Dataset | Score | p-value 1 | p-value 2 | p-value 3 |
---|---|---|---|---|
wolf-screen-ratio-mammosphere-adherent | 0.981 | 2.49e-17 | 8.79e-04 | 1.87e-02 |
Gene Symbol | Entrez Gene ID | Frequency | wolf-screen-ratio-mammosphere-adherent gene score | Best subnetwork score | Degree | wolf adherent-list Hits GI | wolf mammosphere no adherent-list Hits GI |
---|---|---|---|---|---|---|---|
RPA2 | 6118 | 98 | 1.250 | 1.151 | 69 | Yes | - |
KEAP1 | 9817 | 3 | 0.580 | 0.981 | 63 | Yes | - |
RBX1 | 9978 | 97 | 1.185 | 1.151 | 139 | Yes | - |
PSMA1 | 5682 | 61 | 0.996 | 1.052 | 123 | Yes | - |
PSMD11 | 5717 | 121 | 1.095 | 1.106 | 183 | Yes | - |
ACTB | 60 | 167 | 1.153 | 1.151 | 587 | Yes | - |
[ BCL2L1 ] | 598 | 1 | -0.437 | 0.981 | 92 | Yes | - |
CASP8 | 841 | 8 | 0.804 | 1.041 | 141 | - | - |
RPSA | 3921 | 156 | 1.327 | 1.151 | 152 | Yes | - |
Gene Symbol 1 | Entrez Gene ID 1 | Gene Symbol 2 | Entrez Gene ID 2 | Type | Direction | Origin databases / Sources |
---|---|---|---|---|---|---|
BCL2L1 | 598 | KEAP1 | 9817 | pp | -- | int.I2D: BioGrid |
BCL2L1 | 598 | CASP8 | 841 | pp | -- | int.I2D: BCI, BioGrid, HPRD; int.HPRD: in vitro |
KEAP1 | 9817 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid, BioGrid_Mouse |
RPSA | 3921 | PSMD11 | 5717 | pp | -- | int.I2D: IntAct_Yeast |
PSMA1 | 5682 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast, YeastLow |
ACTB | 60 | RPSA | 3921 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct_Yeast, IntAct |
ACTB | 60 | RBX1 | 9978 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | PSMA1 | 5682 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | RPA2 | 6118 | pp | -- | int.Intact: MI:0915(physical association); int.I2D: IntAct |
ACTB | 60 | PSMD11 | 5717 | pp | -- | int.I2D: BioGrid_Yeast |
ACTB | 60 | BCL2L1 | 598 | pp | -- | int.I2D: BioGrid, MINT; int.Mint: MI:0915(physical association) |
Accession number | Name | Hypergeometric test | Corrected p-value | Enrichment ratio | Occurrence in subnetwork | Occurrences in all snw genes | Occurrences in all int/reg genes |
---|---|---|---|---|---|---|---|
GO:0005829 | cytosol | 6.07e-06 | 8.76e-02 | 2.361 | 8 | 132 | 2496 |
GO:0016032 | viral process | 7.60e-06 | 1.10e-01 | 3.907 | 5 | 55 | 534 |
GO:0097284 | hepatocyte apoptotic process | 1.24e-05 | 1.79e-01 | 8.476 | 2 | 3 | 9 |
GO:0000082 | G1/S transition of mitotic cell cycle | 8.67e-05 | 1.00e+00 | 5.012 | 3 | 32 | 149 |
GO:0031463 | Cul3-RING ubiquitin ligase complex | 8.70e-05 | 1.00e+00 | 7.123 | 2 | 3 | 23 |
GO:0031625 | ubiquitin protein ligase binding | 1.47e-04 | 1.00e+00 | 4.755 | 3 | 14 | 178 |
GO:0005654 | nucleoplasm | 2.30e-04 | 1.00e+00 | 2.889 | 5 | 76 | 1082 |
GO:0006915 | apoptotic process | 2.34e-04 | 1.00e+00 | 3.530 | 4 | 33 | 555 |
GO:0016071 | mRNA metabolic process | 2.86e-04 | 1.00e+00 | 4.430 | 3 | 31 | 223 |
GO:0035872 | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 3.08e-04 | 1.00e+00 | 6.220 | 2 | 4 | 43 |
GO:0005515 | protein binding | 3.85e-04 | 1.00e+00 | 1.260 | 9 | 184 | 6024 |
GO:0016070 | RNA metabolic process | 3.86e-04 | 1.00e+00 | 4.283 | 3 | 32 | 247 |
GO:0006521 | regulation of cellular amino acid metabolic process | 4.17e-04 | 1.00e+00 | 6.002 | 2 | 17 | 50 |
GO:0097193 | intrinsic apoptotic signaling pathway | 5.05e-04 | 1.00e+00 | 5.865 | 2 | 6 | 55 |
GO:0000502 | proteasome complex | 5.62e-04 | 1.00e+00 | 5.788 | 2 | 17 | 58 |
GO:0070243 | regulation of thymocyte apoptotic process | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
GO:0071839 | apoptotic process in bone marrow | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
GO:0030690 | Noc1p-Noc2p complex | 6.24e-04 | 1.00e+00 | 10.646 | 1 | 1 | 1 |
GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest | 6.84e-04 | 1.00e+00 | 5.646 | 2 | 19 | 64 |
GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 7.05e-04 | 1.00e+00 | 5.624 | 2 | 22 | 65 |
GO:0051437 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 8.18e-04 | 1.00e+00 | 5.517 | 2 | 22 | 70 |
GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent | 8.65e-04 | 1.00e+00 | 5.476 | 2 | 20 | 72 |
GO:0051439 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle | 9.13e-04 | 1.00e+00 | 5.437 | 2 | 22 | 74 |
GO:0042590 | antigen processing and presentation of exogenous peptide antigen via MHC class I | 9.38e-04 | 1.00e+00 | 5.417 | 2 | 20 | 75 |
GO:0031145 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.04e-03 | 1.00e+00 | 5.342 | 2 | 23 | 79 |
GO:0006407 | rRNA export from nucleus | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0046898 | response to cycloheximide | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0000461 | endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0097199 | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0005055 | laminin receptor activity | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0019050 | suppression by virus of host apoptotic process | 1.25e-03 | 1.00e+00 | 9.646 | 1 | 1 | 2 |
GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I | 1.41e-03 | 1.00e+00 | 5.123 | 2 | 21 | 92 |
GO:0000278 | mitotic cell cycle | 1.47e-03 | 1.00e+00 | 3.620 | 3 | 48 | 391 |
GO:0005730 | nucleolus | 1.61e-03 | 1.00e+00 | 2.288 | 5 | 69 | 1641 |
GO:0005741 | mitochondrial outer membrane | 1.83e-03 | 1.00e+00 | 4.932 | 2 | 7 | 105 |
GO:0043066 | negative regulation of apoptotic process | 1.86e-03 | 1.00e+00 | 3.503 | 3 | 31 | 424 |
GO:0097136 | Bcl-2 family protein complex | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
GO:0036462 | TRAIL-activated apoptotic signaling pathway | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
GO:0060154 | cellular process regulating host cell cycle in response to virus | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
GO:0060715 | syncytiotrophoblast cell differentiation involved in labyrinthine layer development | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
GO:0045604 | regulation of epidermal cell differentiation | 1.87e-03 | 1.00e+00 | 9.061 | 1 | 1 | 3 |
GO:0005815 | microtubule organizing center | 1.97e-03 | 1.00e+00 | 4.878 | 2 | 5 | 109 |
GO:0000209 | protein polyubiquitination | 2.23e-03 | 1.00e+00 | 4.788 | 2 | 20 | 116 |
GO:0010499 | proteasomal ubiquitin-independent protein catabolic process | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 2 | 4 |
GO:0000447 | endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0030686 | 90S preribosome | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0019788 | NEDD8 ligase activity | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0035877 | death effector domain binding | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0031467 | Cul7-RING ubiquitin ligase complex | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0051434 | BH3 domain binding | 2.49e-03 | 1.00e+00 | 8.646 | 1 | 1 | 4 |
GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 3 | 5 |
GO:2000001 | regulation of DNA damage checkpoint | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
GO:0031461 | cullin-RING ubiquitin ligase complex | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
GO:0043248 | proteasome assembly | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
GO:0030891 | VCB complex | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 2 | 5 |
GO:0000730 | DNA recombinase assembly | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
GO:0032025 | response to cobalt ion | 3.12e-03 | 1.00e+00 | 8.324 | 1 | 1 | 5 |
GO:0042981 | regulation of apoptotic process | 3.69e-03 | 1.00e+00 | 4.417 | 2 | 24 | 150 |
GO:0031466 | Cul5-RING ubiquitin ligase complex | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 6 |
GO:0031265 | CD95 death-inducing signaling complex | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 6 |
GO:0030957 | Tat protein binding | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 3 | 6 |
GO:0031264 | death-inducing signaling complex | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 6 |
GO:1900118 | negative regulation of execution phase of apoptosis | 3.74e-03 | 1.00e+00 | 8.061 | 1 | 1 | 6 |
GO:0060546 | negative regulation of necroptotic process | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
GO:0000028 | ribosomal small subunit assembly | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
GO:0090005 | negative regulation of establishment of protein localization to plasma membrane | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
GO:0031462 | Cul2-RING ubiquitin ligase complex | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 2 | 7 |
GO:0071312 | cellular response to alkaloid | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
GO:0097342 | ripoptosome | 4.36e-03 | 1.00e+00 | 7.839 | 1 | 1 | 7 |
GO:0034641 | cellular nitrogen compound metabolic process | 4.76e-03 | 1.00e+00 | 4.228 | 2 | 20 | 171 |
GO:0045087 | innate immune response | 4.89e-03 | 1.00e+00 | 3.012 | 3 | 24 | 596 |
GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 2 | 8 |
GO:0097202 | activation of cysteine-type endopeptidase activity | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 8 |
GO:0070688 | MLL5-L complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 1 | 8 |
GO:0045116 | protein neddylation | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 2 | 8 |
GO:0019773 | proteasome core complex, alpha-subunit complex | 4.98e-03 | 1.00e+00 | 7.646 | 1 | 4 | 8 |
GO:0032403 | protein complex binding | 5.44e-03 | 1.00e+00 | 4.130 | 2 | 10 | 183 |
GO:0005634 | nucleus | 5.94e-03 | 1.00e+00 | 1.299 | 7 | 136 | 4559 |
GO:0010569 | regulation of double-strand break repair via homologous recombination | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 10 |
GO:0001841 | neural tube formation | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 1 | 10 |
GO:0046902 | regulation of mitochondrial membrane permeability | 6.22e-03 | 1.00e+00 | 7.324 | 1 | 2 | 10 |
GO:0001701 | in utero embryonic development | 6.52e-03 | 1.00e+00 | 3.995 | 2 | 8 | 201 |
GO:0010467 | gene expression | 6.76e-03 | 1.00e+00 | 2.845 | 3 | 59 | 669 |
GO:2001239 | regulation of extrinsic apoptotic signaling pathway in absence of ligand | 6.85e-03 | 1.00e+00 | 7.187 | 1 | 1 | 11 |
GO:0031571 | mitotic G1 DNA damage checkpoint | 6.85e-03 | 1.00e+00 | 7.187 | 1 | 4 | 11 |
GO:0045651 | positive regulation of macrophage differentiation | 6.85e-03 | 1.00e+00 | 7.187 | 1 | 1 | 11 |
GO:0005838 | proteasome regulatory particle | 7.47e-03 | 1.00e+00 | 7.061 | 1 | 7 | 12 |
GO:0071480 | cellular response to gamma radiation | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 13 |
GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 13 |
GO:0005662 | DNA replication factor A complex | 8.09e-03 | 1.00e+00 | 6.946 | 1 | 1 | 13 |
GO:0035267 | NuA4 histone acetyltransferase complex | 8.70e-03 | 1.00e+00 | 6.839 | 1 | 4 | 14 |
GO:0030225 | macrophage differentiation | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 1 | 15 |
GO:0005123 | death receptor binding | 9.32e-03 | 1.00e+00 | 6.739 | 1 | 1 | 15 |
GO:0090201 | negative regulation of release of cytochrome c from mitochondria | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
GO:0030101 | natural killer cell activation | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
GO:2000811 | negative regulation of anoikis | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
GO:0051603 | proteolysis involved in cellular protein catabolic process | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 2 | 16 |
GO:0050998 | nitric-oxide synthase binding | 9.94e-03 | 1.00e+00 | 6.646 | 1 | 1 | 16 |
GO:0070584 | mitochondrion morphogenesis | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 1 | 17 |
GO:0022624 | proteasome accessory complex | 1.06e-02 | 1.00e+00 | 6.559 | 1 | 8 | 17 |
GO:0006281 | DNA repair | 1.08e-02 | 1.00e+00 | 3.618 | 2 | 18 | 261 |
GO:0035861 | site of double-strand break | 1.12e-02 | 1.00e+00 | 6.476 | 1 | 1 | 18 |
GO:0010507 | negative regulation of autophagy | 1.12e-02 | 1.00e+00 | 6.476 | 1 | 1 | 18 |
GO:0005839 | proteasome core complex | 1.12e-02 | 1.00e+00 | 6.476 | 1 | 8 | 18 |
GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 1 | 19 |
GO:0048863 | stem cell differentiation | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 1 | 19 |
GO:0004298 | threonine-type endopeptidase activity | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 8 | 19 |
GO:0097194 | execution phase of apoptosis | 1.18e-02 | 1.00e+00 | 6.398 | 1 | 1 | 19 |
GO:0051881 | regulation of mitochondrial membrane potential | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 2 | 20 |
GO:0071353 | cellular response to interleukin-4 | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 1 | 20 |
GO:0006298 | mismatch repair | 1.24e-02 | 1.00e+00 | 6.324 | 1 | 3 | 20 |
GO:0045862 | positive regulation of proteolysis | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 1 | 21 |
GO:0000718 | nucleotide-excision repair, DNA damage removal | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 4 | 21 |
GO:2001243 | negative regulation of intrinsic apoptotic signaling pathway | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 1 | 21 |
GO:0032201 | telomere maintenance via semi-conservative replication | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 5 | 21 |
GO:0008637 | apoptotic mitochondrial changes | 1.30e-02 | 1.00e+00 | 6.254 | 1 | 1 | 21 |
GO:0005856 | cytoskeleton | 1.33e-02 | 1.00e+00 | 3.461 | 2 | 12 | 291 |
GO:0006297 | nucleotide-excision repair, DNA gap filling | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 3 | 22 |
GO:0030863 | cortical cytoskeleton | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 1 | 22 |
GO:0036464 | cytoplasmic ribonucleoprotein granule | 1.36e-02 | 1.00e+00 | 6.187 | 1 | 4 | 22 |
GO:0016567 | protein ubiquitination | 1.37e-02 | 1.00e+00 | 3.442 | 2 | 5 | 295 |
GO:0043236 | laminin binding | 1.43e-02 | 1.00e+00 | 6.123 | 1 | 1 | 23 |
GO:0006513 | protein monoubiquitination | 1.43e-02 | 1.00e+00 | 6.123 | 1 | 1 | 23 |
GO:0043044 | ATP-dependent chromatin remodeling | 1.43e-02 | 1.00e+00 | 6.123 | 1 | 4 | 23 |
GO:0005844 | polysome | 1.43e-02 | 1.00e+00 | 6.123 | 1 | 4 | 23 |
GO:0001836 | release of cytochrome c from mitochondria | 1.49e-02 | 1.00e+00 | 6.061 | 1 | 3 | 24 |
GO:0040007 | growth | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 2 | 25 |
GO:0000722 | telomere maintenance via recombination | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 5 | 25 |
GO:0009566 | fertilization | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 1 | 25 |
GO:0070423 | nucleotide-binding oligomerization domain containing signaling pathway | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 3 | 25 |
GO:0042113 | B cell activation | 1.55e-02 | 1.00e+00 | 6.002 | 1 | 2 | 25 |
GO:0019901 | protein kinase binding | 1.57e-02 | 1.00e+00 | 3.338 | 2 | 21 | 317 |
GO:1900740 | positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 4 | 26 |
GO:0061418 | regulation of transcription from RNA polymerase II promoter in response to hypoxia | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 3 | 26 |
GO:0009409 | response to cold | 1.61e-02 | 1.00e+00 | 5.946 | 1 | 2 | 26 |
GO:0005813 | centrosome | 1.65e-02 | 1.00e+00 | 3.297 | 2 | 14 | 326 |
GO:0034612 | response to tumor necrosis factor | 1.67e-02 | 1.00e+00 | 5.891 | 1 | 2 | 27 |
GO:0043022 | ribosome binding | 1.67e-02 | 1.00e+00 | 5.891 | 1 | 3 | 27 |
GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 1.67e-02 | 1.00e+00 | 5.891 | 1 | 2 | 27 |
GO:0031492 | nucleosomal DNA binding | 1.67e-02 | 1.00e+00 | 5.891 | 1 | 4 | 27 |
GO:0007281 | germ cell development | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 1 | 28 |
GO:0019894 | kinesin binding | 1.73e-02 | 1.00e+00 | 5.839 | 1 | 1 | 28 |
GO:0019005 | SCF ubiquitin ligase complex | 1.80e-02 | 1.00e+00 | 5.788 | 1 | 1 | 29 |
GO:0006271 | DNA strand elongation involved in DNA replication | 1.86e-02 | 1.00e+00 | 5.739 | 1 | 7 | 30 |
GO:0005164 | tumor necrosis factor receptor binding | 1.86e-02 | 1.00e+00 | 5.739 | 1 | 2 | 30 |
GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling | 1.86e-02 | 1.00e+00 | 5.739 | 1 | 1 | 30 |
GO:0046677 | response to antibiotic | 1.92e-02 | 1.00e+00 | 5.692 | 1 | 2 | 31 |
GO:0007093 | mitotic cell cycle checkpoint | 1.92e-02 | 1.00e+00 | 5.692 | 1 | 2 | 31 |
GO:2001244 | positive regulation of intrinsic apoptotic signaling pathway | 2.04e-02 | 1.00e+00 | 5.602 | 1 | 2 | 33 |
GO:0097110 | scaffold protein binding | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 3 | 34 |
GO:0001895 | retina homeostasis | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 1 | 34 |
GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 2 | 34 |
GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | 2.10e-02 | 1.00e+00 | 5.559 | 1 | 2 | 34 |
GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand | 2.16e-02 | 1.00e+00 | 5.517 | 1 | 3 | 35 |
GO:0046982 | protein heterodimerization activity | 2.20e-02 | 1.00e+00 | 3.076 | 2 | 13 | 380 |
GO:0034332 | adherens junction organization | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 1 | 36 |
GO:0051402 | neuron apoptotic process | 2.22e-02 | 1.00e+00 | 5.476 | 1 | 2 | 36 |
GO:0008234 | cysteine-type peptidase activity | 2.29e-02 | 1.00e+00 | 5.437 | 1 | 3 | 37 |
GO:0051084 | 'de novo' posttranslational protein folding | 2.29e-02 | 1.00e+00 | 5.437 | 1 | 4 | 37 |
GO:0006284 | base-excision repair | 2.29e-02 | 1.00e+00 | 5.437 | 1 | 3 | 37 |
GO:0001541 | ovarian follicle development | 2.29e-02 | 1.00e+00 | 5.437 | 1 | 1 | 37 |
GO:0097191 | extrinsic apoptotic signaling pathway | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 3 | 38 |
GO:0071407 | cellular response to organic cyclic compound | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 2 | 38 |
GO:0070527 | platelet aggregation | 2.35e-02 | 1.00e+00 | 5.398 | 1 | 2 | 38 |
GO:0000781 | chromosome, telomeric region | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 3 | 39 |
GO:0022627 | cytosolic small ribosomal subunit | 2.41e-02 | 1.00e+00 | 5.361 | 1 | 4 | 39 |
GO:0030672 | synaptic vesicle membrane | 2.47e-02 | 1.00e+00 | 5.324 | 1 | 1 | 40 |
GO:0042110 | T cell activation | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 3 | 42 |
GO:0071230 | cellular response to amino acid stimulus | 2.59e-02 | 1.00e+00 | 5.254 | 1 | 3 | 42 |
GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 3 | 44 |
GO:0021762 | substantia nigra development | 2.71e-02 | 1.00e+00 | 5.187 | 1 | 2 | 44 |
GO:0044297 | cell body | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 2 | 46 |
GO:0006283 | transcription-coupled nucleotide-excision repair | 2.83e-02 | 1.00e+00 | 5.123 | 1 | 7 | 46 |
GO:0006921 | cellular component disassembly involved in execution phase of apoptosis | 2.90e-02 | 1.00e+00 | 5.092 | 1 | 5 | 47 |
GO:0008630 | intrinsic apoptotic signaling pathway in response to DNA damage | 3.02e-02 | 1.00e+00 | 5.031 | 1 | 5 | 49 |
GO:0003684 | damaged DNA binding | 3.02e-02 | 1.00e+00 | 5.031 | 1 | 7 | 49 |
GO:0034097 | response to cytokine | 3.08e-02 | 1.00e+00 | 5.002 | 1 | 1 | 50 |
GO:0004197 | cysteine-type endopeptidase activity | 3.08e-02 | 1.00e+00 | 5.002 | 1 | 3 | 50 |
GO:0000910 | cytokinesis | 3.14e-02 | 1.00e+00 | 4.974 | 1 | 2 | 51 |
GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding | 3.26e-02 | 1.00e+00 | 4.918 | 1 | 5 | 53 |
GO:0008233 | peptidase activity | 3.32e-02 | 1.00e+00 | 4.891 | 1 | 2 | 54 |
GO:0045216 | cell-cell junction organization | 3.32e-02 | 1.00e+00 | 4.891 | 1 | 2 | 54 |
GO:0044267 | cellular protein metabolic process | 3.33e-02 | 1.00e+00 | 2.757 | 2 | 29 | 474 |
GO:0000724 | double-strand break repair via homologous recombination | 3.38e-02 | 1.00e+00 | 4.865 | 1 | 3 | 55 |
GO:0051291 | protein heterooligomerization | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 2 | 56 |
GO:0000723 | telomere maintenance | 3.44e-02 | 1.00e+00 | 4.839 | 1 | 6 | 56 |
GO:0043433 | negative regulation of sequence-specific DNA binding transcription factor activity | 3.62e-02 | 1.00e+00 | 4.764 | 1 | 2 | 59 |
GO:0006302 | double-strand break repair | 3.80e-02 | 1.00e+00 | 4.692 | 1 | 4 | 62 |
GO:0019903 | protein phosphatase binding | 3.80e-02 | 1.00e+00 | 4.692 | 1 | 4 | 62 |
GO:0071260 | cellular response to mechanical stimulus | 3.98e-02 | 1.00e+00 | 4.624 | 1 | 5 | 65 |
GO:0006289 | nucleotide-excision repair | 4.17e-02 | 1.00e+00 | 4.559 | 1 | 11 | 68 |
GO:0003697 | single-stranded DNA binding | 4.17e-02 | 1.00e+00 | 4.559 | 1 | 5 | 68 |
GO:0034329 | cell junction assembly | 4.17e-02 | 1.00e+00 | 4.559 | 1 | 1 | 68 |
GO:0032355 | response to estradiol | 4.35e-02 | 1.00e+00 | 4.496 | 1 | 5 | 71 |
GO:0038096 | Fc-gamma receptor signaling pathway involved in phagocytosis | 4.53e-02 | 1.00e+00 | 4.437 | 1 | 6 | 74 |
GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 4.59e-02 | 1.00e+00 | 4.417 | 1 | 2 | 75 |
GO:0008584 | male gonad development | 4.59e-02 | 1.00e+00 | 4.417 | 1 | 3 | 75 |
GO:0035666 | TRIF-dependent toll-like receptor signaling pathway | 4.64e-02 | 1.00e+00 | 4.398 | 1 | 3 | 76 |
GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process | 4.70e-02 | 1.00e+00 | 4.379 | 1 | 7 | 77 |
GO:0002756 | MyD88-independent toll-like receptor signaling pathway | 4.76e-02 | 1.00e+00 | 4.361 | 1 | 3 | 78 |
GO:0070062 | extracellular vesicular exosome | 4.77e-02 | 1.00e+00 | 1.417 | 4 | 104 | 2400 |
GO:0034138 | toll-like receptor 3 signaling pathway | 4.82e-02 | 1.00e+00 | 4.342 | 1 | 3 | 79 |
GO:0019083 | viral transcription | 4.94e-02 | 1.00e+00 | 4.306 | 1 | 10 | 81 |
GO:0047485 | protein N-terminus binding | 5.24e-02 | 1.00e+00 | 4.220 | 1 | 5 | 86 |
GO:0045471 | response to ethanol | 5.24e-02 | 1.00e+00 | 4.220 | 1 | 3 | 86 |
GO:0006415 | translational termination | 5.30e-02 | 1.00e+00 | 4.203 | 1 | 10 | 87 |
GO:0016605 | PML body | 5.36e-02 | 1.00e+00 | 4.187 | 1 | 3 | 88 |
GO:0006928 | cellular component movement | 5.54e-02 | 1.00e+00 | 4.138 | 1 | 7 | 91 |
GO:0005200 | structural constituent of cytoskeleton | 5.54e-02 | 1.00e+00 | 4.138 | 1 | 8 | 91 |
GO:0071456 | cellular response to hypoxia | 5.60e-02 | 1.00e+00 | 4.123 | 1 | 6 | 92 |
GO:0006414 | translational elongation | 5.66e-02 | 1.00e+00 | 4.107 | 1 | 13 | 93 |
GO:0005737 | cytoplasm | 5.81e-02 | 1.00e+00 | 1.089 | 5 | 110 | 3767 |
GO:0034142 | toll-like receptor 4 signaling pathway | 5.83e-02 | 1.00e+00 | 4.061 | 1 | 3 | 96 |
GO:0006614 | SRP-dependent cotranslational protein targeting to membrane | 6.31e-02 | 1.00e+00 | 3.946 | 1 | 10 | 104 |
GO:0014069 | postsynaptic density | 6.37e-02 | 1.00e+00 | 3.932 | 1 | 3 | 105 |
GO:0006897 | endocytosis | 6.43e-02 | 1.00e+00 | 3.918 | 1 | 8 | 106 |
GO:0030496 | midbody | 6.54e-02 | 1.00e+00 | 3.891 | 1 | 5 | 108 |
GO:0002224 | toll-like receptor signaling pathway | 6.60e-02 | 1.00e+00 | 3.878 | 1 | 3 | 109 |
GO:0072562 | blood microparticle | 6.72e-02 | 1.00e+00 | 3.852 | 1 | 3 | 111 |
GO:0030529 | ribonucleoprotein complex | 6.78e-02 | 1.00e+00 | 3.839 | 1 | 8 | 112 |
GO:0097190 | apoptotic signaling pathway | 6.84e-02 | 1.00e+00 | 3.826 | 1 | 6 | 113 |
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 6.89e-02 | 1.00e+00 | 3.813 | 1 | 11 | 114 |
GO:0019058 | viral life cycle | 6.95e-02 | 1.00e+00 | 3.801 | 1 | 13 | 115 |
GO:0043524 | negative regulation of neuron apoptotic process | 7.07e-02 | 1.00e+00 | 3.776 | 1 | 2 | 117 |
GO:0006325 | chromatin organization | 7.13e-02 | 1.00e+00 | 3.764 | 1 | 5 | 118 |
GO:0007219 | Notch signaling pathway | 7.25e-02 | 1.00e+00 | 3.739 | 1 | 5 | 120 |
GO:0032496 | response to lipopolysaccharide | 7.30e-02 | 1.00e+00 | 3.727 | 1 | 4 | 121 |
GO:0006260 | DNA replication | 7.30e-02 | 1.00e+00 | 3.727 | 1 | 9 | 121 |
GO:0006511 | ubiquitin-dependent protein catabolic process | 7.60e-02 | 1.00e+00 | 3.669 | 1 | 5 | 126 |
GO:0016020 | membrane | 7.75e-02 | 1.00e+00 | 1.516 | 3 | 90 | 1681 |
GO:0000790 | nuclear chromatin | 7.77e-02 | 1.00e+00 | 3.635 | 1 | 9 | 129 |
GO:0006413 | translational initiation | 7.89e-02 | 1.00e+00 | 3.613 | 1 | 17 | 131 |
GO:0003735 | structural constituent of ribosome | 8.23e-02 | 1.00e+00 | 3.548 | 1 | 10 | 137 |
GO:0007507 | heart development | 8.35e-02 | 1.00e+00 | 3.527 | 1 | 7 | 139 |
GO:0006457 | protein folding | 8.58e-02 | 1.00e+00 | 3.486 | 1 | 7 | 143 |
GO:0061024 | membrane organization | 8.69e-02 | 1.00e+00 | 3.466 | 1 | 7 | 145 |
GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 8.69e-02 | 1.00e+00 | 3.466 | 1 | 4 | 145 |
GO:0045121 | membrane raft | 9.33e-02 | 1.00e+00 | 3.361 | 1 | 8 | 156 |
GO:0043005 | neuron projection | 9.38e-02 | 1.00e+00 | 3.352 | 1 | 6 | 157 |
GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | 9.84e-02 | 1.00e+00 | 3.280 | 1 | 7 | 165 |
GO:0030424 | axon | 9.90e-02 | 1.00e+00 | 3.271 | 1 | 4 | 166 |
GO:0031965 | nuclear membrane | 1.00e-01 | 1.00e+00 | 3.254 | 1 | 3 | 168 |
GO:0001525 | angiogenesis | 1.13e-01 | 1.00e+00 | 3.069 | 1 | 4 | 191 |
GO:0005739 | mitochondrion | 1.25e-01 | 1.00e+00 | 1.683 | 2 | 28 | 998 |
GO:0005759 | mitochondrial matrix | 1.34e-01 | 1.00e+00 | 2.813 | 1 | 14 | 228 |
GO:0006412 | translation | 1.35e-01 | 1.00e+00 | 2.801 | 1 | 20 | 230 |
GO:0008134 | transcription factor binding | 1.41e-01 | 1.00e+00 | 2.727 | 1 | 8 | 242 |
GO:0004842 | ubiquitin-protein transferase activity | 1.48e-01 | 1.00e+00 | 2.652 | 1 | 6 | 255 |
GO:0007283 | spermatogenesis | 1.52e-01 | 1.00e+00 | 2.613 | 1 | 8 | 262 |
GO:0005743 | mitochondrial inner membrane | 1.60e-01 | 1.00e+00 | 2.532 | 1 | 8 | 277 |
GO:0019899 | enzyme binding | 1.60e-01 | 1.00e+00 | 2.532 | 1 | 12 | 277 |
GO:0043234 | protein complex | 1.70e-01 | 1.00e+00 | 2.442 | 1 | 18 | 295 |
GO:0044281 | small molecule metabolic process | 1.71e-01 | 1.00e+00 | 1.404 | 2 | 58 | 1211 |
GO:0007411 | axon guidance | 1.82e-01 | 1.00e+00 | 2.329 | 1 | 13 | 319 |
GO:0008283 | cell proliferation | 1.87e-01 | 1.00e+00 | 2.289 | 1 | 14 | 328 |
GO:0030054 | cell junction | 1.91e-01 | 1.00e+00 | 2.254 | 1 | 5 | 336 |
GO:0003723 | RNA binding | 1.94e-01 | 1.00e+00 | 2.228 | 1 | 20 | 342 |
GO:0005925 | focal adhesion | 2.07e-01 | 1.00e+00 | 2.130 | 1 | 19 | 366 |
GO:0007155 | cell adhesion | 2.08e-01 | 1.00e+00 | 2.119 | 1 | 6 | 369 |
GO:0006508 | proteolysis | 2.13e-01 | 1.00e+00 | 2.084 | 1 | 9 | 378 |
GO:0008284 | positive regulation of cell proliferation | 2.15e-01 | 1.00e+00 | 2.069 | 1 | 8 | 382 |
GO:0007596 | blood coagulation | 2.51e-01 | 1.00e+00 | 1.816 | 1 | 18 | 455 |
GO:0042802 | identical protein binding | 2.65e-01 | 1.00e+00 | 1.727 | 1 | 20 | 484 |
GO:0005783 | endoplasmic reticulum | 2.98e-01 | 1.00e+00 | 1.527 | 1 | 10 | 556 |
GO:0042803 | protein homodimerization activity | 3.16e-01 | 1.00e+00 | 1.429 | 1 | 12 | 595 |
GO:0005615 | extracellular space | 4.61e-01 | 1.00e+00 | 0.744 | 1 | 17 | 957 |
GO:0008270 | zinc ion binding | 4.75e-01 | 1.00e+00 | 0.685 | 1 | 12 | 997 |
GO:0044822 | poly(A) RNA binding | 4.96e-01 | 1.00e+00 | 0.602 | 1 | 49 | 1056 |
GO:0005524 | ATP binding | 5.72e-01 | 1.00e+00 | 0.304 | 1 | 60 | 1298 |
GO:0006351 | transcription, DNA-templated | 6.14e-01 | 1.00e+00 | 0.148 | 1 | 31 | 1446 |
GO:0016021 | integral component of membrane | 7.36e-01 | 1.00e+00 | -0.307 | 1 | 27 | 1982 |
GO:0005886 | plasma membrane | 8.31e-01 | 1.00e+00 | -0.688 | 1 | 45 | 2582 |