3	50
GO:0006879	cellular iron ion homeostasis	3.14e-02	1.00e+00	4.974	1	4	51
GO:0003725	double-stranded RNA binding	3.20e-02	1.00e+00	4.946	1	5	52
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding	3.26e-02	1.00e+00	4.918	1	5	53
GO:0045216	cell-cell junction organization	3.32e-02	1.00e+00	4.891	1	2	54
GO:0044267	cellular protein metabolic process	3.33e-02	1.00e+00	2.757	2	29	474
GO:0002039	p53 binding	3.38e-02	1.00e+00	4.865	1	7	55
GO:0012505	endomembrane system	3.44e-02	1.00e+00	4.839	1	2	56
GO:0000502	proteasome complex	3.56e-02	1.00e+00	4.788	1	17	58
GO:0051087	chaperone binding	3.62e-02	1.00e+00	4.764	1	6	59
GO:0030141	secretory granule	3.80e-02	1.00e+00	4.692	1	2	62
GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	3.92e-02	1.00e+00	4.646	1	19	64
GO:0005524	ATP binding	4.04e-02	1.00e+00	1.889	3	60	1298
GO:0034329	cell junction assembly	4.17e-02	1.00e+00	4.559	1	1	68
GO:0003697	single-stranded DNA binding	4.17e-02	1.00e+00	4.559	1	5	68
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	4.41e-02	1.00e+00	4.476	1	20	72
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis	4.53e-02	1.00e+00	4.437	1	6	74
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	4.59e-02	1.00e+00	4.417	1	20	75
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	4.70e-02	1.00e+00	4.379	1	7	77
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	4.88e-02	1.00e+00	4.324	1	3	80
GO:0001726	ruffle	4.88e-02	1.00e+00	4.324	1	4	80
GO:0019083	viral transcription	4.94e-02	1.00e+00	4.306	1	10	81
GO:0006415	translational termination	5.30e-02	1.00e+00	4.203	1	10	87
GO:0050821	protein stabilization	5.36e-02	1.00e+00	4.187	1	2	88
GO:0042470	melanosome	5.54e-02	1.00e+00	4.138	1	9	91
GO:0006928	cellular component movement	5.54e-02	1.00e+00	4.138	1	7	91
GO:0005200	structural constituent of cytoskeleton	5.54e-02	1.00e+00	4.138	1	8	91
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	5.60e-02	1.00e+00	4.123	1	21	92
GO:0006414	translational elongation	5.66e-02	1.00e+00	4.107	1	13	93
GO:0051082	unfolded protein binding	5.66e-02	1.00e+00	4.107	1	5	93
GO:0010467	gene expression	6.23e-02	1.00e+00	2.260	2	59	669
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	6.31e-02	1.00e+00	3.946	1	10	104
GO:0014069	postsynaptic density	6.37e-02	1.00e+00	3.932	1	3	105
GO:0005506	iron ion binding	6.37e-02	1.00e+00	3.932	1	4	105
GO:0072562	blood microparticle	6.72e-02	1.00e+00	3.852	1	3	111
GO:0030529	ribonucleoprotein complex	6.78e-02	1.00e+00	3.839	1	8	112
GO:0005819	spindle	6.78e-02	1.00e+00	3.839	1	7	112
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	6.89e-02	1.00e+00	3.813	1	11	114
GO:0019058	viral life cycle	6.95e-02	1.00e+00	3.801	1	13	115
GO:0000209	protein polyubiquitination	7.01e-02	1.00e+00	3.788	1	20	116
GO:0044237	cellular metabolic process	7.07e-02	1.00e+00	3.776	1	5	117
GO:0006006	glucose metabolic process	7.13e-02	1.00e+00	3.764	1	7	118
GO:0006325	chromatin organization	7.13e-02	1.00e+00	3.764	1	5	118
GO:0006511	ubiquitin-dependent protein catabolic process	7.60e-02	1.00e+00	3.669	1	5	126
GO:0000790	nuclear chromatin	7.77e-02	1.00e+00	3.635	1	9	129
GO:0006413	translational initiation	7.89e-02	1.00e+00	3.613	1	17	131
GO:0044255	cellular lipid metabolic process	8.00e-02	1.00e+00	3.591	1	6	133
GO:0003735	structural constituent of ribosome	8.23e-02	1.00e+00	3.548	1	10	137
GO:0016887	ATPase activity	8.41e-02	1.00e+00	3.517	1	7	140
GO:0008286	insulin receptor signaling pathway	8.52e-02	1.00e+00	3.496	1	7	142
GO:0006457	protein folding	8.58e-02	1.00e+00	3.486	1	7	143
GO:0061024	membrane organization	8.69e-02	1.00e+00	3.466	1	7	145
GO:0000082	G1/S transition of mitotic cell cycle	8.92e-02	1.00e+00	3.427	1	32	149
GO:0042981	regulation of apoptotic process	8.98e-02	1.00e+00	3.417	1	24	150
GO:0005769	early endosome	9.10e-02	1.00e+00	3.398	1	2	152
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding	9.84e-02	1.00e+00	3.280	1	7	165
GO:0030424	axon	9.90e-02	1.00e+00	3.271	1	4	166
GO:0034641	cellular nitrogen compound metabolic process	1.02e-01	1.00e+00	3.228	1	20	171
GO:0005615	extracellular space	1.16e-01	1.00e+00	1.744	2	17	957
GO:0005765	lysosomal membrane	1.20e-01	1.00e+00	2.981	1	5	203
GO:0005634	nucleus	1.20e-01	1.00e+00	0.814	5	136	4559
GO:0005739	mitochondrion	1.25e-01	1.00e+00	1.683	2	28	998
GO:0007067	mitotic nuclear division	1.33e-01	1.00e+00	2.820	1	14	227
GO:0006412	translation	1.35e-01	1.00e+00	2.801	1	20	230
GO:0044822	poly(A) RNA binding	1.37e-01	1.00e+00	1.602	2	49	1056
GO:0043065	positive regulation of apoptotic process	1.55e-01	1.00e+00	2.580	1	10	268
GO:0005856	cytoskeleton	1.68e-01	1.00e+00	2.461	1	12	291
GO:0006200	ATP catabolic process	1.68e-01	1.00e+00	2.456	1	15	292
GO:0019901	protein kinase binding	1.81e-01	1.00e+00	2.338	1	21	317
GO:0043231	intracellular membrane-bounded organelle	1.82e-01	1.00e+00	2.333	1	9	318
GO:0007411	axon guidance	1.82e-01	1.00e+00	2.329	1	13	319
GO:0005813	centrosome	1.86e-01	1.00e+00	2.297	1	14	326
GO:0005737	cytoplasm	1.87e-01	1.00e+00	0.767	4	110	3767
GO:0008283	cell proliferation	1.87e-01	1.00e+00	2.289	1	14	328
GO:0005925	focal adhesion	2.07e-01	1.00e+00	2.130	1	19	366
GO:0007155	cell adhesion	2.08e-01	1.00e+00	2.119	1	6	369
GO:0005886	plasma membrane	2.08e-01	1.00e+00	0.897	3	45	2582
GO:0009986	cell surface	2.25e-01	1.00e+00	1.995	1	11	402
GO:0055114	oxidation-reduction process	2.34e-01	1.00e+00	1.932	1	12	420
GO:0007596	blood coagulation	2.51e-01	1.00e+00	1.816	1	18	455
GO:0006915	apoptotic process	2.98e-01	1.00e+00	1.530	1	33	555
GO:0005515	protein binding	3.04e-01	1.00e+00	0.412	5	184	6024
GO:0045087	innate immune response	3.16e-01	1.00e+00	1.427	1	24	596
GO:0016021	integral component of membrane	3.57e-01	1.00e+00	0.693	2	27	1982

Wolf-ratios-Mammosphere-Adherent

int-snw-6576

Statistics

Genes (9)

Interactions (16)

Related GO terms (187)